Sexually transmitted disease

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This study tested an experimental HIV vaccine in 132 healthy, HIV-negative adults. The vaccine uses a harmless virus (ALVAC) to deliver HIV proteins, plus a protein boost (gp120) with an adjuvant to strengthen the immune response. The main goals were to check safety and measure w…

This study tests an experimental vaccine called GBS-NN/NN2 against Group B Streptococcus (GBS), a bacteria that can cause serious infections in newborns. The trial includes pregnant women both with and without HIV, giving two doses between 26 and 30 weeks of pregnancy. Researcher…

This early-phase trial is testing two experimental HIV vaccines in 52 healthy adults without HIV. The goal is to see if the vaccines are safe and can stimulate the immune system to produce broadly neutralizing antibodies, which are key to fighting many HIV strains. Participants r…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This study tested an experimental gonorrhea vaccine in healthy adults aged 18 to 50. The goal was to see if the vaccine is safe and can prevent gonorrhea infections. Over 1,000 participants received either the vaccine or a placebo (salt water shot) and were monitored for side eff…

This study tested a new two-step vaccine approach to protect HIV-infected adults from pneumococcal infections, a common cause of serious illness in this group. The standard vaccine often doesn't work well in people with lower immune cell counts. The study involved 212 participant…

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This Phase 1 trial tested a new HIV vaccine in 68 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a DNA-based approach combined with an HIV protein to train the body to fight the virus. While early results are encouraging, this is just the fi…

This study tested an experimental HIV vaccine in 117 healthy, HIV-negative adults to see if it is safe and triggers an immune response. Participants received several injections of the vaccine or a placebo. The main goals were to check for side effects and measure antibody levels.…

This large study tested Moderna's COVID-19 mRNA vaccine in over 14,000 people living with HIV or other conditions that increase the risk of severe COVID-19. The goal was to see how well different vaccine doses prevent COVID-19. Participants received either the original or an upda…

This study tested two different schedules of an experimental HIV vaccine in 147 healthy adults to see which one triggers a stronger immune response. Volunteers received either three DNA shots followed by one booster, or two DNA shots followed by two boosters. The goal was to find…

This study tested whether a double-dose hepatitis B vaccine (40 micrograms) works better than the standard dose (20 micrograms) in people with HIV who did not respond to earlier hepatitis B shots. The goal was to see if the stronger dose could help their immune system produce eno…

This study tested three different ways of giving the hepatitis B vaccine to 437 people with HIV whose CD4 counts were above 200. The goal was to see which schedule—standard dose, double dose, or skin injections—works best to protect them from hepatitis B, a virus that can cause s…

This study tested different COVID-19 booster vaccines (Janssen, Moderna, Pfizer, Novavax) in about 1,900 adolescents and adults aged 12 to 64 in Kenya, Democratic Republic of Congo, and Rwanda. Some participants had HIV, and others did not. The goal was to see if mixing vaccine t…

This study tested an experimental HIV vaccine in 65 healthy adults to see if it is safe and triggers an immune response. The vaccine includes two HIV proteins (A244 and B.63521) plus an adjuvant (ALFQ) to boost the immune system. Participants received three shots over two months,…

This early-stage trial tested an experimental HIV vaccine in 38 healthy infants born to HIV-positive mothers. The vaccine was designed to teach the immune system to recognize HIV. The main goal was to see if it was safe and whether it triggered an immune response. The study is co…

This study tested an experimental Ebola vaccine (V920) in 251 HIV-infected adults and adolescents to see if it is safe and triggers an immune response. Participants received either the vaccine or a placebo, and researchers monitored side effects and antibody levels. The trial too…

This study looked at how well the Pfizer mRNA vaccine triggers an immune response in people with weakened immune systems compared to healthy individuals. About 539 adults received two doses of the vaccine, and researchers measured antibody levels and side effects. The goal was to…

This Phase 1 trial tested a DNA vaccine designed to teach the immune system to recognize HIV. 46 healthy adults received the vaccine with or without a protein boost. The main goal was to see if it is safe and whether it triggers the right immune cells. Results will help decide if…

This study tests an experimental vaginal insert (ABI-2280) to see if it can safely clear persistent high-risk human papillomavirus (HPV) infection in women aged 25 to 55. Participants must have had HPV for at least a year with no serious cervical changes. The study compares diffe…

This study tests whether two lab-made antibodies can safely control HIV in people who stop their regular antiretroviral therapy for a short time. Thirty-two adults in Sub-Saharan Africa who are currently on HIV treatment will receive either the antibodies or a placebo. The goal i…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This phase II trial is testing whether argon plasma coagulation (APC) can safely and effectively treat high-grade anal lesions (AIN 2/3) in HIV-positive men who have sex with men. APC uses ionized argon gas to deliver a controlled electrical current that destroys abnormal cells. …

This early-stage trial is testing an experimental HIV drug called ACC017 in adults with HIV-1 who have never taken HIV medication. The study aims to see if the drug is safe, tolerable, and effective at lowering the amount of virus in the blood, both when used alone and when combi…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

This study in Zambia is testing whether community-based and streamlined models of antiretroviral therapy (ART) care can help people living with HIV stay in treatment. It involves about 3,100 HIV-positive adolescents and adults who are not acutely ill. Participants may receive car…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This trial tests a community-based program called VINA STEAM, designed to help gay and bisexual men in Ho Chi Minh City cope with stress and HIV-related stigma. Participants join small peer-led groups to build skills that may reduce minority stress and stigma. The study measures …

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This study in Zambia evaluates whether dedicated 'viremic clinics'—where people with HIV who have high viral loads receive extra support from a team of healthcare providers—can improve viral suppression. The trial includes 548 participants aged 15 and older who have been on first…

This trial tests two approved antibiotics—azithromycin (a single dose) and doxycycline (twice daily for a week)—to see which is more effective at curing genital chlamydia in young people aged 12-21 living in youth correctional facilities. Participants provide urine samples over a…

This early-stage trial tests the safety and tolerability of two experimental injectable drugs (capsid inhibitors) in 85 healthy adults. Participants receive a single dose or multiple doses of the drug or a placebo. The goal is to see if these drugs are safe enough to study furthe…

This study tested a shorter course of a chemotherapy combination called EPOCH-R in 68 people with HIV and a type of lymphoma. The goal was to see if reducing the amount of chemotherapy could still control the cancer while causing less damage to the immune system. Participants rec…

This phase 3 trial asks whether a dolutegravir-based HIV regimen works as well as or better than an efavirenz-based regimen in pregnant women living with HIV-1. The study compares how well each treatment suppresses the virus at delivery and checks safety for both mothers and thei…

This trial compares an oral antibiotic called linezolid to the standard penicillin injection for treating early syphilis. Linezolid can reach the brain, which may help prevent neurosyphilis. About 224 adults with primary, secondary, or early latent syphilis will be randomly assig…

This study tested a program called SYV (The Voice of Youth) to see if supporting mental health helps young people with HIV take their medication regularly. 690 youth aged 10-24 in Tanzania took part. The goal was to improve viral suppression by addressing mental health challenges…

This trial tests whether a web-based app called Game Plan can help men who have sex with men reduce heavy drinking and sexually transmitted infections. Participants receive home HIV/STI self-testing kits and are randomly assigned to either a 24-hour helpline alone or the helpline…

This study looks at how well the drug ibalizumab works for people with multidrug-resistant HIV in everyday medical practice. It compares patients who receive ibalizumab plus other HIV drugs to similar patients who do not receive ibalizumab. The goal is to understand long-term vir…

This early-stage study tested whether an experimental antibody called VRC01 is safe and can lower the amount of HIV in the blood of 24 adults who were recently infected. Some participants received VRC01 alone, while others received it together with standard HIV medications. The m…

This study looked at two strategies to help Ugandans living with HIV and high blood pressure get better care. One strategy provided free blood pressure medicines and equipment, while the other added extra staff and support. Over 87,000 patients took part. The goal was to see whic…

This trial tests whether giving small cash payments to HIV-positive pregnant women in Nigeria can encourage them to stay in care and reduce the chance of passing HIV to their babies. Women who register their pregnancy, pick up their medication, deliver at a clinic, and get their …

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This study tested whether taking a double dose of the HIV drug dolutegravir (50 mg twice daily) along with the TB drug rifapentine can keep HIV under control in people with both HIV and tuberculosis. Thirty adults participated. The goal was to see if the higher dose is safe and e…

This study surveys HIV-positive adults who switch from taking two or three pills to a single pill containing the same three medicines (tenofovir, emtricitabine, and efavirenz). Researchers want to know if the simpler regimen improves how well patients take their medication, how t…

This study tests two approaches to help people recently involved with the justice system start HIV prevention or treatment and substance use care. One group gets standard patient navigation; the other can choose from a menu of services including in-person clinics, a mobile health…

This study tests whether a virtual environment (VE) can help minority men who have sex with men and are living with HIV adopt healthier behaviors to prevent cardiovascular disease. Participants use a computer-based virtual world to access educational quests and other features. Th…

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This trial compares two surgical methods—carbon dioxide laser ablation and electrocoagulation—for removing genital warts in women. The main goal is to see which technique gives a better cosmetic result six weeks after treatment. Researchers also track operation time, complication…

This study looked at whether taking vitamin D3 for 3 months can lower inflammation and boost immune cells in people with HIV who are already on antiretroviral therapy. Twenty adults with early-stage HIV took vitamin D3 supplements. Researchers measured changes in inflammation mar…

This study looks at whether CABENUVA, a long-acting injectable HIV medication, is safe and effective for people with HIV who also have severe kidney impairment, including those on dialysis. Participants receive the drug as monthly or every-2-month injections. The goal is to see h…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This study looked at whether community health workers can help people with HIV and high blood pressure in northern Tanzania manage their condition. About 100 participants received counseling, doctor visits, and phone calls over 6 months. The goal was to see if this approach helps…

This study looked at whether adults aged 50 and older living with HIV could safely switch from a three-drug pill to a simpler two-drug pill (DTG/3TC) while keeping the virus under control. About 200 participants who already had undetectable virus levels made the switch and were f…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study tests whether baricitinib, a drug used for arthritis, can safely reduce the hidden HIV reservoirs in people who already have the virus under control with standard HIV medication. Thirty adults with HIV will take either baricitinib or a placebo daily for 12 weeks while …

This study tests different ways to help people with HIV take their medication regularly. Researchers will enroll 534 people starting HIV treatment in Cape Town. They will use a device to track pill-taking and try different outreach methods, like calls or texts, to support adheren…

This study tests a program called Maisha (Swahili for 'life') that aims to reduce HIV stigma among pregnant women and their male partners entering antenatal care in Tanzania. The program includes a video and counseling session before HIV testing, plus extra support for those who …

This trial tests a community-based approach to HIV prevention for young people aged 15-30 in rural KwaZulu-Natal, South Africa. Peer navigators guide participants to mobile clinics that offer sexual health services, including HIV testing, PrEP, and contraception. The goal is to r…

This study tests a mobile app designed specifically for Black adults living with HIV who smoke daily. The app includes culturally tailored content and anxiety-reduction techniques to support quitting. Participants are randomly assigned to use either the tailored app or a standard…

This study tested whether brief or in-depth counseling could help people living with HIV in Zambia reduce unhealthy alcohol use and improve HIV treatment. 680 adults who were on HIV medication and had hazardous drinking plus mental health or substance use issues took part. Partic…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This study tests a new way to help vulnerable people with HIV get diagnosed and start treatment right away using a mobile screening unit. Participants receive the once-daily pill Biktarvy on the same day they are enrolled. The goal is to see if this approach helps them stay in ca…

This study looked at whether starting antiretroviral therapy (ART) immediately (within 48 hours) versus waiting until an opportunistic infection is under control affects death rates in HIV/AIDS patients hospitalized with such infections. Researchers enrolled 114 adults with HIV a…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tests a new experimental drug, MK-4646, in people with HIV who have never taken HIV medications. The main goals are to see if the drug is safe and tolerable, and how much it can lower the amount of HIV in the blood. About 28 participants will receive the drug and be mo…

This study tests a combination of three HIV drugs (amprenavir, lopinavir, and ritonavir) in patients whose current treatments are no longer working. The goal is to see if this new mix can lower the amount of HIV in the blood over 26 weeks. Participants are HIV-positive adults who…

This trial compares a once-daily combination of three HIV drugs (emtricitabine, didanosine, and efavirenz) to the standard multi-pill regimen containing a protease inhibitor. The goal is to see if the simpler daily pill works just as well at keeping the virus undetectable, while …

This study tested a once-daily combination of three HIV drugs (FTC, ddI, efavirenz) in 39 adults who had never taken HIV medication before. The goal was to see if this simpler, once-a-day pill routine worked well and had fewer side effects than older treatments. Participants had …

This study tested whether a mobile health unit that offers HIV prevention, treatment, and medication for opioid use disorder all in one place helps people who inject drugs stay on treatment. About 447 adults with opioid use disorder took part. The goal was to see if this approach…

This completed Phase 4 trial tested the HIV drug Biktarvy in 202 people who were newly diagnosed with HIV and had low CD4 counts (under 200), meaning they started treatment late. Participants received either Biktarvy or a standard three-drug combination. The main goal was to see …

This study tested whether personalized text message reminders can help young people with HIV take their medication consistently. 210 participants from 12 clinics received either standard care or tailored text reminders for 6 months. The goal was to see if the texts improved medic…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested the drug pravastatin in 21 HIV-positive people with high cholesterol who were already on HIV medications. The goal was to see if pravastatin could safely lower their cholesterol without affecting their HIV treatment. Participants received either pravastatin or a…

This study tested whether daily cassava root and sesame seed granules, along with nutrition education, could improve the nutritional health of adults with HIV. Sixty-four participants took part, receiving either the granules plus education or education alone for 16 weeks. The goa…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This study tested a new once-daily combination pill (doravirine/islatravir) in 599 adults newly diagnosed with HIV-1 who had never taken HIV medication. The goal was to see if the new pill works as well as a standard three-drug regimen at keeping the virus under control. Results …

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested a two-part vaccine (Ad26.Mos4.HIV and MVA-BN-HIV) combined with three broadly neutralizing antibodies (PGT121, PGDM1400, VRC07-523LS) in 28 adults with HIV who were already on suppressive antiretroviral therapy (ART). The goal was to see if this combination coul…

This study tested a stepped-care program where trained non-specialists provided mental health support and HIV medication adherence help to 280 people in rural Zimbabwe. Participants had both depression and high HIV viral loads. The goal was to see if this approach could improve v…

This study looked at two ways to control HIV in 171 adults who had never been treated before. Everyone started with a daily pill (dolutegravir/lamivudine). Once the virus was undetectable, participants could choose to switch to a shot (cabotegravir plus rilpivirine) given every t…

This study tested a simple tool that helps doctors choose the right stop-smoking medicines for people living with HIV. 371 smokers from three clinics took part. The goal was to see if the tool helped more people quit smoking for at least a week.

This study tested the safety and how the body processes the HIV drug dolutegravir in newborns whose mothers have HIV. A total of 48 mother-infant pairs from four countries participated. Infants received either a liquid or tablet form of the drug during their first weeks of life, …

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 older veterans living with HIV. Participants exercised via video conferencing without needing special equipment. The goal was to improve fitness and quality of life,…

This early study tested a lab-made antibody called 3BNC117-LS in 43 people, some with HIV and some without. The goal was to see if it is safe and how long it stays in the body. If it works, this antibody might one day help control HIV with less frequent dosing.

This completed Phase 2 trial tested a new drug called lipovirtide, given as a weekly or biweekly injection, along with daily oral HIV medications. The study enrolled 64 HIV-positive adults who had never taken antiviral drugs before. Researchers measured how many participants had …

This study tested a combination of peginterferon alfa2a and ribavirin in 17 HIV-positive people with chronic hepatitis C who had not responded to earlier treatment. Participants received weekly injections and daily pills for 48 weeks. The main goal was to see if the virus became …

This study tested whether a vaginal insert containing artesunate, a malaria drug, could help clear HPV after standard cervical precancer treatment in women living with HIV. 120 women in Kenya used the insert or a placebo for 5 nights on and off over 6 weeks. The goal was to see i…

This study tested a new drug called LP-98 in 40 people with HIV who had not taken any HIV medications before. Participants received different doses of LP-98 as a shot under the skin every two weeks for a total of four doses. The main goal was to check if the drug is safe and how …

This early-stage study tested a single injection of a new drug, lipovirtide, in 46 HIV-positive adults who had never taken antiviral medication. The main goal was to check if the drug is safe and how the body processes it. This is a first step toward finding new treatments to con…

This early-stage trial tested multiple doses of an injectable drug called lipovirtide in 24 adults with HIV who had never taken antiretroviral therapy. The main goal was to check safety and how the drug moves through the body, with a secondary look at whether it can lower HIV lev…

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This pilot study tested a text-message game called iTAG that uses points, a scoreboard, and motivational messages to encourage young people with HIV in Ghana to take their medication regularly. Twenty-one participants aged 18-24 received the game for 90 days. Researchers measured…

This phase 2a trial tested a new experimental drug called STP0404 (Pirmitegravir) in 25 adults with HIV-1 who had never taken HIV medications before. Participants received either a low, medium, or high dose of STP0404 or a placebo once daily for 10 days. The study measured how we…

This study tested an experimental mRNA vaccine (mRNA-1608) in 303 healthy adults aged 18 to 55 with recurrent genital herpes caused by HSV-2. The goal was to see if the vaccine is safe and can reduce the number of outbreaks. Participants received different doses of the vaccine or…

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested whether the BCG vaccine, normally used to prevent tuberculosis, could reduce the hidden HIV reservoir in people living with HIV who are on antiretroviral therapy. Sixty participants received either a single BCG shot or a placebo. Researchers measured changes in …

This study tested whether two lab-made antibodies, VRC01LS and 10-1074, could keep HIV under control in 30 children in Botswana who started treatment early. The children received the antibodies by infusion and stopped their regular HIV medication. Researchers monitored how many k…

This study looked at HIV-positive adults who switched from a standard three-drug therapy to either a two-drug or a three-drug regimen. Researchers wanted to see if the two-drug option could reduce long-term side effects while keeping the virus under control. The main focus was on…

This study tested a counseling program for couples in Zambia to help pregnant women living with HIV stay healthy. Nearly 500 couples took part. The program aimed to improve HIV medication adherence and viral suppression through relationship strengthening.

This study tested a program that combined mobile health tools and peer support to help 541 Nigerian adolescents with HIV stick to their treatment and keep the virus under control. Participants were already on antiretroviral therapy and received the program for up to 48 weeks. The…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This study tested whether people with well-controlled HIV can safely take their antiretroviral drugs only 4 days in a row each week, instead of every day. Over 600 adults with stable HIV participated. The main goal was to see if the 4-day schedule kept the virus suppressed just a…

This completed Phase II trial tested the drug pomalidomide in 26 HIV-positive adults with Kaposi sarcoma, a type of skin cancer common in Sub-Saharan Africa. Pomalidomide works by boosting the immune system and blocking blood vessel growth that feeds tumors. Researchers measured …

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This study tested whether adding Interleukin-2 (IL-2) to standard HIV drugs could increase CD4 immune cells in patients whose current treatment was failing and who had very low CD4 counts (≤200). Fifty-seven adults with HIV-1 took part. The main goal was to see if their CD4 count…

This study tested a once-daily combination of three HIV drugs (tenofovir, emtricitabine, and efavirenz) in 70 adults with both HIV and tuberculosis. Participants had not taken HIV medication before and had been on TB treatment for less than three months. The goal was to see if th…

This study tested two versions of the H1N1 flu vaccine in 306 people living with HIV. One vaccine included an adjuvant (a booster ingredient) and the other did not. The goal was to see which vaccine was safer and better at protecting against the flu. Participants were followed fo…

This study tested two different once-daily HIV medication combinations in 101 people who had just been infected with HIV-1. The goal was to see which combo better lowered the amount of hidden virus in immune cells after 48 weeks. Both treatments are standard HIV therapies, so thi…

This study tested whether adding the drug maraviroc to standard HIV treatment could help improve immune function in people whose CD4 counts remain low even when the virus is well-controlled. It involved 60 HIV-positive adults with low CD4 counts and little recent immune improveme…

This study tested a more intensive hepatitis C treatment in 58 adults who have both HIV and hepatitis C (genotypes 1 or 4) and had not responded to previous therapy. Participants received higher doses of two drugs, peginterferon alfa-2a and ribavirin, for up to 18 months. The goa…

This study tested whether HIV patients with long-term viral suppression could switch to a single boosted drug (darunavir/r) instead of staying on a standard combination of drugs. 225 adults with well-controlled HIV took part. The goal was to see if the single-drug approach could …

This study tested whether adding an extra HIV drug (enfuvirtide) to standard treatment for 6 months helps people with very low CD4 counts recover their immune system faster. It included 195 adults newly diagnosed with HIV who had a high risk of getting AIDS. The goal was to see i…

This study looked at how the HIV drug raltegravir works in people with severe liver disease who need a liver transplant. It included 14 HIV-positive adults with end-stage liver failure. Researchers checked how the drug behaves in the body and how it interacts with anti-rejection …

This study looked at whether people with HIV who have their virus under control can switch from the injectable drug enfuvirtide to the oral pill raltegravir. 170 participants were randomly assigned to either stay on their current treatment or switch to raltegravir. The goal was t…

This study looked at 35 people with HIV who had never taken HIV drugs before. They all received a daily combination of three medications (atazanavir, ritonavir, tenofovir/emtricitabine) in special bottles that recorded every time they opened them. The goal was to measure how much…

This study tested whether a single HIV drug, darunavir/ritonavir, could replace the usual combination therapy in pregnant women with well-controlled HIV. The goal was to prevent mother-to-child transmission without using a class of drugs called NRTIs. 91 pregnant women already on…

This study tested whether people with HIV who have high immune cell counts (CD4 above 500) can safely take antiretroviral drugs in 6-month cycles—6 months on treatment, then 6 months off—instead of taking them every day. The goal was to see if this approach could keep their immun…

This study tested a two-drug combination of raltegravir and etravirine in 170 adults with HIV who were at least 45 years old and already had the virus well-controlled. Participants switched from a standard three-drug regimen to this simpler two-pill combo. After 96 weeks, over 98…

This study tested whether adding a powerful HIV drug called FUZEON® to standard antiretroviral therapy could help people with HIV who also have a rare brain infection called PML. PML is caused by a virus that attacks the brain when the immune system is weak. The goal was to see i…

This study tested a three-drug combination (raltegravir, emtricitabine, and tenofovir) as a first treatment for people with HIV-2, a less common form of HIV found mainly in West Africa. The goal was to see if this combination could control the virus better than standard treatment…

This study tested whether alendronate, a drug used for osteoporosis, can improve bone density in people with HIV. 140 participants received either alendronate or a placebo, along with calcium and vitamin D, for 2 years. The goal was to see if the drug could strengthen bones and r…

This study tests whether interleukin-2 (IL-2) can help maintain CD4 cell counts in people with HIV who have not yet started antiretroviral therapy. 130 participants with CD4 counts between 300 and 500 will receive IL-2 injections. The goal is to see if IL-2 can delay the need for…

This study looked at whether a lower daily dose of the HIV drug darunavir (400 mg instead of 800 mg) can keep the virus suppressed in people whose HIV is already well-controlled. The trial involved 100 adults with HIV who had undetectable viral loads for at least a year. The goal…

This study tested two different two-drug combinations in 61 HIV patients who had never taken protease inhibitors before. The goal was to see if these combinations could lower the amount of virus in the blood to very low levels (below 50 copies/mL) after 16 weeks. The study also c…

This phase 2 study tested a combination of three drugs—telaprevir, peginterferon, and ribavirin—in 70 adults with both HIV and hepatitis C who had not been helped by standard treatment before. The goal was to see if this triple therapy could clear the hepatitis C virus from the b…

This study tested two statin drugs, rosuvastatin and pravastatin, in 86 people with HIV who also had high cholesterol. The goal was to see which drug lowered LDL (bad) cholesterol better and was safer when taken with HIV medications. Participants took one of the two statins for 4…

This study tested a program to help men who have sex with men (MSM) stay on daily PrEP (a pill that prevents HIV) and reduce sexually transmitted infections (STIs). 240 men in Atlanta used a mobile app that flagged when they might stop PrEP, then a peer counselor and doctor stepp…

This early-stage study tested a new drug called ABI-5366 in 115 people to see if it is safe and how the body processes it. Part A involved healthy volunteers receiving a single dose, while Part B included people with recurrent genital herpes who received multiple doses. The goal …

This phase 3 trial tested whether people with HIV whose virus is already suppressed can safely switch to a new two-drug pill (doravirine/islatravir) instead of staying on their current three-drug regimen (BIC/FTC/TAF). About 643 participants were randomly assigned to either switc…

This study tested two different drug combinations for people with HIV whose first treatment stopped working. 558 participants received either standard second-line drugs plus a newer integrase inhibitor (raltegravir) or the standard second-line drugs alone. The main goal was to se…

This study tested a program for 160 HIV-positive fisherfolk in Uganda who were heavy drinkers and struggling to stick with their HIV medication. The program combined individual and group counseling with help opening savings accounts and building social support. The goal was to re…

This study looked at whether it is safe to stop giving annual azithromycin to communities with low levels of trachoma, an eye infection that can cause blindness. Over 3,900 people in Niger took part. Researchers compared stopping treatment after at least 5 years versus continuing…

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study tested a smartphone app called LetSync designed to help Black men who have sex with men and their partners stay engaged in HIV care and take their medications as prescribed. About 144 participants (80 couples) used the app for up to 14 months. The researchers measured …

This study tested whether a drug called sacubitril-valsartan (Entresto) can improve early signs of heart failure in people with HIV. The 39 participants had well-controlled HIV but showed subtle heart changes on scans. The goal was to see if the drug could reduce inflammation and…

This early-stage trial tested a therapeutic DNA vaccine called ICVAX in 45 people with HIV who were already stable on antiretroviral therapy (ART). The goal was to see if the vaccine is safe and whether it can boost the immune system to better control the virus. Participants rece…

This completed study tested a behavioral program called WeCare for men who have sex with men (MSM) in South Africa. The program included individual sessions to identify problems and create action plans, plus group sessions for social support and coping with stigma. The goal was t…

This study tested whether a weekly injection of PRO 140 (Leronlimab) could keep HIV under control in people whose virus was already suppressed by daily pills. Over 500 participants switched from their regular medication to the shot alone for 48 weeks. The goal was to see how many…

This study tested whether a vaccine already approved for meningitis B (Bexsero) can also protect against gonorrhea infection. Healthy men aged 18–35 received either the meningitis vaccine or a placebo, then were exposed to the gonorrhea bacteria in a controlled setting. The goal …

This study tested a low-cost tool to help health workers in Mozambique better diagnose and manage high blood pressure in people with HIV. The tool uses cycles of evaluation and improvement to streamline care. Researchers worked with 18 health facilities to see if this approach co…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested the safety and immune response of the R21/Matrix-M malaria vaccine in 122 African children aged 5-36 months, some living with HIV and some without. The goal was to see if the vaccine is safe and produces an immune response in these children. The trial has been c…

This study tested a smartphone app called START to help men with HIV who use stimulants like methamphetamine take their medication regularly. The goal was to lower their viral load and improve health. The app provided support and reminders, and the study measured how well it work…

This completed Phase 3 study tested whether switching to a once-daily combination pill (doravirine/islatravir) works as well as staying on standard HIV therapy. 672 adults with HIV whose virus was already suppressed took part. Results showed the new pill kept the virus under cont…

This study tested a type of talk therapy (CETA) in 399 women in South Africa who have HIV, experienced intimate partner violence, and had trouble keeping the virus under control. The goal was to see if the therapy could help more women achieve an undetectable viral load and reduc…

This study looked at whether using an anti-cancer cream (5-fluorouracil) in the vagina after surgery is an acceptable and feasible way to treat cervical precancer in 180 South African women living with HIV. The goal was to see if women would stick with the treatment and find it a…

This study looked at 33 adults with well-controlled HIV who switched from a monthly injectable treatment (CAB+RPV) to a daily oral pill (B/F/TAF). The main goal was to check if the switch was safe, especially for those who couldn't or didn't want to continue injections. Over 12 w…

This study tested whether a mobile care van linked to a needle exchange program could improve HIV prevention and treatment for people who inject drugs. 720 participants received services like HIV testing, treatment, and risk reduction through the van. The goal was to see if this …

This study offers continued access to the HIV medication dolutegravir for children and teenagers who previously took part in related studies. About 100 participants who tolerated the drug well and still need it will receive age-appropriate doses every 12 weeks until the drug is l…

This study tested a mobile app designed to help gay and bisexual men reduce their methamphetamine use and risky sexual behaviors. The app includes games, lessons, and resources. 226 men who use meth took part. The goal was to see if the app could help them cut back on meth and lo…

This study looked at whether the HPV vaccine can help prevent high-grade cervical lesions (precancerous growths) in women living with HIV who were already being treated for HPV. About 536 women took part, receiving either the HPV vaccine or a placebo. The goal was to see if the v…

This study tested whether switching from a daily HIV pill (Biktarvy) to a once-weekly combination of two experimental drugs (islatravir and ulonivirine) is safe and tolerable. It involved 161 adults whose HIV was already well-controlled on daily therapy. The goal was to see if a …

This study tested a mobile phone app called 'My Personal Health Guide' that uses a friendly, talking avatar to help African American men who have sex with men (ages 18-34) stick to their HIV medication and stay in care. The app provides private, easy-to-understand information and…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone therapy reduce methamphetamine use and improve HIV outcomes. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to sup…

This study tested whether giving the HPV vaccine (Gardasil) to women with large or extensive genital warts before surgery could prevent the warts from coming back. The trial included 52 women, some with HIV and some without. Researchers measured changes in wart size and antibody …

This study tested a combination of two lab-made antibodies (VRC07-523LS and CAP256V2LS) and an immune-boosting pill (vesatolimod) in 20 women with HIV who were already on standard antiretroviral therapy. The goal was to see if the regimen is safe and might help control the virus …

This study tested whether bringing together groups of friends who all have HIV helps them support each other to stay in medical care and take their medications. Over 300 people in St. Petersburg, Russia, took part. The approach uses everyday friendships to encourage regular docto…

This study tested two nurse-led programs to help women living with HIV in Durban, South Africa, stay in care and keep the virus under control. One program provided HIV treatment through a mobile van, and the other offered personalized support from a peer. The goal was to see whic…

This study tested different ways to deliver HIV treatment to people in South Africa who had detectable virus or were not in care. About 874 adults took part, receiving either incentives, community-based care, or home delivery of medication. The goal was to see which approach help…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This study tested the HIV medication Genvoya (a single daily pill) in 129 teenagers and children with HIV. The goal was to check how the drug is processed in the body, confirm the right dose, and see if it is safe. Participants included teens new to HIV treatment and children who…

This study tested different ways to help people living with HIV quit smoking. Participants received nicotine replacement therapy (like patches or gum), the medications varenicline or bupropion, and financial rewards for staying smoke-free. The goal was to see if these approaches …

This pilot study tested a 'polypill' that combines four heart failure medications into one capsule, aiming to make it easier for patients to stick with their treatment. The trial included 35 adults with heart failure and reduced ejection fraction, some of whom also had HIV. Resea…

This study looked at how safe and effective a hepatitis A vaccine is for people with HIV, aged 1 to 50. About 392 participants received two vaccine doses six months apart. Researchers checked their blood for antibodies and tracked any side effects for a month after each dose. The…

This early-stage study tested a new experimental HIV drug called VH4524184 in 84 healthy adults to see if it is safe and how the body processes it. The study also looked at whether the drug affects a key liver enzyme. Because HIV requires lifelong treatment, this is not a cure bu…

This study tested whether people with HIV who have a low viral reservoir can safely switch from a three-drug regimen to a two-drug regimen (Truvada alone) while keeping the virus under control. The goal is to reduce long-term side effects and treatment costs. The trial involved 2…

This study tested a program that combines small loans and group support to help people with HIV in Kenya. The goal was to improve HIV medication adherence, mental health, and family relationships. 843 people took part, and the program aimed to reduce depression, anxiety, and PTSD…

This study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a …

This study tested whether trained community health workers visiting pregnant women at home could improve health for both mothers and children in a rural area of South Africa. The program focused on supporting women with HIV, depression, or alcohol use, and on improving child grow…

This study compared two different HIV drug combinations in 447 people with advanced HIV (late presenters). One group received a protease inhibitor combo (Symtuza), the other an integrase inhibitor combo (Biktarvy). The goal was to see which works better and has fewer side effects…

This study tested two strategies to improve HIV care among people who inject drugs and men who have sex with men in India. One group received care at integrated centers that offer harm reduction, testing, and treatment all in one place. The other group got the same care plus fina…

This study tested a once-daily pill containing two HIV drugs (dolutegravir and lamivudine) in 32 adolescents aged 12 to 17 who had never taken HIV medication before. The goal was to see if this simpler two-drug regimen could control the virus as well as standard three-drug combin…

This study tested a program called iSTRIVE for 42 adults with HIV who also use opioids or stimulants and were not well engaged in HIV care. The program combined emotion regulation and communication skills training with video check-ins and small rewards to encourage daily HIV medi…

This study tested a program to help HIV-positive men who have sex with men (MSM) who also struggle with substance use. The program aimed to reduce feelings of stigma and shame that can keep them from getting HIV care. Fifty men took part to see if the program was helpful and easy…

This pilot study tested whether screening pregnant women with HIV for their risk of dropping out of care, then offering tailored support (counseling sessions in person or by phone), could help them stay in treatment and keep the virus under control. The study involved 120 women i…

This study tested a mobile app called PeerNaija that sends medication reminders, shows users how their adherence compares to others, and offers a monthly lottery prize for those with the best scores. The goal was to see if the app is easy to use and helps young people living with…

This study tested whether training healthcare teams to share tasks can help people living with HIV better control their high blood pressure. It involved 960 adults across 30 clinics. The approach included measuring blood pressure, providing lifestyle advice, and starting medicati…

This early-stage study tested a new gene therapy in 2 HIV-positive people with high-risk lymphoma. The therapy involved taking their own stem cells and immune cells, adding a gene to block HIV, and giving them back after chemotherapy. The main goal was to see if the procedure was…

This study evaluates a disposable, at-home PCR test that detects chlamydia and gonorrhea from a urine sample. Men aged 14 and older collect their own sample and use the test with app or written instructions. The goal is to see if the test works accurately outside a clinic, potent…

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This study compares a new rapid point-of-care test for chlamydia, gonorrhea, and mycoplasma genitalium to standard lab testing. The goal is to see if the faster test helps doctors give the right antibiotics on the same day, reducing unnecessary or missed treatments. Participants …

This pilot study tested whether low-dose CT scans can help find lung cancer early in HIV-positive people who are heavy smokers. Researchers scanned 450 participants to see how many had lung cancer and what types were found. The goal was to learn if this screening method is useful…

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study tested whether using augmented reality (AR) on a smartphone can help men who have sex with men perform HIV self-tests better than using paper instructions. 349 participants in Hong Kong were randomly assigned to use either AR guidance or standard instruction sheets. Re…

This study tested a new rapid HIV test for infants in Zambia that gives results in under an hour, compared to standard lab tests that take weeks. Researchers wanted to see if faster diagnosis would lead to more babies starting treatment sooner. Over 1,600 HIV-exposed infants were…

This study looks at whether US women at risk for HIV can and will take Truvada, a daily pill that prevents HIV infection. Researchers will measure how well women stick to the pill regimen over 24 weeks and explore their attitudes toward this prevention method. The goal is to see …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This study tests two ways to prevent HIV: a rectal gel used before sex and daily pills. About 150 men will try each method for 8 weeks to see which is safer, easier to use, and more acceptable. The goal is to give people more choices for on-demand HIV prevention.

This study tested a program where trained peer navigators (women with similar experiences) helped women in the criminal justice system access HIV prevention services like PrEP. The goal was to reduce stigma and improve linkage to care. Thirty women participated, and the study mea…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This trial tests a tablet-based decision support tool designed to help women learn about their HIV risk and prevention options, including PrEP. Women aged 18-45 who are not living with HIV will be randomly assigned to use the tool before a clinic visit or to receive standard coun…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study compares different ways of screening pregnant women for three common sexually transmitted infections (chlamydia, gonorrhea, and trichomonas) to see if treating these infections can reduce the risk of preterm birth and low birth weight. Over 2,200 pregnant women in Sout…

This study tests a program called Start the Conversation, designed to help Black cisgender women learn about and start taking PrEP—a daily pill that prevents HIV. The program includes training for gynecology residents to discuss PrEP with patients, plus a social media campaign. R…

This study tested a communication tool to help women in rural Alabama learn about PrEP (a daily pill that prevents HIV). 67 HIV-negative women at risk for HIV took part. The goal was to see if the tool helped more women get referred to and start PrEP.

This study compares two ways to provide HIV prevention pills (PrEP) to young people in South Africa: the usual clinic-based approach versus a community-based model where pills are delivered and monitored outside clinics. Researchers will enroll 2,500 participants aged 16-30 to se…

This study tested whether using an antibacterial mouthwash every day could lower the chance of getting gonorrhea in the throat. Researchers recruited 89 HIV-positive and HIV-negative men at high risk. Participants gargled with either Listerine or a placebo mouthwash daily. The st…

This study expands on a previous mobile van HIV/STI testing program for men who have sex with men (MSM) in online spaces. Researchers will add a peer health navigator to help participants get PrEP or HIV care after testing. The study will compare this navigator approach to a refe…

This study tests a counseling program called ACTPrEP, designed to help young Black men who have sex with men (ages 18-34) start and continue taking PrEP, a daily pill that prevents HIV. The program uses acceptance and commitment therapy to address thoughts and feelings that might…

This pilot study tested whether watching a culturally tailored telenovela (soap opera) online could help Latinas in North Carolina adopt HIV prevention behaviors like using condoms, getting tested, and learning about PrEP. 95 women participated, watching four 10-minute episodes o…

This completed trial in South Africa tested four support strategies—case management, food vouchers, peer buddies, and community PrEP pick-up points—to help female sex workers and young women stay on PrEP, a daily pill that prevents HIV. 304 participants were randomly assigned to …

This study looks at how often cisgender women in Kenya need to take the HIV prevention pill Truvada (TDF-FTC) to keep protective drug levels in their blood. Participants are randomly assigned to take 2, 4, or 7 doses per week for up to 16 weeks, and their drug levels are measured…

This study tested a program designed to make HIV testing easier for men who have sex with men (MSM) in Lima, Peru. The program offered HIV testing at venues where people meet for sex, along with a text-messaging app that provides information and support. Researchers enrolled 161 …

This study tests whether a proven HIV prevention education program can be delivered through Facebook to reach high-risk rural women in Appalachia. Participants are women leaving jail who have a history of drug use and risky sexual behavior. The goal is to see if social media can …

This study tested whether a couples-focused counseling and testing program could help prevent HIV and improve care. 544 couples from rural South Africa took part. The goal was to see if this approach increases viral suppression and engagement in HIV care.

This completed Phase 3 trial tested a program called Safe South Africa, designed for teenage boys aged 15-17 in high-risk South African communities. The program includes two weekly group sessions and home activities to reduce HIV risk behaviors and intimate partner violence. Rese…

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This study tested four practical strategies—training providers, educating patients, improving electronic health records, and offering patient navigation—to increase use of HIV prevention pills (PrEP) among Black women. Over 700 women from 12 community clinics in the Midwest and S…

This pilot study tested whether offering sexual health services like HIV prevention pills (PrEP), STI testing, and birth control in hair salons could reach women who might not visit a clinic. About 436 women in Umlazi, South Africa, took part. Some salons offered these services, …

This study tested whether a peer-driven program could help African American and Hispanic/Latino men who have sex with men start taking PrEP, a daily pill that prevents HIV. 98 men who were not on PrEP joined the program. The goal was to see if talking with trained peers made them…

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This completed study tested a van-based program in Baltimore that offered drug checking and HIV prevention medication (PrEP) to people who use drugs. Nearly 500 participants were recruited to see if the program helped them start or stay on PrEP and reduce risky behaviors. The goa…

This study evaluated a program called PALMS that uses live movement and sound to teach HIV prevention to high-risk minority male teens aged 12-18 in juvenile justice or drug treatment centers. The goal was to see if the program reduces risky sexual behaviors and encourages HIV te…

This study tested a program called PARTI to help gay and bisexual men who use stimulants (like meth or cocaine) take their daily HIV prevention pill (PrEP) consistently. The program combined positive affect skills training with a smartphone-based reward system for taking PrEP. Re…

This large study tested an experimental HIV vaccine in over 5,400 healthy South African adults at risk of HIV. The vaccine was designed to teach the immune system to fight HIV. Unfortunately, the vaccine did not prevent HIV infection, and the trial was stopped early. The results …

This study looked at different ways to help young women in South Africa, ages 18-25, take their daily HIV prevention pill (PrEP) consistently. The goal was to find the best support strategies to keep them protected from HIV. 360 women took part in the study, which tested a step-b…

This study tested a program to help young men (ages 17-24) who have sex with men use HIV self-testing and PrEP (a daily pill to prevent HIV). 118 participants joined the pilot study. The program provided information, motivation, and skills to encourage HIV testing and PrEP use. T…

This study tested a program to help Latino men who have sex with men get access to PrEP (HIV prevention pills), HIV testing, and mental health services. The program included one-on-one outreach sessions and a website with stories from other Latino men. The goal was to see if this…

This study looked at whether men who have sex with men (MSM) in Burkina Faso, Côte d'Ivoire, Mali, and Togo would accept and use PrEP (a daily or on-demand pill) to prevent HIV. Over 600 HIV-negative men at high risk took part, receiving regular check-ups, STI testing, and suppor…

This study tested a special program called 'Estoy PrEParado' designed to help Latino men who have sex with men start taking PrEP, a daily pill that prevents HIV. The program provided information, motivation, and skills tailored to this community. Researchers enrolled 105 particip…

This study tested whether a quarterly HIV prevention program is practical and helpful for men who have sex with men in four African countries. Over 800 men received regular check-ups, STI testing and treatment, counseling, and condoms. The goal was to see if this approach could l…

This large study in South Africa tested whether offering HIV treatment to everyone right after diagnosis, instead of waiting until their immune system weakened, could reduce new HIV infections across entire communities. Over 28,000 people from 22 communities took part. The idea i…

This pilot study tested whether taking doxycycline once a week can prevent bacterial sexually transmitted infections (STIs) in cisgender women who are already taking HIV PrEP. Sixty women in Kisumu, Kenya, received the antibiotic weekly under direct observation for six months. Th…

This study tested whether a community-based program offering flexible HIV prevention and treatment options could lower the number of new HIV infections. Over 80,000 people aged 15 and older in East African communities took part. The approach focused on delivering the right care t…

This study tested a program called Malkia Klabu ("Queen Club") in Tanzania. The program made local drug shops more welcoming for adolescent girls and young women, so they could easily get HIV prevention services and contraception. Researchers looked at whether this approach incre…

This study tested whether a simpler HIV drug combination (lopinavir/ritonavir alone) could safely prevent mothers from passing HIV to their babies during pregnancy, compared to the standard three-drug combo. About 105 pregnant women with well-controlled HIV took part. The goal wa…

This study tested two strategies to prevent sexually transmitted infections (STIs) in men who have sex with men and already take HIV PrEP. One group took doxycycline pills after unprotected sex, and another group received a meningitis vaccine (Bexsero). The goal was to see if the…

This study tested whether training siblings to talk about HIV PrEP helps Latino men who have sex with men start taking it. 288 participants were split into two groups: one where siblings learned to discuss PrEP, and another where siblings discussed vaccines instead. The goal was …

This study tested whether providing HIV prevention pills (PrEP and PEP) at local pharmacies in Kenya helps more people start and continue taking them, compared to the usual clinic referral. Over 5,800 participants from 60 pharmacies were involved. The goal was to see if pharmacy-…

This early-stage trial tests the safety of a new antibody called CAP256J3LS in 24 healthy adults aged 18 to 60. The antibody is designed to target and neutralize HIV. Participants receive either one or three doses, given as a shot under the skin or through an IV. The study monito…

This study tested a smartphone app designed to help Black women in the southern U.S. learn about and access HIV prevention tools, like PrEP, and other sexual health resources. Fifty-six women used the app or received standard information. The goal was to see if the app was easy t…

This study tested two strategies to encourage HIV prevention pill use among adults who visit or work at drinking venues in Kenya and Uganda. Over 9,000 people took part. One approach focused only on HIV testing, while the other offered broader health screenings. The goal was to s…

This study tested two HIV prevention programs for African immigrant women: one-on-one counseling (Dada Kwa Dada) and group sessions (DADA). The goal was to see which approach increases condom use and PrEP uptake. 149 HIV-negative women from the Boston and New York areas took part…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested three different daily doses of the HIV prevention pill PrEP in 54 pregnant women in Sub-Saharan Africa. The goal was to find the dose that gives the best protection without harming the mother or baby. Researchers measured drug levels in the blood and tracked any…

This study tested a combination HIV prevention approach for 120 men in Kisumu, Kenya, who had recently exchanged sex for money or goods. Participants took daily PrEP pills and received real-time feedback from a urine test, HIV self-test kits, and text reminders. The goal was to s…

This study tested a phone app designed to help young Black men who have sex with men in Alabama get HIV tests and learn about prevention. Fifty-nine people took part to see if the app made them more likely to accept a rapid HIV test and get a prescription for PrEP, a daily pill t…

This study tested a new vaccine called V116 in 313 adults with HIV to see if it safely prevents pneumococcal disease (a serious infection that can cause pneumonia and meningitis). Participants received either V116, a placebo, or an existing vaccine. The trial is complete, and res…

This pilot study tested a counseling tool called MyChoice to help pregnant women in Malawi decide whether to use oral PrEP or condoms for HIV prevention. 100 HIV-negative pregnant women were randomly assigned to receive either the MyChoice shared decision-making intervention or s…

This study looked at whether offering HIV self-testing with online supervision helps young men who have sex with men (MSM) in Ho Chi Minh City get tested more often. One hundred participants aged 16-29 either used the supervised self-test or answered a simple yes/no about past te…

This completed trial tested a program called Game Changers, which trained people living with HIV to become advocates for HIV prevention in their social circles. Over 800 participants in Uganda took part in 8 group sessions focused on communication and advocacy skills. The study m…

This study tested an experimental oral drug called MK-8527, taken once a month, to see if it is safe and how it works in the body for HIV prevention. 352 HIV-negative adults at low risk for infection participated. The main goals were to check for side effects and measure drug lev…

This study tested a program to help women get information and access to PrEP, a daily pill that prevents HIV. The program included training for clinic staff, educational materials, and a navigator to guide patients. About 745 women receiving care at the clinic took part, and rese…

This study tested a program called HUG-M+ designed to help young Thai men who have sex with men get tested for HIV and reduce risky behaviors. Over 600 men aged 15-29 took part in two cities, one receiving the program and the other standard care. The goal was to see if the progra…

This study tested whether a program designed specifically for women who use drugs could help them reduce their risk of HIV and other sexually transmitted diseases. 501 women were randomly assigned to receive either standard counseling, standard counseling plus a well-woman exam, …

This pilot study tested whether giving the HIV prevention pill Descovy (PrEP) right at a syringe services program helps people stay HIV-negative. 90 adults who use the syringe program and tested negative for HIV took part. Researchers measured drug levels in blood to see if parti…

This completed study looked at how to best offer cabotegravir, an HIV prevention shot, in US clinics. About 287 men and transgender men at risk for HIV took part. Researchers compared two ways of rolling out the shot to see which worked better in busy and less busy clinics.

This study tested whether offering HIV prevention medication (PrEP) together with gender-affirming hormone therapy and peer support helps transgender women start and stick with PrEP. 304 participants were randomly assigned to get the combined services right away or after a 6-mont…

This pilot study tested whether offering HIV prevention medication (PrEP) in the emergency department is feasible. 26 adults at high risk for HIV were enrolled. The goal was to see if people would start PrEP and follow up with a clinic within 30 days. The study aimed to overcome …

This study tested whether teaching financial skills and providing economic support could reduce alcohol and drug use among teens and young adults living with HIV in poor areas of Uganda. Researchers enrolled 95 participants aged 15-24 who were already in HIV care and had used alc…

This study tested two strategies to prevent HIV among young couples (ages 18-30) in Cape Town who use alcohol or drugs. One strategy was a community workshop to reduce stigma around HIV and drug use. The other was a couples program that provided HIV testing and counseling to help…

This study tested a tablet-based tool and clinic training to help women learn about HIV prevention, including PrEP. 141 women from a Florida clinic participated. The goal was to see if these tools helped women make informed choices and start prevention methods.

This early-stage study tested a vaginal ring that slowly releases the HIV drug tenofovir over 90 days. Researchers wanted to see if the ring is safe and delivers enough drug to the body. 49 healthy women took part, and the study measured drug levels in blood, vaginal fluid, and t…

This study tests a type of brain stimulation called accelerated theta burst stimulation (a form of TMS) to see if it can lower cravings for methamphetamine in people living with HIV. Thirty adults aged 18-65 with HIV and a history of meth use will receive the treatment. The goal …

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This pilot study tests a digital decision aid designed for people who have experienced sexual assault and are considering HIV post-exposure prophylaxis (PEP). The tool helps patients and providers weigh risk, effectiveness, side effects, and personal priorities together. Research…

This study explores whether combining mindfulness meditation with transcutaneous nerve stimulation (TENS) can reduce foot pain in people living with HIV who have peripheral neuropathy. Participants use a home TENS device and practice guided meditation over several weeks. The goal…

This study tested a tablet-based app called COPPEhR designed to help older adults with HIV (age 50+) connect with others, access resources, and reduce loneliness. Sixty-eight participants either got the app or a tablet without it. The main goal was to see if the app was easy to u…

This pilot study tested a six-session culturally adapted cognitive behavioral therapy (Ca-CBT) for depression and anxiety in 50 people living with HIV in Pakistan. The therapy was delivered by trained HIV health workers and included culturally relevant stories and materials. The …

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goa…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This study tested a training program for people living with HIV to help them become more active in managing their health. The program was delivered by psychologists and aimed to improve treatment adherence, quality of life, and emotional well-being. 75 participants took part in t…

This study tested an online program called ORCHID that helps people with HIV feel more positive emotions. The goal was to see if it could reduce depression and improve HIV care. 29 adults from Chicago clinics took part. The program was designed to be used on a phone or computer.

This study looked at whether a 16-week program of aerobic and resistance exercise could improve physical function and reduce inflammation in HIV-infected veterans aged 50 and older. Thirty-three participants completed the program, and researchers measured changes in heart and mus…

This pilot study tested a short form of Acceptance and Commitment Therapy (ACT) in 49 people living with HIV who were hazardous drinkers. The therapy uses mindfulness and values-based action to reduce drinking and improve medication adherence. Researchers measured drinking days, …

This study looked at whether Tai Chi, a gentle mind-body exercise, can help adults over 45 living with both HIV and chronic pain. Researchers tested the program with 36 participants to see if it was practical and liked by patients. The goal was to find a non-drug way to reduce pa…

This study tested two programs to reduce the shame and stigma that adolescents with HIV often face. 89 teens aged 10-14 in Uganda took part in either group therapy, family sessions, or standard care. The goal was to see if these programs could help them feel better about themselv…

This study tested whether tesamorelin, a drug already approved for belly fat in HIV, could improve memory and thinking in 73 older HIV patients with mild cognitive problems. Participants also used a text-messaging app to stay motivated. The trial measured changes in brain perform…

This study tested whether Eye Movement Desensitization and Reprocessing (EMDR) therapy, a proven treatment for trauma, can help people recently diagnosed with HIV. Forty participants were split into two groups: one received standard medical care plus weekly EMDR for up to 6 month…

This study tested whether two short training sessions on resilience and medication adherence could improve the quality of life for 130 HIV-positive mothers and their children in China. The training focused on coping skills, stigma management, and communication. Researchers measur…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study tested an 8-week group program that uses Buddhist principles and cognitive behavioral therapy to help people with HIV in Myanmar cope with stigma. Nineteen participants joined group discussions led by a trained facilitator. The goal was to see if the program could redu…

This study tested whether a 12-week group therapy program based on cognitive behavioral therapy (CBT) is practical and well-liked by older adults (50+) living with HIV. The program teaches skills to manage stress related to aging and HIV, and encourages healthy habits like physic…

This study looked at whether medical cannabis can reduce nerve pain and inflammation in people with HIV. Thirty-five adults with HIV and neuropathic pain used different ratios of THC and CBD over 14 weeks. Researchers measured changes in pain severity and blood markers of inflamm…

This study asks whether common antacids or multivitamins change how the body absorbs raltegravir, an HIV medication. Healthy adult volunteers will take raltegravir alone and alongside different antacids or a multivitamin, with blood samples measuring drug levels over 12 hours. Th…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study will give 100 migrant women in Turkey three structured training sessions on sexually transmitted infections, self-efficacy, and reproductive autonomy. Researchers will measure changes in knowledge, confidence, and decision-making compared to a control group. The goal i…

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study aims to develop a program to help people living with HIV in Zambia re-engage with care after they have missed appointments or stopped taking their medication. Many people cycle in and out of HIV care, and returning is a critical moment to prevent future lapses. Researc…

This trial asks whether a single tablet combining three HIV medications (ACC017, emtricitabine, and tenofovir alafenamide) is absorbed by the body just as well as taking the same drugs separately. Healthy adult volunteers will receive both versions in a random order under fasting…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study looked at markers of inflammation, blood clotting, and blood vessel function in 310 HIV-infected adults and healthy volunteers. Researchers collected blood samples to understand how these markers relate to HIV and risks like heart disease or stroke. The goal was to gat…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looks at how psychological and social factors might help people living with HIV resist self-stigma—the negative feelings and beliefs they may hold about themselves due to their condition. Researchers will survey both patients and their healthcare providers to understan…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study follows about 1,000 adults in South Africa and Uganda who are switching to a common HIV treatment called TLD, which combines three drugs into one pill. The goal is to see how effective TLD is in everyday conditions, not just in controlled trials. If the treatment stops…

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study tests whether a specially designed play can help reduce stigma around PrEP (pills that prevent HIV) for young women in Kenya. About 160 people, including young women who use PrEP and community members, will watch the play and share their thoughts. The goal is to see if…

This study looks at how cumulative stress and trauma influence alcohol use and HIV self-management in young people living with HIV, ages 18 to 29. Researchers will track drinking patterns and viral load to identify modifiable targets for future interventions. The goal is to find …

This completed study tested an online program designed to encourage HIV and syphilis testing, condom use, and PrEP uptake among young American Indian men and gay/bisexual men in rural Oklahoma. Researchers worked with community advisors to tailor health materials to local culture…

This study investigates whether telling others about an HIV diagnosis affects how consistently people take their HIV medications. Researchers believe that disclosure might lead to social support, which could improve adherence. The study follows 120 people with HIV who are already…

This study examines how consistently pregnant women with HIV take their antiretroviral medication during pregnancy and after childbirth. Using electronic monitoring devices, pill counts, and interviews, researchers track changes in adherence and record the barriers and facilitato…

This study tests a program to help caregivers tell children (ages 7-18) their HIV status in a supportive way. It involves 747 children and their caregivers across 12 clinics in Ghana. The goal is to see if this approach improves medication adherence and overall health.

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study is testing whether an AI-powered chatbot on a smartphone can encourage more men in Malaysia to get tested for HIV. The study will enroll 296 men who have sex with men and have not been tested recently. Participants will use the chatbot and report every 30 days whether …

This study looks at cerebral small vessel disease (CSVD) — damage to tiny blood vessels in the brain that can cause memory loss and disability — in people with HIV over age 50. Researchers want to see if CSVD is linked to blood vessel problems in the eyes and kidneys, which could…

This study tested two peer education programs to see which better improves nursing students' knowledge, attitudes, and behaviors about sexually transmitted infections (STIs). Thirty-six first-year nursing students were split into two groups: one received a program based on a beha…

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through su…

This early-stage trial tested whether a combination of two HIV-1 activators is safe for people with HIV subtype B who are on standard antiretroviral therapy and have undetectable virus levels. Nine men participated, and the study focused on tracking side effects. The goal was to …

This study looked at 777 people with HIV in Brazil who failed their first treatment with tenofovir, lamivudine, and dolutegravir. Researchers wanted to understand what types of drug resistance and virus subtypes were involved. The goal is to improve treatment choices for people i…

This study tested whether giving HIV self-test kits to HIV-negative pregnant women for their male partners would increase the number of men who get tested for HIV. Two hundred women in Malawi were split into two groups: one where partners got a clinic referral slip, and another w…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …

This early-stage trial tested a single injection of JL18008, a lab-made protein designed to boost immune cells, in 40 healthy adults. The main goal was to check safety and how the body handles the drug. Researchers also measured changes in immune cell counts over 56 days. This is…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This large study in rural Ethiopia looked at whether providing clean water, sanitation, and face-washing education can reduce trachoma infections in communities that have already received many rounds of antibiotics. Over 47,000 people from 40 communities took part. The goal is to…

This study looked at how people living with HIV in rural Uganda experience stigma, including feelings of shame, loss of self-respect, and mistreatment by others. Researchers surveyed 180 adults to understand these experiences better. The goal was to gather information, not to pro…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study looked at how not having enough healthy food (food insecurity) can lead to insulin resistance in people living with HIV. Researchers tested a community-based "food as medicine" program that provided healthy food and taught cooking and self-care skills. The goal was to …

This study tested a more concentrated version of the long-acting HIV drug cabotegravir in 138 healthy adults. Researchers gave the injection in different ways (into muscle or under the skin) to see how the body processes it and to check for side effects. The goal was to gather sa…

This study tested a streamlined HIV care approach for pregnant and postpartum women and their infants at a hospital in Kenya. The goal was to see if offering simpler, more flexible services could reduce clinic wait times and keep mothers and babies healthy. Researchers tracked vi…

This study examined how veterans with HIV use My HealtheVet (MHV), an online health portal, to manage their condition. Researchers reviewed medical records and interviewed 123 veterans to understand the impact of MHV on HIV care. The goal was to develop and test an intervention t…

This first-in-human study tested a single dose of LP-98 injection in 36 healthy adults to see if it is safe and how the body processes it. Participants received either LP-98 or a placebo by injection under the skin or into a vein. The study is complete, but it only looked at safe…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This study looked at health insurance records of over 81,000 people aged 14 to 44 in Germany to see how often chlamydia leads to serious health problems like infertility or pelvic disease, and how much it costs the healthcare system. Researchers tracked infections, complications,…

This study followed 384 people with HIV who were already taking the medication TAF. Researchers used a special blood test to measure how well participants were taking their pills and whether that predicted if the virus stayed under control. The goal was to see if this test could …

This study tested a 4-session program that helps HIV+ Asian Pacific American men manage their health with support from family. Nineteen men took part to see if the program was acceptable and practical. The goal was to learn if this approach could help this community better manage…

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor ora…

This study looked at how much doxycycline builds up in body tissues after taking it daily for 7 days. Researchers measured levels in rectal and vaginal tissues to help design better ways to prevent bacterial sexually transmitted infections (STIs). 24 healthy adults took part, inc…

This completed study tested a small-group discussion program called SISTA-P for Black women at high risk for HIV. The program covered self-care, HIV and PrEP education, and assertiveness skills. Researchers enrolled 23 women in Washington D.C., Atlanta, and New Orleans to see if …

This study tested simple toolkits to encourage women living with HIV in Ghana to collect their own samples for HPV testing, which can help prevent cervical cancer. About 108 women took part, and the researchers checked if they completed and returned the self-sampling kit or got a…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study investigates why the gut immune barrier remains damaged in people with HIV even after successful antiretroviral therapy. Researchers collected blood and intestinal biopsies from 80 participants to measure immune cells and inflammation. The goal is to understand why the…

This study looked at 167 men who have sex with men and are on HIV treatment with undetectable virus in their blood. Researchers took blood and semen samples to see if the virus could still be found in semen. The goal was to understand if there is still a risk of passing HIV to ot…

This study looked at a genetic variation in the TLR7 gene, which helps the immune system detect viruses like HIV-1. Researchers compared 90 women—some with HIV and some without—to see if this gene difference is more common in infected women. The goal was to understand how this va…

This study checked whether a new HIV medicine called MK-8507 (ulonivirine) causes any changes in heart rhythm. 62 healthy adults took either the study drug, a placebo, or a control drug to compare effects. The main goal was to see if the drug safely affects the heart's electrical…

This study looks at why HIV remains in the body even when standard treatment keeps virus levels undetectable in the blood. Researchers will take small tissue samples from the gut and blood of 30 HIV-positive adults on effective therapy. The goal is to understand how the virus per…

This study tested an online group program designed to help young Black men living with HIV feel more connected and improve their health. Researchers worked with a community board to adapt the program for online delivery, then tested it with 60 participants. The goal was to see if…

This early-stage study tested whether a working memory training program is practical and acceptable for people aging with HIV. Researchers enrolled 100 participants aged 50-85, including those with and without HIV, to see if the training could improve memory and thinking skills. …

This study looked at 99 heterosexual men with HIV who are on effective antiretroviral therapy and have undetectable virus levels, comparing them to healthy men without HIV. Participants filled out questionnaires about their quality of life, depression symptoms, and sexual functio…

This study looked at how pregnancy changes the levels of the HIV drug doravirine in the blood. Seven pregnant women living with HIV took a single dose of doravirine during their second and third trimesters, and again after giving birth. The goal was to find the right dose for pre…

This study tested a 5-month group program called Sweekar to reduce stigma and increase HIV testing and medication adherence among transgender and gender-diverse adults in Nepal. 31 participants joined group sessions to address social stigma and HIV prevention needs. The study mea…

This completed Phase 1 study tested how the experimental HIV prevention drug MK-8527 moves into breast milk. Thirteen healthy lactating women took a single oral dose, then provided milk and blood samples over five days. The goal was to measure how much drug reaches the baby throu…

This study looked at how five common HIV drugs enter breast milk in 20 healthy women who were finishing breastfeeding. The goal was to find out if the drug levels could be too high (risking infant side effects) or too low (risking drug resistance if the baby gets HIV). Participan…

This study looked at whether it is possible and practical to offer rapid HIV testing to men who have sex with men (MSM) in community settings, rather than only at clinics. Researchers worked with teams in France and Canada to test this approach with 357 participants. The goal was…

This study looked at 20 men with HIV who were stable on a common drug combination. Researchers took samples of blood, lymph nodes, rectal tissue, fat, and semen to measure how much of the drugs reached these areas. The goal was to understand why HIV can still hide in some tissues…

This study surveyed 596 people in France who were newly diagnosed with HIV. The goal was to find out why they did not use pre-exposure prophylaxis (PrEP), a medicine that prevents HIV infection. By understanding these missed opportunities, researchers hope to improve how PrEP is …

This study looked at how a single dose of methamphetamine affects the HIV virus in people who are already on effective HIV treatment. Fourteen HIV-positive adults with no history of meth use took part. The goal was to see if meth causes the virus to become more active and increas…

This completed Phase 1 trial from Johns Hopkins University enrolled 13 transgender women to see how the HIV prevention drug Truvada interacts with feminizing hormones like estrogen. Participants took Truvada alone and then with added hormones or a testosterone blocker. The goal w…

This completed study looked at how regular cannabis use affects brain health and thinking skills in people with HIV and those without. Researchers used brain scans, blood and spinal fluid tests, and thinking tasks to compare 276 participants. The goal was to understand the combin…

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This study followed 450 transgender people (300 HIV-negative and 150 living with HIV) from community health centers in Thailand, Vietnam, and the Philippines for 24 months. Researchers tracked new HIV infections, mental health, and social factors like stigma and violence using su…

This study looked at how many hospital patients have undiagnosed HIV. Researchers offered a rapid finger-prick HIV test to 300 patients who had certain medical conditions or behaviors that increase HIV risk. The goal was to find hidden infections and understand how common they ar…

This study tested a vaginal ring that slowly releases two medicines: dapivirine (to prevent HIV) and levonorgestrel (a contraceptive). Forty healthy women without HIV used the ring for 90 days. Researchers measured drug levels in blood and vaginal fluid and checked for side effec…

This study follows 179 volunteers who received an experimental HIV vaccine about 10 years ago. Researchers want to see if the vaccine's immune effects and virus control have lasted. No new treatment is given; this is just an observation to gather long-term data.

This study tested a simple way to get more HIV patients in South Africa the medicine that prevents tuberculosis (TB). Instead of doctors having to choose to prescribe it, the new approach made TB prevention the standard option, requiring doctors to actively opt out if they didn't…

This study tested whether a nurse-led education program could improve women's knowledge about HPV and its effects on health. 84 women aged 30-49 with active sexual lives took part. The program aimed to help them make informed decisions about their reproductive health.

This study measured how common Mycoplasma genitalium (MG) infection is among HIV-positive men in Hong Kong and checked for antibiotic resistance. Researchers collected samples from 573 men attending an HIV clinic. The goal was to understand the spread of MG and whether common ant…

This study looked at whether giving extra training and support to staff at Boys and Girls Clubs helps them run teen sexual health programs better. About 900 youth aged 10-14 took part. The goal was to see if this support leads to better attitudes and behaviors around sex, pregnan…

This study looked at whether an experimental antibody called VRC01 could help people with HIV control the virus after they stop taking their daily HIV medication. Thirteen people who had received VRC01 or a placebo in an earlier study and later got HIV took part. They paused thei…

This study looked at health records of over 2,000 people with HIV from racial and ethnic minority groups to see if seeing a heart specialist (cardiologist) helps prevent heart disease. Researchers tracked who visited a cardiologist and for how long, up to 5 years. The goal is to …

This study tested whether a smartphone app called eWrapper could help young adults with HIV wear an alcohol biosensor for 30 days. Sixty-six participants in Florida used the app, which offered rewards and personalized feedback to encourage sensor use. The goal was to see if these…

This pilot study tested a three-session couple-based program for male couples where one partner has HIV and the other does not. The program focused on seeing HIV as a shared challenge, improving communication, and supporting each other. Researchers measured changes in quality of …

This study tested two digital programs for parents of children aged 3-7 with behavior problems. Both programs had the same core content, but one included extra features like reminders and progress tracking. Researchers wanted to see if these extras helped parents stick with the p…

This study asked 36 women about their opinions and use of vaginal products designed to prevent HIV and other sexually transmitted infections. Participants completed questionnaires about their sexual behavior and how often they would use such products. The goal was to gather insig…

This study tested a reproductive health education program designed for women living with HIV. The program aimed to increase knowledge about reproductive health and encourage healthy behaviors. Sixty women participated, and researchers measured changes in their knowledge and attit…

This study looked at whether people with HIV can receive their long-acting injectable medication at general day hospitals instead of only at specialized HIV clinics. 90 patients who were already prescribed the injections were randomly assigned to one of the two settings. The main…

This study followed about 1,900 pregnant women and their babies for two years to see how HIV and the medication dolutegravir affect weight gain and overall metabolic health. Researchers compared women with HIV to those without, and also looked at differences between women who sta…

This completed study offered free rapid testing for HIV, syphilis, and hepatitis B and C to Ukrainian refugees in Bratislava, Slovakia. Over 660 adults were tested at a health center and a community health day. The goal was to measure how common these infections are in this migra…

This study developed and tested a digital intervention for pregnant unmarried adolescents aged 15-19 living with HIV in Kenya. The app uses stories and lessons to help them understand stigma, build confidence to disclose their HIV and pregnancy status to family, and seek support.…

This study followed 10 people with HIV and AIDS-related Kaposi sarcoma in Tanzania to see how their quality of life changed during treatment with vincristine and bleomycin. Participants filled out questionnaires about their physical, emotional, social, and daily functioning over …

This study asked 32 men and women about their experiences using different microbicide suppositories and gels during sex. Participants rated things like how smooth, wet, or messy the products felt. The goal was to better understand what people like and dislike, which can help desi…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This study looked at how young men who have sex with men search for information about PrEP (a pill or shot that prevents HIV). About 314 participants browsed a mock Google results page, and researchers tracked which links they clicked and how long they stayed. The goal was to fin…

This study involved 18 men and women who used three different rectal products (a gel, a cream, and a liquid) during anal sex and then rated their experience. The goal was to develop a questionnaire that captures how these products feel—like wetness, messiness, and pleasure—to hel…

This study looked back at 30 people with HIV who received a special cancer treatment called CAR T-cell therapy for certain blood cancers. Researchers collected information from medical records to see what side effects occurred and how the immune system changed over time. The goal…

This study followed 56 people with HIV who had never taken HIV medication before. Researchers measured changes in body fat, heart function, and blood vessel health after starting treatment. The goal was to understand how HIV therapy might affect long-term heart and metabolic risk…

This study looked at 320 people with HIV in Chile to understand why they often develop health problems like heart disease and diabetes, even when their HIV is controlled with medication. Researchers collected blood samples and used advanced techniques to measure inflammation and …

This study worked with 51 healthcare professionals at primary care clinics to find ways to reduce stigma toward people who use drugs, especially in HIV prevention and care. The researchers tested a program that combined education for staff and changes to clinic policies. The goal…

This study tested a new communication strategy to encourage HIV testing in Uganda. The messages focused on how HIV testing can help people maintain stable relationships and have healthy families, especially with the availability of PrEP. Over 7,600 people receiving antenatal care…

This study followed 163 children with HIV who started treatment within 12 weeks of birth. Researchers measured their growth, immune health, and virus levels over about seven years. No new treatment was given; the goal was to gather long-term data to help design future studies aim…

This study looked at how aging changes certain enzymes (proteins) in the blood and colon. Researchers collected blood and colon tissue samples from 21 healthy adults, both younger (18-50) and older (65-80). They also checked if the HIV medications tenofovir and emtricitabine affe…

This study tested an online training program for HIV care providers to help them better address stigma and medical mistrust with their Black and Latino patients. 59 providers participated in a pilot study to see if the training was acceptable and feasible. The goal was to improve…

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This study followed 200 transgender and non-binary people living with HIV across Europe for 18 months. Researchers collected data from routine blood tests to see how well HIV treatment was working. The goal is to use these findings to create better treatment guidelines and design…

This study tested 350 detainees in Nîmes, France for HIV, hepatitis B, and hepatitis C using rapid diagnostic tests. Many detainees come from areas where these infections are common and often don't know their status. The goal was to find out how many are infected so that care can…

This study looked at how moderate alcohol use affects inflammation and brain health in people with HIV. Researchers gave controlled amounts of alcohol to 76 healthy volunteers and people with HIV, then used blood tests and brain scans to measure immune and brain changes. The goal…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were on different anti-retroviral regimens, and researchers compared the r…

This study tested a training program for family medicine doctors in Alabama to help them talk about HIV and STI prevention with teenage girls and young women. 46 doctors took part and completed surveys before and after training to see if their knowledge and practices changed. The…

This study looked at 16 mothers with HIV who chose to breastfeed while taking antiretroviral medication. Researchers measured drug levels in the mothers' blood and breastmilk, and in the babies' blood, to see how much medicine the infants received. The goal was to gather informat…

This study aimed to understand the barriers to treating high blood pressure in people living with HIV in South Africa and to design a better care program. Researchers gathered input from healthcare workers and patients at nine clinics to create a practical intervention. The goal …

This study examined how the COVID-19 vaccine affects the immune system in people with HIV compared to those without HIV. Researchers followed 75 participants aged 55 and older for 48 weeks, taking blood and saliva samples. The goal was to understand vaccine effectiveness and any …

This study tested whether a pay-it-forward approach—where one person's donation covers testing for the next person—could increase gonorrhea and chlamydia testing among men in China. Over 1,200 men who had sex in the past year but hadn't been tested recently took part. The goal wa…

This completed Phase 1 trial studied 16 healthy volunteers to see if the HIV drug dolutegravir affects insulin sensitivity, fat metabolism, and hormone levels. Researchers aim to understand why some HIV patients gain weight while taking this medication. Participants took dolutegr…

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and their newborns. Researchers measured drug levels in blood and vaginal fluids to see if dosing needs to change during pregnancy and after birth. Over 1,500 women took p…

This study tested whether an online mindfulness program is practical and well-liked by young gay, bisexual, and queer men who are at risk for HIV. About 60 participants were randomly assigned to either the mindfulness program or a control group. The main goal was to see if the pr…

This study looked at over 1,100 people with HIV whose dolutegravir-based treatment stopped working. Researchers collected blood samples to find drug-resistance mutations in the virus. The goal is to understand why some treatments fail and how to better manage HIV in the future.

This study tested a method called public deliberation to improve how researchers get consent from teens for HIV prevention studies. 128 participants from diverse communities discussed ethical conflicts around parental permission versus teen self-consent. The goal was to see if th…

This study tested an online mindfulness program called Mindfulness-Based Queer Resilience (MBQR) for young gay, bisexual, and queer men at risk for HIV. Nineteen participants joined a nine-week group program to learn meditation and stress-reduction skills. The goal was to see if …

This study tested a program called CJC-TraC, where a nurse case manager helps incarcerated individuals with HIV, hepatitis C, or substance use disorder prepare for release and connect to community healthcare. The program involved up to 4 in-person or telehealth visits before rele…