New Pump-Delivered Parkinson's drug shows promise in Long-Term safety trial

NCT ID NCT04750226

Completed Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested the safety of a new drug, ABBV-951, given as a continuous 24-hour infusion under the skin for people with advanced Parkinson's disease. 118 adults who had completed earlier studies took part. The goal was to see if the drug is safe and tolerable over 96 weeks, while also checking if it helps control symptoms like tremors and stiffness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ABBV-951 (a combination of levodopa and carbidopa given as a continuous infusion under the skin)

What this could lead to

If successful, this could provide a more steady and convenient way to deliver Parkinson's medication, potentially reducing the 'off' times when symptoms return between doses.

What could go wrong

This is an extension study focused on safety, not proof of effectiveness. Side effects from the infusion site or the drug itself may occur, and the treatment requires wearing a pump continuously.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PARKINSON'S DISEASE (PD)

Contacts and locations

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Locations

Alpine Clinical Research Center /ID# 218461

Boulder, Colorado, 80301-1880, United States
Baylor College of Medicine /ID# 217728

Houston, Texas, 77030, United States
CenExel Rocky Mountain Clinical Research, LLC /ID# 217731

Englewood, Colorado, 80113-2736, United States
Coastal Neurology /ID# 222893

Port Royal, South Carolina, 29935-2029, United States
Denver Neurological Research, LLC /ID# 217811

Denver, Colorado, 80210-7009, United States
Duplicate_Cedars-Sinai Medical Center-West Hollywood /ID# 218607

West Hollywood, California, 90048, United States
Duplicate_Medical College of Wisconsin /ID# 217721

Milwaukee, Wisconsin, 53226-3522, United States
Georgetown University Hospital /ID# 218599

Washington D.C., District of Columbia, 20007, United States
Global Neurosciences Institute /ID# 218472

Lawrenceville, New Jersey, 08648-2300, United States
Gold coast University Hospital /ID# 221694

Southport, Queensland, 4215, Australia
Houston Pulmonary Sleep and Allergy Associates /ID# 218473

Cypress, Texas, 77429, United States
Inland Northwest Research /ID# 222520

Spokane, Washington, 99202-1342, United States
KCA Neurology - Franklin /ID# 222811

Franklin, Tennessee, 37067-5914, United States
Legacy Medical Group - Neurology /ID# 217804

Portland, Oregon, 97232-2003, United States
Liverpool Hospital /ID# 221693

Liverpool, New South Wales, 2170, Australia
Loma Linda University Medical /ID# 217724

Loma Linda, California, 92354, United States
M3 Wake Research - Raleigh /ID# 218482

Raleigh, North Carolina, 27612-8106, United States
Movement Disorders Center of Arizona /ID# 218471

Scottsdale, Arizona, 85258-4582, United States
Muhammad Ali Parkinson Center /ID# 218609

Phoenix, Arizona, 85013-4407, United States
Neuro Pain Research Center /ID# 217720

Fresno, California, 93710, United States
Neurological Associates - Forest Ave /ID# 218458

Richmond, Virginia, 23229-4913, United States
Neurology Associates Ormond Beach /ID# 217800

Ormond Beach, Florida, 32174, United States
Northwell Health /ID# 218600

Lake Success, New York, 11042, United States
Parkinson's Disease Treatment Center of Southwest Florida /ID# 222679

Port Charlotte, Florida, 33980, United States
Premiere Research Institute - Palm Beach /ID# 218743

West Palm Beach, Florida, 33407-3209, United States
Prisma Health-Upstate /ID# 217803

Greenville, South Carolina, 29615, United States
Renstar Medical Research /ID# 217837

Ocala, Florida, 34470, United States
Royal Adelaide Hospital /ID# 218417

Adelaide, South Australia, 5000, Australia
Rush University Medical Center /ID# 217807

Chicago, Illinois, 60612, United States
SC3 Research Group - Pasadena /ID# 223018

Pasadena, California, 91105-3149, United States
St Elizabeth's Medical Center - Brighton /ID# 223082

Brighton, Massachusetts, 02135-2907, United States
St. David's Healthcare Partnership, L.P., LLP /ID# 248148

Austin, Texas, 78701-4082, United States
St. Lukes Hosp. of Kansas City /ID# 218604

Kansas City, Missouri, 64111, United States
Texas Movement Disorder Specialists /ID# 218610

Georgetown, Texas, 78628-4126, United States
The Movement Disorder Clinic of Oklahoma /ID# 218580

Tulsa, Oklahoma, 74136-6378, United States
The Orthopedic Foundation /ID# 218608

New Albany, Ohio, 43054-8167, United States
The Royal Melbourne Hospital /ID# 218419

Parkville, Victoria, 3050, Australia
Thomas Jefferson University Hospital /ID# 218594

Philadelphia, Pennsylvania, 19107, United States
University of Alabama at Birmingham - Main /ID# 217814

Birmingham, Alabama, 35233, United States
University of California, Los Angeles /ID# 218460

Los Angeles, California, 90095, United States
University of California, San /ID# 218595

San Diego, California, 92037, United States
University of Chicago Medical Center /ID# 218611

Chicago, Illinois, 60637, United States
University of Colorado Hospital /ID# 218486

Aurora, Colorado, 80045, United States
University of Pennsylvania /ID# 218605

Philadelphia, Pennsylvania, 19104-5502, United States
University of South Florida- Neuroscience Institute /ID# 218481

Tampa, Florida, 33613, United States
University of Utah Health Care /ID# 218597

Salt Lake City, Utah, 84132, United States
Usa Mitchell Cancer Institute /ID# 218467

Mobile, Alabama, 36604, United States
Vanderbilt University Medical Center /ID# 217722

Nashville, Tennessee, 37232-0011, United States
Visionary Investigators Network - Miami /ID# 217726

Miami, Florida, 33176-2148, United States
Washington University-School of Medicine /ID# 217723

St Louis, Missouri, 63110, United States
Westmead Hospital /ID# 218418

Westmead, New South Wales, 2145, Australia
Xenoscience, Inc /ID# 222515

Phoenix, Arizona, 85004, United States