Parkinsonian disorder

This early-phase study tested a gene therapy that delivers a protective protein (GDNF) directly to the brain in 25 people with advanced Parkinson's disease. The goal was to see if it is safe and to gather early information on whether it might help protect dopamine-producing brain…

This study looks at whether dalfampridine, a drug already used for walking problems in multiple sclerosis, can improve mobility in people with vascular parkinsonism or Parkinson-plus syndromes. Participants who do not respond well to standard levodopa treatment will receive dalfa…

This study tests whether a 10-week home exercise program, delivered through eHealth technology, can improve walking, physical activity, and quality of life in people with mild-to-moderate Parkinson's disease. The program combines motor and cognitive exercises tailored to each per…

This phase 2 trial tests whether adding experimental drugs (MK-4830, boserolimab, or lenvatinib) to the standard combination of pembrolizumab and chemotherapy can improve outcomes for people with extensive-stage small cell lung cancer. Participants receive one of these new combin…

This clinical trial is testing a combination of two drugs—an immunotherapy (pembrolizumab/quavonlimab) and a targeted therapy (lenvatinib)—as a first treatment for people with advanced hepatocellular carcinoma, a type of liver cancer that cannot be removed by surgery. The study a…

This phase 3 trial tests whether adding vibostolimab to pembrolizumab (Keytruda) helps people with PD-L1 positive metastatic non-small cell lung cancer live longer than pembrolizumab alone. Over 1,200 participants received either the combination or pembrolizumab every three weeks…

This phase 3 trial tests whether a combination of enfortumab vedotin and pembrolizumab, given before and after bladder removal surgery, works better than standard chemotherapy for muscle-invasive bladder cancer. About 800 participants will be randomly assigned to one of the two t…

This study tested whether adding another drug to the immunotherapy pembrolizumab (Keytruda) can help people with advanced non-small cell lung cancer whose disease got worse after initial treatment. 128 participants received one of three drug combinations. The goal was to see if t…

This study tested a device that uses focused ultrasound to create a small burn in a brain area linked to tremors. It included 26 people with Parkinson's disease whose tremors did not improve with medication. The goal was to see if the procedure is safe and reduces shaking.

This pilot study explores whether the timing and amount of protein in meals can help preserve muscle health and improve sleep in people with Parkinson disease. Participants follow either a protein redistribution diet (low protein during the day, high protein at dinner) or a prote…

This phase 2 trial tested whether infusions of stem cells (HB-adMSCs) from healthy donors could help people with Parkinson's disease. 60 participants received either the stem cells or a placebo (salt water) to see if the treatment improved movement and daily living. The study is …

This Phase 2 study tested whether low doses of nilotinib, a drug already approved for leukemia, are safe and affect brain markers in 75 people with Parkinson's disease. Participants took either a placebo or one of two low doses of nilotinib daily for 12 months. The goal was to se…

This study tested whether matching drug combinations to specific biomarkers in advanced non-small cell lung cancer could improve response. 245 patients who had not received prior treatment were grouped by two biomarkers (GEP and TMB) and given pembrolizumab plus another drug. The…

This phase 3 trial tested a new drug called HRG2010 in 165 people with Parkinson's disease who experience motor fluctuations—times when their symptoms return before the next dose. The study compared HRG2010 to a standard sustained-release levodopa to see if it could reduce daily …

This study tested a drug called BIIB122 in 650 people with early-stage Parkinson's disease. The goal was to see if the drug could slow down the worsening of symptoms like movement problems and daily living tasks. Participants took either BIIB122 or a placebo daily for up to 3 yea…

This study tested whether people with ALS or Parkinson's disease, along with healthy volunteers, could follow the MIND diet — a mix of the Mediterranean and DASH diets thought to protect the brain. Over several weeks, 43 participants received a cookbook, educational materials, an…

This study tested a new under-the-skin shot version of the cancer drug pembrolizumab (Keytruda) in 142 people with advanced solid tumors. The goal was to see how well the body absorbs the drug compared to the standard IV infusion. Researchers also checked for side effects and how…

This study tested the safety of a new drug, ABBV-951, given as a continuous 24-hour infusion under the skin for people with advanced Parkinson's disease. 118 adults who had completed earlier studies took part. The goal was to see if the drug is safe and tolerable over 96 weeks, w…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before and after bladder removal surgery helps people with muscle-invasive bladder cancer live longer without the cancer coming back. About 900 participants took part. The goal was to s…

This study tested whether adding other treatments to the drug pembrolizumab can help people with advanced melanoma that hasn't been treated before. Researchers checked safety and how many people's tumors shrank or disappeared. The trial involved 335 participants and was part of a…

This study tested a drug called lenrispodun in 79 people with Parkinson's disease who experience 'wearing off' symptoms and involuntary movements. Participants took the drug or a placebo once daily alongside their usual treatment. The goal was to see if lenrispodun could improve …

This study looked at whether a newer type of deep brain stimulation (DBS) electrode, which can steer electrical signals more precisely, improves mood and movement in people with Parkinson's disease. 105 participants received the directional electrodes as part of their standard ca…

This Phase 3 trial tested a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard treatments (regorafenib or TAS-102) in 441 people with advanced colorectal cancer that had stopped responding to prior therapy. The goal was to see if the new combin…

This study tested a new drug called vutiglabridin in 99 people with early Parkinson's disease. Participants took either the drug or a placebo daily for 24 weeks. The goal was to see if the drug is safe and can help control symptoms like movement problems. The study is complete, b…

This Phase 3 trial tested whether combining pembrolizumab (an immunotherapy) with epacadostat (a drug that boosts the immune response) works better than standard drugs (sunitinib or pazopanib) for people with advanced kidney cancer that hasn't been treated before. The study enrol…

This study follows one Parkinson's patient who has been receiving A-dopamine directly into the brain via a pump for years. The goal is to monitor safety during long-term use and manage a gradual, individualized dose reduction until the treatment stops, switching to an alternative…

This study tested whether adding two drugs (lenvatinib and pembrolizumab) to a standard liver cancer treatment called TACE helps people with liver cancer that cannot be removed by surgery. About 479 participants received either the drug combo plus TACE or TACE alone. The goal was…

This study is testing the long-term safety of ABBV-951, a drug given as a continuous 24-hour infusion under the skin for people with advanced Parkinson's disease. About 130 adults who completed an earlier study will continue receiving the treatment. Researchers will monitor side …

This early-phase study tested whether low-dose lithium aspartate (30-45 mg/day) could slow Parkinson's disease in 15 people diagnosed within the last 4 years. Researchers measured changes in brain scans and blood markers linked to disease progression. The goal was to see if lithi…

This early study tested a new approach for people with advanced Parkinson's disease who have severe motor fluctuations despite optimized oral medication. A pump placed in the abdomen delivered a special form of dopamine (A-dopamine) directly into the brain's fluid spaces, aiming …

This study tested whether a drug called deferiprone can safely reduce harmful iron buildup in the brains of people with early-stage Parkinson's disease. Forty participants took either deferiprone or a placebo for six months. The goal was to see if lowering brain iron could slow t…

This study tested whether exenatide, a drug already used for type 2 diabetes, can slow the progression of Parkinson's disease. About 194 people with early-stage Parkinson's received either exenatide or a placebo once a week for two years. The goal was to see if the drug could pro…

This large phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) and the targeted therapy olaparib (Lynparza) to standard chemotherapy helps women with advanced ovarian cancer that does not have a BRCA mutation. Over 1,300 participants received eithe…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This phase 3 trial tested whether adding lenvatinib and pembrolizumab to standard chemotherapy helps people with advanced gastroesophageal cancer live longer. About 895 participants received either the new combination or chemo alone. The study is complete, and results will show i…

This large Phase 3 trial tested whether adding the immunotherapy pembrolizumab (Keytruda) to standard hormone therapy (enzalutamide plus ADT) could improve outcomes for men with metastatic hormone-sensitive prostate cancer. Over 1,200 participants were enrolled. The study was unb…

This large phase 3 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) can prevent liver cancer from coming back in people who had successful surgery or ablation. 959 participants received either pembrolizumab or a placebo every three weeks. The study measured ho…

This small safety trial tested a device called ExAblate that uses focused ultrasound to create a tiny lesion in the brain area linked to Parkinson's motor symptoms. Seven people with advanced Parkinson's took part to see if the procedure is safe and might improve movement. The go…

This study tested whether the drug VTX3232 is safe for people with early-stage Parkinson's disease. Eleven participants took the drug for 28 days and were monitored for side effects. The goal was to check safety and how the drug moves through the body, not to cure the disease.

This phase 2 study tested whether a person's own stem cells (called HB-adMSCs) could help control Parkinson's disease symptoms. Twenty-four adults with early to moderate Parkinson's received either stem cell infusions or a placebo over 32 weeks, and were followed for safety. The …

This Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced bile duct cancer live longer. The study enrolled 158 Chinese adults with cancer that had spread or could not be removed by…

This early-phase trial tested a new stem cell treatment for Parkinson's disease in 12 people who had been diagnosed at least 5 years earlier. The treatment uses dopamine-producing cells made from embryonic stem cells, injected into the brain. The main goal was to check safety, bu…

This study tested whether giving amantadine early in Parkinson's disease, before patients develop involuntary movements from their main medication (L-DOPA), could prevent or delay those movements. Researchers enrolled 210 people with early-stage Parkinson's who had been on L-DOPA…

This study tested a device called ExAblate that uses focused ultrasound to create a tiny lesion in the brain area causing Parkinson's motor problems. 36 participants were randomly assigned to receive the real treatment or a sham (fake) procedure. The goal was to see if the treatm…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine/cisplatin) helps people with advanced bile duct or gallbladder cancer live longer. Over 1,000 participants received either the combination or chemo plus a placebo. The goal…

This study tested a new drug called CVN424 in 64 people with early Parkinson's disease who were not yet taking any Parkinson's medications. For 12 weeks, half received CVN424 and half received a placebo. The goal was to see if CVN424 could improve both motor symptoms (like moveme…

This small study tested whether a device that uses focused ultrasound (sound waves) can safely improve movement problems in people with Parkinson's disease. Six participants who already had one side treated received the second side. The goal was to check safety and see if symptom…

This pilot study tested whether a focused ultrasound device could temporarily open the blood-brain barrier to deliver the drug Cerezyme into the brains of 4 people with Parkinson's disease. The main goal was to see if the procedure was safe and could successfully get the drug int…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, against standard chemotherapy in 827 people with advanced endometrial cancer that had worsened after initial treatment. The goal was to see if the combo could delay cancer growth and extend life. Results …

This phase 3 trial tested the drug pembrolizumab (Keytruda) against a placebo in 1,177 people with early-stage non-small cell lung cancer who had already had surgery. The goal was to see if pembrolizumab could delay the cancer from coming back. Participants received either the dr…

This phase 2 trial tested a combination of two drugs, favezelimab and pembrolizumab (MK-4280A), in 163 people with either a type of skin cancer (cutaneous squamous cell carcinoma) or endometrial cancer. The goal was to see if the treatment could shrink or eliminate tumors. The st…

This study tested whether taking citalopram for 26 months could slow the buildup of harmful amyloid plaques in the brain area responsible for visual thinking in people with Parkinson's disease. Fifty-eight participants aged 65 and older were randomly assigned to receive either ci…

This early-stage trial tested a vaccine called UB-312 in 8 people with Parkinson's disease or multiple system atrophy. The vaccine is designed to train the immune system to attack abnormal clumps of a protein called alpha-synuclein, which are linked to these brain disorders. The …

This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can reduce impulse control disorders like compulsive gambling, shopping, or eating. 117 people with Parkinson's and moderate-to-severe impulse control problems took either pimavanse…

This study tested whether long-term aerobic walking can slow the progression of Parkinson's disease. 57 people with mild-to-moderate Parkinson's walked for 150 minutes per week at a moderate pace. Researchers measured changes in movement, thinking, driving safety, and brain healt…

This phase 2 trial tested whether metformin, a widely used diabetes medication, could improve symptoms in people with Parkinson's disease. Sixty participants who were already taking levodopa received either metformin or a placebo. Researchers measured changes in movement and dail…

This early-stage trial tested a drug called allopregnanolone in 10 people with Parkinson's disease. The goal was to see if a larger study is possible and if the drug is safe. Participants received weekly infusions for 12 weeks, and researchers looked for signs of improvement on b…

This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The t…

This phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy before and after surgery helps people with stomach or gastroesophageal junction cancer. Over 1,000 participants received either pembrolizumab plus chemo or placebo pl…

This Phase 3 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) could help prevent kidney cancer from coming back after surgery. Nearly 1,000 participants who had their kidney removed due to renal cell carcinoma received either pembrolizumab or a placebo. The st…

This study tested whether adding the drug pembrolizumab to standard chemotherapy helps Chinese adults with stomach or gastroesophageal junction cancer. Participants received the drug combination or a placebo before and after surgery. The goal was to see if the combination improve…

This study tested whether a combination of olaparib (a targeted therapy) and pembrolizumab (an immunotherapy) works better than standard chemotherapy plus pembrolizumab for people with advanced triple-negative breast cancer that initially responded to chemo-immunotherapy. The tri…

This large Phase 3 trial tested adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy for people with advanced stomach cancer that cannot be removed by surgery. Over 1,500 participants received either pembrolizumab plus chemo or a placebo plus chemo. The…

This phase 3 trial tested whether adding the drug olaparib (Lynparza) to standard treatment with pembrolizumab (Keytruda) and chemotherapy helps people with advanced nonsquamous lung cancer live longer without their disease worsening. Over 1,000 participants received either olapa…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation helps people with high-risk, locally advanced cervical cancer live longer without their cancer growing. About 1,060 participants received either pembrolizumab or a placebo alongside t…

This phase 3 trial tested whether adding lenvatinib to pembrolizumab helps people with untreated advanced non-small cell lung cancer whose tumors have PD-L1 levels of 1% or higher. Over 600 participants received either the combination or pembrolizumab alone. The study measured ho…

This completed Phase 3 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) works better than the targeted drug brentuximab vedotin (Adcetris) for people with classical Hodgkin lymphoma that has relapsed or not responded to prior therapy. 304 participants were ran…

This completed phase II study tested a combination of two drugs—tadalafil (Cialis) and pembrolizumab (Keytruda)—in 7 adults with advanced head and neck cancer that had spread or come back. The goal was to see if the combination was safe and could help control the disease. Because…

This study tested whether adding lenvatinib to pembrolizumab works better than pembrolizumab alone for people with advanced melanoma that hasn't been treated yet. About 674 adults with stage III or IV melanoma took part. The goal was to see if the combination helps people live lo…

This study tested a combination of two drugs, favezelimab and pembrolizumab, in 137 people with certain blood cancers like Hodgkin lymphoma and B-cell lymphoma. The goal was to see if the combination was safe and could shrink tumors. The study also looked at each drug alone in so…

This phase 3 trial tested whether adding the targeted therapy lenvatinib to a standard combination of immunotherapy (pembrolizumab) and chemotherapy could help people with a common type of advanced lung cancer live longer. The study enrolled 761 adults with metastatic nonsquamous…

This study tested whether a drug called deferiprone, which removes extra iron from the body, could slow down Parkinson's disease. 372 adults with early Parkinson's took either the drug or a placebo for 9 months. The goal was to see if the drug could reduce both movement and non-m…

This study tested whether adding lenvatinib to pembrolizumab (immunotherapy) helps people with advanced bladder cancer live longer or keep their cancer from growing. It included 505 people whose cancer had spread and who could not take the chemotherapy drug cisplatin. The trial w…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, against the usual treatments for people with advanced colorectal cancer that had spread and stopped responding to prior therapy. About 563 adults took part. The goal was to see if the new combo helped peo…

This study tested whether adding pembrolizumab (an immunotherapy) to lenvatinib (a targeted therapy) works better than lenvatinib alone for people with advanced liver cancer. About 794 adults took part. The combination did not significantly improve how long patients lived or dela…

This study tested whether directional deep brain stimulation (DBS) can improve walking and balance problems in people with Parkinson's disease. Nineteen patients who already had DBS electrodes implanted took part. Researchers compared different stimulation settings to see which h…

This large Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemoradiation helps people with locally advanced head and neck cancer live longer without the disease getting worse. Over 800 participants received either pembrolizumab plu…

This phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps women with advanced cervical cancer live longer and keep the disease from growing. Over 600 women with persistent, recurrent, or metastatic cervical cancer took part. The …

This completed study tested whether two diabetes medications, sitagliptin and dapagliflozin, are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 participants took either a drug or a placebo daily for a short time. The goal w…

This early-phase study tested whether injecting human neural stem cells into specific brain areas is safe for people with Parkinson's disease. Twelve participants received the cell therapy at one of three dose levels. The main goal was to check for side effects, while also lookin…

This phase 2 trial tests a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard chemotherapy in people with classical Hodgkin lymphoma that has come back or stopped responding to treatment. About 200 participants will be randomly assigned to rece…

This early-phase study tested a gene therapy called BBM-P002 in 10 people with advanced Parkinson's disease. The treatment is given as a single injection directly into the brain during a neurosurgical procedure. The main goal was to check safety, but researchers also looked for s…

This Phase 2 trial tested an experimental capsule called TJ0113 in 149 people with early-stage Parkinson's disease. Participants took either 200 mg, 400 mg, or a placebo daily for 12 weeks. The main goal was to see if the drug improved motor symptoms, measured by a standard ratin…

This study tested whether a combination of platelet-rich plasma (PRP) and stem cell therapy could help people with Parkinson's disease. Thirty patients aged 30–50 received three PRP injections over three months, followed by a booster dose after one year. Researchers measured chan…

This study tested whether adding lenvatinib to pembrolizumab works better than pembrolizumab alone for people with advanced melanoma who haven't had prior treatment. It involved 131 Chinese participants with stage III or IV melanoma that could not be removed by surgery. The goal …

This study tested the safety and effectiveness of tavapadon, an experimental drug, in 992 people with Parkinson's disease over 58 weeks. Participants took flexible doses of the medication to see how well it controlled symptoms and what side effects occurred. The goal was to under…

This study tested a new way to place deep brain stimulation electrodes in people with Parkinson's disease. Instead of the usual method that requires patients to be awake for testing, the new approach uses MRI scans and a computer model to guide the surgery under general anesthesi…

This study tested several combinations of the immunotherapy drug pembrolizumab (Keytruda) with other drugs in 90 people with advanced esophageal cancer that had already progressed after one prior treatment. The goal was to see if these combinations are safe and can shrink tumors …

This early-phase study tested whether a drug called Leukine (sargramostim) is safe for people with Parkinson's disease when taken for 36 months. Seven participants received a weight-based dose 5 days a week. Researchers monitored side effects, immune system changes, and motor sym…

This large Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard trastuzumab plus chemotherapy could improve outcomes for people with advanced HER2-positive stomach or gastroesophageal junction cancer. The study enrolled 738 participants …

This study tested a new deep brain stimulation (DBS) system that uses directional leads to treat Parkinson's disease. 26 adults with Parkinson's whose symptoms were not well controlled by medication took part. The goal was to see if the system could improve motor function and qua…

This study tested whether adding an experimental drug (epacadostat) to an immunotherapy (pembrolizumab) works better than standard chemotherapy for people with advanced head and neck cancer that has come back or spread. 89 adults took part. The main goal was to see how many patie…

This study tested whether a combination of two drugs, lenvatinib and pembrolizumab, could help people with head and neck cancer that has returned or spread and is no longer responding to standard treatments. About 408 participants were randomly assigned to receive the combination…

This study tested two different brain areas for deep brain stimulation (like a pacemaker for the brain) in 27 people with tremor-dominant Parkinson's disease. The goal was to see which target—the posterior subthalamic area or the subthalamic nucleus—better reduces shaking. Each p…

This study tested a combination of two drugs, pembrolizumab and lenvatinib, in 160 people with a rare type of advanced kidney cancer (non-clear cell renal cell carcinoma) that had not been treated before. The goal was to see if the drugs could shrink tumors. The study found that …

This completed Phase 2 trial tested whether lixisenatide, a daily injection already used for diabetes, could slow the worsening of motor symptoms in 156 people with early Parkinson's disease. Participants received either the drug or a placebo for 12 months, alongside their usual …

This phase 3 trial tests a new drug combination, MK-4280A (favezelimab plus pembrolizumab), against standard treatments (regorafenib or TAS-102) in 94 Chinese adults with advanced, PD-L1 positive colorectal cancer that has worsened after prior therapy. The main goal is to see if …

This study tested a combination of the immunotherapy drug pembrolizumab with two investigational drugs (MK-4830 or MK-0482) in 102 people with advanced non-small cell lung cancer that had not been treated before and tested positive for a protein called PD-L1. The main goal was to…

This Phase 3 trial tested whether tavapadon, a daily pill, can improve movement and daily activities in people with early Parkinson's disease. Over 300 participants took either tavapadon or a placebo for 27 weeks. The study measured changes in motor function and daily living skil…

This study tested an experimental drug called IkT-148009 (risvodetinib) in 137 people with early, untreated Parkinson's disease. Participants took one of three doses or a placebo daily for 12 weeks. The goal was to check safety and see if the drug improves movement and daily livi…

This early-phase study tested the safety and tolerability of a new drug called PDM608 in 64 healthy adults. The goal was to see if the drug is safe enough to study further in people with Parkinson's disease. Participants received either PDM608 or a placebo, and researchers monito…

This completed Phase 2 trial tested a drug called DAAOI-P in 61 people with Parkinson's disease who also have dementia. The goal was to see if the drug could improve walking, reduce falls, and ease neuropsychiatric symptoms. Participants received either DAAOI-P or a placebo pill …

This early-phase study tested a new drug called boserolimab (MK-5890), either alone or combined with the immunotherapy pembrolizumab (KEYTRUDA), in 182 adults with advanced solid tumors, including lung and breast cancers. The main goals were to check safety and how the drug moves…

This study tested an experimental oral drug, UCB0599, in 496 people with early-stage Parkinson's disease. The goal was to see if the drug could safely slow down the worsening of symptoms over 18 months compared to a placebo. Participants were randomly assigned to receive either t…

This study tested several combinations of the immunotherapy drug pembrolizumab (Keytruda) with other experimental drugs in people with stage III melanoma that can be surgically removed. The goal was to see if these combinations are safe and more effective than current treatments …

This study tested a new drug (MK-1454) injected directly into tumors, combined with the immunotherapy pembrolizumab, for people with advanced head and neck cancer that had not been treated before. The goal was to see if the combination worked better than pembrolizumab alone. 18 a…

This early-phase study tested an experimental drug (MK-1454) injected directly into tumors, either alone or with pembrolizumab (Keytruda), in 156 people with advanced solid tumors or lymphomas. The main goals were to find the safest dose and check for side effects. The study also…

This completed phase 1/2 trial tested the safety and effectiveness of pembrolizumab (Keytruda) alone or combined with other drugs (quavonlimab or lenvatinib) in 56 people with melanoma that had spread to the brain. Participants had not received steroids recently and were neurolog…

This study tested whether adding vibostolimab to the standard immunotherapy pembrolizumab can better prevent melanoma from returning after surgery. About 1,600 people with high-risk stage II to IV melanoma took part. The goal was to see if the combination keeps cancer away longer…

This study tested a new type of deep brain stimulation (DBS) that adapts in real time to help people with Parkinson's disease who experience freezing of gait—a sudden inability to move their feet. Standard DBS delivers constant stimulation, but this adaptive system uses brain sig…

This early-stage trial tested a new drug called vibostolimab, either alone or combined with other cancer drugs, in 474 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the dr…

This study tested whether adding the immunotherapy drug pembrolizumab to standard hormone therapy (enzalutamide plus ADT) could help men with metastatic hormone-sensitive prostate cancer live longer or delay cancer growth. The trial enrolled 186 Chinese men and was stopped early …

This phase 3 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to best supportive care helps Asian patients with advanced liver cancer live longer. 453 patients who had already received one prior treatment were randomly assigned to get either pembrolizum…

This study tested whether rivastigmine, a drug already used for memory problems in Parkinson's, can reduce falls. 600 people with Parkinson's who had fallen in the past year took either the drug or a placebo patch for 12 months and recorded their falls. The goal was to see if the…

This completed Phase 3 trial tested whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can slow the progression of early Parkinson's disease. 410 people with early-stage Parkinson's took either the supplement or a placebo for 52 weeks. Researchers meas…

This early-stage trial tested the safety of a new drug called BIIB094 in 62 adults with Parkinson's disease. The drug was given as a spinal injection to see if it is safe and how the body processes it. The study included people with and without certain genetic variations. Results…

This early-stage trial tested the safety of a new drug called HER-096 for Parkinson's disease. It involved 32 people: healthy volunteers who got a single dose, and Parkinson's patients who received multiple doses over four weeks. The main goal was to check for side effects and ho…

This Phase 3 trial tested whether adding the targeted drug lenvatinib to standard chemotherapy plus the immunotherapy pembrolizumab helps people with advanced nonsquamous non-small cell lung cancer live longer without their cancer growing. The study enrolled 201 adults in China w…

This early-stage trial tested a gene therapy for Parkinson's disease. The treatment involved delivering a gene called GAD into a brain region that controls movement. Only 14 people took part, and the main goal was to check safety, not whether it works. The study is now complete.

This study tested whether digital analysis of voice recordings can help doctors tell apart Parkinson's disease and multiple system atrophy, two brain disorders with similar early symptoms. Researchers recorded the voices of 28 people (patients with each condition and healthy cont…

This study tested whether artificial intelligence (AI) can help diagnose Parkinson's disease by analyzing brain scans called DaTSCAN SPECT. Researchers used machine learning to tell the difference between healthy people, those with Parkinson's, and those with similar conditions. …

This study developed and tested a self-questionnaire called the 3PDQ to help diagnose pain that is directly caused by Parkinson's disease, rather than from other causes. Researchers enrolled 227 Parkinson's patients with chronic pain and compared their questionnaire answers with …

This completed study tested a new radioactive tracer called [18F] - FD17 for PET imaging to detect clumps of a protein called alpha-synuclein in the brain. These clumps are linked to Parkinson's disease, multiple system atrophy, and a sleep disorder that often precedes Parkinson'…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tested a new blood test that uses a microfluidic chip to detect Alzheimer's disease. Researchers collected blood and urine samples from 150 people, including those with Alzheimer's, other brain diseases, and healthy volunteers. The goal was to see if the test could acc…

This study tested a new PET scan tracer, [18F] LBT-999, to see if it can distinguish Parkinson's disease from essential tremor as well as the current standard SPECT scan. Researchers compared the two imaging methods in 152 patients. If the PET scan works equally well, it could of…

This study tested whether a brain scan (fMRI) can detect early signs of Parkinson's disease by looking at a part of the brain called the superior colliculus. Researchers compared newly diagnosed Parkinson's patients (not yet on medication) with healthy volunteers. The goal is to …

This completed trial tested a software called mPDia that uses MRI brain scans to help doctors diagnose neurodegenerative parkinsonism, a group of movement disorders including Parkinson's disease. The study involved 221 adults and compared mPDia's accuracy to standard PET scans. T…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether group drumming classes could improve quality of life and motor skills in people with Parkinson's or Huntington's disease. Eighteen participants took drum lessons twice a week for 12 weeks. Researchers measured changes in anxiety, depression, hand functio…

This study tests whether a home-based, virtually-supervised exercise program combining high-intensity endurance and resistance training is safe and feasible for people with Parkinson's disease. It also looks at how exercise affects thinking skills and related biological markers. …

This study tested whether virtual reality exercises can improve balance and mobility in people with Parkinson's disease as well as or better than standard physical therapy. Sixty-two participants were split into two groups: one did virtual reality therapy and the other did conven…

This study tested whether combining a non-invasive brain stimulation technique (rTMS) with daily smell training could help people with Parkinson's disease recover their sense of smell and taste. 120 participants were split into four groups to compare the combo therapy against eac…

This study tested whether a gentle, non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) can improve movement problems in people with Parkinson's disease. Thirty-seven participants received either real or sham stimulation over 10 se…

This pilot study compares two types of virtual reality (VR) rehabilitation for people with Parkinson's disease: immersive VR using a headset and non-immersive VR using a tablet. The goal is to see which approach better improves walking, balance, and thinking skills. Sixteen parti…

This study tested whether a software tool (Guide XT) can replace the long, exhausting process of choosing the best stimulation settings for Parkinson's patients with brain implants. Twenty-six patients took part. The goal was to see if the software was at least as good as the sta…

This trial compares four different spinal cord stimulation settings to see which one best improves walking and balance in people with Parkinson's disease. Eleven participants who already have a spinal cord stimulator will try each setting in a random order. The study measures cha…

This study tested whether doing both physical and mental exercises together, delivered through remote sessions, can improve quality of life and balance in people with Parkinson's disease. Thirty participants completed the program, which focused on tasks like walking while solving…

This pilot study tested whether a specially adapted mindfulness program is feasible for people with Parkinson's disease. The program included shorter meditations, more movement, and extra breaks. Researchers enrolled 20 patients to see if they could complete the program and if it…

This pilot study tested a wrist-worn device called Felix that delivers gentle electrical stimulation to suppress hand tremors. The device uses artificial intelligence to adjust stimulation in real time based on each person's tremor. 38 adults with essential tremor or Parkinson's …

This study tested whether adding action observation therapy (watching videos of movements) to standard physical therapy could help people with Parkinson's disease who experience freezing of gait. 42 participants aged 50-80 completed the trial. The goal was to see if this approach…

This study tested whether an apomorphine pump can improve quality of life for people in the early stages of Parkinson's disease who have just started experiencing motor complications. 134 adults aged 65 or younger with mild Parkinson's used either the pump plus standard care or s…

This study tested whether full-spectrum CBD oil can help with anxiety and depression in people with Parkinson's disease. Twenty-seven participants took one of three daily doses (30, 60, or 300 mg) for two months. Researchers measured changes in anxiety and depression scores, alon…

This small pilot study tested whether using inflatable cuffs on the legs (blood flow restriction) during low-intensity stepping exercise could safely improve mobility and quality of life in people with advanced Parkinson's disease. Three participants exercised twice a week for 8 …

This study tested two types of deep brain stimulation in 20 people with Parkinson's disease: standard omnidirectional stimulation and a newer directional steering method. The goal was to see if steering the stimulation could better control motor symptoms like muscle rigidity. Par…

This study tested a spinal stimulation device to help people with advanced Parkinson's disease walk better and improve balance. Two participants received an implanted stimulator and underwent rehabilitation for 3 to 5 months. The goal was to see if the approach is safe and could …

This study tested whether adding a swallowing behavioral therapy to standard medical care helps Parkinson's patients who have trouble swallowing. 32 people took part. The goal was to improve swallowing safety and reduce choking risk.

This study looked at whether a structured 8-week mindfulness-based stress reduction (MBSR) program is practical for people with Parkinson's disease. Thirty-one participants were enrolled to see how many could complete the program, including weekly group sessions and a full medita…

This study tested a wearable system (a haptic module and insole device) designed to detect freezing of gait in people with Parkinson's disease and then trigger cues to help them start walking again. The study enrolled 31 participants and aimed to validate the device's performance…

This study tested whether a non-invasive ultrasound treatment can improve movement in people with Parkinson's disease. Ten participants received both real and placebo treatments in a random order, with neither they nor the evaluators knowing which was which. The main goal was to …

This study tested whether doing fast bodyweight exercises at home, supervised remotely, can reduce bradykinesia (slowness of movement) in people with Parkinson's disease. Forty-six participants aged 50 and older were assigned to either high-speed or usual-speed exercises for 12 w…

This study tested whether a rehabilitation program that combines physical balance exercises with mental tasks (like counting or decision-making) improves balance more than standard physical therapy alone in people with Parkinson's disease. Sixty participants with early-to-moderat…

This study tested a smartphone-based wearable system that gives real-time feedback to people with Parkinson's disease while they do balance exercises at home. Nine participants aged 50 to 75 with mild to moderate Parkinson's used the system or followed a paper-based routine. The …

This study tested whether high doses of methylphenidate (Ritalin) could improve walking and attention in 69 people with advanced Parkinson's disease who still had severe gait problems despite standard treatments. Participants received either methylphenidate or a placebo for three…

This study tested whether training with rhythmic sounds (like a beat) could help people with Parkinson's disease move their arms better. 38 participants did arm exercises with or without the sounds for 21 days. Those who used rhythmic sounds showed lasting improvements in hand de…

This study tested whether memantine, a drug that reduces overactive brain signals, can improve walking and attention in people with advanced Parkinson's disease. Twenty-eight non-demented patients with severe gait issues took memantine or a placebo for three months. The goal was …

This study tested whether people with Parkinson's disease can safely use a brain stimulation device (tDCS) at home. Six participants aged 40 to 70 used the device for 20 minutes daily over a week, with video call support. The goal was to see if it's practical and safe, and to che…

This pilot study tested a new way of using deep brain stimulation (DBS) to help Parkinson's disease patients who experience freezing of gait—a sudden inability to move their feet—even with standard DBS. Ten participants received stimulation at different frequencies in two brain a…

This study tested whether two drugs, oxycodone (a strong painkiller) and levodopa (a Parkinson's medication), can reduce nerve pain caused by Parkinson's disease. 67 adults with Parkinson's and chronic nerve pain took one of the drugs or a placebo for 8 weeks, alongside their usu…

This study looked at vision problems in people with Parkinson's disease compared to healthy individuals. Researchers tested eye and visual skills, then had some Parkinson's patients do simple eye exercises. The goal was to see if these exercises could slow vision decline or reduc…

This study tested if a one-time, non-invasive foot stimulation treatment (called AMPS) could temporarily improve movement, balance, and heart function in people with Parkinson's disease. 40 participants with mild to moderate Parkinson's were included. The goal was to see if this …

This study tested a program that teaches people with early-stage Parkinson's disease how to add more physical activity into their daily lives. 89 participants either received the program or were placed on a waiting list. Researchers measured their daily moderate-to-vigorous activ…

This study tested whether personalized sound cues (like a custom beat) played through a smartphone could improve walking in people with Parkinson's disease. 60 participants walked while their steps were measured by sensors. The goal was to see if tailored cues could make steps mo…

This study tested whether a self-administered, mild electrical brain stimulation technique (transcranial direct current stimulation) can improve walking in people with Parkinson's disease. Twenty-four participants used the device at home while performing walking tasks, both alone…

This study tested whether adding kinesiotaping (a special tape applied to the forearm) to a home exercise program can reduce hand tremor in people with Parkinson's disease. 45 adults were randomly assigned to receive either therapeutic taping plus exercise, sham (placebo) taping …

This study tested three types of group psychological therapy for people with Parkinson's: one for adjusting to diagnosis, one for anxiety and depression, and one for memory and thinking problems. 138 participants took part, and the therapy was designed to be delivered by non-ment…

This study looked at whether combining exercise training with a ketone ester drink can improve muscle endurance and heart fitness in people with Parkinson's disease. Nineteen participants completed a cycling program while taking the supplement. Researchers measured changes in how…

This study tested an 8-session stress management program for people recently diagnosed with Parkinson's disease and their caregivers. The program teaches relaxation techniques, healthy habits, and ways to change negative thinking. Researchers wanted to see if the program was prac…

This pilot study tested whether a daily prebiotic fiber bar is safe and tolerable for people with Parkinson's disease. Twenty adults (ages 60-75) ate one bar each day for four weeks. Researchers checked gut symptoms, quality of life, and markers of intestinal inflammation from bl…

This study tested whether injections of Myobloc (botulinum toxin type B) into the salivary glands can safely reduce drooling in people with Parkinson's disease. Fifty-four participants received either Myobloc or a placebo. The main goal was to see if drooling severity and frequen…

This Phase 3 study tested whether injections of MYOBLOC (a botulinum toxin type B) into the salivary glands can safely reduce troublesome drooling in adults. 187 participants received either MYOBLOC or a placebo. The main goals were to measure changes in saliva flow and overall i…

This Phase 2 trial tested an experimental drug called UCB0022 in 207 people with advanced Parkinson's disease. The goal was to see if adding UCB0022 to standard treatment could reduce the daily hours spent in the 'OFF' state, when Parkinson's symptoms return. Participants took ei…

This study tested two rhythm-based walking exercises in 74 people with mild-to-moderate Parkinson's disease. Participants walked to music or while singing for 12 weeks. Researchers measured walking speed and brain activity to see which method worked better.

This study looked at whether adding resistance or aerobic exercise to standard rehab helps walking and muscle strength in people with Parkinson's disease who also have muscle loss (sarcopenia). 32 participants were assigned to either resistance or aerobic exercise for 6 weeks. Th…

This study tested whether specially designed virtual reality exercises could improve arm and hand function in people with Parkinson's disease. 44 participants completed the program, which focused on matching arm positions. The goal was to see if this approach could help with ever…

This study tested whether adding arm and hand exercises to leg exercises during high-intensity circuit training helps people with Parkinson's disease more than leg exercises alone. Sixty-four participants completed eight exercise classes. Researchers measured changes in reaction …

This study tested whether adding a device that applies pressure to specific points on the feet (automated mechanical peripheral stimulation, or AMPS) to a regular exercise program could improve heart health and movement in people with Parkinson's disease. Forty participants were …

This small study tested a robotic device that massages the back to see if it helps people with Parkinson's disease move better, feel less back pain, and sleep better. Nineteen adults with mild to moderate Parkinson's took part in four 40-minute sessions over two weeks. The result…

This study tested whether people with Parkinson's disease can use augmented reality glasses (Cue X) to do daily rehabilitation exercises at home. 30 participants used the glasses for 6 weeks, guided remotely by a physiotherapist. The goal was to see if this technology is practica…

This study tested whether dihydroergotine mesylate extended-release tablets can reduce drooling in people with Parkinson's disease. 120 patients took either the drug or a placebo for 12 weeks. Researchers measured changes in saliva weight and also looked at effects on thinking sk…

This study tested a modified Mediterranean-ketogenic diet in 52 people with Parkinson's disease to see if it is safe for their gut microbiome. The diet limits carbs and emphasizes healthy fats and lean proteins. Researchers measured gut inflammation and other markers to check for…

This study tested whether bright light therapy can help with sleepiness and mood problems in people with Parkinson's disease. 69 participants were randomly assigned to receive bright light, a placebo light, or an active control. The goal was to see if the therapy reduces daytime …

This study tested whether a split-belt treadmill (where each leg moves at a different speed) can reduce freezing of gait during turning in people with Parkinson's disease. 26 participants completed a 4-week training program that included practicing everyday turning scenarios. The…

This study tested a new type of deep brain stimulation (DBS) called adaptive DBS (aDBS) in 25 people with Parkinson's disease. Unlike standard continuous DBS, aDBS adjusts stimulation in real time based on brain signals. The goal was to see if aDBS uses less total electrical ener…

This study tested a special brace (STIL Orthosis) designed to reduce shaking (tremor) in people with Parkinson's disease. 25 participants had their tremor measured while wearing the active brace, a fake brace, and no brace. The goal was to see if the device could make everyday ta…

This study looked at whether a special exercise program focusing on muscle power (moving quickly) could help people with Parkinson's disease who have slow movements (bradykinesia). Twenty-two adults with Parkinson's were split into two groups: one did standard exercises, and the …

This small study tested whether a spinal cord stimulator (a device that sends mild electrical pulses to the spinal cord) could reduce freezing of gait in people with Parkinson's disease. Ten participants who did not get relief from standard treatments received the implant. Resear…

This study tested a wearable device called PDVibe2 that delivers vibration therapy to improve walking and balance in people with Parkinson's disease. 12 participants with mild to moderate Parkinson's used the device while researchers measured their gait and movement. The goal was…

This study tested a psychological intervention to help people with Parkinson's disease who experience freezing of gait triggered by anxiety. 41 participants learned strategies to manage stress and attention while walking. The goal was to see if this approach could reduce the time…

This study tested whether infusing tiny bubbles of oxyhydrogen gas could help people with Parkinsonism. 35 adults received the infusion alongside their usual care. Researchers measured changes in disease severity, thinking ability, and quality of life. The goal was to see if this…

This small study tested whether donepezil (Aricept), a drug that boosts the brain chemical acetylcholine, could improve walking and balance in 6 people with Parkinson's disease. Researchers also looked at how brain shrinkage in a key area relates to gait problems. The goal is to …

This small pilot study tested whether a weekly hula dance program is practical and enjoyable for people with Parkinson's disease. Fifteen participants took hula classes for three months, and researchers measured how many completed the program and assessed changes in movement and …

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants used either bright-white or dim-red light boxes at different times of day. The goal was to find the most effective dose to ease slee…

This early study tested a new drug called Lu AF28996 in 57 people with Parkinson's disease. The main goal was to see if the drug is safe and how the body handles it. Researchers measured side effects and drug levels in the blood. This is a first step to see if the drug might help…

This study looked at whether nicergoline, a drug that improves blood flow in the brain, can help people with swallowing problems caused by stroke, Parkinson's disease, or dementia. 92 adults were given either a low or high dose for 12 weeks. The goal was to see if swallowing impr…

This study tested whether a non-invasive magnetic stimulation of the spinal cord, combined with treadmill walking, could improve gait problems in people with Parkinson's disease. 76 participants with moderate Parkinson's and walking difficulties received either real or sham stimu…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve balance and walking in people with Parkinson's disease. 21 participants received both low- and high-frequency stimulation in a double-blind …

This study tested a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for musculoskeletal pain in people with Parkinson's disease. Researchers aimed to see if stimulating a specific brain area could reduce pain and improve quality of life. 62 parti…

This study tested whether a 6-month in-home cycling program, combined with social engagement and coaching calls, can improve daily function and sleep in people with Parkinson disease. Fourteen participants cycled at home with staff support and received follow-up calls. The goal w…

This study looked at whether inner ear problems cause balance issues in Parkinson's disease and if a headset that stimulates the inner ear can help. 72 people with Parkinson's took part. They received a 20-minute stimulation session while researchers measured freezing of gait and…

This completed phase 2 trial tested whether a non-invasive magnetic coil placed on the upper back could improve walking in 42 Parkinson's patients who already have deep brain stimulation but still have gait problems. Participants received either active or placebo stimulation in a…

This Phase 2 trial tested whether insulin sprayed into the nose is safe for people with Parkinson's disease. Over 3 weeks, 31 participants received either intranasal insulin or a placebo. Researchers monitored safety events like low blood sugar and weight loss, and also looked at…

This study tested whether doing special handwriting exercises at home for 12 weeks could improve hand function in people with Parkinson's disease. Fifty-three participants were split into two groups: one did the handwriting program, the other did not. The main goal was to see if …

This study tested whether low-intensity focused ultrasound (LIFUP) can safely improve motor symptoms like tremor and stiffness in people with Parkinson's disease. 31 participants received either real or sham ultrasound to a specific brain area. The goal was to see if this non-inv…

This pilot study tested whether using a voice-activated smart speaker (Apple HomePod mini) could improve psychosocial well-being in 48 people with Parkinson's disease. Participants in the intervention group received a user protocol, the device, training, and tech support for 8 we…

This study looked at whether a type of physical therapy called proprioceptive neuromuscular facilitation (PNF) can help people with Parkinson's disease improve their trunk mobility, walking, and balance, and reduce fear of falling. The study involved 42 participants with mild to …

This study tested a drug called suvecaltamide for people with Parkinson's disease who still have moderate to severe tremor despite taking other medications. Over 17 weeks, 169 participants received either the drug or a placebo, with doses adjusted for best effect. The goal was to…

This study tested whether weekly improvisational dance classes could improve thinking and daily function in people with Parkinson's disease. Twenty participants were randomly assigned to either take the 12-week dance class or continue their usual routine. Researchers measured cha…

This study tested whether a virtual reality treadmill (C-Mill) could improve walking and balance in people with Parkinson's disease better than standard physical therapy. Twenty patients aged 60-80 with mild to moderate Parkinson's were randomly assigned to either VR treadmill re…

This pilot study tested whether adding a low dose of methylphenidate (Ritalin) or atomoxetine (Strattera) to standard physical therapy improves gait and balance in people with Parkinson's disease more than physical therapy alone. 23 participants were randomly assigned to one of t…

This study tested whether a special reaction training program using lights and quick movements can improve balance, reaction time, and movement control in people with Parkinson's disease. 26 participants were split into two groups: one did the reaction training plus standard exer…

Nearly 90% of people with Parkinson's disease experience speech problems. This study tested a home-based program combining speech exercises and physical activity, delivered via telemedicine, to improve speech intelligibility. 104 veterans with Parkinson's and speech impairment pa…

This study tested whether electrical stimulation of the spinal cord could improve walking in people with Parkinson's disease whose symptoms are not well controlled by medication. Five participants received a spinal cord stimulator, and researchers measured changes in walking abil…

This study tested if a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve thinking and walking in people with Parkinson's disease. 41 participants received either real or fake rTMS sessions over two weeks. The results…

This study tested whether adding Baduanjin, a gentle mind-body exercise, to standard physical therapy helps older adults with Parkinson's disease. 27 people in a nursing home took part, doing either standard therapy alone or standard therapy plus Baduanjin for 12 weeks. Researche…

This study looked at whether nutritional supplements, specifically N-acetyl cysteine (NAC) given orally and intravenously, could support brain function in people with Parkinson's disease. The researchers measured dopamine activity and markers of inflammation in the brain using sp…

This study looked at whether a gentle electrical stimulation of the vagus nerve through the ear, combined with physical therapy, can help people with Parkinson's disease move better and feel better. Twenty-five adults with Parkinson's who could walk without help took part. The go…

This study looked at whether combining two types of exercises—Otago and Frenkel's—could help people with Parkinson's disease strengthen key muscles and improve balance. Forty participants aged 55 to 75 with mild to moderate Parkinson's took part. The exercises focused on muscles …

This study tested a new way to program deep brain stimulation (DBS) in 15 people with Parkinson's disease. The goal was to see if this different programming pattern could improve their quality of life. Participants already had DBS devices implanted and were monitored for changes …

This study tested whether repeated doses of ketamine, given through an IV, can safely and effectively reduce depression in people with Parkinson's disease. 51 adults aged 40-80 with both conditions took part. Researchers compared ketamine to a placebo and used brain scans to expl…

This study tested whether Erickson hypnosis can reduce chronic pain in people with Parkinson's disease. 33 participants were split into two groups: one received weekly hypnosis sessions for 2 months, the other got usual care. The main goal was to see if pain intensity changed fro…

This trial tested a wearable device called STAT-ON, which automatically records when Parkinson's patients have trouble moving ('Off' periods) and when they move well ('On' periods). The goal was to see if giving this detailed information to doctors helps them adjust medication mo…

This small study tested a non-invasive device called Transcranial Pulse Stimulation (TPS) in 14 people with Parkinson's disease. TPS uses sound wave pulses to stimulate the brain. Participants received 12 sessions over four weeks. Researchers checked if TPS safely improved moveme…

This study tested whether playing a special video game that involves movement could improve walking and balance in people with Parkinson's disease. Twenty-five patients with stubborn gait problems played either the active game or a placebo game without movement. Researchers measu…

This completed study tested a smart electric vehicle designed to detect and improve walking problems in 120 people aged 60-85 with Parkinson's disease or dementia. The vehicle uses artificial intelligence to monitor gait, provide feedback, and assist with balance. The main goal w…

This study tested whether online dance classes or online therapeutic exercises, both with music, could improve quality of life for people with Parkinson's disease. Forty adults with mild to moderate Parkinson's took part. The goal was to see if these social, online programs could…

This study tested whether a virtual reality exercise program (exergames) could improve balance and reduce fall risk in people with mild to moderate Parkinson's disease. One hundred participants were randomly assigned to either VR exercise or standard therapy for 3 months. Researc…

This study tested whether a culturally tailored program using a fitness tracker and a peer partner could help older Latino adults with Parkinson's disease become more active. Ten participants wore activity monitors, watched educational videos, met weekly with a peer online, and j…

This study tested whether a daily 20-minute nerve stimulation (TENS) applied to the ankle could improve bladder control in people with Parkinson's disease or multiple system atrophy. A total of 110 participants used either an active or a sham device for 3 months. The main goal wa…

This completed study tested whether low-frequency magnetic stimulation (rTMS) on the cerebellum could help people with Parkinson's disease. Forty participants received either real or sham stimulation daily for two weeks. Researchers measured changes in movement, brain activity, a…

This study tested whether a mild electrical current applied to the front of the brain (tACS) could improve speech and thinking in people with Parkinson's disease. 28 participants received either real or fake (sham) stimulation for 20 minutes daily over two weeks. Researchers meas…

This study tested whether stimulating the front part of the brain could improve mood and behavioral symptoms in people with Parkinson's disease. Five participants received a special brain device that could record and stimulate brain activity. The goal was to see if this approach …

This study tested whether adding video-based games to standard exercise could improve arm movement, balance, and quality of life in people with Parkinson's disease. Thirty participants aged 50-80 with mild to moderate Parkinson's and a stooped posture took part. One group did sta…

This study tested whether an 8-week mindfulness program (MBSR) could improve quality of life, thinking, and mood in 107 people with Parkinson's disease. Participants were randomly assigned to MBSR or a supportive education group, with sessions held online due to COVID-19. The goa…

This study tested a new drug called UCB0022 in 100 healthy volunteers and people with Parkinson's disease. The main goal was to check if the drug is safe and how the body processes it. This is an early-stage trial, so it does not prove the drug works for Parkinson's symptoms yet.

This study tested whether using immersive virtual reality or computer-based brain training could improve thinking and memory in people with Parkinson's or Huntington's disease who have mild cognitive problems. Sixty-four participants were randomly assigned to one of three groups:…

This study tested whether music therapy can prevent hospital-related confusion (delirium) in people with Parkinson's disease or Lewy body dementia. 30 hospitalized adults took part, receiving either music therapy sessions, self-directed music listening, or standard care. Research…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This study tested a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) for swallowing difficulties (dysphagia) in people with Parkinson's disease. 26 patients received either 5 Hz or 10 Hz stimulation to the part of the brain that controls swallowin…

This study looked at how partnered tango dancing affects brain activity in people with Parkinson's disease. Researchers measured brain signals during leg movements before and after dance training. The goal was to see if dance could improve motor control by changing how brain regi…

This small study tested whether combining aerobic exercise with virtual reality games could improve thinking, walking, and balance in people with Parkinson's disease. Ten participants used a recumbent stepper while playing VR games. The goal was to see if this approach is feasibl…

This study tested whether a walker that provides visual and auditory cues (lights and sounds) can help people with Parkinson's disease who experience freezing of gait. Thirty participants walked on a 7-meter path with and without the cueing walker. The goal was to see if the cues…

This study tested whether practicing two tasks at once (like walking while talking) with different priorities can help people with Parkinson's disease. 30 participants completed various balance, walking, and thinking tests. The goal was to see if this training improves physical p…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This small study tested a digital therapy called DART that uses augmented reality to help people with Parkinson's disease and a deep brain stimulator improve their walking and balance. Seven adults participated, and researchers measured changes in motor function and walking dista…

This pilot study tested whether an 8-week mindfulness meditation program could reduce embarrassment from tremor in 21 people with Parkinson's disease. Participants wore a smartwatch to track tremor during daily life. The study aims to see if this approach is worth testing in a la…

This study tested a new way of caring for people with Parkinson's disease. The goal was to help 214 participants achieve their personal goals and improve their quality of life. The approach involved proactive, integrated care and patient empowerment, compared to standard care.

This small study tested an experimental drug called SAGE-718 in 18 people with Parkinson's disease who also had mild thinking and memory problems. The main goal was to see if the drug was safe and tolerable. Researchers also looked at whether it might help with thinking, mood, an…

This study tested a drug called SAGE-718 in 86 people with Parkinson's disease who have mild memory or thinking problems. Participants took either the drug or a placebo pill for a set time. The main goal was to see if SAGE-718 could improve processing speed, measured by a symbol-…

This study tested whether deep brain stimulation of a specific brain region could improve walking and balance in people with advanced Parkinson's disease. Six participants received both real and sham stimulation in a blinded crossover design. The goal was to see if this approach …

This study tested whether a gait re-education program using a sequential square treadmill (Tapiz Fisior) could help people with mild-to-moderate Parkinson's disease walk better and reduce fall risk. Fifty-two participants were randomly assigned to either the treadmill program plu…

This study tested whether a high-intensity functional training (HIFT) program could improve both thinking and physical abilities in people with Parkinson's disease. Fifteen participants with early-stage Parkinson's completed the program, which included strength and coordination e…

This pilot study tested whether clonidine, a drug used for high blood pressure, can reduce impulse control disorders (like gambling or overeating) in people with Parkinson's disease. 38 participants received either clonidine or a placebo for 8 weeks. The study measured changes in…

This study tested two non-invasive treatments—brain stimulation (tDCS) and neuromuscular electrical stimulation (NMES)—to help people with swallowing difficulties caused by stroke or Parkinson's disease. A total of 110 adults aged 18 to 85 took part. The goal was to see if these …

This study tested whether learning Argentine tango can improve thinking, mood, and movement in people with mild-to-moderate Parkinson's disease. Forty-five participants took either tango lessons or did general walking and stretching twice a week for six weeks. Researchers measure…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This study tests a device that synchronizes two types of brain stimulation — deep brain stimulation (DBS) and transcranial alternating current stimulation (tACS) — in people with Parkinson's disease. Only 2 participants will be enrolled to see if the device can lock the timing of…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study tested whether a simple pegboard ring test can reliably measure arm and hand function in people with Parkinson's disease. 47 volunteers completed the test along with other standard assessments. The goal was to see if this test could be a useful tool for doctors and the…

This study looked at how the brain's emotional centers work in people with Parkinson's disease who had just received a deep brain stimulator implant. Researchers measured brain activity while patients listened to sounds or saw images with emotional meaning. The goal was to better…

This study looked at 69 people with Parkinson's disease to see if sleep quality is linked to thinking skills and disease severity. Participants completed tests of sleep, memory, attention, and movement in one session. The goal is to better understand how these factors relate, whi…

This completed study from France examined perfectionism, depression, and anxiety in 59 people with Parkinson's disease. Participants filled out standard questionnaires about perfectionism, mood, and anxiety. The goal was to better understand how these psychological factors relate…

This study looked at how the brain chemical serotonin works in people with multiple system atrophy (MSA), a rare and serious nerve disease. Researchers used special PET scans to measure serotonin receptors in the brains of 53 adults with MSA or Parkinson's disease. The goal was t…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study used body-worn sensors to track movement in 132 people with early, untreated Parkinson's disease over 12 months. The goal was to see if digital measurements could accurately measure disease progression and match standard clinical assessments. The findings may help deve…

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This study looked at how alcohol affects tremors in people with essential tremor, dystonia, and Parkinson's disease. 45 participants received either an alcoholic drink or a non-alcoholic placebo on separate days. Researchers measured tremor changes using a motion sensor and clini…

This study looked at 733 people with Parkinson's disease to see if certain genetic variations in the AQP4 gene are linked to worse motor, cognitive, and sleep symptoms. Participants provided blood samples, wore sleep monitors, and completed online tests. The goal is to better und…

This study looked at 158 people with Parkinson's disease to see if different thinking patterns are linked to differences in brain structure and activity. Researchers grouped participants based on their cognitive profiles and compared brain scans and EEG readings. The goal was to …

This study looked at how leg muscles work in people with Parkinson's disease when they walk forward and backward while also doing a mental task. Researchers compared 30 Parkinson's patients to healthy people of similar age. The goal was to understand why multitasking while walkin…

This completed study looked at how the drug deferiprone affects blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers. Researchers measured markers of oxidative stress and iron levels in the lab. The goal was to better understand these diseases, not to t…

This study looked at why people with Parkinson's disease often gain weight after deep brain stimulation of the subthalamic nucleus. Researchers measured energy use and metabolism in 20 patients before and after treatment. The goal was to understand if weight gain is due to change…

This study aims to create a better way to help older adults with muscle, bone, or nerve problems who are at risk of falling. Researchers will first study patients' health profiles and balance, then test a simple exercise program called OTAGO to see if it prevents falls. The goal …

This study looked at 70 Parkinson's patients to see if their personality, coping style, and social support could predict how much their quality of life improved after six months of continuous apomorphine infusion. Researchers measured personality traits before treatment and compa…

This study tested whether using a special scanner (O-ARM) in the operating room is as good as standard imaging done before surgery for placing brain electrodes in Parkinson's patients. 24 people took part, and researchers measured how accurately the electrodes were placed. The go…

This study looked at how brain circuits in people with Parkinson's disease produce abnormal electrical rhythms. Researchers measured these rhythms in 23 patients with implanted brain electrodes. The goal was to understand why these patterns occur, which could lead to better treat…

This study looked at whether it's possible and safe for people with early-stage Parkinson's disease to stop their medication for one week while being monitored with brain scans and wearable sensors. Twenty participants were followed to see how their symptoms and brain activity ch…

This study used eye-tracking to see how people with Alzheimer's, Parkinson's, or frontotemporal dementia look at faces when trying to recognize emotions. Researchers compared their eye movements to healthy adults. The goal was to understand if different visual strategies explain …

This study looked at whether a special workshop about Parkinson's medications could change how patients think about their drugs. 24 people with Parkinson's took part. The goal was to see if learning more about their medicines helps them manage treatment better.

This study tested whether wearable sensors can reliably measure movement problems in people with Parkinson's disease. Fifty participants wore sensors while performing tasks like finger tapping and walking. The goal was to see if these sensors could provide objective data to help …

This study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…

This study used MRI scans to look at brain activity in people with Parkinson's disease while they moved their arms and legs. The goal was to understand how the brain changes affect motor symptoms. 40 people took part, including those with Parkinson's and healthy volunteers.

This study looked at pain thresholds in people with multiple system atrophy (MSA) and Parkinson's disease. Researchers tested how levodopa, a common Parkinson's drug, affects pain perception. The goal is to better understand the causes of pain in MSA and improve future treatment.

This study looked at how an abdominal compression binder (like a tight belt) helps people with autonomic failure who get dizzy or faint when standing due to low blood pressure. Researchers compared the binder to a standard medication (midodrine) and a placebo in 21 adults. The go…

This study looked at how a gentle electrical current applied to the scalp (tDCS) affects brain signals in 20 people with Parkinson's disease. Researchers measured brain activity during a reaching task to see exactly how tDCS changes movement-related signals. The goal was to bette…

This completed study tested whether low-intensity focused ultrasound aimed at a brain area called the zona incerta (ZI) can reduce tremors in 20 people with Parkinson's disease. Researchers compared this approach to the standard target (Vim) and used brain scans to understand how…

This completed study at Rutgers University looked at how the brain and body communicate in 30 people with conditions like autism, ADHD, Alzheimer's, and Parkinson's. Participants performed natural movements like walking and pointing while their brain, heart, and motion signals we…

This completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mu…

This study followed 700 Parkinson's patients who received deep brain stimulation to see which factors predict a meaningful improvement in quality of life after 1, 3, and 5 years. Researchers analyzed clinical, imaging, and genetic data to identify who benefits most. The goal is t…

This study looked at whether simple eye-tracking tests can help measure how Parkinson's disease changes over time. About 300 people with early-stage Parkinson's had their eye movements recorded and compared with standard clinical exams. The goal was to see if eye tests could dete…

This study looked at two different strength training methods in 38 people with mild to moderate Parkinson's disease. One method focused on fast, powerful movements, while the other cycled through different training phases. The goal was to see which approach better improved muscle…

This study observed over 20,000 people with Parkinson's disease to find genetic links and potential biomarkers. Participants were between 30 and 80 years old and diagnosed within the last 5 years. No treatments were tested; the goal was to better understand the disease's genetic …

This study looked at whether balance and walking problems in people with Parkinson's disease are caused by changes in the inner ear (vestibular system) rather than just a lack of dopamine in the brain. 60 participants with Parkinson's underwent balance tests and brain scans. The …

This study tested whether a daily probiotic supplement called Bacillus subtilis can change certain gut bacteria and blood markers in people with Parkinson's disease. Twenty-six participants took either the probiotic or a placebo for a period. The goal was to see if the supplement…

This study tested whether a mix of online lessons and hands-on simulation suits could help nursing students feel more empathy for people with Parkinson's disease. 84 third-year nursing students took part, with one group using special suits that mimic Parkinson's symptoms in a hom…

This study tested how accurately a robot system called Neurolocate helps place electrodes in the brain during deep brain stimulation surgery. It involved 18 adults with Parkinson's disease, dystonia, or tremor. The goal was to see if the robot could improve precision, reduce surg…

This completed study looked at how common muscle loss (sarcopenia) is in people with Parkinson's disease. Researchers compared 43 Parkinson's patients (early and moderate stages) with 22 healthy adults. They used ultrasound to measure thigh muscle thickness, handgrip strength, an…

This study looked at back tissue thickness, trunk flexibility, and hand dexterity in people with Parkinson's disease. Researchers compared 80 participants aged 50-80 with mild to moderate Parkinson's to healthy individuals. They used ultrasound and physical tests to measure diffe…

This completed study enrolled 230 people with Parkinson's disease, a related sleep disorder, and healthy volunteers. Participants used a smartphone app to track their movements daily and underwent brain scans. Some also gave skin biopsies to test for a protein linked to Parkinson…

This study looked at vitamin B6 levels in 288 people with Parkinson's disease. Researchers wanted to find out how common abnormal B6 levels are and whether they relate to age, sex, race, or other factors. The study did not test any treatment—it only measured and compared B6 level…

This completed study looked at over 2,500 people with Parkinson's disease who were admitted to the hospital through the emergency room. Researchers wanted to find the main reasons for these hospital stays and compare them to people of the same age without Parkinson's. The goal wa…

This study looked at how forced and voluntary exercise change brain signals and thinking skills in 25 people with Parkinson's disease who have a brain pacemaker (DBS). Participants did one session of each exercise type while off their usual medications and DBS. The goal was to fi…

This study looked at 115 adults with advanced non-small cell lung cancer to see if muscle loss (sarcopenia) and a blood-based score called CTI affect how well immunotherapy works. Researchers reviewed medical records to measure muscle on CT scans and calculate CTI from routine bl…

This study tested a French version of a questionnaire that measures physical activity levels in people with physical disabilities. Fifty participants with conditions like stroke, multiple sclerosis, or Parkinson's disease filled out the questionnaire twice, two weeks apart. The g…

This study looked at 70 people with Parkinson's disease to see if following the DASH diet (a heart-healthy eating plan) was linked to better heart health. Researchers measured blood fats, inflammation, and other risk markers. They found that those who followed the DASH diet more …

This study looked at whether a special balance training called protective step training can help people with Parkinson's disease react better to trips or pushes. Twelve participants completed the training, which involved standing and walking while being gently disturbed to test t…

This study adapted the Parkinson's Disease Quality of Life 7 (PDQoL7) questionnaire into Turkish and tested its reliability and validity with 129 Parkinson's patients. Participants completed the PDQoL7 along with other standard questionnaires. The goal was to ensure the Turkish v…

This completed study looked at 129 people with Parkinson's disease to understand what factors are linked to fatigue. Researchers measured fatigue, sleep, mood, and physical function using questionnaires and a walking test. The goal was to identify which aspects of Parkinson's mos…

This study looked at how deep brain stimulation (DBS) changes the way people with Parkinson's disease explain positive and negative events, known as attributional style. Researchers measured this in 32 French-speaking adults with Parkinson's who had stable treatment. The goal was…

This study used a very powerful 7 Tesla MRI to look for tiny brain changes in 15 people with idiopathic REM sleep behavior disorder (iRBD) compared to 15 healthy volunteers. iRBD is a sleep condition that often leads to Parkinson's disease years later. The goal was to find early …

This study looked at the DNA of 2500 people, including those with Parkinson's disease and healthy volunteers, to find genetic changes linked to the condition. Researchers focused on specific genes like parkin, DJ-1, PINK1, and LRRK2. The goal was to better understand the disease'…

This study looked at why Hispanic people with Parkinson's disease may have more thinking and memory problems. Researchers checked 40 participants for heart-related risks like diabetes, high blood pressure, and obesity. The goal was to understand how these factors might contribute…

This study looked at brain signals in 21 people with essential tremor or Parkinson's disease during deep brain stimulation (DBS) surgery. Researchers placed temporary recording strips on the brain's surface to capture electrical activity. The goal was to learn how DBS calms the t…

This study looked at how muscle strength in the shoulders and arms relates to hand function in people with Parkinson's disease. Researchers measured strength in key upper body muscles and tested hand dexterity in 70 participants. The goal was to better understand these connection…

This study looked at how different types of exercise change brain activity in 15 people with Parkinson's disease who have a brain pacemaker (deep brain stimulation). Participants cycled while off their medication, and researchers measured brain signals and movement skills. The go…

This study tested a new questionnaire called the NF-scale, designed to measure sudden mood and thinking changes (neuropsychiatric fluctuations) that can occur in Parkinson disease. 130 French-speaking participants with Parkinson disease and motor fluctuations filled out the quest…

This study looked at how people with Parkinson's disease who have trouble swallowing and their caregivers work together during meals. Researchers filmed 22 patient-caregiver pairs and interviewed them to understand the verbal and non-verbal strategies used to make eating safer an…

This study followed 29 people with Parkinson's disease, along with healthy volunteers and people with a similar condition, to better understand speech and movement issues that don't respond to standard Parkinson's medication. Researchers used brain scans, breathing tests, and wal…

This study used a special brain imaging technique called HD-DOT to see how deep brain stimulation (DBS) changes brain network activity in 49 people with Parkinson's disease. Researchers compared scans with DBS turned on and off, while participants did motor and cognitive tests. T…

This study tested whether adding lateral stepping exercises to a regular group exercise class is feasible and helpful for people with middle to late-stage Parkinson's disease. Five participants did the exercises twice a week for 8 weeks. Researchers measured balance, fall risk, a…

This study used PET scans to examine brain changes in people with Parkinson's disease at different stages. Researchers looked at two brain chemical systems—dopamine and serotonin—to understand non-motor symptoms like mood and thinking problems. 49 participants, including healthy …

This study looked at whether practicing a fine motor task while doing a second task (like counting lights) helps people with Parkinson's disease remember the motor skill better. Eighty participants, including people with Parkinson's and healthy controls, practiced a finger moveme…

This study looked at 80 people with Parkinson's to see if there is a link between how much their trunk sways and how well they can use their hands. Researchers used a motion sensor to measure trunk sway and a pegboard test to measure hand dexterity. The goal is to understand if b…

This early-stage study tested a new oral drug, ATH-399A, in 76 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed to develop a treatment for Parkinson's disease. Participants took single or multiple doses, and researchers a…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study looked at how Parkinson's disease changes the way people perceive time. Researchers measured eye movements in 40 participants (Parkinson's patients and healthy volunteers) to understand the role of dopamine in timing. Patients were tested both on and off their medicati…

This study followed 83 people with Parkinson's disease and healthy volunteers to see if daily walking patterns measured at home can track how the disease progresses. Participants wore special insoles for 10 days at a time to record their gait. The goal was to find simple, real-wo…

This completed study looked for genetic and environmental factors that increase the risk of developing Parkinson's disease. Researchers compared DNA and lifestyle data from over 2,200 people, including Parkinson's patients, people with related brain diseases, and healthy voluntee…

This study looked at whether a special video game could help improve walking and balance in 10 people with Parkinson's disease who had already had brain surgery. The goal was to see if the game was easy and enjoyable to use. Researchers measured how well participants could walk a…

This study investigated why humans swing their arms during walking, a common but poorly understood movement. Researchers had 25 participants, including healthy individuals and those with conditions like stroke or Parkinson's disease, walk on a force-sensing treadmill. They measur…

This early-phase study tested the safety of a drug called sargramostim (Leukine) in 11 people with Parkinson's disease over 48 weeks. Researchers also looked for changes in immune cells and other biomarkers that might help track the disease. The goal was not to cure Parkinson's b…

This study used virtual reality to recreate situations that cause freezing of gait in people with Parkinson's disease who have a deep brain stimulator. Fifteen participants walked through a virtual home and grocery store while their brain signals were recorded. The goal was to be…

This study tested whether ultrasound imaging can help understand and suppress tremors in people with Parkinson's disease or essential tremor. Researchers used ultrasound to watch hand muscles during grasping motions and developed models to predict tremor. They then used mild elec…

This study tested a new imaging software called HoloDBS to see if it helps doctors plan deep brain stimulation (DBS) surgery better than current methods. Researchers reviewed medical records from 20 adults with Parkinson's disease who were already scheduled for DBS. No extra visi…

This study tested a wrist-worn device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants wore the device while researchers compared its readings to standard clinical tests and video…

This completed study tested a new device that can record brain activity even while deep brain stimulation (DBS) is turned on. Current recorders only work after stimulation stops. The study involved one person with Parkinson's disease undergoing DBS surgery. The goal was to better…

This completed study examined how a specific serotonin receptor (5-HT4) is expressed in the brains of people with mild to moderate Parkinson's disease compared to healthy older adults. Researchers used PET scans and a special tracer to measure receptor levels, alongside cognitive…

This study tested new ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease. Instead of constant stimulation, researchers tried intermittent patterns to see if they could control movement symptoms while causing fewer thinking or memory problems. Sixte…

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, such as family history, loss of smell, blood pressure drops, or a sleep disorder. Participants underwent brain scans, spinal taps, and other tests over several y…

This completed observational study looked at how people with Parkinson's disease perceive the world, including unusual experiences like visual hallucinations. Researchers surveyed 54 participants online to see how these perceptual experiences relate to cognition, mood, and sleepi…

This study looked at how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Fifteen patients who already had a DBS device implanted performed movement and impulse control tasks while their brain activity was measured using a special light-base…

This study tested whether artificial intelligence (AI) could better predict fall risk in people with Parkinson's disease by analyzing walking tests under single and dual-task conditions. Thirty participants completed balance and mobility assessments while being recorded on video.…

This completed online study looked at whether natural environments like parks, gardens, and lakesides can improve mood and cognition in people with and without Parkinson's disease. 97 participants filled out surveys about their connection to nature, depressive symptoms, sleep, an…

This completed study examined gut bacteria in 15 people with inflammatory bowel disease (IBD) or Parkinson's disease, comparing them to healthy individuals. Researchers analyzed stool and blood samples to see if bacteria from the gut move into the bloodstream. The goal was to und…

This study looked at whether giving feedback after a delay, instead of immediately, helps people with Parkinson's disease learn better. Forty participants completed a computer task where they got either instant or 25-minute-delayed feedback. The goal was to see if delayed feedbac…

This study tested whether showing older hospitalized patients their own activity levels on a bedside screen could encourage them to move more. 130 adults aged 60+ with conditions like COPD, heart failure, or Parkinson's wore a small sensor and saw real-time feedback on time spent…

This completed study used eye-tracking to explore how the brain adapts movements in people with dystonia, essential tremor, or Parkinson disease. Researchers measured eye movements before and after a task to look for signs of cerebellar dysfunction. The study included 14 particip…

This study tested whether a short questionnaire about falls, called the Dresden Falls Questionnaire, works well for Turkish-speaking people with Parkinson's disease. Researchers asked 64 patients to fill out the questionnaire along with other surveys during rehab sessions. The go…