Autoimmune disease

This study tests a drug called ocrelizumab in children and teens aged 10 to 17 with relapsing-remitting multiple sclerosis (MS). The goal is to see how the drug moves through the body, if it is safe, and how it affects the immune system. Participants will receive the drug as a sh…

This study tests the drug upadacitinib (Rinvoq) in 30 people with rare genetic disorders that overactivate the JAK-STAT immune pathway. The trial has four phases over 12 months, including an open-label phase to find the best dose and a randomized withdrawal phase to compare the d…

This early-stage trial tests a small, soft implant that holds donor insulin-making cells (islets) and protects them from the immune system. The goal is to see if the device is safe and keeps the cells alive and working in adults with type 1 diabetes. Some participants are also on…

This study tests whether a cream containing ruxolitinib (Opzelura) combined with corticosteroid injections or pills can improve facial vitiligo. It includes people aged 12 and older with active, non-segmental vitiligo affecting the face. Participants use the cream twice daily and…

This study looks at 112 people with immune thrombocytopenia (ITP) whose platelet counts didn't improve after standard treatment with rhTPO. After a two-week break, they will either get a higher dose of rhTPO or switch to a different drug called eltrombopag. The goal is to see whi…

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This study tests an experimental drug called empasiprubart in people with a specific type of generalized myasthenia gravis (gMG) who have AChR antibodies. The goal is to see if the drug is safe and can improve symptoms like muscle weakness that affect daily activities. Participan…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This study tests whether high-intensity breathing exercises can improve respiratory muscle strength, lung function, fatigue, and quality of life in people with multiple sclerosis (MS). Participants are randomly assigned to high-intensity interval breathing training, low-intensity…

This Phase 3 study tests SAB-142, an antibody that targets immune cells, in 108 people aged 5 to 40 with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin over 12 months. Participants receive either the drug or a placebo alongside standa…

This phase 2 trial tests whether eye drops containing infliximab, a drug that blocks a key inflammatory protein, can safely improve severe dry eye in people with Sjögren's syndrome. 38 adults will receive either the active drops or a steroid drop for 6 weeks. The study measures s…

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This early-stage trial tests a new treatment called P-CD19CD20-ALLO1, a type of CAR-T cell therapy, for people with severe lupus that hasn't improved with standard treatments. The study will enroll 162 participants and aims to check if the therapy is safe and tolerable. It also l…

This trial investigates whether combining atorvastatin (a cholesterol-lowering drug), N-acetyl-L-cysteine (an antioxidant), and romiplostim (a platelet-boosting drug) can help adults with immune thrombocytopenia (ITP) who no longer respond to steroids. The goal is to see if this …

This study will look at whether a remote patient monitoring system, called Steno Detektor, helps people with diabetes control their blood sugar. About 12,000 patients will be monitored as part of their regular care. Researchers will compare blood sugar levels and hospital visits …

This study tests two surgical techniques to treat stable white patches on the skin that are not caused by vitiligo. Both methods involve transplanting the patient's own skin cells, followed by laser therapy to boost color return. Twenty-two adults will each receive both treatment…

This study tests whether combining mycophenolate mofetil (MMF) with prednisone can better treat liver inflammation caused by checkpoint inhibitor cancer drugs. The trial includes adults with moderate to severe immune-related hepatitis who need to pause their cancer therapy. The m…

This phase 2 trial tests whether adding baricitinib to standard TPO-RA therapy helps adults with immune thrombocytopenia (ITP) who did not respond to TPO-RA alone. One hundred participants will be randomly assigned to receive either baricitinib plus TPO-RA or TPO-RA alone for 14 …

This phase 2 trial tests whether adding ianalumab to eltrombopag helps children aged 5 to 17 with primary immune thrombocytopenia (ITP) who didn't improve after steroids. The goal is to see if the combination can raise platelet counts and prevent bleeding. About 36 children will …

This phase 2a trial tests whether a daily pill called ACT-777991 can help return color to the face of adults with non-segmental vitiligo. About 30 participants will take either the drug or a placebo for 24 weeks. Researchers will measure changes in skin color using a standard sco…

This study tests the drug ublituximab in children aged 10 to 18 with relapsing multiple sclerosis (MS). It compares ublituximab to another drug, fingolimod, to see which better controls relapses. The trial involves 240 participants and will also monitor long-term safety and effec…

This Phase 3 trial tests whether the oral drug nerandomilast can slow disease progression in adults with systemic sclerosis (scleroderma). About 448 participants will be randomly assigned to receive either nerandomilast or a placebo twice daily for up to 4 years. Researchers will…

This study tests a drug called ravulizumab in 20 Chinese adults with generalized myasthenia gravis, a condition that causes severe muscle weakness. The drug is given through a vein and works by blocking a part of the immune system to reduce symptoms. Researchers will measure how …

This trial tests a one-time treatment called CAR-T cell therapy for people with systemic lupus erythematosus (lupus) that hasn't improved with standard medications. The therapy uses a patient's own immune cells, which are modified in a lab to find and destroy the B cells that dri…

This study tests whether removing a specific type of immune cell (naive T cells) from a donor's stem cell graft can prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The trial enrolls people with non-malignant blood di…

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to afford healthy food. Participants also get group classes on diabetes, nutrition, and cooking, plus help finding other resources. The goal is to see…

This early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …

This study tests whether teprenone, a stomach-protecting drug, can reduce gastrointestinal damage caused by high-dose steroids in people with lupus. One hundred participants will be randomly assigned to take either teprenone or the standard acid-blocker omeprazole for 12 weeks. T…

This phase 2 trial tests whether ursodeoxycholic acid (UDCA), a drug already used for other liver conditions, can treat cholestatic hepatitis—a liver inflammation caused by immunotherapy—better than standard steroids. About 94 adults with cancer (excluding liver cancer) who devel…

This phase 3 trial tests whether claseprubart (DNTH103) can improve symptoms of generalized myasthenia gravis, a condition causing muscle weakness. About 195 adults with a specific antibody type are randomly assigned to receive the drug or a placebo. The main goal is to see if th…

This study tests a new medicine called GR2301, given as shots under the skin, together with light therapy for people with vitiligo (a condition that causes white patches on the skin). The trial has two parts: first, finding the right dose, then testing how well it works. About 11…

This study tests a computer program called PRIMUS that helps neurologists choose treatments for people with relapsing-remitting multiple sclerosis (MS). The tool uses data from past patients to predict how the disease might progress under different therapies. Doctors in some clin…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study tests whether freeze-dried fecal bacteria, given as oral capsules, can improve symptoms in 40 adults with active rheumatoid arthritis that hasn't responded to standard drugs. Participants will receive either the fecal transplant or a placebo for 24 weeks. The main goal…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This study tests whether adding blood flow restriction cuffs to light leg exercises can help people with relapsing-remitting multiple sclerosis build bigger, stronger thigh muscles. Thirty participants will do the same exercise twice a week for 8 weeks, but some will have the cuf…

This study tests a new automated insulin delivery system for people with type 1 or type 2 diabetes in a hospital setting. Six participants will have their blood sugar controlled by the system for 24 hours while eating standard meals. The goal is to see if the system can keep bloo…

This study tests a new medicine called empasiprubart in teenagers aged 12 to 17 who have a rare nerve disease called CIDP. The goal is to find the right dose and see if the drug is safe and helps control the disease. Participants will receive the drug for about 27 months and be f…

This study tests whether an interactive educational video, added to standard diabetes education, helps children aged 8 to 14 with type 1 diabetes improve their blood sugar control. The video lets kids make decisions in everyday situations and see the results. Researchers will mea…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This early-stage study tests a new injection called CM336 in 30 adults with active Sjogren's syndrome. The main goal is to check safety and how the body handles the drug. Researchers will also look for signs that it helps control the disease. This is a Phase 1 trial, so it's one …

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This early-stage trial tests a one-time infusion of donor immune cells (CAR-γδT cells) designed to target and destroy faulty B cells in people with severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and find the right dose in 9 adults whose di…

This study tests an experimental drug called ATH-063 in 120 adults with moderate to severe ulcerative colitis who have not responded to or can no longer use biologic therapies. Participants will receive either the drug or a placebo for 12 weeks to see if it can reduce symptoms an…

This study will compare two drugs, tofacitinib and upadacitinib, added to standard methotrexate treatment for rheumatoid arthritis. One hundred adults in Pakistan will take one of the two drugs daily for six months. Researchers will measure disease activity and side effects to se…

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests whether adding a Chinese herbal formula (Si Miao Xiao Bi Tang) to standard rheumatoid arthritis medication can improve symptoms. About 132 adults with active RA will receive either the herbal medicine or a placebo for 12 weeks. The main goal is to see if more peo…

This early-stage trial will test the safety and tolerability of a new drug, cevostamab, in 46 people with systemic lupus erythematosus, some of whom also have active lupus nephritis. The drug is given intravenously, and researchers will monitor side effects and how the drug moves…

This study tests anifrolumab, a drug already used in adults with lupus, in children aged 5 to 17. The goal is to see how the drug moves through the body and if it is safe. Twenty-four children with moderate to severe lupus will receive the drug as a shot under the skin, while con…

This study follows 115 adults with multiple sclerosis who are switching from ocrelizumab to ofatumumab because their antibody levels dropped. Researchers want to see if the switch stops or slows that decline over 24 months. The goal is to better manage immune health while still t…

This study tests an experimental drug called D-2570 in 160 adults with non-segmental vitiligo, a condition that causes white patches on the skin. Participants take either D-2570 or a placebo pill once daily for 24 weeks, with an optional 24-week extension. The goal is to see if t…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard narrowband UVB light treatment can help restore skin color in people with vitiligo. Five adults with non-segmental vitiligo will receive UVB twice a week for 24 …

This study tests a treatment called extracorporeal photopheresis (ECP) for people with advanced melanoma who develop severe colitis or hepatitis from immunotherapy. ECP filters a patient's blood, treats it with a light-activated drug, and returns it to the body. The trial compare…

This early-stage study tests a new drug called JCXH-213 in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The trial includes only 4 people whose ITP did not improve with standard treatments. The main goal is to…

This study tests a drug called IMM0306 in 125 people with IgG4-related disease, a condition where the immune system attacks organs causing swelling and damage. The goal is to see if IMM0306 can prevent disease flare-ups and allow patients to safely stop taking steroids. Participa…

This study tests an experimental pill (cadisegliatin) taken alongside insulin in people with type 1 diabetes who already use a hybrid closed-loop insulin pump. The goal is to see if the pill helps keep blood sugar in a healthy range more consistently. About 40 adults will receive…

This study tests whether SHR-2173, added to usual care, improves symptoms of generalized myasthenia gravis (gMG) better than a placebo. About 60 adults with confirmed gMG will receive the drug or placebo for 24 weeks. The main goal is to see if daily muscle weakness and fatigue s…

This study tests whether the shingles vaccine Shingrix and the diabetes drug semaglutide, alone or together, can help preserve the body's ability to make insulin in adults recently diagnosed with type 1 diabetes. The goal is to slow the immune attack on insulin-producing cells an…

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests whether low-dose colchicine, a drug used for gout, can reduce inflammation and symptoms in people with autoimmune or subacute thyroiditis. About 300 adults will be randomly assigned to colchicine, corticosteroids, or supportive care. The goal is to see if colchic…

This Phase 1 trial will test PB018, a biosimilar to the MS drug Ocrevus, in 222 people with multiple sclerosis. The study compares how the body processes PB018 versus Ocrevus and checks for safety. Participants will receive either PB018 or Ocrevus, but neither they nor their doct…

This early-phase trial tests a three-step immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months). The goal is to preserve the body's remaining insulin production by calming the immune attack and teaching the immune system to tolerate insulin. Sixty …

This study looks at whether people with multiple sclerosis can safely switch from their current anti-CD20 therapy to a new under-the-skin version of ocrelizumab. About 100 participants will be followed for up to 48 weeks to see if brain lesions stay stable and if they are satisfi…

This early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …

This phase 2 trial tests a personalized CAR T cell therapy called zolacabtagene autoleucel in 52 adults with chronic immune thrombocytopenia (ITP) or autoimmune hemolytic anemia (AIHA). The treatment uses the patient's own immune cells, modified to target and destroy faulty B cel…

This study compares two drugs, ATG and teplizumab, to see if they can delay or prevent type 1 diabetes in people who are at high risk. About 60 participants aged 4 to 35 will receive either two infusions of ATG or 14 daily infusions of teplizumab. Researchers will monitor them fo…

This early-phase study tests whether combining two drugs (Zuberitamab and Orelabrutinib) can help people with immune thrombocytopenia (ITP) or autoimmune hemolytic anemia (AIHA) that hasn't responded to other treatments. The drugs work together to calm the immune system and stop …

This study tests an investigational drug called efgartigimod for adults with Graves' disease whose thyroid levels are still high despite taking standard antithyroid medications. About 230 participants will receive either the drug or a placebo as a shot under the skin. The goal is…

This study tests a next-generation automated insulin delivery system (Omnipod M) in up to 40 adults with type 1 diabetes. The goal is to see if the system safely improves blood sugar control by reducing dangerously low and high levels. Participants will use the device during hote…

This study tests whether tirzepatide, a drug used for type 2 diabetes, can help people with type 1 diabetes. Researchers will measure how the body responds to insulin and meals before and after 6 weeks of treatment. 44 adults with type 1 diabetes who use an automated insulin pump…

This study tests a cream called ruxolitinib on children aged 2 to 11 with a common type of vitiligo (white patches on skin). The goal is to see if the cream can safely bring back skin color over 24 weeks. About 20 children will apply the cream daily and visit the clinic for check…

This study tests an experimental drug called remibrutinib in 20 people with relapsing or progressive multiple sclerosis (MS). Participants take the drug twice daily for 2 years and undergo powerful 7T MRI scans to measure changes in brain volume, lesions, and tissue health. The g…

This phase 2 trial will test two drugs, finerenone and sotagliflozin, in 57 people with type 1 diabetes who are at risk for heart and kidney problems. The goal is to see if matching the right drug to each person's specific diabetes subtype can improve early signs of heart and kid…

This study tests all-trans retinoic acid (ATRA), a form of vitamin A, in adults with immune thrombocytopenia (ITP) whose platelet counts stay low despite steroid treatment. About 192 participants will receive either ATRA or a placebo for 24 weeks. The goal is to see if ATRA can s…

This study tests a drug called inebilizumab in 180 adults with autoimmune hepatitis, a condition where the immune system attacks the liver. The goal is to see if the drug can reduce liver inflammation and allow patients to take lower doses of steroids. Participants will receive e…

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study will test whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and nutrition. About 80 participants will be randomly assigned to CGM-guided care or stand…

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This early-phase study tests a new treatment called IASO206 for people whose autoimmune hemolytic anemia (AIHA) has not responded to standard therapies. AIHA is a condition where the immune system mistakenly destroys red blood cells, causing fatigue and other symptoms. The study …

This early-phase trial tests whether specially modified immune cells, called CD6-CAR Tregs, can safely control type 1 diabetes. The cells are made from the patient's own blood and designed to stop the immune system from attacking insulin-producing cells. Six adults with stage 3 t…

This Phase 2 trial tests efgartigimod PH20 SC, a drug that lowers harmful antibodies, in 170 adults and teens with autoimmune encephalitis (AIE). Participants receive either the drug or a placebo, and researchers measure changes in disability and symptoms over up to 3 years. The …

This study will give 12 families of children with type 1 diabetes and food insecurity either weekly boxes of fresh produce or semi-prepared meal kits, plus nutrition coaching. The goal is to see if these programs are practical and improve diet quality and blood sugar stability. I…

This study tests whether a structured 12-week program focusing on nutrition, exercise, sleep, and stress management can improve fatigue, physical function, and quality of life in people with relapsing-remitting multiple sclerosis. Thirty participants will first be observed for 12…

This study looks at whether adding pioglitazone (a type 2 diabetes drug) to dapagliflozin (an SGLT2 inhibitor) can reduce the liver's glucose production, fat breakdown, and ketone production in people with type 1 diabetes. These effects from dapagliflozin can raise the risk of ke…

This early-stage study tests a new treatment called LVIVO-TaVec400 in 44 people with severe autoimmune diseases like lupus, multiple sclerosis, and myasthenia gravis that have not responded to standard therapies. The main goals are to check the treatment's safety and find the rig…

This early study tests a new treatment called S103 (BCMA-CAR T cells) in 9 adults with progressive or hard-to-treat multiple sclerosis (MS). The main goal is to see if the treatment is safe and to find the best dose. Researchers will also look for early signs that it might help c…

This phase 2 trial is testing a new treatment called FT819 for people with lupus nephritis, a serious kidney complication of lupus. FT819 is made from donor immune cells that are engineered to target and destroy faulty B cells. The study will enroll 53 participants and aims to se…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on weight. The goal is to see if the simpler fixed-dose method works just as we…

This early-stage study tests a new treatment called SR-02 for adults with type 1 diabetes who experience dangerously low blood sugar. The treatment involves implanting insulin-producing cells into the belly lining. Nine participants will receive the implant and must take lifelong…

This phase 2 trial tests whether TQH3906, a pill that blocks a protein called TYK2, can safely control lupus symptoms. About 198 adults with lupus will receive either the drug or a placebo for up to 48 weeks. The main goal is to see if more people on the drug achieve a meaningful…

This study tests whether adding the drug cofrogliptin to standard treatment (metformin, insulin, and vitamin D3) can help preserve beta-cell function in adults with latent autoimmune diabetes (LADA). Over 52 weeks, 84 participants will take either cofrogliptin or a placebo, and r…

This early-phase study tests whether the drug efgartigimod (VYVGART) can lower harmful collagen VII antibodies and improve wound healing in people with two rare blistering skin conditions: recessive dystrophic epidermolysis bullosa (RDEB) and epidermolysis bullosa acquisita (EBA)…

This study tests a drug called inebilizumab in 15 children aged 2 to 17 who have IgG4-related disease, a rare condition that causes swelling and damage in organs. The drug is given through an IV and works by lowering certain immune cells to reduce inflammation. Researchers will c…

This early-phase study tests a new drug called budoprutug in 30 adults with active lupus who haven't responded well to standard treatments. The drug targets and depletes certain immune cells (B cells) to help control the disease. The main goals are to check safety and how the bod…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This early-stage trial tests a new drug called KT502 in 27 adults with moderate to severe rheumatoid arthritis. The drug is designed to deplete certain immune cells (B cells) that contribute to joint inflammation. The main goal is to check safety and find the right dose, not yet …

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests a drug called efgartigimod, given as a shot under the skin, for adults with Graves' disease whose thyroid levels are still too high despite taking standard antithyroid drugs. About 230 people will take part, and some will get the drug while others get a placebo. …

This phase IIa trial tests a personalized cell therapy for people with progressive multiple sclerosis (MS). The treatment uses the patient's own immune cells, turned into 'tolerogenic dendritic cells' that are designed to calm the immune system and stop it from attacking the nerv…

This study tests whether dihydroartemisinin, a drug used for malaria, can help treat discoid lupus erythematosus (DLE), a chronic skin condition causing red, scaly patches. Researchers will compare two doses of the drug to a standard lupus treatment (hydroxychloroquine) in 100 ad…

This early study tests a new treatment called HN2301 in 6 adults with generalized myasthenia gravis, a disease that causes muscle weakness. The treatment uses the body's own immune cells to target and reduce harmful immune activity. The main goal is to check safety and see how we…

This study tests an experimental pill called LW402 in 180 adults with non-segmental vitiligo, a condition that causes white patches on the skin. The pill works by blocking certain immune signals. Participants will take one of three doses or a placebo for up to 52 weeks to see if …

This study tests whether a Mediterranean diet can improve gut bacteria, reduce disease activity, and boost nutrition in children with systemic lupus erythematosus (SLE). Sixty children with SLE and their healthy family members will take part. Participants will receive personalize…

This study tests a new automated insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals. Participants will use either the NMX8 system or another approved system to see which helps keep blood sugar in the target range more oft…

This study looks at whether a 12-week Mediterranean diet can lower oxidative stress and improve blood sugar control in girls aged 10-18 with type 1 diabetes who have high HbA1c levels. Researchers will measure changes in blood markers and glucose levels. The goal is to see if thi…

This study compares two treatments for stable vitiligo: microneedling with a topical solution (minoxidil) alone versus microneedling with the same solution plus narrow-band UV light therapy. Thirty adults with stable non-segmental vitiligo will be enrolled. The goal is to see if …

This phase 2 trial tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are overweight. Twenty adults with active arthritis despite standard treatment will take either disulfiram o…

This early-stage trial tests a new treatment for multiple sclerosis (MS) that combines a drug called ofatumumab with NK042, a therapy made from immune cells donated by healthy people. The study will include 20 adults with different types of MS and will primarily check for safety …

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This early-stage trial tests a stem cell injection (HS_SW01) in 21 adults with systemic sclerosis, a disease where the immune system attacks the body, causing skin hardening and organ damage. The main goal is to see if the treatment is safe and tolerable. Researchers will also ch…

This early-phase trial tests a new stem cell treatment (HS_SW01) for people with ankylosing spondylitis, a type of arthritis that causes spine pain and stiffness. The study will include 18 adults aged 18 to 65. Researchers aim to check if the treatment is safe and if it helps red…

This study tests a new medicine, SCTC21C, in 159 adults with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The goal is to see if the drug is safe and can reduce lupus symptoms. Participants must be on stable standard treatments and will receive the study drug …

This early-stage trial will test a new drug called firsekibart in 30 people with systemic sclerosis (scleroderma), a disease that causes skin thickening and organ damage. Firsekibart is an antibody that blocks a protein involved in inflammation. The study will measure changes in …

This study tests whether providing free, medically tailored meals to children with Type 1 Diabetes who face food insecurity can improve their health. Fifty kids will either receive standard care or standard care plus 10 healthy meals per week for 6 months. Researchers will track …

This early study tests a new drug called HN2302, which aims to create CAR-T cells inside the body to target and control autoimmune diseases like lupus and scleroderma. The trial will enroll 12 adults to check safety and see if the treatment works. It is a first step, so results w…

This study looks at whether people with type 1 diabetes can safely start using an advanced hybrid closed-loop insulin pump system at home instead of in the hospital. Researchers will track blood sugar levels, quality of life, and costs over 12 months in 80 adults. Participants re…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study tests whether adding deucravacitinib to standard therapy helps adults with psoriatic arthritis that is not well controlled. About 128 participants will receive the combination and be monitored for 48 weeks. The goal is to reduce skin and joint symptoms and improve qual…

This early-stage trial will test the safety of a new immune cell therapy called universal STAR-T cells in 24 adults with multiple sclerosis (MS) who have no other treatment options. The therapy involves infusing specially engineered cells that may help control the disease. The st…

This very early study will test the drug talquetamab in just 2 people with refractory generalized myasthenia gravis, a chronic autoimmune disease that causes muscle weakness. The drug is designed to help the immune system attack the cells that produce harmful antibodies. The goal…

This study tests whether exosomes from umbilical cord stem cells can safely help restore skin color in adults with vitiligo. 96 participants with active or stable vitiligo will receive either exosome infusions or injections alongside standard light therapy and ointment. The goal …

This study tests whether adding artificial intelligence to an automated insulin delivery system can improve blood sugar control for people with type 1 diabetes. The AI learns each person's meal patterns and automatically gives insulin boluses without requiring them to announce me…

This study tests whether giving two strong medications one after the other—rituximab then cladribine—is safe and works well for people with relapsing-remitting multiple sclerosis (MS). Sixty adults aged 18 to 50 with active MS within the last year will receive the treatment and b…

This study tests whether adding sirolimus to standard steroid treatment helps people with newly diagnosed mild autoimmune hemolytic anemia (AIHA) achieve lasting remission. About 216 adults will be randomly assigned to get either steroids alone or steroids plus sirolimus for 6 mo…

This early-stage trial is testing a new drug called YKST02, given alone or with another drug YK012, in 30 people with active or hard-to-treat lupus. The main goal is to see if the drugs are safe and tolerable. Participants will receive intravenous infusions and be monitored for a…

This study tests whether adding a special cell secretion (called secretome) to standard light therapy helps restore skin color better in people with vitiligo. About 150 adults with stable vitiligo will receive either light therapy alone, or light therapy plus secretome applied th…

This study looks at whether starting an automated insulin delivery (AID) system within two weeks of a type 1 diabetes diagnosis helps young patients manage their blood sugar more easily. Sixteen youth newly diagnosed with type 1 diabetes will be offered the system and followed fo…

This study tests a drug called ublituximab, given as a shot under the skin, in 350 people with relapsing multiple sclerosis. Researchers want to see how the drug moves through the body when injected in different spots (like the belly or thigh) and whether an autoinjector pen work…

This study tests whether adding venlafaxine, a common antidepressant, to standard rheumatoid arthritis (RA) treatment can better control disease activity. About 70 adults with moderate to severe RA who are already on stable medication will receive either venlafaxine or a placebo …

This early-stage trial will test whether injecting adalimumab (Humira) into the eye during Boston KPro surgery is safe for 8 patients with severe corneal damage. The study focuses on side effects and tolerability, not yet on how well it works. It is for people who have run out of…

This study follows 150 adults with moderate-to-severe rheumatoid arthritis who have received the SetPoint System, an implanted device that uses nerve stimulation to control inflammation. Researchers will monitor device safety, ease of use, and how well it controls disease activit…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This study tests whether regularly measuring the amount of mycophenolate mofetil in the blood helps more people with lupus kidney disease achieve kidney remission. One hundred adults with active lupus nephritis will be split into two groups: one gets standard dosing, the other ge…

This study tests whether temporarily stopping methotrexate for 2 weeks after receiving a pneumonia vaccine (PCV20) helps the vaccine work better in adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus. About 192 participants with stable, low disease activi…

This study tests a new drug called IMC-S118AI in people with type 1 diabetes who have a specific genetic marker (HLA-A*02:01). The main goal is to check if the drug is safe and how it works in the body. Researchers will also look at whether it can help preserve the cells that mak…

This study tests two drugs, diroximel fumarate and dimethyl fumarate, in children with relapsing multiple sclerosis. About 185 kids will be split by weight and randomly assigned to one of the drugs or a standard treatment (fingolimod). The goal is to see which drug is safer and b…

This study looks at whether starting automated insulin delivery (AID) early in children aged 7–16 with type 1 diabetes improves blood sugar control, reduces stress for patients and families, and prevents long-term complications compared to standard insulin injections. One hundred…

This early-stage study tests a new drug called IASO-782 in 20 adults with systemic lupus erythematosus (SLE). The main goal is to see if the drug is safe and tolerable. Participants will receive either the drug or a placebo, and researchers will monitor for side effects.

This study tests whether adding low-dose steroid pills to a standard vitiligo skin-cell transplant surgery helps prevent a pale ring around the treated area and improves overall skin color restoration. About 60 people with stable vitiligo will be randomly assigned to get surgery …

This study follows 40 adults with type 1 diabetes who previously used an automated insulin delivery system. Researchers want to see if the system's benefits, like better blood sugar control, last for years. They will also check if long-term use leads to weight gain.

This study looks at the long-term safety and effectiveness of a drug called rozanolixizumab for adults with ocular myasthenia gravis, a condition that causes muscle weakness in the eyes. About 100 people who have already taken the drug in a previous study will continue treatment.…

This study tests whether clemastine fumarate, an over-the-counter allergy medication, can repair damaged nerve insulation (myelin) in people with multiple sclerosis. About 44 adults with relapsing-remitting MS will receive either the drug or a placebo for 3 months, then all will …

This early-phase trial tests a new drug called TGD001 in about 70 adults with acute episodes of immune-mediated thrombotic thrombocytopenic purpura (iTTP) or related blood clotting conditions. The main goal is to check the drug's safety and how the body processes it, while also l…

This phase 3 trial tests QL0911, a weekly injection, in 60 children aged 1 to 17 with chronic immune thrombocytopenia (ITP) who have low platelet counts. The goal is to see if the drug can safely raise platelet levels to reduce bleeding risk. Participants receive either QL0911 or…

This study tests a drug called Telitacicept in 30 children with ocular myasthenia gravis, a condition that causes droopy eyelids and double vision. The drug aims to reduce relapses and the need for steroids. It is given as a weekly shot alongside standard care. The trial is open-…

This Phase 4 trial tests ivarmacitinib, a once-daily pill, in 100 adults with moderate-to-severe rheumatoid arthritis who did not improve on standard drugs. The study will measure joint symptom improvement after 12 weeks and monitor safety. Ivarmacitinib works by blocking inflamm…

This early-stage trial tests a new cell therapy called YTS109 for people with autoimmune hemolytic anemia that hasn't improved after at least three prior treatments. The therapy uses specially engineered immune cells to target and destroy the faulty cells causing the anemia. The …

This study tests whether a low dose of glucagon, given before exercise, can prevent blood sugar drops in adults with type 1 diabetes who use an automated insulin pump. Eighteen participants will exercise after a meal, comparing glucagon to a standard glucose drink. The goal is to…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This early study tests whether semaglutide, a drug already used for type 2 diabetes, can protect the body's insulin-producing cells in people with stage 1 type 1 diabetes. The goal is to see if it can delay or prevent the disease from progressing to the next stage. Fifteen adults…

This early-stage study tests a new drug, BMS-986528, in 84 adults with rheumatoid arthritis that hasn't responded well to other treatments. The main goal is to check safety and how the body processes the drug. Researchers will also look for signs that it might help control the di…

This early-stage trial will test whether a personalized immune cell therapy called CAR T-cells is safe for 8 adults with severe lupus that hasn't improved with standard treatments. Participants will receive a single infusion of their own genetically modified cells after a short c…

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This early-phase trial will test a new type of CAR T-cell therapy, called QT-019C, in 27 adults with refractory immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding. The therapy uses donor-derived immune cells engineered to targe…

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors, a drug class that raises DKA risk. About 75 adults with type 1 diabetes will be en…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This study tests a new drug called TQH3906 for people with active psoriatic arthritis, a condition causing joint pain and skin patches. About 156 adults will receive either TQH3906, a placebo, or an existing drug (tofacitinib) for 12 weeks. The main goal is to see if TQH3906 impr…

This phase 2 trial tests whether the cancer drug sorafenib can help people newly diagnosed with type 1 diabetes keep making their own insulin. Ten adults aged 18-60 will receive either sorafenib or a placebo daily, along with their usual insulin. The study measures changes in ins…

This early-phase trial will test a new treatment called QT-019C in up to 15 adults with relapsed or refractory neurological autoimmune diseases, including multiple sclerosis, neuromyelitis optica, and myasthenia gravis. The treatment uses donor-derived CAR T-cells that target two…

This phase 2 study tests whether combining orelabrutinib (a targeted drug) with romiplostim (a platelet booster) can improve platelet counts in adults with chronic immune thrombocytopenia (ITP) who haven't responded well to standard treatments. About 28 participants will receive …

This study compares two treatment combinations for adults with psoriatic arthritis who did not get enough relief from methotrexate alone. One group will receive apremilast plus methotrexate, the other adalimumab plus methotrexate. Researchers will measure joint and skin disease a…

This early-phase study tests a new mRNA drug that targets two proteins (CD19 and BCMA) on immune cells. The goal is to clear the faulty B cells and plasma cells that attack the body in autoimmune diseases. 27 adults aged 18-70 with relapsed or hard-to-treat autoimmune diseases wi…

This study tests whether taking high-dose omega-3 (fish oil) pills for 12 weeks can reduce inflammation and cell damage in women with lupus who are in remission. Researchers will measure changes in blood markers and telomere length, which is linked to aging. The goal is to see if…

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This Phase 2 trial tests an experimental drug called ESG206 in 40 adults with primary Sjögren's syndrome, an autoimmune disease causing dry eyes and mouth. The drug targets a protein to reduce immune system attacks on the body. Researchers will compare high and low doses against …

This pilot study tests Firsekibart, a biologic that blocks IL-1, in 15 adults with mild to moderate lupus who still have symptoms despite standard therapy. Participants receive three shots over 8 weeks, then stop the drug to see if symptoms return. The goal is to see if this appr…

This study compares two drugs, telitacicept and belimumab, for controlling systemic lupus erythematosus (SLE) in adults aged 18-65. Participants choose their treatment with their doctor, and researchers track how well each drug reduces lupus activity and kidney problems. The goal…

This early-phase study tests a new treatment called C-CAR168 for people with lupus nephritis that hasn't improved with standard therapies. C-CAR168 is made from a patient's own immune cells, which are modified to target and attack faulty immune cells. The study will enroll 24 adu…

This trial tests whether a traditional Chinese medicine called Yishen Daluo Yin granule can help people with relapsing-remitting multiple sclerosis. About 152 participants will take either the granule or a placebo twice a day for 24 weeks. The main goal is to see if the treatment…

This study tests an experimental drug called QLS12010 in 180 adults with moderate-to-severe rheumatoid arthritis. Participants are randomly assigned to receive different doses of the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces joint swelling and te…

This study tests a digital program that gives people with multiple sclerosis personalized strategies to avoid falls. About 80 participants who have trouble walking and have fallen recently will take part. The program uses each person's fall history to create tailored advice, and …

This study compares two treatments for generalized vitiligo: PUVA therapy (a light-based treatment) and the pill Tofacitinib. Researchers will enroll 64 adults with stable vitiligo covering more than 10% of their body. The goal is to see which treatment works better and is safer …

This early-stage trial tests whether a single infusion of ripertamab can safely improve daily living activities in 20 adults with generalized myasthenia gravis, a condition causing muscle weakness. Participants are randomly assigned to receive the drug or a placebo, and are follo…

This study will enroll 120 children and teens with type 1 diabetes who use automated insulin pumps. Participants will be randomly assigned to follow either the standard blood sugar target (70-180 mg/dL) or a tighter target (70-140 mg/dL) for 12 months. Researchers want to see if …

This study tests whether a daily probiotic called LP-LDL® can improve cholesterol, blood sugar, inflammation, and memory in 210 adults with prediabetes, type 1, or type 2 diabetes who also have high cholesterol or triglycerides. Participants take either the probiotic or a placebo…

This early-stage study tests a new medicine called HC022 in 32 adults with lupus (SLE or CLE). The main goal is to see if the drug is safe and how the body handles it. Participants will receive multiple doses or a placebo, and researchers will monitor for side effects and measure…

This early study tests a new drug called STR-P004 in 9 adults with immune-mediated kidney diseases. The goal is to see if the drug is safe and how the body processes it. Participants receive up to 8 infusions over 28 days, with possible dose increases. This is not a cure; it aims…

This early-phase study tests a new mRNA therapy that targets CD19, a protein on immune cells, to treat autoimmune diseases like lupus and immune anemia. The treatment uses lipid nanoparticles to deliver mRNA that helps the body clear harmful B cells. About 47 participants aged 14…

This early-phase trial is testing a new treatment called CRC01 for people with severe lupus nephritis, a serious kidney complication of lupus. The therapy uses a patient's own immune cells, which are modified in a lab to target and destroy certain immune cells that drive the dise…

This study tests a web-based education program for teens with type 1 diabetes and their mothers. The goal is to see if the program helps improve eating habits, blood sugar control, and self-management. About 72 teens and their moms will take part, with some teens getting the prog…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that haven't responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the di…

This early-stage trial tests a new treatment called KN5501 for people with moderate to severe lupus that hasn't responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) to target and destroy faulty B cells that drive the disease. Partic…

This study looks at whether baricitinib, a drug for rheumatoid arthritis, can improve blood clotting and cholesterol levels compared to standard treatments. About 100 adults with active RA will take baricitinib for 3 months. Researchers will measure changes in clotting markers an…

This early-stage trial is testing a new treatment called C-CAR168, which uses a patient's own immune cells modified to attack harmful cells in the body. It is for 15 adults with multiple sclerosis, neuromyelitis optica, autoimmune encephalitis, or stiff person syndrome that have …

This study tests whether surgically removing the central mole (halo nevus) in people with vitiligo leads to better skin color restoration than using medication alone. Sixty participants aged 6 to 45 will be randomly assigned to either have the mole removed plus standard treatment…

This early-stage trial tests a new treatment called CD19/BCMA CAR-T cell therapy for people with a severe type of autoimmune anemia that hasn't responded to standard treatments. The therapy uses a patient's own immune cells, modified in a lab to attack the faulty immune cells cau…

This early-phase trial tests a new type of cell therapy called BCMA-CD19-IL-15/IL15sushi compound CAR T cells in 20 people with severe lupus that hasn't improved with standard treatments. The therapy aims to reset the immune system by targeting and eliminating faulty immune cells…

This early-stage trial is testing a new treatment called ACE1831 for people with lupus that has not responded to standard therapies. ACE1831 is made from healthy donor immune cells and is given after a short course of chemotherapy. The study will enroll 22 adults aged 18 to 60 wi…

This early-stage trial is testing three different daily doses of zanubrutinib (80, 160, or 240 mg) combined with high-dose dexamethasone in 60 adults newly diagnosed with immune thrombocytopenia (ITP). The goal is to find the safest and most effective dose that helps maintain pla…

This study looks at whether it is safe to avoid antibiotics before bladder Botox injections in people with multiple sclerosis or spinal cord injury who have bacteria in their urine but no symptoms. About 526 participants will be randomly assigned to receive either antibiotics or …

This study tests a smartphone app called DailyDose that gives personalized advice on insulin doses and carbohydrate intake for people with type 1 diabetes who use multiple daily injections. The app uses data from continuous glucose monitors and insulin pens. Researchers want to s…

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This early-phase study tests a new treatment called KN5601, which uses specially engineered natural killer (NK) cells to target and destroy disease-causing immune cells in people with relapsed or refractory IgG4-related disease. The trial will enroll 18 adults and primarily check…

This early-stage study tests a single infusion of stem cells from donated umbilical cords in 16 adults with moderate to severe rheumatoid arthritis that hasn't improved with standard treatments. The main goal is to check safety and side effects over 52 weeks, while also looking f…

This study tests a mobile app called Diactive-1 that provides personalized resistance training and education for children and adolescents with type 1 diabetes. Over 12 weeks, participants follow a tailored exercise program (like strength training or high-intensity intervals) and …

This study tests whether two doses of stem cells, given four months apart, can improve saliva production and reduce dry mouth in people who had radiation for head and neck cancer or have Sjögren's disease. One hundred participants will receive either stem cells or a placebo. The …

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This early-phase trial tests a new cell therapy called YTS109 in 13 adults with autoimmune hemolytic anemia that has not responded to at least three prior treatments. The therapy uses specially engineered immune cells to target and control the disease. The main goals are to check…

This study tests whether adding all-trans retinoic acid (ATRA) to the drug avatrombopag can help adults with immune thrombocytopenia (ITP) maintain normal platelet levels without needing ongoing treatment. About 248 participants who have not responded well to first-line therapy o…

This Phase 2 trial tests whether adding a lab-made antibody called natrunix to standard methotrexate treatment helps people with moderate to severe rheumatoid arthritis who haven't improved enough on methotrexate alone. About 108 participants will receive weekly shots of either n…

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diag…

This study tests a urine test that detects gluten peptides in children with celiac disease who are on a gluten-free diet. The goal is to see if this test helps doctors and families identify accidental gluten exposure better than standard blood tests. One hundred children aged 2 t…

This study will screen about 2,200 children aged 2-10 for autoantibodies that signal early type 1 diabetes. The goal is to find the disease before symptoms appear and test if educational programs help families. Researchers will also check if this screening is practical and cost-e…

This study compares a quick visual check of the roof of the mouth (palate) with measurements from a 3D X-ray (CBCT) to see if the simple exam is accurate enough. About 50 adults who already have a CBCT scan will have their palate shape classified by two examiners looking at photo…

This study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether an AI-powered educational platform can help parents of children with type 1 diabetes count carbohydrates more accurately and manage diabetes better. About 80 parents will either use the AI platform plus usual care or usual care alone for 12 weeks. The goa…

This study tests a three-session training program to help older adults (65+) who use insulin learn to use a continuous glucose monitor (CGM). Participants will be randomly assigned to the program or standard training. The goal is to see if the program improves how often they wear…

This study tests whether an activity book called 'Think-Find-Solve' can improve insulin self-management in children aged 8-12 with type 1 diabetes. Forty children and their parents will take part, with one group using the book for three months. The goal is to see if the book help…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests whether a 12-week program combining individual physiotherapy, group movement-awareness sessions, and group psychotherapy can improve physical function, reduce fatigue, and enhance quality of life in 45 adults with multiple sclerosis. Each participant serves as th…

This study tests whether a device that delivers high-intensity focused electromagnetic pulses can strengthen core muscles and improve balance in people with multiple sclerosis. Sixty participants will either receive the electromagnetic therapy plus balance exercises, or balance e…

This study tests a six-month personalized telenursing program for 110 adults with multiple sclerosis. Participants receive monthly educational videos and nurse-led video calls to help them better understand their health and navigate the healthcare system. The goal is to improve h…

This study tests a medicine called IGIV 10% (a type of antibody treatment) against a placebo in 38 adults aged 18-70 with Stiff Person Syndrome, a rare condition causing muscle stiffness and spasms. The main goal is to see if the drug helps people walk faster (measured by a 25-fo…

This study tests whether individualized video consultations can help adults with type 1 diabetes manage exercise and blood sugar more confidently. Sixty participants will receive up to three 30-minute sessions with a doctor or exercise specialist. The goal is to improve self-mana…

This study tests whether breathing low-oxygen air for short periods right before walking training helps people with multiple sclerosis walk better and farther. Thirty-five participants will receive either the low-oxygen breathing or a sham (placebo) version, followed by treadmill…

This study tests whether an internet-based program called My MS Toolkit can help reduce depression in people with multiple sclerosis. The toolkit teaches skills based on cognitive behavioral therapy to manage common MS symptoms like fatigue, pain, and low mood. Researchers will c…

This early-stage study tests whether short periods of breathing low-oxygen air (called acute intermittent hypoxia) are safe and tolerable for people with multiple sclerosis. Nine participants at different disease stages will be closely monitored for side effects like low oxygen l…

This study looks at whether a 12-week aerobic exercise program can improve thinking skills and reduce disease activity in people with lupus. Researchers will test memory, attention, and walking ability before and after the program. The goal is to see if exercise can ease lupus-re…

This phase 3 study tests whether ianalumab, given as a monthly injection, can reduce dry mouth and other symptoms in people with Sjögren's disease who have a high symptom burden. About 570 adults will receive either the drug or a placebo for 52 weeks. The main goal is to see if t…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests a 16-week exercise program designed specifically for Hispanic people with multiple sclerosis who have walking problems. About 66 participants will either join the exercise group or a waitlist. The goal is to see if the program improves walking ability and quality…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests whether a daily topical blend of lavender and rosemary essential oils can reduce urinary urgency, frequency, and leakage in adults with multiple sclerosis. Sixty participants will use either the essential oil blend or a placebo oil for six weeks. Researchers will…

This study will test whether high-intensity interval training (HIIT) on a stationary bike can improve walking, balance, and thinking in people with multiple sclerosis (MS). Forty adults with mild to moderate MS will be randomly assigned to either HIIT or moderate-intensity contin…

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This study tests an 8-week mindfulness program for people with type 1 or type 2 diabetes who have trouble sensing when their blood sugar drops too low. The program teaches body awareness techniques like mindful eating and body scanning to help patients catch early warning signs. …

This study tests whether the drug vilamakitug can reduce symptoms of axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. About 150 adults with active disease will receive either the drug or a placebo. The main goal is to see if more people get at lea…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This early-phase trial tests whether the steroid prednisone can improve core autism symptoms in 32 adult males with an immune-mediated subtype of autism. Participants take prednisone or a placebo daily for 16 weeks, with regular check-ins and questionnaires. The goal is to see if…

This study explores whether augmented reality (AR) exercises can help people with multiple sclerosis (MS) improve both their walking and thinking at the same time. Researchers will create AR scenarios that combine physical and mental tasks, then test them in 40 adults with MS. Th…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) is safe and helpful for depression and fatigue in adults with multiple sclerosis (MS). About 20 participants will receive daily rTMS sessions for 5 days, with assessments before, after, and at a 4-…

This study tests whether a six-week, nurse-led virtual group program can help adult women with Multiple Sclerosis (MS) find more meaning and purpose in life, and improve their quality of life. Participants attend weekly online group sessions focused on reflection and values explo…

This study tests if a gentle brain stimulation technique called tDCS can improve movement, balance, fatigue, sleep, and thinking in people with multiple sclerosis. Forty adults with MS will receive either real or sham stimulation over two weeks. Researchers will check if the trea…

This study will test whether a 12-week aerobic exercise program is practical and safe for 12 people with advanced multiple sclerosis who use wheelchairs. Participants will exercise twice a week under supervision. Researchers will measure fitness, daily function, thinking skills, …

This study tests if adding sodium hyaluronate (a common moisturizer in artificial tears) to autologous serum eye drops provides better relief for moderate-to-severe dry eye disease. About 20 adults with dry eye from conditions like Sjögren's syndrome will use the new mix in one e…

This pilot study will test whether a nurse-led telehealth self-monitoring program is acceptable and practical for people with rheumatoid arthritis. 104 adults who recently had a flare or medication change will use a web platform to report symptoms monthly. A rheumatology nurse wi…

This study will test whether a 12-week progressive resistance training program can improve brain health and daily function in people with relapsing-remitting multiple sclerosis. Thirty participants will be randomly assigned to either an exercise group or a control group. Research…

This study tests whether a home-based virtual reality (VR) headset program can improve manual dexterity in people with multiple sclerosis (MS). Sixty participants with MS who have trouble with hand function will be randomly assigned to either the VR dexterity training or a sham m…

This study tests whether a color-coded rotation training program helps people with diabetes improve their insulin self-management skills. Researchers will teach 112 participants how to rotate injection sites and change needles using a colorful chart and a mannequin. The goal is t…

This study aims to see if a stress management program can help adults with myasthenia gravis feel less anxious and stressed, and improve their quality of life. About 62 participants will take part in an 8-session program and report their symptoms before and after. The goal is to …

This study tests whether a structured progressive resistance training program can improve muscle strength in adults with rheumatoid arthritis (RA). About 118 participants will either do supervised exercises 3 times a week for 6 weeks or continue their usual care. Researchers will…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study will test whether a 6-week aerobic exercise program can improve quality of life, mood, and fatigue in women with rheumatoid arthritis. Sixty-four participants with low disease activity will either continue standard care or add five weekly exercise sessions. Researchers…

This study tests whether acetaminophen (Tylenol) can reduce walking fatigue in people with multiple sclerosis. Twenty participants will take either the drug or a placebo, then walk on a treadmill until they get tired. A week later, they repeat the test with the opposite pill. The…

This study tests a wearable brain-computer interface (BCI) that gives real-time feedback during mental exercises to improve arm movement in people with multiple sclerosis. Forty participants will either receive BCI training plus standard rehab or standard rehab alone for 12 weeks…

This study tests whether cetirizine (Zyrtec) causes less sleepiness than diphenhydramine (Benadryl) when used as a pre-medication before anti-CD20 infusions for multiple sclerosis. Sixty participants will receive either drug 30-60 minutes before their infusion, and researchers wi…

This study will test whether resistance training and breathing exercises can reduce depression and improve sleep and quality of life in women with type 1 diabetes. About 78 women with good blood sugar control and mild to moderate depression will take part. The exercises target ma…

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults with stable medication will be randomly assigned to get the massage or not. Researchers will measure pai…

This study tests whether a home-based video game exercise program can improve arm and hand function in people with multiple sclerosis (MS). Forty adults with MS will be randomly assigned to either the exergame program or standard home exercises, both supervised remotely. The goal…

This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing drug (bupivacaine) can provide longer pain relief after thoracoscopic thymectomy in people with myasthenia gravis. Sixty patients will be randomly assigned to one of three groups. The main goal…

This pilot study looks at whether it is safe and practical for pregnant women with type 1 or type 2 diabetes to continue using their insulin pump during labor, instead of switching to IV insulin. About 30 women who already use an insulin pump will be allowed to keep using it whil…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study tests whether sensory integration therapy can improve walking stability and quality of life in people with multiple sclerosis (MS). About 44 adults with relapsing-remitting MS will be randomly assigned to receive either the therapy or standard care. The therapy uses sp…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce chronic pain in people with psoriatic arthritis. Researchers will give 40 adults with low disease activity but ongoing pain either real rTMS o…

This pilot study tests whether a special virtual reality headset that delivers rhythmic light and sound (gamma sensory stimulation) can reduce fatigue in people with multiple sclerosis. Thirty participants with moderate to severe fatigue will receive either the active stimulation…

This study tests whether a mild electrical stimulation (called subthreshold stimulation) can reduce fatigue and improve leg muscle function in people with rheumatoid arthritis. Researchers will also measure inflammation and daily function. The study will include 84 adults aged 30…

This study tests whether a 12-week program of high-intensity interval training and strength training can improve heart and metabolic health in people with psoriatic arthritis. Researchers will also measure changes in fitness, pain, fatigue, and quality of life. The trial plans to…

This study tests whether hypnotherapy can reduce pain and anxiety in children aged 6 to 18 during needle procedures like injections or blood draws. About 70 kids with conditions like juvenile arthritis or lupus will be randomly assigned to receive either hypnotherapy or standard …

This study tests whether a single, one-on-one session focused on depression can help teens with type 1 diabetes feel better and improve their blood sugar levels. Eighty teens aged 11-18 with mild depression will either get the special session or standard diabetes education. Resea…

This study looks at whether a gluten-free diet can reduce inflammatory back pain. Researchers will split 50 people into two groups: one gets standard treatment, the other adds a gluten-free diet for a year. They'll measure pain levels and immune markers to see if the diet makes a…

This study tests whether injections of stem cells from donated fat tissue can help loosen mouth fibrosis in people with systemic scleroderma. Fifty adults with limited mouth opening will receive either stem cell or placebo injections around the mouth and be followed for 24 weeks.…

This study tests a new type of cycling called eccentric cycling for people with multiple sclerosis. Researchers want to see if it improves muscle strength, walking ability, fatigue, and quality of life better than standard cycling. Sixty adults with MS who can walk independently …

This study tests whether an advanced telerehabilitation system, which uses AI to give instant feedback, can improve mobility in people with multiple sclerosis. 94 participants will either use the smart system or follow paper-based exercises at home. The goal is to see if this tec…

This study tests whether an internet-based physical activity program can improve sexual dysfunction in women with relapsing-remitting multiple sclerosis. Thirty women with MS and sexual problems will use a website and have video chats with a coach to increase their physical activ…

This pilot study will test whether five weekly sessions of Swedish massage can reduce stress and improve blood sugar control in 20 adults with type 1 diabetes. Researchers will measure stress hormones, inflammation, and glucose levels before and after the massage program. The goa…

This study will test two non-drug approaches—pain neuroscience education and vagus nerve stimulation—against traditional exercise in 36 people with rheumatoid arthritis. The goal is to see which method best reduces pain, improves quality of life, and lowers inflammation over 8 we…

This study aims to see if a remote breathing exercise program, which adjusts the difficulty based on each person's maximum effort, can improve breathing strength, endurance, quality of life, and physical function in people with multiple sclerosis. Sixty adults with stable MS will…

This early-stage trial tests whether a combination of two drugs, dasatinib and quercetin, can safely remove aged, damaged cells that may contribute to inflammation and nerve damage in people with secondary progressive multiple sclerosis (MS). The study enrolls 30 adults aged 50-8…

This pilot study tests a new continuous glucose monitor (CGM) called SAVA in 20 adults with Type 1 Diabetes. Participants wear three SAVA sensors and one standard sensor for 15 days to check how well the SAVA measures blood sugar compared to lab tests. The study also looks at com…

This study investigates sexual and urinary problems in people with generalized myasthenia gravis, an autoimmune disease that causes muscle weakness. While visible symptoms like droopy eyelids are well-known, issues like sexual dysfunction and bladder problems are often ignored. R…

This study investigates whether balance problems explain why fatigue leads to a greater fear of falling in people with multiple sclerosis (MS). Researchers will assess fatigue, balance, and fear of falling in 40 adults with MS who can walk independently or with a device. The goal…

This study looks at children with immune thrombocytopenic purpura (ITP) who also have certain antibodies, as they are at higher risk of developing lupus. Researchers will analyze blood samples to track immune cell changes and markers that may signal the transition to lupus. The g…

This study investigates whether a specific gene variation (ICOS) is linked to developing systemic lupus erythematosus (SLE) and how severe the disease becomes. Researchers will analyze blood samples from 30 people diagnosed with SLE to look for patterns in the ICOS gene. The goal…

This study tests whether two different capsule forms of the experimental drug SKI-O-703 are absorbed similarly in the body. About 48 healthy adults (Korean and Caucasian) will take a single dose of each form on separate days, with blood samples taken to compare drug levels. The r…

This study tests how well the adhesive parts of a future patch pump stick to the skin of children aged 7 to 17 who need insulin for diabetes. The device is a dummy—it has no electronics and just mimics the shape and weight of a real pump. Researchers will see if the patch stays a…

This study aims to identify newborns with a high genetic risk of developing type 1 diabetes. Researchers will screen 50,000 infants using a simple genetic test to find those with a greater than 10% risk. The goal is not to treat diabetes, but to find eligible babies for future pr…

This pilot study will test how easy it is for 20 adults with diabetes to set up and use the Feetsee foot monitoring device at home over 8 weeks. Participants will use the device and app on their own, following the instructions provided. The goal is to see if people can use it cor…

This French study will collect medical data and biological samples from 800 people with autoimmune liver diseases. Researchers hope to identify new markers that explain why some patients respond well to treatment while others do not. The goal is to better understand the immune me…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study looks at two types of liver disease — autoimmune hepatitis and non-alcoholic fatty liver disease — to see if fats in blood cells and tiny particles called extracellular vesicles differ between them. Researchers will collect blood samples from 24 adults and analyze thes…

This study looks at how eltrombopag is actually used and how well it works in patients with immune thrombocytopenia (ITP) who have already tried steroids. Researchers will collect data from healthcare providers in the US, UK, and Germany, focusing on platelet count improvements w…

This study aims to create stem cell lines from blood samples of 16 people: 4 with severe scleroderma, 4 with mild scleroderma, and 8 of their healthy relatives. These stem cells will be turned into various tissue types (like heart, skin, and immune cells) in the lab to study how …

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study will test if blocking a protein called TL1A can reverse skin scarring in systemic sclerosis, a rare autoimmune disease. Researchers will take blood and skin samples from 10 patients with early diffuse scleroderma and 10 healthy people. They will treat the samples in th…

This study looks at how different types of exercise—aerobic and resistance training—affect the immune system and physical abilities in people with relapsing-remitting multiple sclerosis (MS). Researchers will measure changes in blood markers of inflammation and functional tests l…

This study looks at whether the time of day you eat can affect brain health in people with multiple sclerosis. Twenty-two adults with MS will follow a daily eating schedule for a set period. Researchers will measure markers of nerve health and inflammation in the blood. A small g…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study will follow 2,000 people with multiple sclerosis (MS) for five years to understand why some get worse faster than others. Researchers will use brain scans, eye exams, blood tests, and activity monitors to track changes. The goal is to find factors—like inflammation, bl…

This study will test how accurate and safe two continuous glucose monitoring (CGM) systems, the Anytime 5Pro and Anytime 4Pro, are in adults with type 1 or type 2 diabetes. About 70 participants will wear both devices at the same time and have their blood sugar measured during cl…

This study will follow 400 people recently diagnosed with polymyalgia rheumatica, a condition causing shoulder and hip pain. Researchers will track symptoms, treatments, and outcomes over 5 years to better understand the disease and improve diagnosis. Participants will provide bl…

This study looks at 199 children with type 1 diabetes who have been using insulin for at least 6 months. Researchers will check for skin problems like lumps under the skin (lipohypertrophy) caused by injections. They will also measure fat thickness with ultrasound and ask caregiv…

This study looks at whether it's possible to screen children for type 1 diabetes during their regular well-child visits. Researchers will ask parents and doctors about their experience with the screening and track how many families complete the test. The goal is to find the best …

This study will ask 75 people with diabetes and their healthcare providers about their experience using the Instara-1 continuous glucose monitor. Participants will wear the device and answer questionnaires about comfort, ease of use, and how it helps manage their diabetes. The go…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This observational study follows 400 adults with psoriatic arthritis who are starting a new biologic or targeted synthetic drug as part of their routine care. Researchers want to see if treatment response differs based on how many prior advanced therapies a person has tried, and …

This observational study will check if diathermy, a tool used during surgery to stop bleeding, affects the accuracy of continuous glucose monitors in people with Type 1 Diabetes. About 126 adults and children will have their glucose readings compared before and after diathermy us…

This study tracks 32 people who received Azer-Cel, an experimental cell therapy for B-cell related autoimmune diseases, to monitor long-term safety for up to 15 years. Participants are checked for serious side effects and disease changes. The goal is to understand risks over time…

This study tracks physical activity in 175 pregnant women with type 1 or type 2 diabetes to see how it relates to blood sugar control and mental health. Participants wear an activity monitor for a week each trimester and complete questionnaires. The goal is to understand current …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at how multiple sclerosis (MS) might change a person's sense of smell and the related nerve sensations in the nose. Researchers will test 200 women with MS using simple smell and tickle tests, along with questionnaires about mood and thinking. The goal is to bett…

This study examines patients who have internuclear ophthalmoplegia, a condition that causes trouble moving the eyes sideways, to see how many later develop multiple sclerosis (MS). Researchers will review medical records of 200 patients to identify factors that predict MS convers…

This study will enroll 80 adults with multiple sclerosis and chronic pain to take part in an 8-week online Mindfulness-Based Cognitive Therapy (MBCT) program. Researchers want to understand what emotional, physical, and environmental factors make it easier or harder to practice m…

This study looks at whether a finger-stick device (Coaguchek) can accurately measure blood thickness in people with antiphospholipid syndrome who take blood thinners. Currently, these patients need regular blood draws from a vein, which is inconvenient. The study will compare fin…

This early study tests a new device: a small patch with tiny, painless needles that sits on the skin and measures glucose and ketone levels continuously. Ten people with type 1 diabetes will wear the patch for 4 hours while briefly stopping their insulin pumps. Researchers will c…

This study aims to find out which daily habits and surroundings are linked to poor sleep in people with lupus. Researchers will survey 250 adults with lupus from different parts of Spain about their sleep, physical activity, screen time, and bedroom environment. The goal is to id…

This observational study will follow 40 adults with thymic abnormalities or myasthenia gravis (MG)-related antibodies to better understand how the disease develops and progresses. Researchers will analyze blood, thymus tissue, and muscle samples, along with clinical assessments, …

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This pilot study will test whether a musical tool called Ipsilon can screen for and possibly improve cognitive function in people with multiple sclerosis (MS). Thirty-two participants will either use the Ipsilon for 15 minutes daily for a week or start with no intervention, then …

This study looks back at medical records of 3,500 adults who had a first-time knee replacement to compare different brands of knee implants. Researchers want to see which implant leads to better knee function, fewer complications, and lower costs over time. The goal is to help do…

This study investigates why women with type 1 diabetes (T1D) frequently develop polycystic ovary syndrome (PCOS), a condition of high androgen levels. Researchers will compare five groups of 12 participants each, including women with T1D and PCOS, women with T1D alone, men with T…

This study looks at 70 children and teens with juvenile lupus to check for early signs of heart disease using an ultrasound of the neck artery. Researchers will see if things like cholesterol, blood pressure, and lupus activity are linked to artery thickness. No treatment is give…

This study looks at whether people with relapsing-remitting multiple sclerosis (RRMS) can have a relapse—new or worsening symptoms—without any visible inflammation on an MRI scan. Researchers will follow 136 adults who are having a suspected relapse, performing early brain and sp…

This study will check if three substances in the blood (GFAP, NfL, and VEGF) are linked to how quickly disability gets worse in people with progressive multiple sclerosis. Researchers will measure these markers and compare them to standard tests of disability and thinking. The go…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at whether fear of hypoglycemia (low blood sugar) affects the heart, physical activity, and exercise ability in children and teens with type 1 diabetes. About 67 participants aged 10-18 will answer questionnaires and have their heart rate, blood pressure, and oxy…

This observational study looks at how walking fatigability—getting tired while walking—changes the way people with multiple sclerosis walk and increases their risk of falling. Researchers will compare two groups of 62 participants: those who experience walking fatigue and those w…

This study aims to learn which FDA-approved rheumatoid arthritis (RA) medication works best for each individual patient. Researchers will enroll 18 adults with newly diagnosed, moderately to severely active RA. Participants will try up to four different RA drugs in a random order…

This observational study will enroll 1,000 pregnant women and their fetuses to establish normal ranges for heart sounds and ECGs. The goal is to develop early warning systems for serious heart events in mothers, progression of fetal heart defects, and autoimmune-related fetal hea…

This study is translating and testing a short questionnaire called the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) into Turkish. It will involve 120 adults with spinal cord injury or multiple sclerosis who have bladder problems. The goal is to make sure the Turkish vers…

This early-stage trial is the first time ISH0613 will be given to humans. It aims to check the drug's safety and how it moves through the body in 26 healthy Chinese adults. Participants receive a single intravenous dose of either ISH0613 or a placebo and are closely monitored for…

This study will compare frailty, physical fitness, and levels of a hormone called irisin in 782 people with multiple sclerosis and healthy volunteers aged 18-65. Researchers will use tests like the Frailty Index, Berg Balance Scale, and 6-Minute Walk Test, along with blood sample…

This study will test whether a 12-week progressive resistance training program can improve brain health in people with relapsing-remitting multiple sclerosis. Researchers will measure brain volume and a nerve damage marker in the blood. The trial involves 26 participants and aims…

This study creates a UK-wide registry for people with vitiligo, a skin condition causing white patches. It will track the safety and effectiveness of current treatments in up to 30 patients. The goal is to improve long-term care by collecting real-world data from dermatologists.

The SIRENA study will follow 300 children and adults who have tested positive for islet autoantibodies, which are early markers of type 1 diabetes. Over up to 10 years, researchers will track how their blood sugar, immune system, and metabolism change. The goal is to better predi…

This study will look at the health records of 350 people with psoriasis in Costa Rica to find out how many also have conditions like obesity, diabetes, high blood pressure, heart disease, or psoriatic arthritis. Researchers want to understand how these problems relate to psoriasi…

This study looks at how people with multiple sclerosis (MS) understand and use their medicines at home. Researchers will visit participants once to review all medications and supplements, ask about routines and challenges, and check for safety issues. No changes to treatment will…

This study will measure the activity of a gene called TNFAIP3 in 110 people with ankylosing spondylitis or psoriatic arthritis. The goal is to see if the gene's expression is linked to how active the disease is. Researchers will use a blood test to check gene levels and compare t…

This study looks at people with autoimmune thyroid disease (like Hashimoto's or Graves') to see if they have hidden signs of type 1 diabetes risk. Researchers will test blood for diabetes-related antibodies and use genetic data to build a risk model. The goal is to better underst…

This study looks at how a device called the L300, which uses mild electrical pulses to lift the foot during walking, affects people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults to see if …

This study looks at whether a new tool helps young adults (ages 18-30) with type 1 diabetes and their doctors work together better to make care plans that fit daily life. Researchers will compare usual doctor visits with visits using the tool, and interview participants afterward…

This study looks at how different temperatures—cold, normal, and hot—affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in a special room at each temperature for two hours while researchers monitor their blood sugar, hear…

This study will examine how the painkiller nefopam works in 24 adults hospitalized with acute rheumatic pain. Researchers will measure how the drug is processed in the body, including its peak levels and how long it stays active. The goal is to better understand the drug's effect…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study looks at how the amount of fat in a meal and a woman's menstrual cycle affect blood sugar after eating in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat standardized low-fat and high-fat meals while wearing continuous glucose monitors. The goal i…

This study will follow 5,000 adults with immune system problems to see if certain blood cell mutations (called clonal hematopoiesis) are linked to their condition. Researchers will track new cases of immune-related diseases over time. No treatments or drugs are tested—this is pur…

This study will test whether a new e-learning app can help school nurses feel more confident and knowledgeable about diabetes devices like insulin pumps and continuous glucose monitors. About 86 school nurses in Pennsylvania will use the app over 16 weeks and complete surveys bef…

This study will check if a specific cholesterol ratio (non-HDL to HDL) is linked to kidney disease in people with diabetes. Researchers will measure this ratio and kidney function in 84 adults. The goal is to better understand risk factors, not to test a new treatment.

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This study tests whether a 'serious game'—a video game designed to train thinking skills—can change how the brain works in people with multiple sclerosis who have memory or attention problems. Forty participants will play the game and have brain scans before and after to see if b…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to use their anti-rheumatic drugs more safely. About 144 adults will either use the app or receive standard care with a website. The goal is to…

This study tests whether taking statins (a common cholesterol drug) can protect the heart and brain from the harmful effects of breathing bushfire smoke. Healthy adults aged 18-64 will be exposed to simulated smoke in a controlled setting, with some taking statins short-term (2 d…

This observational registry will follow 50 patients with psoriasis or psoriatic arthritis who are receiving IL-23 inhibitors (guselkumab or risankizumab) as part of their routine care in Costa Rica. Researchers will track how well the drugs improve skin and joint symptoms and qua…

This study explores whether a simple ultrasound and a blood test can track celiac disease activity, potentially replacing the need for invasive intestinal biopsies. Researchers will scan the small bowel and measure antibody levels in 140 people, including newly diagnosed patients…

This study compares levels of two proteins, Klotho and FGF23, in 150 adults with Hashimoto's thyroiditis versus healthy controls. The goal is to see if these proteins are linked to inflammation in the disease. No treatment is given—only blood samples are taken.

This study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…

This study looks at whether it's practical to screen close relatives of people with type 1 diabetes for early signs of the disease. About 1,000 adults in Quebec will have blood tests and answer questionnaires. If they show early markers, they will be monitored either by the resea…

This study looks at how fear of movement (kinesiophobia) affects daily function in people with rheumatoid arthritis. Researchers will compare 200 RA patients with 200 healthy volunteers to understand links between fear, pain, fatigue, mood, and muscle loss. The goal is to find no…

This study follows up with 220 people who previously took part in the Sjögren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Researchers will collect tears, saliva, blood, and other samples, along with eye and mouth exams, to trac…

This study looks at whether adding computer-based cognitive training to walking and resistance exercises can improve walking and reduce falls in older veterans with multiple sclerosis. Thirty veterans will take part in a 10-week program, and their falls will be tracked for a year…

This study aims to understand how insulin deprivation and high blood sugar affect protein synthesis in muscles and blood of people with type 1 diabetes. Researchers will use muscle biopsies and special amino acid labels to track protein production. The study involves 70 participa…

This study will look at how the lupus medication Saphnelo (anifrolumab) is being used in women aged 15 to 50 who could become pregnant. Researchers will track how many women use the drug each year and describe their health characteristics. The goal is to gather real-world informa…

This study is creating an AI tool to help doctors decide the best heart treatment for people who have both immune thrombocytopenia (ITP) and coronary artery disease. Researchers will look at past patient data to build the tool, then test it on 600 new patients. The goal is to bet…

This study looks at how non-nutritive sweeteners (like those in diet drinks) affect the heart and blood vessels of young people aged 15-24 with type 1 diabetes. Researchers will measure blood vessel function before and after drinking a sweetened sports drink. The goal is to under…

This study will examine whether lead exposure is linked to multiple sclerosis (MS). Researchers will measure blood lead levels, oxidative stress markers, and epigenetic changes in 140 people with MS and healthy controls. The goal is to better understand how environmental factors …

This study tests a wrist-worn device that uses light sensors and AI to estimate blood sugar without piercing the skin. Up to 100 adults with type 1 diabetes, type 2 diabetes, or prediabetes will wear the device for 15 days while researchers collect data to improve its accuracy. P…

This study will look back at medical records of 500 Chinese adults with type 1 diabetes to see if adding glucose-lowering pills to insulin helps control blood sugar better than insulin alone. The main goal is to check changes in HbA1c (average blood sugar over 2-3 months) and how…

This study will check the gum health of 100 people—half with multiple sclerosis (MS) and half without—by measuring gum pockets, plaque, and inflammation. Researchers will also test saliva for certain bacteria and viruses to see if they are linked to MS. The goal is to better unde…

This study looks at whether chewing function is linked to cognitive skills, disease severity, and nutrition in people with multiple sclerosis. Researchers will assess 86 adults with MS using tests for disability, thinking, swallowing, chewing, and nutrition. The goal is to unders…

This study looks at whether measuring a specific antibody, anti-Ro52, in the blood of people with Sjögren's syndrome can help predict who will develop serious problems like lymphoma or organ damage. Researchers will follow 150 patients over time to see if higher antibody levels a…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This early-stage study will test the safety and tolerability of a new drug called ACT100 in 48 healthy adults. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure how the drug moves through the body. This is the first …

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and the HLA-B27 gene in 84 people with ankylosing spondylitis and a healthy control group. The goal is to see if these markers are linked to disease activity and severity. No treatment i…

This study aims to see if certain markers in the blood (CCR6 and CCL20) are linked to rheumatoid arthritis. Researchers will compare 60 adults with RA to healthy people. The goal is to learn more about the disease, not to test a new treatment.

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at how treatment failure impacts the quality of life, anxiety, depression, and daily activities of 150 adults with relapsing-remitting multiple sclerosis. Researchers will use questionnaires to measure patients' well-being and their experience with care. The goal…

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis and systemic sclerosis, as well as healthy volunteers, and compare them with standard tests and lung functi…

This observational study will compare teens with celiac disease who follow a gluten-free diet strictly versus those who don't, along with healthy peers. Researchers will test walking while doing mental tasks, memory, attention, muscle strength, quality of life, and fatigue. The g…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study will check if a protein called Tim-3 on certain white blood cells (neutrophils) is linked to disease activity in people with ankylosing spondylitis. Researchers will measure Tim-3 levels and compare them with inflammation markers and MRI scans of the hip and sacroiliac…

This study looks at whether simple breathing tests can help detect disability levels in people with multiple sclerosis (MS). Researchers will measure respiratory muscle strength and endurance in 40 adults with MS and compare the results to their disability scores. The goal is to …

This study looks at a protein called isthmin-1 in the blood of people with rheumatoid arthritis (RA) compared to healthy volunteers. Researchers want to see if higher levels of this protein match up with more active disease, as seen on ultrasound scans. The goal is to find a simp…

This observational study will look at how trunk (core) stability is related to balance, walking ability, arm function, and fatigue in 64 people with mild to moderate multiple sclerosis. Participants will complete a series of standard physical tests in one session, such as timed w…

This observational study will test whether computer analysis of voice recordings can detect a deep type of exhaustion called central fatigue in people with generalised myasthenia gravis. 240 adults in the US and UK will record themselves speaking twice daily, twice a week for 4 w…

This study follows 250 adults in Finland who were previously screened for celiac disease to see how early diagnosis affects their long-term health, diet habits, and quality of life. Researchers will track symptoms, gluten-free diet adherence, and overall well-being. The goal is t…

This study looks at how doing other things at the same time—like listening, watching, or moving—affects chewing in people with multiple sclerosis. Researchers will compare 48 adults with MS to healthy volunteers. The goal is to understand chewing problems better, not to test a tr…

This study will test whether mixed reality (using Meta Quest 3 goggles) can reliably measure walking, standing, and balance in 75 people with multiple sclerosis. Participants will perform standard mobility tests both conventionally and in a mixed reality environment. The goal is …

This study looks at 400 people with lupus to compare those with typical symptoms versus those with unusual or 'atypical' symptoms. The goal is to understand how these differences affect disease activity, organ damage, and treatment needs over time. By identifying these patterns, …

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday medical practice. Researchers will measure disabili…

This study looks at how well university students with type 1 diabetes can estimate carbohydrates in their meals and whether that affects their blood sugar control. Researchers will give a one-time educational session on carb counting and insulin adjustment, then check blood sugar…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study looks at how two different exercise programs—high-intensity intervals and moderate continuous activity—affect a blood marker called irisin, as well as disease activity, physical function, and quality of life in people with axial spondyloarthritis. About 75 adults with …

This study will analyze blood samples from 24 adults with generalized myasthenia gravis who are being treated with ravulizumab. Researchers will look for changes in thousands of proteins over 26 weeks to find markers that show how well the treatment is working and whether the ner…

This study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…

This study will collect health data and samples from 100 people with multiple sclerosis over several years. Researchers will use artificial intelligence and data science to find patterns that could help predict how the disease will progress. The goal is to eventually personalize …

This study explores whether a smartphone app called MyoSense 360 can help track changes in generalized Myasthenia Gravis (gMG) symptoms over 12 months. About 100 adults with gMG will use the app at home to collect data. The goal is to see if the app can detect when symptoms get b…

This study will design and test web-based decision aids for parents in Canada considering screening their children for type 1 diabetes. Researchers will work with parents and experts to create the tools, then test them in online studies with 350 participants. The goal is to see i…

This study looks at whether young people (ages 8–25) with chronic immune thrombocytopenic purpura (ITP) have lower aerobic fitness than healthy peers. Fatigue is a major problem for many with ITP, and the researchers want to see if it's linked to a 'vicious cycle' of being less a…

This study will compare 100 people with either multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) to find better ways to tell them apart. Researchers will measure specific proteins in the blood and look at MRI scans. The goal is to improve diagnosis and man…

This study will measure 12 immune-signaling proteins (cytokines) in the blood of 125 people with vitiligo and healthy volunteers. The goal is to create a model that can predict when the disease will become active and how well a patient will respond to treatment. Currently, doctor…

This study looks at two genes (IL-1β and IL-33) in 300 adults with low platelet counts caused by either primary immune thrombocytopenia (ITP) or lupus (SLE). Researchers will measure gene activity from a blood sample to see if these genes can help tell the two conditions apart. T…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study aims to see if artificial intelligence can predict how multiple sclerosis (MS) will progress over time. Researchers will collect medical information from 53 people with MS and use that data to train a computer model. The goal is to better understand the disease and pot…

This study looks at eating behaviors in teenagers aged 11-17 with celiac disease compared to healthy teens. Participants fill out questionnaires about their eating habits and concerns. A smaller group newly diagnosed with celiac disease will be followed for two years to see how t…

This study will compare how often autonomic nervous system problems occur in people with neuromyelitis optica spectrum disorder (NMOSD) versus multiple sclerosis (MS). Researchers will use questionnaires and bedside heart tests to measure symptoms like dizziness, bladder issues, …

This study will compare blood test results and ultrasound images of joints in 72 people with rheumatoid arthritis. Half are taking JAK inhibitors, and half are on traditional treatments. The goal is to see if certain blood markers can reliably show how active the disease is, whic…