New hope for daytime sleepiness in Prader-Willi syndrome?
NCT ID NCT04257929
First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 29 times
Summary
This study tests a drug called pitolisant to see if it can safely reduce severe daytime sleepiness in people with Prader-Willi syndrome, a genetic condition. About 65 participants aged 6 to 65 will receive either pitolisant or a placebo for 11 weeks, followed by an open-label phase where everyone gets the drug. The main goal is to measure changes in sleepiness using a standard questionnaire.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ann and Robert H Lurie Children's Hospital
Chicago, Illinois, 60611, United States
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CTI
Cincinnati, Ohio, 45212, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Johns Hopkins School of Medicine
Baltimore, Maryland, 21205, United States
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Nemours Alfred I duPont Hospital for Children
Wilmington, Delaware, 19803, United States
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Rady Children's Hospital - San Diego
San Diego, California, 92123, United States
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Road Runner Research
San Antonio, Texas, 78249, United States
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Santa Monica Clinical Trials
Santa Monica, California, 90404, United States
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Sleep Medicine Specialists of California
San Ramon, California, 94583, United States
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Texas Children's Hospital/Baylor College of Medicine
Houston, Texas, 77030, United States
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University of Florida College of Medicine
Gainesville, Florida, 32608, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68114, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37203, United States
Conditions
Explore the condition pages connected to this study.