Scientists dig into DNA to unlock secrets of early Parkinson's

NCT ID NCT02511015

Completed Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mutations lead to the disease, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help identify specific genetic defects linked to early-onset Parkinson's, paving the way for future targeted therapies.
What could go wrong: This is an observational study with only 31 participants, so findings may not apply to all cases. It does not test any treatment, so direct benefits are unlikely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal recessive early-onset Parkinson disease 6 autosomal recessive early-onset Parkinson disease 7 autosomal recessive juvenile Parkinson disease 2 Neuroinflammatory Diseases Parkinson disease parkinsonian disorder young-onset Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON DISEASE (AUTOSOMAL RECESSIVE, EARLY ONSET) 7, HUMAN PARKINSON DISEASE 6, EARLY-ONSET PARKINSON DISEASE AUTOSOMAL RECESSIVE, EARLY ONSET PARKINSON DISEASE, AUTOSOMAL RECESSIVE EARLY-ONSET, DIGENIC, PINK1/DJ1

Contacts and locations

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

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