Botox-Like shots may calm shaky hands in essential tremor

NCT ID NCT04766723

Completed Symptom relief Sponsor: Merz Pharmaceuticals GmbH Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single injection of botulinum toxin (NT 201) can reduce hand tremors in people with essential tremor. 78 participants received either the drug or a placebo, and neither they nor the researchers knew who got what. The main goal was to measure tremor improvement using a wearable sensor and a clinical rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Botulinum toxin (NT 201, also known as incobotulinumtoxinA or Xeomin)
What this could lead to: If it works, this could provide a new treatment option to reduce hand tremors in people with essential tremor.
What could go wrong: This is an early phase 2 trial with only 78 participants. The treatment may not work better than placebo, and botulinum toxin can cause muscle weakness or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

essential tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESSENTIAL TREMOR OF THE UPPER LIMB

Contacts and locations

Locations

Cleveland Clinic Lou Ruvo Center for Brain Health, Merz Investigational Site #0010457

Las Vegas, Nevada, 89106, United States
Houston Methodist Neurological Institute, Merz Investigational Site #0010226

Houston, Texas, 77030, United States
Instytut Zdrowia Dr. Boczarska-Jedynak

Oświęcim, 32-600, Poland
London Health Sciences Centre, Merz Investigational Site #0010087

London, Ontario, N6A 5A5, Canada
Mazowiecki Szpital Bródnowski, Merz Investigational Site #0480064

Warsaw, 03-242, Poland
Medstar Georgetown Neurology, Merz Investigational Site #0010231

McLean, Virginia, 22101, United States
Mount Sinai Medical Center, Merz Investigational Site #0010191

New York, New York, 10029, United States
NeuroKlinika Gabinet Lekarski, Merz Investigational Site #0480101

Lodz, 90-640, Poland
Selkirk Neurology, Merz Investigational Site #0010456

Spokane, Washington, 99202, United States
Specjalistyczne Gabinety, Merz Investigational Site #0480059

Krakow, 30-539, Poland
USF, Department of Neurology, Merz Investigational Site #0010020

Tampa, Florida, 33612, United States
UW Medical Center - Montlake, Merz Investigational Site #0010450

Seattle, Washington, 98195, United States
University of Nebraska Medical Center, Merz Investigational Site #0010269

Omaha, Nebraska, 68131, United States
Vanderbilt University Medical Center, Neuroscience Institute, Merz Investigational Site #0010206

Nashville, Tennessee, 37232, United States