HIV treatment showdown: which combo works best for Late-Stage patients?

NCT ID NCT03696160

Completed Disease control Sponsor: NEAT ID Foundation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two different HIV drug combinations in 447 people with advanced HIV (late presenters). One group received a protease inhibitor combo (Symtuza), the other an integrase inhibitor combo (Biktarvy). The goal was to see which works better and has fewer side effects. Results help doctors choose the best treatment for this group.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV/AIDS

Contacts and locations

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Locations

ASST Santi Paolo

Milan, Italy
Barts Health

London, United Kingdom
CHU Saint-Pierre

Brussels, Belgium
CHU de Nantes

Nantes, France
Chelsea and Westminister

London, United Kingdom
Clinica of Infectious Diseases

Modena, Italy
Goethe University Hospital Frankfurt

Frankfurt, Germany
Groupe Hospitalier Sud Ile-de-France (Melun)

Melun, France
Guy's Hospital

London, United Kingdom
Homerton University Hospital

London, United Kingdom
Hopital Europeen Marseille

Marseille, France
Hopital Lariboisiere

Paris, France
Hopital Saint-Louis

Paris, France
Hospital 12 Octubre

Madrid, Spain
Hospital Bellvitge

Barcelona, Spain
Hospital Clinic (Helios Building)

Barcelona, Spain
Hospital General Universatario Alicante

Alicante, Spain
Hospital General Universitatrio de Elche

Elche, Spain
Hospital Ramon y Cajal

Madrid, Spain
Hospital Trias i Pujol

Barcelona, Spain
Hospital Universitari Vall d'Herbon

Barcelona, Spain
Hospital Universitatrio La Paz

Madrid, Spain
Hospital Virgen de la Victoria

Málaga, Spain
Hospital de la Princesa

Madrid, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Spain
Hospital del Mar

Barcelona, Spain
Hôpital Gui de Chauliac

Montpellier, France
Hôpital Saint Antoine

Paris, France
ICH Study Center Gmbh & Co. KG

Hamburg, Germany
INMI Lazzaro Spallanzani, Rome

Rome, Italy
Imperial College Healthcare Trust

London, United Kingdom
Institute of Tropical Medicine

Antwerp, Belgium
Kings College London

London, United Kingdom
Leeds Teaching Hospital

Leeds, United Kingdom
Luigi Sacco Hospital

Milan, Italy
Mater Misericordiae University Hospital

Dublin, Ireland
Medizinische Hochschule Hannover

Hanover, Germany
Medizinische Klinik und Poliklinik Universitätsklinikum Bonn

Bonn, Germany
Mortimer Market Centre

London, United Kingdom
North Manchester General Hospital

Manchester, United Kingdom
Ospedale San Raffaele

Milan, Italy
Pitié-Salpêtrière Hospital

Paris, France
Royal Bournemouth Hospital

Bournemouth, United Kingdom
Royal Free Hospital

London, United Kingdom
Sheffield Teaching Hospital

Sheffield, United Kingdom
Southmead Hospital

Bristol, United Kingdom
St George's Hospital

London, United Kingdom
St Vincent's University Hospital

Dublin, Ireland
University Hospital Geissen

Geißen, Germany
University Hospital Ghent

Ghent, Belgium
University Hospital Klinikum rechts der Isar der TUM

Munich, Germany
University Hospital Koln

Cologne, Germany
University Hospital Lewisham

London, United Kingdom