New epilepsy drug shows promise for Long-Term seizure control

NCT ID NCT03961568

Completed Disease control Sponsor: SK Life Science, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at the long-term safety of the drug cenobamate when added to existing treatment for people with primary generalized tonic-clonic seizures. A total of 147 participants who completed an earlier study took cenobamate for up to 52 weeks. Researchers tracked side effects, lab results, and vital signs to see how well the drug was tolerated over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cenobamate

What this could lead to

If successful, this could confirm cenobamate as a safe long-term add-on treatment to reduce seizure frequency in people with generalized epilepsy.

What could go wrong

This is an open-label extension study, so there is no placebo group for comparison. Side effects may still emerge, and the results may not apply to all epilepsy types.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

idiopathic generalized epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY GENERALIZED TONIC CLONIC SEIZURES IN THE SETTING OF IDIOPATHIC GENERALIZED EPILEPSY

Contacts and locations

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Locations

Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD

Sofia, Sofia, 1407, Bulgaria
Centrum Leczenia Padaczki i Migreny

Krakow, Lesser Poland Voivodeship, 31-209, Poland
Centrum Medyczne Pratia Warszawa

Warsaw, Masovian Voivodeship, 01-868, Poland
Cerebrovaskularni poradna

Ostrava-Poruba, 708 52, Czechia
Clinical Research Center Spólka z Ograniczona Odpowiedzialnoscia Medic-R sp. k.

Poznan, Greater Poland Voivodeship, 60-848, Poland
Communal Institution "Dnipropetrovsk Regional Clinical Hospital n.a. I.I. Mechnikov", Regional Center

Dnipro, 49005, Ukraine
Communal Non-Commercial Enterprise of Kharkiv Regional Council

Kharkiv, 61068, Ukraine
Consultants in Epilepsy and Neurology, PLLC

Boise, Idaho, 83702, United States
Diagnostic Consultative Center Equita EOOD

Varna, Varna, 9000, Bulgaria
Diagnostic Consultative Center Neoclinic EAD

Sofia, Sofia, 1408, Bulgaria
Duke University

Durham, North Carolina, 27705, United States
Fakultni nemocnice v Motole

Prague, 150 06, Czechia
Five Towns Neuroscience Research

Woodmere, New York, 11598, United States
Forbeli s.r.o.-Neurologicka ambulance

Prague, 160 00, Czechia
Górnoslaskie Centrum Medyczne im. prof. Leszka Gieca Slaskiego Uniwersytetu Medycznego w Katowicach

Katowice, Silesian Voivodeship, 40-635, Poland
Hawaii Pacific Neuroscience

Honolulu, Hawaii, 96814, United States
IN MEDIC s.r.o.

Bardejov, 085 01, Slovakia
Konzilium, s.r.o.

Dubnica nad Váhom, 018 41, Slovakia
MUDr. Beata Dupejova, neurologicka ambulancia, s.r.o.

Banská Bystrica, 974 04, Slovakia
Maine Medical Center

Scarborough, Maine, 04074, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 01056, United States
Medical Center Medica Plus OOD

Veliko Tarnovo, Veliko Tarnovo, 5000, Bulgaria
Mid-Atlantic Epilepsy and Sleep Center

Bethesda, Maryland, 20817, United States
Minneapolis Clinic of Neurology

Golden Valley, Minnesota, 55422, United States
MultiCare Rockwood Neurology Center

Spokane, Washington, 99204, United States
Multiprofile Hospital for Active Treatment Puls AD

Blagoevgrad, Blagoevgrad, 2700, Bulgaria
Multiprofile Hospital for Active Treatment Sv. Ivan Rilski Gorna Oryahovitsa EOOD

Veliko Tarnovo, Veliko Tarnovo, 5100, Bulgaria
Municipal Institution "Dnipropetrovsk City Clinical Hospital No16" of Dnipropetrovsk Regional Council

Dnipro, Dnipropetrovsk Oblast, 49027, Ukraine
Municipal Institution "Dnipropetrovsk Regional Clinical Hospital named after I. I. Mechnikov"

Dnipro, 49005, Ukraine
Municipal Institution "Vinnytsia Regional Psychoneurological Hospital named after Acad. O.I. Yushch

Vinnytsia, 21005, Ukraine
Municipal Institution Odesa Regional Clinical Hospital, Department of Cerebro-Vascular Diseases

Odesa, Odesa Oblast, 65025, Ukraine
Municipal Institution Zaporizhzhia Regional Clinical Hospital of Zaporizhzhia Regional Council

Zaporizhzhya, Zaporizhzhya, 69600, Ukraine
Municipal Institution of Lviv Regional Council

Lviv, 79010, Ukraine
Neurologicka ambulance

Zlín, 760 01, Czechia
Northeast Regional Epilepsy Group

Hackensack, New Jersey, 07601, United States
Regional Clinical Center of Neurosurgery and Neurology "Uzhhorod National University"

Uzhhorod, Zakarpattia Oblast, 88018, Ukraine
Regional Psyconeurology Hospital #3

Ivano-Frankivsk, 76011, Ukraine
Semmelweis Egyetem I. Sz. Gyermekgyogyaszati Klinika

Budapest, 1083, Hungary
Ternopil Regional Municipal Psychoneurological Hospital

Ternopil, 46020, Ukraine
The Neurology Research Group, LLC.

Miami, Florida, 33176, United States
University of California, San Diego (UCSD)

La Jolla, California, 92093, United States
University of Missouri Medical School

Columbia, Missouri, 01074, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19140, United States
University of South Florida

Tampa, Florida, 33606, United States
Valley Medical Center

Renton, Washington, 98057, United States