New drug combo may offer fewer side effects for early breast cancer patients
NCT ID NCT01853748
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a drug called T-DM1 causes fewer side effects than the standard treatment of paclitaxel plus trastuzumab in people with stage I HER2-positive breast cancer. About 500 participants were randomly assigned to one of the two treatments. The researchers also tracked how long participants remained cancer-free after treatment. The goal was to find a gentler but effective option for early-stage disease.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arnold Palmer Cancer Center-Greensburg
Greensburg, Pennsylvania, 15601, United States
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Arnold Palmer Medical Oncology Oakbrook
Greensburg, Pennsylvania, 15642, United States
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Arnold Palmer Medical Oncology-Mt Pleasant
Mount Pleasant, Pennsylvania, 15666, United States
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Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
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Baylor College of Medicine-Baylor Clinic
Houston, Texas, 77030, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Dana Farber Cancer Institute at Faulkner Hospital
Boston, Massachusetts, 02130, United States
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Dana-Farber Cancer Insitute at Londonderry Hospital
Londonderry, New Hampshire, 03053, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute at Milford Hospital
Milford, Massachusetts, 01757, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Eastern Maine Medical Center's Cancer Care
Brewer, Maine, 04412, United States
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Florida Cancer Specialists
Fort Myers, Florida, 33916, United States
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Florida Cancer Specialists
St. Petersburg, Florida, 337054, United States
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Georgetown Hospital
Washington D.C., District of Columbia, 20007, United States
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Harris County Hospital District-Ben Taub General Hospital
Houston, Texas, 77030, United States
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Harris County Hospital District-Smith Clinic
Houston, Texas, 77054, United States
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Hartford Healthcare Cancer Institute at The Hospital of Central Connecticut
New Britain, Connecticut, 06050, United States
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Hartford Hospital
Hartford, Connecticut, 06102, United States
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Indiana University - Springmill Medical Clinic
Indianapolis, Indiana, 46290, United States
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Indiana University - Wishard Hospital
Indianapolis, Indiana, 46202, United States
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Indiana University Health - Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202, United States
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Indiana University Health - University Hospital
Indianapolis, Indiana, 46202, United States
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Johns Hopkins - Green Spring Station
Lutherville, Maryland, 21093, United States
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Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21287, United States
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Lehigh Valley Hospital/Lehigh Valley Health Network
Allentown, Pennsylvania, 18103, United States
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Lowell General Hospital
Lowell, Massachusetts, 01854, United States
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Loyola University Medical Center
Maywood, Illinois, 60153, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mass General North Shore Cancer Center
Danvers, Massachusetts, 01923, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center Westchester
East White Plains, New York, 10604, United States
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Memorial Sloan Kettering Cancer Center-Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Cancer Center-Mercy
Rockville Centre, New York, 11570, United States
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Memorial Sloan Kettering Cancer Center-Sleepy Hollow
Sleepy Hollow, New York, 10591, United States
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Memorial Sloan Kettering Cancer Center-Suffolk
Commack, New York, 11725, United States
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Midstate Medical Center
Meriden, Connecticut, 06451, United States
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Mountain States Tumor Institute
Boise, Idaho, 83712, United States
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Mountain States Tumor Institute
Fruitland, Idaho, 83619, United States
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Mountain States Tumor Institute
Meridian, Idaho, 83642, United States
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Mountain States Tumor Institute
Nampa, Idaho, 83686, United States
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Mountain States Tumor Institute
Twin Falls, Idaho, 83301, United States
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New Hampshire Oncology-Hematology, PA
Concord, New Hampshire, 03301, United States
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New Hampshire Oncology-Hematology, PA
Hooksett, New Hampshire, 03106, United States
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New Hampshire Oncology-Hematology, PA
Laconia, New Hampshire, 03246, United States
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Northwell Health/Monter Cancer Center
Lake Success, New York, 11042, United States
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Queens Hospital Center, Comprehensive Cancer Center
Jamaica, New York, 11432, United States
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Rex Cancer Center
Raleigh, North Carolina, 27607, United States
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Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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Siteman Cancer Center - South County
St Louis, Missouri, 63129, United States
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Siteman Cancer Center - St. Peters
City of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center - West County
St Louis, Missouri, 63141, United States
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Suburban Hospital Cancer Program
Bethesda, Maryland, 20817, United States
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Tennessee Oncology/Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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The Ohio State University
Columbus, Ohio, 43212, United States
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UPMC Cancer Center Jefferson Regional Med Ctr
Jefferson Hills, Pennsylvania, 15025, United States
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UPMC Cancer Center St. Clair Hospital
Pittsburgh, Pennsylvania, 15232, United States
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UPMC CancerCenters Butler
Butler, Pennsylvania, 16001, United States
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UPMC Conemaugh Cancer Center
Johnstown, Pennsylvania, 15905, United States
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UPMC East
Monroeville, Pennsylvania, 15146, United States
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UPMC Horizon (Greenville)
Greenville, Pennsylvania, 16125, United States
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UPMC Horizon (Shenango)
Farrell, Pennsylvania, 16121, United States
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UPMC Jameson Cancer Center
New Castle, Pennsylvania, 16105, United States
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UPMC McKeesport
McKeesport, Pennsylvania, 15132, United States
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UPMC Northwest (Franklin)
Seneca, Pennsylvania, 16346, United States
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UPMC Northwest (Oil City)
Seneca, Pennsylvania, 16346, United States
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UPMC Passavant
Pittsburgh, Pennsylvania, 15237, United States
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UPMC Pinnacle Harrisburg
Harrisburg, Pennsylvania, 17101, United States
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UPMC Presbyterian Shadyside
Pittsburgh, Pennsylvania, 15232, United States
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UPMC St. Margaret
Pittsburgh, Pennsylvania, 15215, United States
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UPMC and the Washington Hospital Center
Washington, Pennsylvania, 15301, United States
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UPMC/HVHS Cancer Center, UPMC Beaver
Beaver, Pennsylvania, 15143, United States
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Univeristy of Michigan Health System
Ann Arbor, Michigan, 48109, United States
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University of Alabama Birmingham
Birmingham, Alabama, 35249, United States
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University of California San Francisco
San Francisco, California, 94115, United States
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University of Chicago Comprehensive Cancer Center at Silver Cross Hospital
New Lenox, Illinois, 60451, United States
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University of Chicago Medical Center for Advanced Care Orland Park
Orland Park, Illinois, 60462, United States
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University of North Carolina
Chapel Hill, North Carolina, 27599, United States
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University of Washington Seattle Cancer Care Alliance
Seattle, Washington, 98109, United States
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Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232, United States
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Washington Cancer Institute at Medstar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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Washington University, School of Medicine
St Louis, Missouri, 63110, United States
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William W Backus Hospital
Norwich, Connecticut, 06360, United States
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