New program boosts PrEP adherence in Stimulant-Using men

NCT ID NCT04899024

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a program called PARTI to help gay and bisexual men who use stimulants (like meth or cocaine) take their daily HIV prevention pill (PrEP) consistently. The program combined positive affect skills training with a smartphone-based reward system for taking PrEP. Researchers enrolled 239 men across multiple sites to see if this approach reduced HIV risk by improving medication adherence and reducing risky sex.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

behavioral intervention (PARTI: positive affect skills training plus contingency management)

What this could lead to

If successful, this approach could help high-risk men better adhere to PrEP and reduce new HIV infections.

What could go wrong

This is a completed behavioral study, not a drug trial. Results may not apply to all populations, and adherence improvements may not last long-term.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Medication Adherence HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of California, San Francisco

    San Francisco, California, 94143, United States

  • University of Miami Miller School of Medicine

    Miami, Florida, 33136, United States