New injection may curb drooling in Parkinson's patients
NCT ID NCT00515437
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether injections of Myobloc (botulinum toxin type B) into the salivary glands can safely reduce drooling in people with Parkinson's disease. Fifty-four participants received either Myobloc or a placebo. The main goal was to see if drooling severity and frequency improved four weeks after treatment. The trial also looked at safety and how long any benefits might last.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Botulinum Toxin Type B (Myobloc)
- What this could lead to
- If it works, this could provide a safe, effective treatment to reduce drooling in people with Parkinson's disease, improving comfort and quality of life.
- What could go wrong
- This is a small, early-phase trial with only 54 participants. The results may not apply to everyone, and there are risks like swallowing problems or aspiration. More research is needed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dr Hubert Fernandez
Gainesville, Florida, 32610, United States
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Dr Virgilio Evidente
Scottsdale, Arizona, 85259, United States
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Dr. Alan Freeman
Atlanta, Georgia, 30329, United States
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Dr. Brad Racette
St Louis, Missouri, 63110, United States
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Dr. Eric Molho
Albany, New York, 12205, United States
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Dr. Fernando Pagan
Washington D.C., District of Columbia, 20007, United States
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Dr. Gordon Smith
Salt Lake City, Utah, 84132, United States
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Dr. James Sutton
Oxnard, California, 93030, United States
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Dr. Joseph Friedman
Warwick, Rhode Island, 02886, United States
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Dr. Katie Kompoliti
Chicago, Illinois, 60612, United States
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Dr. Madhavi Thomas
Dallas, Texas, 75231, United States
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Dr. Olga Klepitskaya
Denver, Colorado, 80262, United States
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Dr. Patrick Hogan
Tacoma, Washington, 98405, United States
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Dr. Robert Rodnitzky
Iowa City, Iowa, 52242, United States
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Dr. Ronald Ziman
Northridge, California, 91325, United States
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Dr. Sam Kabbani
Knoxville, Tennessee, 37923, United States
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Dr. Stephen Reich
Baltimore, Maryland, 21201, United States
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Dr. Vanessa Hinson
Charleston, South Carolina, 29401, United States
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