Virus injected into tumors shows promise in early breast cancer safety trial
NCT ID NCT05376527
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tested a modified vaccinia virus (VV-GMCSF-Lact) injected directly into tumors of 34 women with recurrent or metastatic breast cancer that no longer responded to standard treatments. The main goal was to check safety and find the highest safe dose. Researchers monitored side effects, virus levels in blood, and any tumor response. Because this is a Phase 1 study, it focuses on safety, not on curing the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- modified vaccinia virus (VV-GMCSF-Lact) injected into tumors
- What this could lead to
- If successful, this could point toward a new treatment option for hard-to-treat metastatic breast cancer by using a virus to attack tumors from within.
- What could go wrong
- This is a very early Phase 1 safety trial with only 34 people. It is designed to find safe doses, not to prove effectiveness. The virus may cause side effects like fever or liver issues, and it may not shrink tumors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Moscow, Russia, 115478, Russia
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N.N. Petrov National Medical Research Center of Oncology
Saint Petersburg, Russia, 197758, Russia
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National Medical Research Radiological Centre (NMRRC) of the Ministry of Health of the Russian Federation
Obninsk, Russia, 249036, Russia
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Oncology Research Center, LLC
Saint Petersburg, Russia, 197758, Russia