Fat grafting before implant may improve breast reconstruction after mastectomy

NCT ID NCT04343820

Completed Disease control Sponsor: Institut Cancerologie de l'Ouest Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a breast reconstruction method for women who had a mastectomy, with or without radiation. Surgeons first used fat grafting to prepare the chest wall, then placed a breast implant just under the skin (not under the muscle) to reduce pain and animation. The study followed 60 women for 12 months to check for complications and evaluate how the breast looked and felt.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: breast reconstruction procedure (prepectoral implant with lipo-preparation)
What this could lead to: If successful, this approach could offer women a less painful breast reconstruction option with better aesthetic results and fewer complications after mastectomy.
What could go wrong: This is a small, completed feasibility study with 60 participants, so results may not apply to all patients. Complications like infection, implant removal, or poor cosmetic outcome are possible.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm female breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER FEMALE

Contacts and locations

Locations

Institut de Cancérologie de l'Ouest René Gauducheau

Saint-Herblain, 44805, France

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