Old arthritis drug shows promise against aggressive breast cancer

NCT ID NCT03709446

Completed Disease control Sponsor: Joseph Sparano Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested leflunomide, a pill usually used for arthritis, in 17 women with metastatic triple negative breast cancer (a fast-growing type). The goal was to see if it is safe and can help control the cancer. The drug works by blocking a protein the cancer needs to grow.

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Conditions

The condition(s) this trial relates to.

breast disorder breast neoplasm Her2-receptor negative breast cancer triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST DISEASES BREAST NEOPLASMS METASTATIC TRIPLE-NEGATIVE BREAST CANCER

Contacts and locations

Locations

Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Mt Sinai Chelesa

New York, New York, 10011, United States
Mt Sinai West

New York, New York, 10019, United States

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