Could a pill replace daily shots for growth hormone deficiency?

NCT ID NCT05250063

Completed Disease control Sponsor: Lumos Pharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an oral drug called LUM-201 in 15 children with growth hormone deficiency who had already received daily injections for a year. The goal was to see if LUM-201 could maintain or improve growth over 12 months. The drug was given once daily by mouth, and researchers measured height changes and monitored for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LUM-201 (oral drug)
What this could lead to: If successful, this could offer a more convenient oral treatment option for children with growth hormone deficiency, reducing the need for daily injections.
What could go wrong: This is a small, early-phase study with only 15 participants, so results may not apply to all children. The drug may not work as well as current treatments or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

isolated congenital growth hormone deficiency pituitary dwarfism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GROWTH HORMONE DEFICIENCY

Contacts and locations

Locations

Children's National Hospital

Washington D.C., District of Columbia, 20010, United States
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
Klinika Endokrynologii i Chorob Metabolicznych, Instytut Centrum Zdrowia Matki Polki

Lodz, Poland
Klinika Endokrynologii i Diabetologii, Instytut "Pomnik Centrum Zdrowia Dziecka

Warsaw, Poland
M Health, Fairview Pediatric Specialty Clinics- Discovery Clinic

Minneapolis, Minnesota, 55454, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Rady Children's Hospital

San Diego, California, 92123, United States
Sonomed - Centrum Medyczne

Szczecin, Poland
The Children's Mercy Hospital

Kansas City, Missouri, 64111, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States

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