Hereditary neurological disease

This trial tests a gene therapy for people with a rare inherited eye disease called Leber congenital amaurosis, caused by mutations in the RPE65 gene. A harmless virus is used to deliver a working copy of the gene into cells under the retina. The goal is to restore vision with a …

This early-stage trial tested a combination of two oral drugs, tipifarnib and alpelisib, in 45 adults with recurrent or metastatic head and neck squamous cell carcinoma that has specific genetic changes (HRAS overexpression or PIK3CA mutations). The goal was to find a safe dose a…

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

This phase 2 trial tests an oral drug called ARD-101 in adults with Prader-Willi syndrome, a genetic condition that causes an unrelenting feeling of hunger. Researchers give the drug twice daily for 28 days to see if it safely reduces hyperphagia, the intense drive to eat, using …

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This phase 3 trial tests whether soticlestat, an experimental oral drug, can reduce convulsive seizures in children and young adults with Dravet syndrome, a severe form of epilepsy. Participants continue their standard antiseizure therapy and also receive either soticlestat or a …

This trial tests whether a brain-computer interface (BCI) can help people with Parkinson's disease improve their motor skills. Participants wear an EEG cap that reads brain activity while they imagine moving their legs. The system then provides feedback through electrical stimula…

This study tests whether changing the way deep brain stimulation is delivered can improve tremor control in people with essential tremor who don't get enough relief from their current settings. Researchers will use computer models and brain scans to see how the new stimulation pa…

This study tested a drug called RTA 408 (omaveloxolone) in 172 people with Friedreich's ataxia, a rare genetic disease that affects movement and coordination. The goal was to see if the drug is safe and can improve exercise ability and daily function. Participants took the drug o…

This trial tests whether a new auto-focusing imaging feature on the ExAblate Neuro system can safely guide focused ultrasound to treat essential tremor that has not responded to medication. Researchers will enroll about 20 adults with medication-resistant essential tremor and che…

This trial tests whether repeat infusions of stem cells from healthy donors can slow the progression of Parkinson's disease. About 45 people with Parkinson's will receive either one of two doses of these stem cells or a placebo. Researchers will measure changes in motor symptoms …

This study tested whether adding the immunotherapy drug pembrolizumab to standard hormone therapy (enzalutamide plus ADT) could help men with metastatic hormone-sensitive prostate cancer live longer or delay cancer growth. The trial enrolled 186 Chinese men and was stopped early …

This phase 3 trial tests an experimental drug called AOC 1001 in 159 adults with myotonic dystrophy type 1, a genetic condition that causes muscle weakness and stiffness. Participants receive either the drug or a placebo by intravenous infusion. The main goal is to see if the dru…

This trial is testing whether combining the immunotherapy drug pembrolizumab with other experimental agents can help people with advanced melanoma whose cancer has stopped responding to standard anti-PD-1 treatment. The study includes several treatment arms, each pairing pembroli…

This phase 2 trial tests a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard chemotherapy in people with classical Hodgkin lymphoma that has come back or stopped responding to treatment. About 200 participants will be randomly assigned to rece…

This study looks at how well a biosimilar drug called Yesafili works for people with wet age-related macular degeneration (AMD). About 54 participants will switch from the standard drug Eylea to Yesafili. Doctors will check vision and eye health to see if the biosimilar is a safe…

This study tests whether a home eye-scanning device can improve care for people with wet age-related macular degeneration (AMD) who are switching to the medication faricimab. Participants will scan their own retinas at home several times a week, and the images will be sent to the…

This trial tests whether having a nurse specialist coordinate care for people with Parkinson's or related conditions improves their quality of life over 12 months. Participants are randomly assigned to either standard care with their neurologist or additional support from a nurse…

This study tests whether pneumatic retinopexy, a procedure that injects a gas bubble into the eye, can successfully reattach a detached retina without traditional surgery. Researchers will follow 33 adults with a specific type of retinal detachment for two years, tracking how oft…

This phase 3 trial tests whether a new drug combination (MK-7684A) plus chemoradiotherapy helps people with stage III non-small cell lung cancer live longer than the current standard treatment. About 611 participants will receive either the new combo or durvalumab. The study is a…

This study tests whether a brain shunt—a device that drains extra fluid—can improve walking and thinking in older adults with idiopathic normal pressure hydrocephalus (iNPH). One hundred participants will either receive an active shunt or a placebo procedure. The main goal is to …

This early feasibility trial tests a new retinal implant called PRIMA in 5 people with advanced dry age-related macular degeneration who have lost central vision. The device is surgically placed in the eye to stimulate remaining retinal cells. Researchers are checking if it is sa…

This trial tests a program called PD_Pal, where a specially trained nurse helps people with Parkinson's and their family caregivers create a personalized care plan. The plan covers current care, future needs, and end-of-life preferences, aiming to ensure that care matches what th…

This study tests whether a single low dose of ketamine can quickly reduce obsessive-compulsive disorder (OCD) symptoms. Adults with OCD will receive either ketamine or a comparison drug, and researchers will measure symptom changes using a standard OCD scale. The trial also uses …

This trial is testing whether a piece of the patient's own eye tissue, called Tenon's capsule, can help close large or recurrent macular holes—tears in the center of the retina that can blur or distort vision. During standard vitrectomy surgery, the tissue is harvested and placed…

This long-term study is testing higher doses of nusinersen (Spinraza) in people with spinal muscular atrophy who already completed a previous nusinersen study. The main goal is to check safety over several years, including side effects, heart health, and growth. Participants rece…

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This phase 2 trial tests a powerful mix of short-course radiation, chemotherapy (mFOLFOX6), an immunotherapy (PD-1 antibody), and a targeted drug (cetuximab or bevacizumab, depending on genetic markers) in people with high-risk rectal cancer that is mismatch repair proficient (pM…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This study tests whether a week of intensive therapy involving horses can improve motor skills, posture, and breathing in children with spinal muscular atrophy (SMA). Children with SMA types I, II, or III will receive either horse-assisted physiotherapy or standard individual phy…

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where …

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before and after bladder removal surgery helps people with muscle-invasive bladder cancer live longer without the cancer coming back. About 900 participants took part. The goal was to s…

This trial investigates whether deep brain stimulation of the subthalamic nucleus can improve quality of life for people aged 70 and older with Parkinson's disease. Participants are randomly assigned to receive the stimulation or standard care. The study measures changes in motor…

This study tested a new medicine called AOC 1020 in 90 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. The goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a p…

This study investigates whether a non-invasive light treatment called photobiomodulation can improve vision and slow vision loss in people with dry age-related macular degeneration (AMD). Participants receive either active light therapy or a sham (inactive) treatment over 12 mont…

This study tests a new way to deliver levodopa—the main Parkinson's medication—through a continuous infusion under the skin. It is designed for people with Parkinson's who experience at least two hours of 'off' time each day, when symptoms return between oral doses. The trial wil…

This study tests a long-acting growth hormone called TransCon hGH, given as a once-weekly injection, in children with growth hormone deficiency who have already completed a prior TransCon trial. The goal is to see if the weekly shot remains safe and effective over the long term. …

This phase 3 trial investigates whether a once-weekly injection of lonapegsomatropin, a long-acting growth hormone, can safely and effectively treat adults with growth hormone deficiency. The study compares the weekly drug against a placebo and a standard daily growth hormone pro…

This study follows people with two inherited eye conditions—choroideremia and X-linked retinitis pigmentosa—who previously received gene therapy. Researchers monitor their safety and vision over several years to see if the treatment remains safe and helps preserve sight. Particip…

This study tests whether a 10-week home exercise program, delivered through eHealth technology, can improve walking, physical activity, and quality of life in people with mild-to-moderate Parkinson's disease. The program combines motor and cognitive exercises tailored to each per…

This study tests an oral medication called LUM-201 in children with growth hormone deficiency who have not yet received treatment. The goal is to see if taking a pill daily can improve growth as effectively as standard daily injections. The trial also looks for a way to identify …

This Phase 2 study tested whether low doses of nilotinib, a drug already approved for leukemia, are safe and affect brain markers in 75 people with Parkinson's disease. Participants took either a placebo or one of two low doses of nilotinib daily for 12 months. The goal was to se…

This study tested a brain implant (RNS System) that delivers targeted electrical stimulation to the thalamus to reduce seizures in people aged 12 and older with drug-resistant idiopathic generalized epilepsy. The goal was to see if the device is safe and effective at cutting down…

This study tested whether people with ALS or Parkinson's disease, along with healthy volunteers, could follow the MIND diet — a mix of the Mediterranean and DASH diets thought to protect the brain. Over several weeks, 43 participants received a cookbook, educational materials, an…

This study tested whether N-acetylcysteine (NAC), an antioxidant drug, can improve motor skills and learning in children with neurofibromatosis type 1 (NF1). Twenty-five children aged 8 to 16 took NAC or a placebo for 8 weeks. The goal was to see if NAC is safe and helps with mov…

This study tested whether a special oil called triheptanoin can slow brain damage in people with early Huntington's disease. 100 participants took either the oil or a placebo for 6 months, followed by 6 months where everyone got the oil. The main goal was to see if it reduced bra…

This early-stage study tested a new drug, VP-001, given as an injection into the eye to see if it is safe for people with a rare genetic eye disease caused by a PRPF31 mutation. Seventeen adults took part. The main goal was to check for side effects, not to measure vision improve…

This study looked at whether a newer type of deep brain stimulation (DBS) electrode, which can steer electrical signals more precisely, improves mood and movement in people with Parkinson's disease. 105 participants received the directional electrodes as part of their standard ca…

This study tested a malaria drug called artesunate in 20 people with Friedreich ataxia, a rare genetic disorder that affects movement and coordination. The goal was to find a safe dose that could help control iron levels in cells, which may slow the disease. Researchers started w…

This early study tested a new approach for people with advanced Parkinson's disease who have severe motor fluctuations despite optimized oral medication. A pump placed in the abdomen delivered a special form of dopamine (A-dopamine) directly into the brain's fluid spaces, aiming …

This study tested an oral drug called AZ-3102 in 13 people with GM2 gangliosidosis (Tay-Sachs or Sandhoff disease) or Niemann-Pick type C disease. The main goal was to check safety and how the drug moves through the body over 12 weeks. It was a randomized, double-blind, placebo-c…

This study tested whether a drug called deferiprone can safely reduce harmful iron buildup in the brains of people with early-stage Parkinson's disease. Forty participants took either deferiprone or a placebo for six months. The goal was to see if lowering brain iron could slow t…

This phase 2 trial tested sodium valproate, a drug used for seizures, in 41 children with Rubinstein-Taybi syndrome (RTS), a rare genetic condition causing intellectual disability. Participants aged 6 to 21 received either the drug or a placebo for one year. Researchers measured …

This study tested magnetic seizure therapy (MST) in 239 adults with treatment-resistant depression to see if it works as well as electroconvulsive therapy (ECT) but with fewer memory side effects. MST uses magnetic pulses to trigger a controlled seizure, aiming to relieve depress…

This study tested whether exenatide, a drug already used for type 2 diabetes, can slow the progression of Parkinson's disease. About 194 people with early-stage Parkinson's received either exenatide or a placebo once a week for two years. The goal was to see if the drug could pro…

This completed Phase 2b/3 trial tested the drug AMX0035 in 139 people with progressive supranuclear palsy (PSP), a rare brain disease that causes problems with balance, movement, and thinking. The study compared the drug to a placebo to see if it could slow the disease. The resul…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. 36 children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet for a month, then switched. Researchers measured their resting energy use and body com…

This study tested a program called Positive Minds-Strong Bodies Enhanced (PMSB-E) in 427 older adults from racial, ethnic, and linguistic minority groups who had depression, anxiety, and some mobility issues. The program combined mental health support with physical exercises to h…

This Phase 3 trial tested a gene therapy called GS010 in 98 people with Leber hereditary optic neuropathy (LHON), a genetic condition that leads to rapid vision loss. Participants received injections of the therapy or a placebo into both eyes. The study measured changes in vision…

This study tested an experimental drug called vatiquinone in 146 people with Friedreich ataxia, a rare genetic disease that affects movement and coordination. Participants took either the drug or a placebo for 72 weeks to see if it slowed worsening of symptoms, measured by a stan…

This study tested whether giving amantadine early in Parkinson's disease, before patients develop involuntary movements from their main medication (L-DOPA), could prevent or delay those movements. Researchers enrolled 210 people with early-stage Parkinson's who had been on L-DOPA…

This study tested a tiny implant called the PRIMA Bionic Vision System in 5 people with advanced dry age-related macular degeneration who had lost central vision. The implant is placed under the retina and uses electrical stimulation to replace damaged light-sensing cells. The go…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine/cisplatin) helps people with advanced bile duct or gallbladder cancer live longer. Over 1,000 participants received either the combination or chemo plus a placebo. The goal…

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whet…

This study tested whether pimavanserin, a drug already approved for hallucinations in Parkinson's, can reduce impulse control disorders like compulsive gambling, shopping, or eating. 117 people with Parkinson's and moderate-to-severe impulse control problems took either pimavanse…

This phase 2 trial tested the drug crizotinib in 12 people with neurofibromatosis type 2 (NF2) who had growing tumors in the ear area called vestibular schwannomas. Participants took crizotinib pills daily for up to 12 months. The main goal was to see if the drug could shrink the…

This study tested whether long-term aerobic walking can slow the progression of Parkinson's disease. 57 people with mild-to-moderate Parkinson's walked for 150 minutes per week at a moderate pace. Researchers measured changes in movement, thinking, driving safety, and brain healt…

This study tested a new drug called AOC 1001 in 39 adults with myotonic dystrophy type 1, a genetic muscle disorder. Participants received either the drug or a placebo by IV infusion. The goal was to check safety and how the drug moves through the body. Results will help decide i…

This early-stage trial tested a drug called allopregnanolone in 10 people with Parkinson's disease. The goal was to see if a larger study is possible and if the drug is safe. Participants received weekly infusions for 12 weeks, and researchers looked for signs of improvement on b…

This phase 3 trial tested a single injection of GS010 gene therapy in 39 people with Leber Hereditary Optic Neuropathy (LHON) who had vision loss for 6 months or less. The treatment aims to improve vision by delivering a working copy of the ND4 gene to the eye. Results measured c…

This study tested a one-time gene therapy injection, GS010, in 37 adults with Leber Hereditary Optic Neuropathy (LHON), a genetic condition that causes rapid vision loss. Participants had vision loss for 6 to 12 months before treatment. The goal was to see if the therapy could im…

This study tested whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the eye could slow the progression of advanced dry age-related macular degeneration (AMD). Fourteen people with advanced dry AMD received three PRP injections…

This study looked at whether early surgery (vitrectomy) or waiting with ultrasound monitoring is better for people with sudden, dense bleeding inside the eye. The goal was to see if early surgery could lower the chance of the retina detaching. Only 8 adults with recent bleeding f…

This study aims to develop computer models that can help diagnose and monitor Parkinson's disease by analyzing eye movements and walking patterns. Researchers will collect data from 100 people with Parkinson's or similar conditions using special devices. The goal is to make diagn…

This study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…

This study is testing whether a blood test can tell apart the DNA from a vanishing twin and the living twin in pregnancies where one twin stops developing. The goal is to improve non-invasive prenatal screening for chromosome conditions like trisomy 21, 18, and 13 in the survivin…

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study compares a new mass spectrometry technique to the standard radioimmunoassay for measuring orexin-A levels in cerebrospinal fluid. Orexin-A is a key brain chemical that is low in people with type 1 narcolepsy. The study involves 117 people with excessive daytime sleepin…

This study tested whether digital analysis of voice recordings can help doctors tell apart Parkinson's disease and multiple system atrophy, two brain disorders with similar early symptoms. Researchers recorded the voices of 28 people (patients with each condition and healthy cont…

This study tested whether artificial intelligence (AI) can help diagnose Parkinson's disease by analyzing brain scans called DaTSCAN SPECT. Researchers used machine learning to tell the difference between healthy people, those with Parkinson's, and those with similar conditions. …

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested a new MRI technique to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method uses a special 3D FLAIR sequence without contrast dye, compared to the standard method that requires an injection. The goal was …

This study tested a new genetic screening approach to find cases of a rare inherited nerve disease called TTR-FAP in 130 patients with chronic neuropathy of unknown cause. The goal was to see how many of these patients actually have TTR-FAP, which is often missed due to varied sy…

This completed pilot study tested whether a computer algorithm could diagnose facioscapulohumeral muscular dystrophy (FSHMD) by analyzing video recordings of people's faces. Researchers recorded 17 participants, including patients with FSHMD, other muscle diseases, and healthy co…

This study tested an artificial intelligence platform that screens for cognitive dysfunction by analyzing eye movements. Over 1,500 participants, including people with various dementias and healthy individuals, took part. The AI aims to detect cognitive impairment and provide ref…

This study developed and tested a self-questionnaire called the 3PDQ to help diagnose pain that is directly caused by Parkinson's disease, rather than from other causes. Researchers enrolled 227 Parkinson's patients with chronic pain and compared their questionnaire answers with …

This study tested whether a powerful genetic test called exome sequencing can find the cause of severe epilepsy in children when standard tests fail. Researchers studied 15 children with epileptic encephalopathy of unknown genetic origin. The goal was to see if this test could im…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

This study tests whether a pharmacist-led program to stop certain medications (anticholinergics) can lower dementia risk in older adults. 344 participants aged 65+ who take these drugs will be followed for 2 years, comparing cognitive changes and quality of life between those who…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether a special sitting position that centers the hip joint can prevent hip dislocation in children with severe cerebral palsy. Seventeen children aged 1-6 years participated, using either the experimental or usual sitting method for at least 5 hours daily ove…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests whether adding motor imagery—mentally practicing movements without actually moving—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. Forty-two participants will be randomly assigned to receive either …

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

Researchers at the University of Reading are testing an online guided-writing program for people who care for a loved one with Parkinson's disease. The program asks caregivers to complete four writing exercises that encourage them to respond to their own struggles with the same k…

This phase 2 trial tests whether pitolisant, a wake-promoting drug, can reduce excessive daytime sleepiness in adults aged 18 to 65 with myotonic dystrophy type 1. Participants receive either pitolisant or a placebo for a period, and researchers measure changes in sleepiness, fat…

This trial tests whether playing different types of music during retinopathy of prematurity (ROP) eye exams can reduce pain and improve comfort in premature infants. ROP exams are necessary but can be painful and stressful for babies. Researchers will compare pain and comfort sco…

This study tested whether a split-belt treadmill (where each leg moves at a different speed) can reduce freezing of gait during turning in people with Parkinson's disease. 26 participants completed a 4-week training program that included practicing everyday turning scenarios. The…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general mental health education group. Researchers wi…

Researchers are testing whether psilocybin, the active compound in magic mushrooms, can safely help people with Parkinson's disease who also struggle with depression or anxiety. In this pilot study, 12 participants receive two oral doses of psilocybin with psychological support. …

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This trial tests whether a digital cognitive behavioral therapy (CBT) app called Daylight can reduce anxiety and improve health behaviors in adults who have had a heart event, such as a heart attack or stroke, and also experience significant anxiety. Participants will either use …

This study tests whether giving a small amount of the sedative midazolam during anesthesia can lower the risk of delirium (sudden confusion) and anxiety in older adults after surgery. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to r…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This study tests whether using a virtual reality headset during labor can help reduce pain and anxiety and make the childbirth experience more satisfying. About 92 women in Taiwan will be randomly assigned to either use VR with calming nature scenes and music or receive standard …

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

This study tests whether a web-based training program helps people with COPD who use a noninvasive ventilator (NIV) at home stick to their therapy and sleep better. Participants receive online lessons on using the device, and researchers measure their compliance and insomnia seve…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This study tested two sleep medications (suvorexant and zolpidem) against a placebo in 40 adults with Progressive Supranuclear Palsy (PSP). The goal was to see if targeting the brain's wake-promoting system could improve sleep quality and daytime well-being. Each person tried all…

This study tests whether a 6-week group class on nonviolent communication (NVC) can improve mental well-being in parents of primary-school children. About 172 parents with mild to severe anxiety or depression symptoms will be randomly assigned to take the class right away or wait…

This trial tests whether communication training helps first-time hearing aid users with mild to moderate hearing loss adapt better. Participants receive training either in a group or one-on-one, and researchers compare their hearing-related quality of life, communication strategi…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This trial tests whether watching short family videos or virtual reality nature scenes can reduce anxiety, agitation, and pain in adults staying in intensive care. Researchers will randomly assign 72 participants to one of three groups: family videos, family videos plus VR nature…

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This study tested a non-invasive treatment called radial pressure wave therapy for people with mild to moderate carpal tunnel syndrome. 60 adults received three weekly sessions of either a constant or modulated dose of the therapy. Researchers measured pain, hand function, and ne…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This trial tests whether virtual reality-based breathing yoga can reduce pain and anxiety in adults before chest tube removal after cardiac surgery. Participants are randomly assigned to either watch breathing yoga videos through VR glasses for 15-20 minutes before the procedure,…

This trial tests whether botulinum toxin type A, commonly known as Botox, can ease the involuntary muscle contractions of oromandibular dystonia, a condition that affects the jaw, tongue, and face. Researchers inject the toxin into specific muscles using electromyography (EMG) to…

This trial tests whether acupressure applied to the Yintang point—a spot on the forehead—can reduce pain, anxiety, and improve satisfaction during childbirth. About 104 first-time mothers in active labor will receive either Yintang acupressure or a light touch at a non-therapeuti…

This trial tests whether adding neural mobilization—gentle exercises that help the median nerve move freely—to a standard physical therapy program can improve symptoms and hand function in women with carpal tunnel syndrome. Participants receive either the combined treatment or st…

This trial tests whether a robotic pet or a video can reduce pain, fear, and anxiety in children aged 5-10 during a blood draw (venipuncture). Children are randomly assigned to interact with a robotic pet, watch an animal video, or receive routine care during the procedure. Resea…

This trial tests whether using real-world props, like a kayak paddle or sitting in an actual kayak, can lower anxiety during a virtual reality (VR) kayaking game in adolescents with mild to moderate intellectual disabilities. Participants will be randomly assigned to play the VR …

This trial tests whether adding DIR/Floortime™—a play-based, relationship-focused therapy—to standard care can improve emotional development and everyday skills in children aged 4-12 with mild to moderate intellectual developmental disorder. Over 10 weeks, some children receive t…

This trial asks whether letting mothers use their personal cellphones during a planned C-section under spinal anesthesia can lower anxiety and stress and improve satisfaction. About 82 low-risk pregnant women will be randomly assigned to either use their phones freely during surg…

This pilot trial tests whether pediatric primary care providers can effectively deliver a brief intervention called the Anxiety Action Plan (AxAP) to help children aged 6-17 with elevated anxiety symptoms. Providers receive training and coaching to administer the intervention, wh…

This study tests a drug called bezisterim (NE3107) in 60 people with early Parkinson's disease who have not yet started standard treatment. The goal is to see if it can improve movement symptoms like stiffness and slowness. Participants take the drug or a placebo twice daily for …

This trial tests whether a smartphone app called MindBoba, which uses problem-solving therapy techniques, can help Chinese Americans reduce stress and anxiety. Participants will be randomly assigned to use MindBoba, a standard cognitive-behavioral therapy app, or receive no app. …

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This study tested whether a rehabilitation program that combines physical balance exercises with mental tasks (like counting or decision-making) improves balance more than standard physical therapy alone in people with Parkinson's disease. Sixty participants with early-to-moderat…

This trial tests whether an augmented reality (AR) app-based cognitive behavioral therapy (CBT) program can help children aged 6 to 12 who are undergoing chemotherapy for cancer cope with treatment-related distress and improve their quality of life. Participants are randomly assi…

This study tests whether adding electroconvulsive therapy (ECT) to usual care can safely reduce severe agitation in people with moderate to severe dementia, including Alzheimer's and other types. Fifty participants will receive ECT sessions with anesthesia, and researchers will m…

This trial investigates whether transcranial magnetic stimulation (TMS) can help people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. Participants first receive standard TMS to the motor cortex; those who don't imp…

This trial tests whether using an immersive virtual reality headset during the first postoperative orthopedic dressing change can reduce anxiety and pain in children and adolescents aged 6 to 18. Participants are randomly assigned to either wear the VR headset during the procedur…

This trial tests whether coloring pre-drawn mandala patterns for at least 30 minutes each day can lower anxiety and depression in adults awaiting open-heart surgery. About 69 first-time heart surgery patients will be randomly assigned to either the coloring activity or usual care…

This study tests whether giving family members of ICU patients a QR code that links to an educational video can improve their understanding of the ICU and reduce their anxiety. Participants are randomly assigned to receive either standard verbal information or the same informatio…

This study tests whether watching an animated educational video before laparoscopic tubal ligation reduces anxiety and pain more than standard verbal counseling. Eighty women are split into two groups: one receives routine verbal information, the other watches a video. Researcher…

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This small pilot study tested whether a weekly hula dance program is practical and enjoyable for people with Parkinson's disease. Fifteen participants took hula classes for three months, and researchers measured how many completed the program and assessed changes in movement and …

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This study tests a wrist-worn device called Felix that uses artificial intelligence to deliver gentle nerve stimulation, aiming to reduce hand tremors in people with essential tremor. Participants wear the device daily for up to 90 days and are compared to a group using a sham (i…

This study tests whether a 10-week storytelling (narrative therapy) program can reduce anxiety and depression in middle school students living in refugee camps in northern Palestine. About 120 students aged 12-15 with moderate-to-severe symptoms took part. The program uses cultur…

This study tests whether a one-day Acceptance and Commitment Therapy (ACT) workshop can improve psychological flexibility and well-being in university students who have moderate to severe anxiety or depression. Participants are randomly assigned to either attend the workshop or j…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests whether writing about imagined future scenarios (worst-case, best-case, or neutral) can reduce social anxiety symptoms. 270 adults with elevated social anxiety will complete three online writing sessions over three weeks. Researchers will measure changes in anxie…

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This trial tests whether a brief online group therapy called EMDR Flash can help adults who survived the 2023 Kahramanmaraş earthquakes in Türkiye. Participants receive two 60-90 minute group sessions via Zoom and are compared to a waitlist group. The study measures changes in PT…

This study tested a 5-month early time-restricted eating plan (eating only between 7 AM and 3 PM) in 100 highly trained young male judo athletes. Researchers measured changes in body composition, muscle damage markers, and psychological factors like anxiety and self-confidence. T…

This study tested whether combining a non-invasive brain stimulation technique (rTMS) with daily smell training could help people with Parkinson's disease recover their sense of smell and taste. 120 participants were split into four groups to compare the combo therapy against eac…

This pilot study compares two types of virtual reality (VR) rehabilitation for people with Parkinson's disease: immersive VR using a headset and non-immersive VR using a tablet. The goal is to see which approach better improves walking, balance, and thinking skills. Sixteen parti…

This pilot study tested whether a non-invasive device that uses magnetic pulses to stimulate the brain (rTMS) could safely help cancer survivors with depression and anxiety. Twenty-four adults who had been treated for any type of cancer and still had major depression received eit…

This trial investigates whether a double-reading animated film, watched by both children and their parents before surgery, can reduce anxiety in children aged 3 to 7. The film uses avatars to walk the child through their hospital journey, from room to operating room. Researchers …

This study tested whether a software tool (Guide XT) can replace the long, exhausting process of choosing the best stimulation settings for Parkinson's patients with brain implants. Twenty-six patients took part. The goal was to see if the software was at least as good as the sta…

This study tested whether repeating positive affirmations during a routine pregnancy test (Non-Stress Test) can lower pain, anxiety, fear, and stress. 90 pregnant women participated, with some using affirmations and others receiving standard care. The goal is to see if this simpl…

This study tested whether daily gummies containing L-theanine and lion's mane mushroom extract could reduce stress, anxiety, and improve sleep in university students. 67 students aged 18-25 took either the gummies or no supplement for 8 weeks. The goal was to see if this natural …

This pilot study tested whether a specially adapted mindfulness program is feasible for people with Parkinson's disease. The program included shorter meditations, more movement, and extra breaks. Researchers enrolled 20 patients to see if they could complete the program and if it…

This study tested whether Swedish massage with lavender or chamomile oils can help reduce pain, fear, and anxiety during labor. 90 pregnant women were split into three groups: one got massage with chamomile oil, one with lavender oil, and one with plain carrier oil. Researchers m…

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This study tested whether an apomorphine pump can improve quality of life for people in the early stages of Parkinson's disease who have just started experiencing motor complications. 134 adults aged 65 or younger with mild Parkinson's used either the pump plus standard care or s…

This study tested whether full-spectrum CBD oil can help with anxiety and depression in people with Parkinson's disease. Twenty-seven participants took one of three daily doses (30, 60, or 300 mg) for two months. Researchers measured changes in anxiety and depression scores, alon…

This study tested a virtual reality app called StoryTelling Medicine (STM) to see if it could reduce anxiety in children aged 8–13 before elective surgery. The app guides kids through hospital settings in a fun, interactive way. Researchers measured anxiety, heart rate, and stres…

This study looked at whether music therapy can lower anxiety in women with early-stage breast cancer during chemotherapy. Twenty-seven patients took part, with some receiving music therapy sessions while others did not. Researchers measured anxiety levels before and after each ch…

This study looked at whether using a virtual reality hypnosis headset during a frozen embryo transfer is practical and can help lower anxiety. Fifty women undergoing IVF used the headset during the procedure. The main goal was to see if the headset could be used without technical…

This study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…

This study tested two types of deep brain stimulation in 20 people with Parkinson's disease: standard omnidirectional stimulation and a newer directional steering method. The goal was to see if steering the stimulation could better control motor symptoms like muscle rigidity. Par…

This study tested two numbing methods for carpal tunnel surgery in 100 adults. One method uses lidocaine with epinephrine and no tourniquet (WALANT), while the other uses lidocaine alone with a tourniquet. The main goal was to see which method causes less pain during the operatio…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study tested a new way to guide deep brain stimulation (DBS) surgery for essential tremor. Normally, patients must be awake during surgery to help doctors find the right spot in the brain. The new method uses a computer model to target the area while the patient is asleep. T…

This study tested a spinal stimulation device to help people with advanced Parkinson's disease walk better and improve balance. Two participants received an implanted stimulator and underwent rehabilitation for 3 to 5 months. The goal was to see if the approach is safe and could …

This study looked at whether a structured 8-week mindfulness-based stress reduction (MBSR) program is practical for people with Parkinson's disease. Thirty-one participants were enrolled to see how many could complete the program, including weekly group sessions and a full medita…

This study tested whether squeezing a stress ball during an ultrasound-guided biopsy can reduce pain and anxiety. 79 adults were randomly assigned to either use a stress ball or receive standard care alone. Researchers measured pain, anxiety levels, and vital signs before and aft…

This study tested a brief, community-based psychological program called Problem Management Plus to see if it can reduce depression, anxiety, and distress. Over 1,200 adults with mild to moderate symptoms took part. The program focuses on practical problem-solving skills in just f…

This study tested an experimental drug called AXS-12 (reboxetine) in 90 people with narcolepsy who experience cataplexy (sudden muscle weakness) and excessive daytime sleepiness. Participants took either the drug or a placebo twice daily for several weeks. The main goal was to se…

This study tested a speech therapy called ASSIST for children aged 4 to 9 with childhood apraxia of speech, a disorder that makes it hard to plan speech movements. Fifty-one children received 16 hours of individual therapy using repetition and cues. The goal was to see if the the…

This study tested whether aromatherapy with essential oils can reduce anxiety in adults before elective upper limb surgery. 289 participants were randomly assigned to either receive aromatherapy or not. The goal was to see if the scent helped people feel calmer in the operating r…

This study tested whether high doses of methylphenidate (Ritalin) could improve walking and attention in 69 people with advanced Parkinson's disease who still had severe gait problems despite standard treatments. Participants received either methylphenidate or a placebo for three…

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part in card-sorting sessions, phone calls, and home exercises.…

This study tested whether memantine, a drug that reduces overactive brain signals, can improve walking and attention in people with advanced Parkinson's disease. Twenty-eight non-demented patients with severe gait issues took memantine or a placebo for three months. The goal was …

This study tested whether a 6-session educational program could help people receiving electroconvulsive therapy (ECT) feel less stigma and anxiety about their mental health treatment. Sixty adult inpatients with conditions like depression or bipolar disorder took part. Those who …

This study tested whether wearing virtual reality goggles showing relaxing nature scenes and music during IUD insertion could reduce pain and anxiety. 70 women were randomly assigned to either VR or standard care. Researchers measured pain, anxiety, comfort, and vital signs. The …

This study tested whether the drug acetazolamide can improve walking in people with normal pressure hydrocephalus (NPH), a condition where excess fluid in the brain causes trouble walking, thinking, and bladder control. Fifty adults with NPH were randomly assigned to receive eith…

This study tested whether two drugs, oxycodone (a strong painkiller) and levodopa (a Parkinson's medication), can reduce nerve pain caused by Parkinson's disease. 67 adults with Parkinson's and chronic nerve pain took one of the drugs or a placebo for 8 weeks, alongside their usu…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested a personalized internet-based program (WebTIPS) to help children ages 1-12 feel less anxious before surgery and recover more smoothly. Over 1,200 parent-child pairs took part, with some using the tailored program and others receiving standard online information.…

This study tested whether personalized sound cues (like a custom beat) played through a smartphone could improve walking in people with Parkinson's disease. 60 participants walked while their steps were measured by sensors. The goal was to see if tailored cues could make steps mo…

This study tested a version of cognitive behavioral therapy (CBT) that was adapted to fit the cultural background of Canadians of South Asian origin. Researchers worked with 146 adults who had depression or anxiety to see if this tailored therapy could help reduce their symptoms.…

This study looked at whether adding pramipexole (a drug used for Parkinson's) for 6 months can safely reduce anhedonia — the loss of pleasure or interest — in people with depression. 55 adults who had already been in a shorter trial took pramipexole alongside their usual treatmen…

This study tested an 8-session stress management program for people recently diagnosed with Parkinson's disease and their caregivers. The program teaches relaxation techniques, healthy habits, and ways to change negative thinking. Researchers wanted to see if the program was prac…

This study tested whether a mild electrical current applied to the back of the head (cerebellum) can reduce shaking in people with essential tremor. Sixteen adults whose usual treatments weren't working well took part. Researchers measured tremor changes using rating scales and m…

This study tested whether N-acetylcysteine (NAC), an over-the-counter antioxidant, could improve learning and motor skills in children with neurofibromatosis type 1 (NF1). Five children aged 8 to 16 took NAC or a placebo to see if it helped with movement and attention problems. T…

This study tested a ketogenic drink made from medium chain triglycerides (MCTs) in 43 people with Alzheimer's disease or a type of frontotemporal dementia. The goal was to see if it was safe and tolerable, and to measure ketone levels in the blood. It was a small, early-stage tri…

This study tested whether botulinum toxin (Botox) injections can reduce head shaking in people with essential head tremor, a condition that often doesn't respond to standard medicines or surgery. About 120 adults with troublesome head tremor received either Botox or a placebo sho…

This Phase 3 study tested whether injections of MYOBLOC (a botulinum toxin type B) into the salivary glands can safely reduce troublesome drooling in adults. 187 participants received either MYOBLOC or a placebo. The main goals were to measure changes in saliva flow and overall i…

This study tested whether letting patients watch their own ACL reconstruction surgery live on a screen helps them feel less afraid of moving after the operation. 65 adults having ACL surgery under spinal anesthesia either watched the procedure or received standard care. The goal …

This study tested whether an interactive virtual reality (VR) system could help children aged 5–10 with Duchenne muscular dystrophy (DMD) stick to their physiotherapy exercises at home. Fourteen children used the VR system for 8 weeks, and researchers measured how often and how l…

This study tested a brief virtual therapy called MAPP (Mindful Adaptive Practice in Pregnancy) to help pregnant women manage COVID-19-related anxiety. 69 women participated, comparing MAPP to usual care. The goal was to see if the therapy is feasible and acceptable, not yet to pr…

This study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …

This study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…

This study tested a mindfulness-based program (including breathing exercises and meditation) in 39 Generation Z nursing students during their clinical internship. The goal was to see if it could improve mental health and reduce anxiety, depression, and stress compared to usual ca…

This study looked at whether a short virtual reality mindfulness session could help patients feel less anxious and stressed after heart surgery. 34 adults who had heart bypass or valve repair took part. One group did a 15-minute VR mindfulness exercise, while the other group rece…

This study tested whether breathing high-flow oxygen for 15 minutes can stop dystonic or plegic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder causing temporary paralysis and muscle spasms. 24 participants used oxygen or a placebo (med…

This completed Phase 3 trial tested whether two widely available drugs—fluvoxamine (an antidepressant) and metformin (a diabetes drug)—can reduce fatigue and other symptoms in people with long COVID. 399 adults with confirmed prior COVID-19 infection and persistent symptoms took …

This study tested if a simpler numbing method called WALANT works as well as a standard arm block for carpal tunnel release surgery. WALANT involves injecting numbing medicine directly into the wrist area, avoiding the need for a tourniquet or sedation. The trial included 130 adu…

This study tested a program that combines counseling (behavioral activation) with medication adjustments to reduce depression and anxiety in adults aged 60 and older who were scheduled for hip or knee replacement surgery. 116 participants were randomly assigned to receive the pro…

This small pilot study tested whether mirabegron, a drug typically used for overactive bladder, can raise blood pressure and reduce fainting in people with POTS who have low blood pressure that standard treatments didn't help. Twenty adults took either 25 mg or 50 mg of the drug …

This study tested whether using the WALANT technique (numbing the hand with local anesthetic and epinephrine) along with nerve blocks at the wrist could make carpal tunnel release surgery more comfortable than using a standard tourniquet. 60 adults having endoscopic carpal tunnel…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study tested a minimally invasive procedure for carpal tunnel syndrome using ultrasound guidance. 40 patients who did not get better with standard treatments received the procedure. Researchers measured pain, hand function, quality of life, and how quickly patients could ret…

This study tested a 5-week online group program called Rare Group Problem Management Plus (PM+) for parents of children with rare diseases. The program teaches stress management and problem-solving skills to help reduce anxiety, depression, and distress. Eight parents participate…

This study tested a program where parents and children prepare together before surgery to see if it lowers children's anxiety when they get anesthesia. Fifty children aged 5 to 12 having planned surgery took part. The program involved parents being present and prepared for the op…

This study tested a modified Mediterranean-ketogenic diet in 52 people with Parkinson's disease to see if it is safe for their gut microbiome. The diet limits carbs and emphasizes healthy fats and lean proteins. Researchers measured gut inflammation and other markers to check for…

This study tested whether a mild electrical current applied to the scalp for 5 days in a row could help adults who stutter speak more fluently. 36 participants received either real or sham stimulation while doing fluency exercises. Researchers measured changes in stuttering durin…

This study tested a special brace (STIL Orthosis) designed to reduce shaking (tremor) in people with Parkinson's disease. 25 participants had their tremor measured while wearing the active brace, a fake brace, and no brace. The goal was to see if the device could make everyday ta…

This study tested whether listening to positive affirmations along with classical music during a cesarean section could lower anxiety and improve breastfeeding. 99 women were split into three groups: one listened to affirmations with music, one listened to music only, and one had…

This study tested whether a trained nurse using 'hypnotic communication'—a calm, supportive way of talking—could help men feel less anxious and experience less pain during a prostate biopsy. One hundred men were randomly assigned to receive either standard care or standard care p…

This small study tested whether a spinal cord stimulator (a device that sends mild electrical pulses to the spinal cord) could reduce freezing of gait in people with Parkinson's disease. Ten participants who did not get relief from standard treatments received the implant. Resear…

This study looked at behavior problems in 101 children aged 3 to 6 with tuberous sclerosis complex (TSC). Families completed assessments online, and those with elevated behavior issues were offered a parent-training therapy (PCIT) over the internet. The goal was to help parents m…

This study tested whether wearing a virtual reality headset showing a nature video could reduce pain and anxiety in 90 adults undergoing coronary angiography, a heart procedure where patients are awake. One group watched the VR video during the procedure, while the other received…

This small pilot study tested whether a temporary spinal cord stimulator (like a pacemaker for the spine) could help people with spinal muscular atrophy types 3 and 4 move their legs better. Three adults who could stand independently received the implant for up to 29 days. The go…

This study tested whether using virtual reality (VR) glasses for 30 minutes each evening could improve sleep quality, reduce anxiety, and stabilize vital signs in intensive care patients with COPD. Fifty patients were split into two groups: one received VR sessions for a week, th…

This study tested whether listening to music during radionuclide treatment helps prostate cancer patients feel less anxious and distressed. Sixty men were split into two groups: one listened to their choice of instrumental music through headphones during treatment, while the othe…

This study tested whether a program called MindUP could help lower depression, anxiety, and stress in orphan teenagers in Pakistan. 61 boys aged 11-16 living in orphanages took part. Some did the MindUP program, which teaches mindfulness and emotional skills, while others did the…

This study tested a psychological intervention to help people with Parkinson's disease who experience freezing of gait triggered by anxiety. 41 participants learned strategies to manage stress and attention while walking. The goal was to see if this approach could reduce the time…

This study tested whether infusing tiny bubbles of oxyhydrogen gas could help people with Parkinsonism. 35 adults received the infusion alongside their usual care. Researchers measured changes in disease severity, thinking ability, and quality of life. The goal was to see if this…

This study tested whether progressive muscle relaxation (PMR) — a technique where you tense and then relax different muscle groups — could help nursing students feel less depressed, anxious, and stressed. Over 100 students were split into two groups; one group practiced PMR three…

This study looked at whether taking an NAD+ precursor (a vitamin-like supplement) along with exercise training can improve aerobic capacity (how well the body uses oxygen during exercise) in people with Friedreich's ataxia. The trial included 75 participants aged 10 to 40. Resear…

This study tested a gel called ZYN002, applied to the skin, in 20 children and teens (ages 4-17) with 22q11.2 deletion syndrome. The main goal was to see if the gel is safe and tolerable over 38 weeks. Researchers also looked at whether it could improve behavior and other symptom…

This study tested whether a gentle electrical current applied to the scalp (tDCS) can reduce symptoms of major depression, schizophrenia, OCD, generalized anxiety, and insomnia. 320 adults aged 16–65 received multiple sessions over weeks. Researchers measured symptom changes usin…

This study tested a stepped-care telehealth program for cancer survivors living in rural areas who experience anxiety, depression, or sleep problems. Participants received either low-intensity check-ins or high-intensity phone therapy with a licensed therapist, depending on sympt…

This small pilot study looked at whether osteopathic manipulative therapy (OMT) can reduce stiffness in the median nerve and improve symptoms in people with mild to moderate carpal tunnel syndrome. Ten participants received OMT along with standard care. Researchers measured nerve…

This study tested whether using virtual reality (VR) during tooth extractions can lower anxiety in adults. 119 people having at least two teeth pulled under local anesthesia were randomly assigned to either use VR or not. Researchers measured anxiety before and during the procedu…

This study tested a daily microalgae extract (Tetrasol) in 62 healthy adults with mild stomach issues to see if it helps gut health, anxiety, and immune function. Participants took the supplement for 4 weeks, and researchers measured symptoms, stress levels, and safety through bl…

This completed phase 2 trial tested whether a non-invasive magnetic coil placed on the upper back could improve walking in 42 Parkinson's patients who already have deep brain stimulation but still have gait problems. Participants received either active or placebo stimulation in a…

This Phase 2 trial tested whether insulin sprayed into the nose is safe for people with Parkinson's disease. Over 3 weeks, 31 participants received either intranasal insulin or a placebo. Researchers monitored safety events like low blood sugar and weight loss, and also looked at…

This study tested whether a non-invasive brain stimulation technique called TMS could reduce symptoms of obsessive-compulsive disorder (OCD) in 26 adults. The treatment targeted a brain area involved in movement planning. Researchers also looked for clues about how TMS works and …

This study looked at whether adding low-level laser therapy or nerve mobilization (gentle stretching of the median nerve) after carpal tunnel release surgery improves nerve function more than surgery alone. Forty-five adults who had carpal tunnel surgery were split into three gro…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study followed 180 adults with syringomyelia, a condition where a cyst forms in the spinal cord, for up to 5 years. Researchers tracked symptoms, muscle strength, and MRI scans to learn how the disease progresses and how surgery affects outcomes. The goal was to gather knowl…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study looks at how the constant vibration from tattoo machines may damage nerves in the hands of tattoo artists. Researchers will test touch, strength, and sensation in 20 tattoo artists and compare them to 20 people who don't use vibrating tools. The goal is to understand i…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study looked at the genetics of Chiari I malformation, a condition where part of the brain pushes into the spinal canal. Researchers analyzed DNA and family histories from 152 participants to find genes that may cause the malformation. The goal was to better understand why i…

This study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

Researchers at the University of Barcelona are comparing the teeth, jaws, and facial structure of 25 people with hereditary spastic paraplegia (HSP) against 25 people without the condition. They use non-invasive scans and X-rays to measure jaw relationships, tooth alignment, and …

This study compares two ways of teaching nurses about Parkinson's disease: a PechaKucha presentation with 20 slides that auto-advance every 20 seconds, versus a traditional PowerPoint with flexible pacing. Seventy-two nurses are split into two groups, each receiving the same educ…

This study uses advanced PET brain scans to measure dopamine, acetylcholine, and tau protein levels in people with GBA gene mutations, both with and without Parkinson's disease. Researchers also analyze typing patterns on a computer or touchscreen to detect subtle motor changes. …

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This study looks at X-linked juvenile retinoschisis (XLRS), a rare inherited eye disease that causes vision loss in young males. Researchers will examine 351 participants, including affected males and female carriers, using eye exams, retinal photos, and genetic tests. The goal i…

This completed study by the National Human Genome Research Institute looked at 207 people with Moebius syndrome or similar congenital facial weakness disorders, along with their family members. Researchers aimed to better understand the genetic and clinical features of these cond…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

Researchers at the University of Aberdeen are investigating whether gut bacteria differ in people with Parkinson's disease, especially those with constipation. They will collect stool samples from 30 participants: newly diagnosed Parkinson's patients who have not yet started medi…

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study followed 78 people with GNE myopathy, a rare genetic disease that causes progressive muscle weakness starting in young adulthood. Researchers collected medical history, blood samples, and muscle function tests over up to two years to understand how the disease progress…

This study follows 400 Parkinson's disease patients who are scheduled for deep brain stimulation (DBS) surgery, a treatment that uses implanted electrodes to ease motor symptoms. After the operation, some patients experience postoperative delirium, a state of confusion that can s…

This study tests whether brain scans and decision-making tasks can predict how well people with anxiety and depression respond to different types of talk therapy. Participants will be randomly assigned to one of three therapies: behavioral activation, exposure-based therapy, or s…

This study follows people who have a 50% chance of inheriting a gene for spinocerebellar ataxia, a group of progressive brain disorders that affect movement and coordination. The goal is to identify the earliest clinical signs and biological markers that appear before the disease…

This study investigates why some girls with Turner syndrome find it hard to make friends, read emotions, and control their feelings. Researchers will compare 35 girls with Turner syndrome to 35 girls with isolated growth hormone deficiency, all aged 7 to 16. Through puzzles, memo…

This study looks at medical records from public hospitals in Spain to count how many children, teenagers, and adults have Dravet syndrome or Lennox-Gastaut syndrome, and how many new cases are diagnosed each year. It is an observational study, meaning no treatment or intervention…

This study investigates whether proteins from the Hippo signaling pathway—known to control cell growth and bone health—are present at different levels in the gum fluid of people with healthy gums, gingivitis, or periodontitis. Researchers will collect fluid samples from 75 partic…

This study aims to understand the lived experiences of family caregivers who provide unpaid care to people with mental health conditions like depression, anxiety, and trauma in Zambia during the COVID-19 pandemic. Researchers will interview caregivers and mental health experts to…

This study looks at how children over age 3 with pyridoxine-dependent epilepsy, a rare genetic condition, develop cognitively over time. Researchers will use a standardized questionnaire called Vineland II to measure adaptive behaviors like communication and daily living skills. …

This study tests a gene therapy technique in the lab using skin cells from people with Huntington's disease. The goal is to see if the therapy can correct the genetic mistake that causes the disease. If it works in these cells, it could be a step toward a future treatment.

This study investigates whether brain signals can be recorded at home in people with essential tremor who have a deep brain stimulation (DBS) device. The goal is to see if these recordings are clear enough to understand how the brain responds to stimulation during rest and moveme…

This study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…

This study looked at how the brain uses energy in people with early Huntington disease. Ten adults had an MRI scan to measure brain energy levels while resting and watching flashing lights. The goal was to understand brain metabolism, not to test a new treatment.

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

This study follows 40 people with Friedreich's ataxia, a hereditary neurological condition that affects movement and speech, to see how their oral communication changes over one year. Researchers will assess speech clarity, voice quality, and hearing using speech therapy evaluati…

This study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…

This study tests whether a special camera called the OcuMet Beacon can detect stressed cells in the retina of people with geographic atrophy, an advanced form of age-related macular degeneration. Researchers want to see if the patterns of stress match areas of damage seen on stan…

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This project creates a central repository of medical records, genetic test results, and patient-reported information from people with Duchenne or Becker muscular dystrophy, as well as carriers. Anyone aged 4 weeks or older with a confirmed diagnosis can join. The goal is to provi…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study compared two different eye imaging machines (Clarus and Optos) to see how well they measure geographic atrophy, a form of vision loss from age-related macular degeneration. Researchers enrolled 62 patients and took images with each device, then compared the measurement…

This study looks at how much protein adults with facioscapulohumeral muscular dystrophy (FSHD) need each day to support muscle health. Researchers will test different amino acid intakes in 10 participants using a non-invasive technique. The goal is to improve dietary recommendati…

This study investigates whether a quick, painless electrical measurement called transimpedance matrix (TIM) can detect scar tissue (fibrosis) that sometimes forms inside the cochlea after cochlear implant surgery. Researchers will compare TIM results with CT scans in 180 adults w…

This study investigates whether levels of the hormone ghrelin in the blood differ between people with various types of dementia, including Alzheimer's disease and dementia with Lewy bodies. Researchers will collect blood samples from 85 participants over age 60, both fasting and …

This study tests whether a remote monitoring program can reliably track the health of people who have had surgery for pheochromocytoma or paraganglioma (PPGL), rare adrenal tumors. Participants use an internet platform to report their data, which is compared to information collec…

This study tests whether a new, high-field 3T MRI technique can more accurately pinpoint the subthalamic nucleus — a key brain area targeted during deep brain stimulation (DBS) for Parkinson's disease. Researchers will compare images from the new method with standard 1.5T MRI in …

This study looks at whether certain slow brain waves in the prefrontal cortex can be a sign of social anxiety. Researchers will measure brain activity in 30 people with social anxiety disorder while they wait to give a speech. The goal is to better understand the brain's role in …

This study looks at tiny nerve fibers in the skin of people with Long COVID, POTS, diabetic neuropathy, and those who had COVID-19 without lasting symptoms. By comparing skin samples, researchers hope to find unique patterns that help explain ongoing symptoms like pain and dizzin…

This completed study created the first international database of Datscan imaging values from 300 patients. The goal was to help doctors better diagnose Parkinson's disease and other neurodegenerative conditions by comparing brain scan results. Researchers hope this database will …

This study tested whether three weekly sessions of basic disaster awareness education could improve disaster literacy and reduce earthquake anxiety in adolescents aged 10-14. A total of 128 students from two middle schools in Erzincan took part, with half receiving the education …

This study looks at what people with age-related macular degeneration (AMD) know about their disease and what they need to manage it better. Researchers will survey and interview 118 patients to understand their knowledge, daily challenges, and support needs. The goal is to use t…

This completed study looked for specific gene patterns in the blood that could help diagnose Parkinson's disease and distinguish it from similar conditions. Researchers analyzed blood samples and brain scans from 219 people with Parkinson's or related disorders. The goal is to de…

This completed study followed 316 people with idiopathic generalized epilepsy, including those newly diagnosed and those already known to respond or not respond to treatment. Researchers collected data from seizure diaries, fitness trackers, quality-of-life surveys, and cognitive…

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This study looks at whether a specific gene variant (ApoE4) is more common in people with certain brain MRI patterns that suggest cerebral amyloid angiopathy (CAA), a condition where proteins build up in brain blood vessels. Researchers will analyze genetic samples from 100 patie…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study looked at how the brain's emotional centers work in people with Parkinson's disease who had just received a deep brain stimulator implant. Researchers measured brain activity while patients listened to sounds or saw images with emotional meaning. The goal was to better…

This study tested whether using augmented reality (AR) or a 3D hip model helps first-year nursing students learn how to give intramuscular injections better than traditional methods. 146 students were randomly assigned to practice with AR, a 3D model, or a standard model. Researc…

This study from the University of Oxford aims to understand how specific physiotherapy exercises (neurodynamic exercises) work for carpal tunnel syndrome. Researchers will compare these exercises to standard steroid injections and simple advice in 78 patients with mild to moderat…

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…

This study tested whether a computer program could predict which older patients (over 75) would have unnecessary days in the hospital. Researchers analyzed electronic health records from 102 patients in an acute geriatric unit. The goal was to create an algorithm that flags when …

This study explores whether a special type of MRI called flow MRI can improve the diagnosis and management of normal pressure hydrocephalus, a condition where excess fluid builds up in the brain's cavities. Researchers will measure how cerebrospinal fluid and blood move through t…

This completed study from France examined perfectionism, depression, and anxiety in 59 people with Parkinson's disease. Participants filled out standard questionnaires about perfectionism, mood, and anxiety. The goal was to better understand how these psychological factors relate…

This study looked at how Doose syndrome, a rare form of epilepsy, affects children's ability to learn and develop. Researchers followed 9 children and asked their parents about the disease's impact on school and daily life. The goal was to better understand the link between seizu…

This study looked at 75 older adults with suspected normal pressure hydrocephalus, a condition that can cause a reversible form of dementia. Researchers used a combination of fluid infusion tests and special MRI scans to better understand how brain fluid and pressure interact. Th…

This study looked at how the brain chemical serotonin works in people with multiple system atrophy (MSA), a rare and serious nerve disease. Researchers used special PET scans to measure serotonin receptors in the brains of 53 adults with MSA or Parkinson's disease. The goal was t…

This completed study in Russia checked how many people with carpal tunnel syndrome also have a rare inherited nerve condition called hereditary transthyretin amyloidosis. Researchers reviewed medical records of 721 patients and will test some for the genetic mutation. The goal is…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study looked at 120 people with Friedreich's ataxia, a rare genetic disease that causes progressive movement problems. Researchers examined tiny interruptions in the DNA expansion that causes the disease to see if they influence when symptoms start and how severe they become…

This study used body-worn sensors to track movement in 132 people with early, untreated Parkinson's disease over 12 months. The goal was to see if digital measurements could accurately measure disease progression and match standard clinical assessments. The findings may help deve…

This study looked at whether people with essential tremor have trouble making decisions or recognizing facial emotions. Researchers compared 39 patients with healthy volunteers using special tests. The goal was to understand how the condition might affect daily social life.

This study looked at MRI scans from 72 people with two common types of small vessel disease in the brain: hypertensive arteriopathy and cerebral amyloid angiopathy. Researchers focused on tiny fluid-filled spaces in a part of the brain called the dentate nucleus. The goal was to …

This study looked at the extra costs that families of people with Duchenne muscular dystrophy (DMD) in France have to pay out of their own pockets. It included 28 patients of any age who had been diagnosed for at least six months. The researchers measured things like uninsured me…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study tested whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home, avoiding long trips to the clinic. It involved 40 patients and their caregivers, with half using the system for up to 18 months. The goal was to see…

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This study looked at how the way words sound (phonotactic probability) and how they are spelled (orthography) affect vocabulary learning in 23 children with low oral language skills (DLD). All children took part in the same 12-week program, which used real words to improve vocabu…

This study looked at 158 people with Parkinson's disease to see if different thinking patterns are linked to differences in brain structure and activity. Researchers grouped participants based on their cognitive profiles and compared brain scans and EEG readings. The goal was to …

This study followed 516 older adults in France for 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers used eye exams and imaging to track the disease and look for risk factors like genetics and lifestyle. The goal is …

This study looked at how a specific brain chemical system (cholinergic) might be involved in dystonia, a condition causing muscle spasms and abnormal postures. Researchers used PET scans to measure chemical activity in the brains of 40 adults with a genetic form of dystonia (DYT1…

This study looked at how leg muscles work in people with Parkinson's disease when they walk forward and backward while also doing a mental task. Researchers compared 30 Parkinson's patients to healthy people of similar age. The goal was to understand why multitasking while walkin…

This completed study looked at how the drug deferiprone affects blood cells from 90 people with Parkinson's disease, ALS, or healthy volunteers. Researchers measured markers of oxidative stress and iron levels in the lab. The goal was to better understand these diseases, not to t…

This study examined how vision loss progresses in people with geographic atrophy, an advanced form of dry age-related macular degeneration. Researchers analyzed past medical records and eye images from 60 patients to see which retinal changes are linked to faster vision decline. …

This study aims to create a better way to help older adults with muscle, bone, or nerve problems who are at risk of falling. Researchers will first study patients' health profiles and balance, then test a simple exercise program called OTAGO to see if it prevents falls. The goal …

This study looked at 70 Parkinson's patients to see if their personality, coping style, and social support could predict how much their quality of life improved after six months of continuous apomorphine infusion. Researchers measured personality traits before treatment and compa…

This study looked at whether a special walking test (3D gait analysis) can help identify movement problems in people with rare genetic diseases like Tuberous Sclerosis and STXBP1. About 40 participants aged 6 and older who could walk without help took part. The goal was to see if…

This study tested whether using a special scanner (O-ARM) in the operating room is as good as standard imaging done before surgery for placing brain electrodes in Parkinson's patients. 24 people took part, and researchers measured how accurately the electrodes were placed. The go…

This study looked at whether a food safety training program helps food service employees improve their knowledge, attitudes, and practices around safe food handling. About 200 adult workers took part, and the training covered personal hygiene and safe food preparation. The goal w…

This study used eye-tracking to see how people with Alzheimer's, Parkinson's, or frontotemporal dementia look at faces when trying to recognize emotions. Researchers compared their eye movements to healthy adults. The goal was to understand if different visual strategies explain …

This study tested whether wearable sensors can reliably measure movement problems in people with Parkinson's disease. Fifty participants wore sensors while performing tasks like finger tapping and walking. The goal was to see if these sensors could provide objective data to help …

This study looked at pain thresholds in people with multiple system atrophy (MSA) and Parkinson's disease. Researchers tested how levodopa, a common Parkinson's drug, affects pain perception. The goal is to better understand the causes of pain in MSA and improve future treatment.

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This study looked at 70 people with idiopathic normal pressure hydrocephalus (iNPH), a condition that causes walking problems, memory loss, and bladder control issues. The goal was to find better ways to predict which patients would benefit from a surgery that drains extra fluid …

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This study followed 700 Parkinson's patients who received deep brain stimulation to see which factors predict a meaningful improvement in quality of life after 1, 3, and 5 years. Researchers analyzed clinical, imaging, and genetic data to identify who benefits most. The goal is t…

This study looked at whether simple eye-tracking tests can help measure how Parkinson's disease changes over time. About 300 people with early-stage Parkinson's had their eye movements recorded and compared with standard clinical exams. The goal was to see if eye tests could dete…

This study looked at families with at least two members who developed Alzheimer's before age 65. Researchers wanted to find new genes that cause the disease, beyond the three already known. They collected medical and genetic information from 150 people across 23 centers in France…

This study looked at whether digital services like smartphone apps can help people with psychosomatic disorders continue their treatment during the COVID-19 pandemic, when social distancing and hygiene rules limit in-person therapy. About 2000 patients from clinics took part, usi…

This study tested whether holding a newborn skin-to-skin right after a C-section (within 5 minutes) or within the first hour helps with breastfeeding, reduces anxiety, and keeps mom and baby healthy. 92 mothers and their newborns took part. The results showed that early contact c…

This study observed over 20,000 people with Parkinson's disease to find genetic links and potential biomarkers. Participants were between 30 and 80 years old and diagnosed within the last 5 years. No treatments were tested; the goal was to better understand the disease's genetic …

This completed study involved over 2,200 people diagnosed with or suspected of having frontotemporal dementia (FTD). Researchers collected blood samples to look for genetic changes linked to the disease. The goal was to find out how common these genetic causes are in people with …

This study looked at why girls with Rett syndrome often develop weak bones (osteoporosis) at a very young age. Researchers checked bone density, looked at medical history, and measured certain proteins in the blood. The goal was to find risk factors and understand the biological …

This study looked at 70 people who had a brain hemorrhage (bleeding stroke) to see if a special PET scan could tell whether the bleeding was caused by amyloid buildup in blood vessels or by high blood pressure. Participants received an injection of a radioactive tracer called Flo…

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This study tested two methods for moving canine teeth in people wearing braces. One method used force only from the front (labial), while the other added force from the roof of the mouth (palatal) at the same time. The goal was to see which approach moves teeth faster and with fe…

This study looked at how people with Alzheimer's disease or a type of frontotemporal dementia remember personal events from their past. Researchers tested 39 participants using a detailed scale to see if memories were specific (like a single event in time and place) or more gener…

This study looked at 78 people in Pakistan who had surgery for a detached retina. Doctors compared two types of fillers used inside the eye after surgery—gas or silicone oil—to see if one caused more shifting of the retina afterward. The goal was to learn how the choice of filler…

This study followed 72 children who were diagnosed before birth with a missing or abnormal corpus callosum, the bundle of nerves connecting the brain's two halves. Researchers tested their thinking, movement, and behavior at age 3 to understand how they develop. The goal was to g…

This study followed 80 people with newly diagnosed Cushing's disease for three years to see how the disease affects the heart, bones, metabolism, and quality of life. Researchers used blood tests, heart scans, bone density tests, and questionnaires to track complications before a…

This completed study looked at 200 people with cerebral amyloid angiopathy (CAA), a condition where protein builds up in brain blood vessels, raising the risk of bleeding and cognitive decline. Researchers collected clinical data, brain scans, and samples of spinal fluid and bloo…

This study tested how accurately a robot system called Neurolocate helps place electrodes in the brain during deep brain stimulation surgery. It involved 18 adults with Parkinson's disease, dystonia, or tremor. The goal was to see if the robot could improve precision, reduce surg…

This study examined 186 people with Alzheimer's, Lewy body, frontotemporal, or corticobasal dementia, plus healthy controls, to see if subtle physical signs (like coordination or reflexes) differ between dementia types. Participants had simple exams and cognitive tests. The goal …

This study looked at proteins in the eye fluid of 100 people with wet age-related macular degeneration (AMD). The goal was to measure certain growth factors that might explain why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers collected a …

This pilot study examined whether inflammation, measured by cytokines in the blood, plays a role in type 1 facioscapulohumeral muscular dystrophy (FSHD1). Researchers compared 20 FSHD1 patients with healthy controls to see if certain inflammatory markers are higher in the disease…

This study looked at 70 family caregivers of stroke patients who also have bladder issues. Researchers measured how much burden, fatigue, poor sleep, and depression caregivers experience. The goal was to understand the challenges these caregivers face, not to test a new treatment…

This completed study looked for genetic causes of Chiari type I malformation, a condition where part of the brain pushes into the spinal canal. Researchers took blood samples from 40 people with the condition and their relatives to analyze their DNA. The goal was to find specific…

This study followed 609 nearsighted adults who had lens surgery to see if a natural eye change called posterior vitreous detachment (PVD) affects their risk of retinal detachment. Participants were grouped by whether they had PVD before surgery or not, and were monitored for up t…

This completed observational study enrolled 1,141 participants with mild cognitive impairment or Alzheimer's disease. Researchers tracked changes in memory tests, brain scans, and other biomarkers over time. The goal was to improve how future clinical trials measure the disease, …

This completed study enrolled 230 people with Parkinson's disease, a related sleep disorder, and healthy volunteers. Participants used a smartphone app to track their movements daily and underwent brain scans. Some also gave skin biopsies to test for a protein linked to Parkinson…

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This study tested a special fiber-optic sensor that can measure breathing and heart rate during MRI scans. The goal was to see if these measurements could show how anxious a patient feels. 200 MRI patients took part, and their sensor readings were compared to anxiety questionnair…

This completed study enrolled 150 people with Duchenne muscular dystrophy to create a video database of their movement abilities. Caregivers recorded children doing specific tasks at home using a secure app. The goal was to help validate a new tool called the Duchenne Video Asses…

This study looked at 30 adults in rehabilitation who needed a walking aid for the first time. Researchers checked their hand and wrist health before and after using the aid, using questionnaires and nerve tests. The goal was to see if using canes or walkers might lead to carpal t…

This study looked at 44 people with a rare inherited eye condition called Leber Hereditary Optic Neuropathy (LHON) that causes vision loss. Researchers reviewed medical records and asked participants about their vision, health, and quality of life. The goal was to better understa…

This study involved 116 people with Limb Girdle Muscular Dystrophy (LGMD), a group of rare muscle-weakening disorders. Researchers measured how well participants could walk, move their arms, and breathe, and asked about their daily activities and overall health. The goal was to i…

This completed registry study collected information from 82 people with Angelman syndrome in Italy. The goal was to track medical and behavioral problems linked to the condition. No treatments or interventions were tested; instead, the data will help researchers better understand…

This completed study looked at over 2,500 people with Parkinson's disease who were admitted to the hospital through the emergency room. Researchers wanted to find the main reasons for these hospital stays and compare them to people of the same age without Parkinson's. The goal wa…

This study looked at 77 people with Alzheimer's or frontotemporal dementia to understand why some lose awareness of their condition (anosognosia). Researchers used EEG and brain scans to measure how the brain responds to mistakes and emotional signals. The goal is to find brain m…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study tested whether a generic selegiline skin patch works the same as the brand-name EMSAM patch. Twelve healthy adults wore both patches to measure how much drug got into their blood and to check for skin irritation. The goal was to see if the generic version is a safe and…

This completed study surveyed 3,100 adults in Slovakia to find out how many people have mental disorders like depression, anxiety, PTSD, or addiction. Researchers used a standard interview tool to measure current and lifetime rates, and looked at who gets help and who doesn't. Th…

This study measured anxiety levels in 543 nurses who have worked in psychiatric settings for over a year. Researchers used a standard anxiety questionnaire to understand how stress from unpredictable patients, violence risk, and emotional demands affects these healthcare workers.…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study looked at how the brain chemical dopamine behaves in people with idiopathic generalized epilepsy compared to healthy volunteers. Researchers measured yawning and blinking after giving a low dose of apomorphine, a drug that mimics dopamine. The goal was to understand br…

This study tested a French version of a questionnaire that measures physical activity levels in people with physical disabilities. Fifty participants with conditions like stroke, multiple sclerosis, or Parkinson's disease filled out the questionnaire twice, two weeks apart. The g…

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study collected blood and DNA samples from 26 people with early-onset Alzheimer's disease and their close family members. Researchers analyzed the samples to find genetic changes and biomarkers that could help doctors diagnose, treat, and monitor the disease in the future. T…

This completed study looked at 150 children with severe to profound hearing loss to find how many have a specific genetic form called DFNB9. Researchers collected medical and genetic data from routine care. The goal was to better understand this condition and pave the way for fut…

This study tested whether a mobile app (myFSHD) can help doctors monitor patients with facioscapulohumeral muscular dystrophy (FSHD) remotely. 70 adults with FSHD used the app at home for 12 months, completing questionnaires and video-recorded exercises. The goal was to see if pa…

This completed observational study looked at 29 people with suspected normal pressure hydrocephalus (NPH), a condition where fluid builds up in the brain. Researchers used a special MRI technique called DTI-ALPS to measure the function of the brain's waste-clearing 'glymphatic sy…

This study looked at 91 people with a type of bleeding in the eye caused by age-related macular degeneration (AMD). It compared two treatments: surgery followed by anti-VEGF injections, or a gas injection followed by anti-VEGF injections. The goal was to see which approach helps …

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at 202 people who had surgery for retinal detachment, a condition where the light-sensitive layer at the back of the eye pulls away. Researchers used high-resolution eye scans and vision tests to see how the eye heals over a year. The goal was to better understa…

This 18-week open-label study examines the effectiveness of Full-Spectrum Medicinal Cannabis Plant Extract containing 0.08% THC (NTI164) in treating Rett syndrome (RTT) in children and young people. The study aims to determine the impact of NTI164 on RTT symptoms over a 16-week t…

This study investigates the relationship between heart-beat haptic feedback on interoceptive awareness and mental-wellbeing. Previous research showed non-significant results in short-term emotion regulation tasks when given heartbeat haptic feedback, suggesting the need for an ex…

The goal of this clinical trial is to evaluate the immediate effects of individualized 130 Hz STN-tTIS(Subthalamic Nucleus - transcranial Temporal Interference Stimulation)on motor symptoms in early-to-mid-stage PD patients during both medication "on" and "off" states. The main q…

It's a multicentric, randomized, controlled study concerning 100 patients with treatment-resistant obsessive compulsive disorders (OCD). The aim of this study is to evaluate the effect of transcranial direct current stimulation (tDCS) on OCD patients.

The purpose is to show that bifocal tDCS with an anodal stimulation on the orbitofrontal cortex and cathodic stimulation on supplementary motor areas is an effective treatment for patients with resistant and severe obsessive compulsive disorders.