Leftover tumor after breast cancer treatment: a hidden risk revealed
NCT ID NCT07714382
First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time
Summary
This study looks back at medical records of women with triple-negative breast cancer who had chemotherapy and radiation before surgery. It focuses on those who still had cancer cells left after treatment (residual disease) and tracks how long they lived without the cancer coming back. The goal is to understand which factors are linked to worse outcomes, so doctors can better identify who needs more aggressive follow-up.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help identify which patients with residual TNBC are at highest risk, guiding more personalized follow-up and treatment decisions.
- What could go wrong
- As a retrospective study, it can show associations but not prove cause and effect. Results may be limited by the quality and completeness of medical records.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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100 people
The number who actually took part.
- Started
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May 2026
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult female patients with histologically confirmed triple-negative breast cancer (TNBC) who received neoadjuvant systemic therapy followed by definitive surgery and were treated at the study institution during the study period. Data will be collected retrospectively from medical records to evaluate the association between residual disease after neoadjuvant therapy and survival outcomes.
- Ages
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18 years and older
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female patients aged ≥18 years. Histologically confirmed triple-negative breast cancer (TNBC). Received standard neoadjuvant systemic therapy. Underwent definitive breast surgery after completion of neoadjuvant therapy. Availability of postoperative pathological assessment documenting residual disease or pathological complete response (pCR). Complete clinical, pathological, treatment, and follow-up data available in the medical records. Exclusion Criteria: * Patients with metastatic disease at initial diagnosis. Patients who did not complete neoadjuvant therapy or did not undergo definitive surgery. Patients with incomplete or missing essential clinical, pathological, or follow-up data. Patients with a history of another primary malignancy that could affect survival analysis.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Sohag university
Sohag, Egypt
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Other studies related to the condition(s) this trial covers.
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