Can exercise tweak tumor biology? new trial tests aerobic vs. resistance training in breast cancer

NCT ID NCT05297773

Completed Disease control Sponsor: Fundacao Champalimaud Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether structured exercise—either aerobic cycling or resistance training—can improve health-related biomarkers in women with breast cancer undergoing neoadjuvant therapy (chemotherapy or endocrine therapy before surgery). The main focus is on changes in Ki-67, a marker of tumor cell growth, along with secondary measures like body composition, fitness, quality of life, and tumor biology. Participants are randomly assigned to aerobic training, resistance training, or a relaxation control group for the duration of their treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exercise (aerobic training or resistance training)
What this could lead to: If exercise proves beneficial, it could become a standard part of breast cancer treatment to improve outcomes and well-being.
What could go wrong: This is a mid-sized trial, and results may not apply to all patients. Exercise may not significantly affect tumor biology.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm insomnia Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER

Contacts and locations

Locations

Faculdade de Motricidade Humana - Universidade de Lisboa

Lisbon, Cruz-Quebrada, 1495-751, Portugal
Fundação Champalimaud

Lisbon, Lisbon District, 1400-038, Portugal

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