Gene test may spare some breast cancer patients from chemo

NCT ID NCT03843346

Completed Knowledge-focused Sponsor: Cancer Trials Ireland Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a tumor gene test called the 21 gene Recurrence Score (OncotypeDx) changes doctors' recommendations for chemotherapy in women with early-stage, hormone receptor-positive breast cancer that has spread to lymph nodes. Researchers tracked how often chemotherapy was recommended before and after the test results were known. The goal was to see if the test helps avoid unnecessary chemotherapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors better decide which patients need chemotherapy, avoiding unnecessary treatment.
What could go wrong: This is a small, completed observational study in Ireland, so results may not apply to all populations. The test itself is already commercially available, so the main question is about its real-world impact.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BREAST CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Beaumont Hospital

Dublin, Dublin 9, Ireland
Bon Secour Cork

Cork, Ireland
Cork University Hospital

Cork, Ireland
Letterkenny University Hospital

Letterkenny, Co. Donegal, Ireland
Mater Misericordiae University Hospital & Mater Private Hospital

Dublin, Dublin 7, Ireland
St James' Hospital

Dublin, Ireland
St Vincent's University Hospital

Dublin, Dublin 4, Ireland
University Hospital Galway

Galway, Ireland
University Hospital Limerick

Limerick, V94 F858, Ireland
University Hospital Waterford

Waterford, Ireland

More trials for these conditions

Other studies related to the condition(s) this trial covers.