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Can food vouchers and peer support keep women on HIV prevention pills?

NCT ID NCT06274060

Completed Prevention Sponsor: Johns Hopkins Bloomberg School of Public Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed trial in South Africa tested four support strategies—case management, food vouchers, peer buddies, and community PrEP pick-up points—to help female sex workers and young women stay on PrEP, a daily pill that prevents HIV. 304 participants were randomly assigned to different combinations of these strategies. The goal was to see which approaches best encourage long-term PrEP use, so these services can be expanded to other districts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
case management, food vouchers, peer support buddies, community-based PrEP pick-up points
What this could lead to
If successful, this could identify the best support strategies to help women at high risk for HIV consistently take PrEP, potentially reducing new HIV infections in South Africa.
What could go wrong
This is a completed phase 2b trial with 304 participants, so results may not apply to all women or regions. The strategies may not work as well outside the study setting.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS PRE EXPOSURE PROPHYLAXIS

Contacts and locations

Locations

  • TB HIV Care

    Pietermaritzburg, KwaZulu-Natal, 3200, South Africa

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