Immune system disorder

This trial is testing a new type of immune cell therapy called CD123 CAR-NK cells in people with relapsed or refractory acute myeloid leukemia (AML) or blastic plasmacytoid dendritic cell neoplasm (BPDCN). The cells are designed to find and attack cancer cells that carry a protei…

This trial is for adults with relapsed or refractory acute myeloid leukemia (AML) who have no standard curative options. Researchers are testing whether giving the drug gemtuzumab ozogamicin followed by an infusion of donor white blood cells can stimulate the immune system to att…

This study tests a personalized vaccine made from a patient's own leukemia cells fused with immune cells, combined with a drug that blocks PD-1, to help the immune system recognize and destroy any remaining leukemia cells after chemotherapy. The goal is to prevent the cancer from…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This pilot study is testing whether a dietary supplement made from the tinder fungus can safely ease gut symptoms in adults with mild-to-moderate ulcerative colitis or Crohn's disease. Participants will drink the supplement and be monitored for changes in symptoms, inflammation m…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This early-stage trial is testing an experimental HIV drug called ACC017 in adults with HIV-1 who have never taken HIV medication. The study aims to see if the drug is safe, tolerable, and effective at lowering the amount of virus in the blood, both when used alone and when combi…

This study tested an investigational drug called VRDN-001 in 143 people with thyroid eye disease who did not improve in earlier studies. The drug aims to reduce inflammation and eye bulging by blocking a specific receptor. Researchers measured how many participants had at least a…

This study will follow about 1,000 adolescents and adults in China who are prescribed upadacitinib for moderate to severe atopic dermatitis (eczema). Researchers will track how patients use the medication, any dose changes, and how well they stick to their treatment over 12 month…

This study tests whether the oral drug upadacitinib works better than the injected drug adalimumab for adults with moderate to severe rheumatoid arthritis who still have symptoms after trying one TNF blocker. About 480 participants will be randomly assigned to receive either upad…

This phase 1 trial is testing an investigational drug called AEB1102 in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or stopped responding to standard treatments. AEB1102 is a modified human enzyme that breaks down arginine, an amin…

This study follows about 140 people in Korea who have steroid-refractory graft-versus-host disease (GvHD) — a serious complication after a stem cell transplant where donor immune cells attack the recipient's body. Researchers are tracking how well the drug ruxolitinib (Jakavi) wo…

This study tested a new drug called amlitelimab, given as a shot under the skin, for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that wasn't controlled by creams. The trial included 643 participants and compared amlitelimab to a placebo, while ever…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This Phase 3 study tests amlitelimab, an injected drug, in 589 people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that hasn't responded well to topical treatments. The goal is to see if amlitelimab can clear or nearly clear the skin and reduce eczema seve…

This Phase 3 trial tested an investigational drug called veligrotug (VRDN-001) in 188 people with chronic thyroid eye disease. The drug is an antibody that blocks a protein involved in the disease. The main goal was to see if it could reduce eye bulging (proptosis) compared to a …

This trial tests a digital health program designed to help young adults with type 1 diabetes improve their blood sugar control. Participants use the SweetGoals app to set and track behavioral goals, and some also receive financial incentives for meeting those goals or access to w…

This study is testing whether upadacitinib, an oral medication, can safely and effectively manage Crohn's disease over the long term. Participants who completed a previous year-long study will continue taking the drug and be monitored for up to a year. The goal is to see if the d…

This study tested a drug called batoclimab in 35 adults with Graves' disease whose thyroid hormone levels were still high despite taking standard antithyroid drugs. The goal was to see if batoclimab could help bring those levels back to normal or below over 24 weeks. Batoclimab w…

This study tested a gel called SGX302, which is activated by visible light, on 15 people with mild-to-moderate plaque psoriasis. The goal was to see if it could clear or nearly clear skin lesions over 18 weeks. The treatment is applied to the skin and then exposed to light, aimin…

This completed Phase 3 trial tested a drug called VRDN-001 in 231 people with thyroid eye disease (TED). The drug works by blocking a receptor involved in inflammation and swelling. The main goal was to check safety and tolerability, with secondary goals including measuring chang…

This study looked at whether people with chronic myeloid leukemia (CML) who have done very well on the drug nilotinib can safely stop taking it. 215 patients who had been on nilotinib for at least two years and had very low levels of cancer cells were enrolled. The main goal was …

This trial tests whether veligrotug, an antibody that blocks a receptor involved in inflammation, can reduce eye bulging and swelling in people with active thyroid eye disease. Participants receive five infusions of the drug or a placebo. The study measures how many people see a …

This trial tests whether injecting a specially processed form of a patient's own fat tissue, called nanofat, can improve repigmentation in stable vitiligo when combined with standard narrowband UVB light therapy. In each of 20 adults, one vitiligo patch receives nanofat plus ligh…

This study tested a combination of the targeted drug brentuximab vedotin (ADCETRIS) plus standard CHP chemotherapy in 82 people with newly diagnosed peripheral T-cell lymphoma (PTCL) that has low CD30 levels. The goal was to see how many patients' tumors shrank or disappeared. Re…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This trial is testing whether a chemotherapy drug called treosulfan, given in different doses along with fludarabine, can safely prepare patients with advanced blood cancers for a stem cell transplant. The study focuses on patients who are not eligible for the standard, more inte…

This phase I trial is testing a combination of drugs—avelumab, utomilumab, rituximab, ibrutinib, and chemotherapy—in people with diffuse large B-cell lymphoma or mantle cell lymphoma that has returned or not responded to treatment. The goal is to find the safest dose and see how …

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This trial compares two surgical approaches for total hip replacement: the minimally invasive SuperPATH technique and the conventional posterior approach. Adults with hip arthritis or related conditions are randomly assigned to one of the two procedures. The study tracks recovery…

This study looked at whether people with chronic myeloid leukemia (CML) who had very low levels of cancer cells could safely stop taking the drug nilotinib (Tasigna). Participants had already been treated with imatinib (Gleevec) and then nilotinib for at least 3 years. The main g…

This study tests the long-term safety and effectiveness of zilucoplan, a daily injection, in people with generalized myasthenia gravis (gMG), a condition that causes muscle weakness. About 200 participants who completed a prior zilucoplan trial will receive the drug for an extend…

This early-stage trial tests a combination of two drugs, venetoclax and azacitidine, in people with a serious type of myelodysplastic syndromes (MDS) who have not had treatment before. The goal is to find the safest dose and see how well the drugs work together to control the dis…

This early-stage trial tests a new drug called SG301, given as an injection under the skin every two weeks, for systemic lupus erythematosus (SLE). The study first gives a single dose to healthy volunteers to check safety, then gives multiple doses to people with lupus. The main …

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This study is testing whether a subcutaneous (under the skin) injection of ocrelizumab works as well as the standard intravenous (IV) infusion for people with relapsing or primary progressive multiple sclerosis. The trial will compare how the drug is absorbed, its safety, and its…

This trial is testing an experimental drug called BST-236 in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not improved after initial treatment. Participants receive BST-236 as a one-hour intravenous infusion for six …

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This study tests whether a mobile app can help people with type 1 diabetes adjust their insulin doses better than standard care. About 50 participants over age 15 will use the app or receive usual care for 3 months. The main goal is to see if the app improves blood sugar control,…

This phase III trial is testing whether adding selinexor to a standard two-drug regimen (bortezomib and dexamethasone) can help people with relapsed or refractory multiple myeloma—a blood cancer that has returned or stopped responding to treatment. About 154 adults with measurabl…

This early-phase study tested an experimental drug called NT-I7 (efineptakin alfa) in 17 people with relapsed or refractory large B-cell lymphoma who had already received CAR-T cell therapy. The goal was to see if giving NT-I7 after CAR-T is safe and tolerable, and to look for ea…

This trial is testing an investigational drug called OPT101 in adults with type 1 diabetes. The goal is to see if it is safe and how it affects the immune system. Participants will receive multiple doses of the drug, and researchers will monitor for side effects and measure drug …

This study tested a new daily medicine called ESK-001 in 862 adults with moderate to severe plaque psoriasis. The goal was to see if it reduces psoriasis severity and is safe, comparing it to a placebo and an existing drug (apremilast). Participants took the medicine for 24 weeks…

This study tested whether a new daily pill, ESK-001, can safely reduce psoriasis severity in adults with moderate to severe plaque psoriasis. Over 900 participants took either ESK-001, a placebo (dummy pill), or an approved psoriasis drug (apremilast) for 24 weeks. Researchers me…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This trial tests whether a series of allergy shots, called PURETHAL Mites, can reduce symptoms like sneezing, runny nose, and congestion in adults with moderate to severe house dust mite allergies, with or without asthma. Participants receive either the active treatment or a plac…

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This trial tests whether stem cells grown in the lab before being returned to the body can help blood counts recover faster after a stem cell transplant for multiple myeloma. Adults aged 18 to 65 with myeloma in first response will receive their own amplified stem cells. The main…

This study tested a new oral medication called iptacopan in 34 adults with a rare disease called atypical hemolytic uremic syndrome (aHUS), which causes blood clots, low platelets, and kidney damage. The goal was to see if the drug could improve blood counts and kidney function w…

This phase II trial investigates whether eltrombopag, a drug that stimulates platelet production, can help older adults with acute myeloid leukemia (AML) recover their platelet counts faster after initial chemotherapy. Older patients often experience slow platelet recovery, which…

This trial tests whether a once-daily application of ARQ-151 cream 0.3% is safe and well-tolerated in children aged 2 to 5 with plaque psoriasis. Over four weeks, researchers measure how much of the drug enters the bloodstream and watch for any side effects or skin reactions. The…

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and g…

This phase 2 trial is testing whether a combination of two drugs, venetoclax and azacitidine, can effectively treat adults aged 18 to 59 who have been newly diagnosed with acute myeloid leukemia (AML) and have not yet received any treatment. Participants take both drugs in cycles…

This trial tests a drug called briquilimab for adults with chronic spontaneous urticaria (CSU) — long-lasting hives and itching that don't get better with standard antihistamines or omalizumab. The study has three parts, with some participants getting the drug and others a placeb…

This trial is testing whether a prebiotic supplement called 2'-FL, found in human milk, can safely ease gut symptoms in young people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Participants, aged 11 to 25, are in remission and already …

This study looked at 159 people with granulomatosis with polyangiitis (GPA), a rare disease that causes inflammation of blood vessels. Participants were randomly assigned to either stay on a low 5 mg daily dose of prednisone or slowly stop it over six months. The goal was to see …

This study tested a new medicine called rocatinlimab, given as an injection, for adults with moderate-to-severe eczema that wasn't well controlled with standard creams. About 746 participants received either the study drug or a placebo, along with topical treatments. The goal was…

This phase 3 trial is testing whether a hydrocortisone acetate suppository, given once or twice daily, can safely and effectively treat ulcerative proctitis, a form of ulcerative colitis limited to the rectum. About 200 adults with active disease will receive either the active su…

This study in Zambia evaluates whether dedicated 'viremic clinics'—where people with HIV who have high viral loads receive extra support from a team of healthcare providers—can improve viral suppression. The trial includes 548 participants aged 15 and older who have been on first…

This study looks at how a shorter tuberculosis (TB) treatment regimen works for children and adolescents with non-severe TB in Zambia. It involves children, caregivers, health workers, and policymakers to understand how well the regimen is accepted, followed, and feasible in real…

This phase III trial is testing whether a long-acting form of glatiramer acetate, called GA Depot, given as a monthly injection, can reduce the number of relapses in people with relapsing-remitting multiple sclerosis (MS). The study involves about 1,000 adults aged 18 to 55 with …

This trial looks at whether children with juvenile spondyloarthritis who have stable, inactive disease can safely reduce or stop their TNFi medication without causing a flare. Participants are randomly assigned to continue their usual TNFi dose, take it less frequently, or stop i…

This study tested a drug called tralokinumab for people with moderate-to-severe atopic hand eczema that hasn't improved with standard treatments. 235 adults received either the drug or a placebo every two weeks for 16 weeks, then everyone got the drug for another 16 weeks. The go…

This study tests whether baricitinib, an oral anti-inflammatory drug, is safe and effective for children aged 2 to 17 with moderate to severe atopic dermatitis (eczema). About 516 participants will receive either baricitinib or a placebo, along with standard topical steroids. The…

This trial tests whether a smart insulin pen called DIA:CONN P8 can help people with type 1, type 2, or pancreatogenic diabetes better control their blood sugar. Participants use the pen for 12 weeks, and the pen automatically calculates bolus insulin doses based on meal informat…

This study follows about 600 adults with Crohn's disease who are receiving ustekinumab (Stelara) as part of their routine care. The goal is to see how many achieve steroid-free remission after one year, using a standard symptom score. By including patients from both large researc…

This Phase III trial is testing an investigational biologic called LZM012 in adults with moderate-to-severe plaque psoriasis. The drug targets two inflammatory proteins, IL-17A and IL-17F, to potentially reduce skin symptoms. Participants will receive LZM012 injections, and resea…

This early-stage trial tests the safety and tolerability of two experimental injectable drugs (capsid inhibitors) in 85 healthy adults. Participants receive a single dose or multiple doses of the drug or a placebo. The goal is to see if these drugs are safe enough to study furthe…

This trial tests whether a topical ozonated vegetable oil can reduce the severity of mild-to-moderate atopic dermatitis (eczema) in children aged 1 month to 6 years. Over 14 days, researchers compare the oil against a placebo, measuring changes in a standard eczema severity score…

This phase 2 trial tests an experimental drug called DZD8586 in 59 adults with diffuse large B-cell lymphoma that has come back or not responded to previous treatment. The study aims to see if the drug can shrink tumors and to understand its side effects and how the body processe…

This study tests a drug called certolizumab pegol (Cimzia) in children aged 6 to 17 with moderate to severe plaque psoriasis. The goal is to see how the drug moves through the body and whether it is safe. Some children will get the drug, others a placebo. The study is active but …

This trial is testing an experimental oral drug called PXS-5505 (amsulostat) in people with myelofibrosis, a type of bone marrow cancer. The study focuses on patients who are not eligible for a stem cell transplant. The main goal is to see if the drug is safe and tolerable, and t…

This phase II trial is testing whether an experimental drug called MG-K10 can reduce the severity of moderate-to-severe atopic dermatitis, a chronic inflammatory skin condition. About 60 adults who have not responded well to topical treatments will receive either MG-K10 or a plac…

This Phase 3 trial tests whether an experimental oral drug, HPP737, can reduce psoriasis severity in adults with moderate-to-severe plaque psoriasis. Participants take HPP737 or an active control drug daily for 16 weeks. Researchers measure skin clearance using standard scores li…

This Phase 3 trial tests whether an oral drug called HPP737 can safely improve moderate-to-severe plaque psoriasis in adults. Participants take HPP737 or a placebo daily for 16 weeks, with doctors measuring skin clearance using standard scores like PASI. The study aims to see if …

This study tested two doses of bimekizumab, a drug that targets inflammation, in 41 adolescents aged 12 to 17 with moderate to severe plaque psoriasis. The main goals were to measure how the drug behaves in the body and to check its safety. Researchers also looked at how well it …

This trial tests whether an oral drug called HPP737 can safely improve moderate-to-severe plaque psoriasis in adults. Participants take either HPP737 or a placebo daily for 85 days. Researchers measure skin improvement using standard scoring tools and track any side effects. The …

This study tested a shorter course of a chemotherapy combination called EPOCH-R in 68 people with HIV and a type of lymphoma. The goal was to see if reducing the amount of chemotherapy could still control the cancer while causing less damage to the immune system. Participants rec…

This trial tests whether ferric maltol, an oral iron supplement, can safely raise hemoglobin levels in adults with inflammatory bowel disease (IBD) who have iron deficiency anemia and have not responded to or cannot tolerate standard ferrous iron pills. Participants take either f…

This trial tests whether a specially designed mealtime insulin, HDV-insulin lispro, can reduce nighttime low blood sugar (hypoglycemia) in adults with type 1 diabetes. Participants will use continuous glucose monitors and work with doctors to adjust doses. One group receives the …

This trial investigates whether drinking pomegranate juice for 12 weeks can reduce gut inflammation in people with Crohn's disease or ulcerative colitis who are in remission. Participants will drink either pomegranate juice or a placebo beverage twice daily, and researchers will …

This trial is investigating whether a targeted drug called CMC-544 (inotuzumab ozogamicin), given alone or later combined with rituximab, can control acute lymphoblastic leukemia (ALL) that has returned or not responded to standard treatment. The study enrolls adults and older ch…

This phase 2 trial is investigating whether adding the targeted drug copanlisib to the standard R-CHOP chemoimmunotherapy regimen can help people with previously untreated diffuse large B-cell lymphoma (DLBCL) live longer without their cancer progressing. The study enrolls adults…

This study tracks adults with relapsed or refractory multiple myeloma who are already receiving isatuximab as part of their routine care. Researchers will measure how many patients respond to treatment, how long the response lasts, and how the drug affects quality of life and sid…

This study tests whether adding a targeted drug called brentuximab vedotin to standard chemotherapy can help people with adult T-cell leukemia/lymphoma (ATLL), a rare and aggressive blood cancer. The combination, known as BV-CHEP, aims to improve response rates by targeting a mar…

This study looks at how well the drug glofitamab works in adults with B-cell non-Hodgkin lymphoma that has come back or stopped responding to treatment. Researchers are tracking how many patients achieve a complete response after receiving glofitamab through a compassionate use p…

This trial tests whether cladribine tablets change key immune cells and nerve damage markers in the spinal fluid of people with relapsing forms of multiple sclerosis. Participants take cladribine as prescribed and undergo up to two lumbar punctures to measure these biomarkers ove…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This phase 3 trial investigates whether adding alpha-1 antitrypsin (AAT) to standard corticosteroid therapy improves outcomes for people with high-risk acute graft-versus-host disease (GVHD) after a stem cell transplant. Participants receive either AAT plus steroids or a placebo …

This phase 2 trial tests whether a Chinese medicine formula called Inflammatory Skin Disease Formula (ISDF) can reduce the severity of plaque psoriasis, a common inflammatory skin condition. Adults with mild to moderate psoriasis will take either ISDF granules or a placebo twice …

This pilot study tests whether a modified Chinese herbal formula, Modified Huang-Lian-Jie-Du Decoction (MHLJDD), can reduce eczema symptoms in children aged 4 to 17. Participants take either the herbal granules or a placebo twice daily for 12 weeks. The study measures changes in …

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial is testing the long-term safety and tolerability of the drug filgotinib in people with rheumatoid arthritis who have already completed an earlier filgotinib study. Researchers are monitoring side effects, lab abnormalities, and vital signs over an extended period. The …

This trial investigates whether injecting bleomycin directly into low-flow vascular malformations (abnormal clusters of blood or lymph vessels) in the head and neck can shrink them. Twenty participants will receive up to four sessions of the drug under local anesthesia. The main …

This study looks at two surgical options for people with stage II Kümmell's disease, a condition where a spinal bone collapses after a minor injury. Researchers are comparing standard vertebroplasty (injecting bone cement) against a newer method that combines cement with small sc…

This trial tests whether adding a clinical pharmacist to standard drug therapy helps people with early rheumatoid arthritis achieve better disease control. Participants receive pharmacist-led education, counseling, and medication management alongside their usual DMARD treatment. …

This Phase 2 trial tests whether the oral drug gilteritinib works better than midostaurin for adults with a specific genetic subtype of acute myeloid leukemia (FLT3-mutated AML). All 181 participants also receive standard chemotherapy. The goal is to see which drug leads to more …

This study follows about 269 people with chronic lymphocytic leukemia (CLL) who are starting venetoclax, a targeted pill. Researchers will track how well the drug shrinks or controls the cancer over the first year, and how long it takes before patients need another treatment. The…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This trial tests whether the gas xenon can reduce heart muscle damage during coronary artery bypass surgery compared to two standard anesthetics: sevoflurane and propofol. About 500 adults with coronary artery disease scheduled for elective bypass surgery will be randomly assigne…

This study tests whether an advanced hybrid closed loop insulin pump (MiniMed 780G) can improve blood sugar control, quality of life, thinking skills, and physical abilities in people over 60 with type 1 diabetes. Participants are randomly assigned to either continue their usual …

This phase 2 trial tests whether an experimental oral drug called TLL018 can improve skin clearance in adults with moderate-to-severe plaque psoriasis. Participants receive one of two doses of TLL018 or a placebo for 12 weeks. The main goal is to see if at least 75% of skin plaqu…

This study tests whether a specific diet, called the IBD-AID, can improve symptoms of inflammatory bowel disease (IBD) by changing the bacteria in the gut. Participants aged 15 and older with IBD will follow the diet for 8 weeks, with guidance from study staff and cooking classes…

This phase 2 trial tests an experimental drug called JS005 in adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants receive different doses of JS005 or a placebo as a shot under the skin. The study measures whether JS005 improv…

This study tests whether a substance produced by umbilical cord cells can help control moderate rheumatoid arthritis. Participants receive weekly injections of either the cell substance or a placebo for six weeks, alongside their usual medication. The goal is to see if it improve…

This study tests whether treating low blood sugar (hypoglycemia) at a slightly lower threshold of 65 mg/dL, instead of the standard 70 mg/dL, can prevent rebound high blood sugar in children with type 1 diabetes. Each child undergoes both approaches in a crossover design, receivi…

This study investigates whether chiropractic spinal manipulation can reduce inflammation and improve symptoms in people with relapsing-remitting multiple sclerosis (MS). Participants receive either real or sham spinal adjustments over four weeks. Researchers measure changes in bl…

This study looks back at health records from over 46,000 people in Denmark and Sweden with allergic rhinitis (hay fever), some of whom also have asthma. It compares those who used SQ sublingual immunotherapy (SLIT) tablets — a daily tablet placed under the tongue containing grass…

This study tests how different amounts of dietary carbohydrates affect insulin needs and blood sugar control in adults with type 1 diabetes. Participants are randomly assigned to one of three diets: a traditional diet with 50-60% of calories from carbs, a moderately low-carb diet…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This phase 2 trial tests an experimental drug called JS005 in adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. JS005 is a lab-made antibody that blocks IL-17A, a protein involved in inflammation. The study compares JS005 injections to …

This study tests whether adding the targeted drug venetoclax to standard chemotherapy helps more adults with acute myeloid leukemia (AML) achieve remission. It enrolls people aged 18 to 65 with intermediate- or high-risk AML who have not yet been treated. The main goal is to see …

This study tests whether lebrikizumab, an injectable biologic, can improve skin symptoms in adults and adolescents (aged 12 and older) with moderate-to-severe atopic dermatitis, also known as eczema. Participants receive lebrikizumab for 24 weeks, and doctors measure changes in e…

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests an experimental oral medication called QY201 in adolescents aged 12 to 17 with moderate to severe atopic dermatitis (eczema). Participants take either 10 mg or 20 mg of QY201 twice daily for 28 days. The main goal is to understand how the drug moves through the b…

This study tests a simple idea: giving lupus doctors a quick look at their patients' pharmacy refill history during a clinic visit. The goal is to help doctors spot when someone is struggling to take their lupus medications and talk about ways to overcome those barriers. The stud…

This study tests a new dissolving film called DESF that delivers epinephrine under the tongue. It is designed for children ages 7 to 17 who weigh at least 30 kg and have a history of allergic reactions that put them at high risk for severe episodes like anaphylaxis. The goal is t…

This phase III trial tests whether the drug tipifarnib can prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. Participants include adults over 60 in first remission, those in second or later remission, or those who achieved remission a…

This study tests whether a low-carbohydrate diet (under 75 grams per day) can help adults with type 1 diabetes preserve their remaining insulin production. The idea is that the diet might calm the immune attack on insulin-making cells. Participants will follow the diet for a peri…

This phase 2 study tests whether rilzabrutinib, an oral medication, can reduce eczema severity in adults with moderate-to-severe atopic dermatitis who do not respond well to or cannot tolerate topical corticosteroids. Participants receive either rilzabrutinib or a placebo for 16 …

This study looks at whether combining two drugs—upadacitinib and ustekinumab—at lower doses can help people with Crohn's disease that hasn't improved with standard treatments. Participants are adults aged 18 to 65 who have already tried and failed other therapies. The goal is to …

This study tracks the safety and effectiveness of bosutinib (Bosulif) in people with chronic myelogenous leukemia (CML) who are either newly diagnosed or have not responded to or tolerated prior treatments. Researchers will monitor side effects and how well the drug controls the …

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include th…

This study looks at how allergy shots (subcutaneous allergen immunotherapy) affect immune markers in adults with allergic asthma. Researchers will measure changes in eosinophil cationic protein and sputum eosinophils over six months, along with asthma symptom scores. The goal is …

This study tests a four-week virtual program designed to help teens aged 12-21 with type 1 diabetes use technology like insulin pumps and continuous glucose monitors. Participants complete surveys and interviews about their diabetes management and technology use. The goal is to u…

This study tracks 300 adults with type 1 diabetes who use the Omnipod 5, an automated insulin delivery system, as part of their routine care. Researchers will compare blood sugar control—measured by time in target range and HbA1c levels—before starting the system and at 6, 12, an…

This study tracks 282 adults with moderate-to-severe ulcerative colitis who are taking mirikizumab as part of their routine care. Researchers will measure how many achieve clinical remission at 12 weeks and endoscopic remission at 24 and 52 weeks, along with changes in symptoms a…

This study tests whether using a continuous glucose monitor (CGM) — a small sensor that tracks blood sugar levels in real time — helps teens and young adults (ages 14 to under 25) with type 1 diabetes improve their blood sugar control compared to standard fingerstick testing. Par…

People with inflammatory bowel disease (IBD) have a higher risk of colorectal cancer and need regular colonoscopies to catch early warning signs. This study compares two techniques—narrow-band imaging (a special light) and an artificial intelligence (AI) system—to see which finds…

This phase 2 trial tests whether giving ruxolitinib (Jakafi) before, during, and after a stem cell transplant can improve outcomes for people with myelofibrosis. The study includes patients with intermediate-2 or high-risk disease, or intermediate-1 with additional risk factors. …

This study tests whether injecting a person's own fat-derived stem cells into stable vitiligo patches, alone or combined with excimer light therapy, can safely bring back skin color. Fifteen adults with stable vitiligo patches will receive the treatment. The goal is to see if the…

This study tests whether regular video or phone calls with a nurse (tele-nursing) can help teenagers with type 1 diabetes improve their blood sugar control, feel more confident managing their condition, and reduce anxiety. Participants aged 12–18 receive diabetes education both i…

This study tests a software upgrade for an automated insulin pump system (Control-IQ) in adults with type 1 diabetes. The upgrade adds an adaptive biobehavioral control module that learns from the user's patterns to improve blood sugar management. Participants use the standard sy…

This trial investigates whether intravenous infusions of cells from the human placenta (PDA001) can reduce inflammation and improve symptoms in adults with moderate-to-severe Crohn's disease. Participants receive either one of three doses of PDA001 or a placebo, and researchers t…

This phase 2 trial is testing whether combining two drugs, ponatinib and 5-azacitidine, can improve survival in people with advanced chronic myeloid leukemia (CML). The study includes adults whose CML has progressed to an accelerated phase or a more aggressive blast crisis. Parti…

This study tests whether adjusting the daily dose of the leukemia drug dasatinib based on a patient's blood levels can improve safety and effectiveness. Adults newly diagnosed with chronic phase chronic myeloid leukemia (CML) will receive either standard dosing or a dose tailored…

This phase 2 trial tests whether adding pioglitazone (a diabetes drug) to the standard leukemia medication imatinib can eliminate remaining cancer cells in people with chronic-phase chronic myeloid leukemia (CML). Participants must have been on imatinib for at least two years and…

This trial tests whether adding the targeted drug ponatinib to standard chemotherapy (cytarabine) can help prevent relapse in adults with a specific, high-risk genetic form of acute myeloid leukemia (FLT3-ITD AML) who are already in first remission. The study includes two age gro…

This phase 2 trial tests whether the drug RAD001 (everolimus) can help control systemic mastocytosis, a rare condition where too many mast cells build up in organs like the bone marrow. Ten adults with the disease take a daily pill for 30 days. Researchers measure success by chan…

This trial investigates whether adjusting the dose of imatinib (Gleevec) based on the drug's level in the blood can improve outcomes for people newly diagnosed with chronic phase chronic myeloid leukemia (CML). Participants whose imatinib blood level is low after 28 days are rand…

This Phase 3 study tests a cream called roflumilast (Zoryve) for treating plaque psoriasis in Chinese patients aged 6 years and older. The cream is applied once daily to reduce skin plaques. Researchers will measure how many patients achieve clear or almost clear skin after 8 wee…

This phase 3 trial tests whether mavorixafor can raise neutrophil levels in people with WHIM syndrome, a rare genetic condition that weakens the immune system. Participants receive either mavorixafor or a placebo to see if the drug helps maintain infection-fighting white blood ce…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This study tests an experimental drug called SHR-1819 in children and adolescents aged 6 to 17 with moderate-to-severe atopic dermatitis (a type of eczema). The main goal is to check the drug's safety and how the body processes it. Researchers will also look at changes in skin-re…

This early-stage trial tests an experimental oral drug called DZD8586 in adults with B-cell Non-Hodgkin lymphoma that has returned or stopped responding to standard treatments. The study aims to find a safe dose and check whether the drug can shrink tumors. Participants take the …

This study tested whether Naderin, an immune-boosting drug, could prevent low white blood cell counts in 79 women with breast cancer receiving first-line chemotherapy. Participants either received Naderin alongside chemotherapy or chemotherapy alone. The results showed that only …

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study compares two common substances—hydrogen peroxide and adrenaline—for controlling bleeding during tonsillectomy in children and teens aged 5 to 18. Surgeons apply one of the two to the surgical site and measure how quickly bleeding stops and how much blood is lost. The g…

This phase 2 trial investigates ANX005, an investigational drug given intravenously, for people with warm autoimmune hemolytic anemia (wAIHA). The study aims to assess the safety and tolerability of repeated doses, and to measure changes in blood markers like hemoglobin and bilir…

This early-stage trial is testing a new treatment called ACE1831 for adults with B-cell lymphoma that has come back or not responded to at least two prior treatments. ACE1831 uses immune cells from healthy donors that are modified to target and kill cancer cells. The study aims t…

This study tests a new intravenous immunoglobulin (IGIV) called PlasmaCap IG in adults and children aged 2 to 70 with primary immune deficiency diseases (PIDD). Participants receive regular infusions of the therapy for 12 months. The goal is to see if it prevents serious bacteria…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This study tests a drug called FT-2102 (olutasidenib) in people with acute myeloid leukemia or myelodysplastic syndrome whose cancers have a specific IDH1 gene mutation. The drug is given alone or combined with standard chemotherapy drugs (azacitidine or cytarabine). The goal is …

This study investigates whether giving vitamin D supplements to adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who also have low vitamin D levels can improve their iron status. Participants take high-dose vitamin D3 weekly for 8 weeks, then a lower…

This study investigates whether drinking galactose before cycling can prevent low blood sugar (hypoglycemia) in people with type 1 diabetes. Fourteen participants will try four different drinks—dextrose, galactose, lactose, or a sweetened placebo—on separate days, then cycle for …

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This Phase 3 trial tested the drug blinatumomab in 111 children with high-risk relapsed B-precursor acute lymphoblastic leukemia (ALL). Blinatumomab is an immunotherapy that helps the body's immune cells attack cancer cells. The study compared blinatumomab to standard chemotherap…

This pilot study tested whether the multiple myeloma drug carfilzomib can be safely given at home instead of in a hospital. Seventeen patients received their first cycle in the clinic and later cycles at home, with nurses administering the short infusion. The main goal was to see…

This phase 3 study tested a drug called rocatinlimab in 726 adults with moderate-to-severe atopic dermatitis (eczema) that wasn't well controlled by creams. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goals were to see if the…

This study looked at whether taking oral azacitidine (Onureg) as maintenance therapy can help older adults with acute myeloid leukemia (AML) stay in remission longer after treatment with CPX-351 chemotherapy. The study included 100 patients aged 65 and older who had achieved remi…

This study tested two drugs, plerixafor and G-CSF, in 20 people with WHIM syndrome, a rare genetic condition that causes frequent infections and warts. Participants received each drug for a year and tracked their infections. The goal was to see which drug better reduced infection…

This study tested whether adding ixazomib to the standard drug ibrutinib can help people with mantle cell lymphoma that has returned or not responded to prior treatment. Forty-three adults received both pills by mouth in cycles. Researchers looked for the best dose and measured h…

This large phase 3 trial studied nearly 1,900 children and young adults with newly diagnosed T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma. Researchers compared different chemotherapy combinations, including varying doses of methotrexate and adding the drug…

This phase 2 trial tested the immunotherapy drug pembrolizumab (Keytruda) alone or combined with idelalisib or ibrutinib in 65 patients with chronic lymphocytic leukemia (CLL) or low-grade B-cell non-Hodgkin lymphoma (NHL) that had returned or stopped responding to treatment. The…

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This study tested whether using two advanced drugs together (either two biologics or one biologic plus a small molecule) is safe and effective for people with inflammatory bowel disease (IBD) who haven't gotten better on standard treatments. Researchers followed 117 patients in C…

This study tested a chemotherapy drug called CPX-351 in 59 adults aged 60 to 75 with a high-risk form of acute myeloid leukemia (AML). The goal was to see how well it could put the cancer into remission. Participants received the drug through an IV, and some also had a stem cell …

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This early-phase study tested the safety of a new drug, CUG252, in 40 adults with mild-to-moderate systemic lupus erythematosus (SLE). Participants received multiple doses of the drug or a placebo by injection. The main goal was to see if the drug is safe and tolerable, and to un…

This study tests whether adding the targeted drug inotuzumab ozogamicin to a milder chemotherapy regimen improves survival in adults over 55 with a specific type of acute lymphoblastic leukemia (ALL) that is Philadelphia chromosome-negative and CD22-positive. Participants receive…

This phase 3 trial tests whether a personalized cell therapy called bb2121 works better than standard drug combinations for people with relapsed and refractory multiple myeloma. About 386 participants were randomly assigned to receive either bb2121 or one of several standard regi…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This phase 3 trial is testing whether a combination of three drugs—azacitidine, venetoclax, and ATRA—can safely and effectively treat adults newly diagnosed with acute myeloid leukemia (AML). The drugs work together to stop cancer cell growth by demethylating DNA, promoting cell …

This phase II trial tested the drug imetelstat in 13 patients with multiple myeloma who had stable disease or partial response after prior therapy but not a complete remission. The goal was to see if adding imetelstat could improve their response. Patients received imetelstat int…

This study tested a daily pill called E7820 in 12 adults with relapsed or treatment-resistant acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. All participants had specific mutations in splicing factor genes. The goal was to see if the drug c…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether transplanting insulin-producing islet cells, along with immune-suppressing drugs, could safely prevent severe low blood sugar episodes in people with type 1 diabetes who don't feel warning signs. Ten participants received the transplant and were monitore…

This study tested whether taking tempeh powder (a source of isoflavones) and vitamin D3 daily for 8 weeks could improve vitamin D levels, reduce inflammation, and boost quality of life in people with inflammatory bowel disease (IBD). Fifty adults with ulcerative colitis or Crohn'…

This completed trial tested a herbal ointment made from Syzygium formosum leaves in 90 people with mild to moderate atopic dermatitis (eczema). The ointment was compared to standard moisturizers to see if it was safe and effective. The study measured skin severity, water loss, an…

This study tested the drug RAD001 (everolimus) in 29 patients with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and myelofibrosis. The goal was to find the safest highest dose and see if it helps control the disease. It was a small early-phase trial at a singl…

This study looked at 144 people with aggressive relapsing multiple sclerosis to compare two treatment plans over three years: monthly natalizumab infusions versus a six-month course of mitoxantrone followed by another immune-modulating drug. Researchers measured cost-effectivenes…

This study tested a new drug, JYB1904, in 69 adults with allergic asthma. Participants received either JYB1904 every 8 weeks or the standard drug omalizumab every 2 to 4 weeks for 24 weeks. The goal was to see how the drug behaves in the body, how safe it is, and how well it cont…

This early-phase trial tested two drugs, lenalidomide and idelalisib, in 8 people with follicular lymphoma that had returned after previous treatment. Lenalidomide helps the immune system fight cancer, while idelalisib blocks enzymes that cancer cells need to grow. The main goal …

This trial compares a standard mastectomy closure to a technique that adds padding stitches between the skin and chest muscle, aiming to reduce lymphoceles (painful fluid pockets). About 90 women with breast cancer undergoing mastectomy will be randomly assigned to one of the two…

This study tested whether an educational mobile game could help children aged 7 to 14 with type 1 diabetes better manage their blood sugar. 76 children played the game alongside their usual care. Researchers measured changes in HbA1c (a long-term blood sugar marker) and how satis…

This study tested whether adding idelalisib to lenalidomide helps people with mantle cell lymphoma that has returned or is resistant to treatment. Lenalidomide boosts the immune system to fight cancer, while idelalisib blocks enzymes that help cancer cells grow. The trial involve…

This phase 2 trial investigates whether combining rituximab with lenalidomide works as well as standard rituximab-based chemotherapy for patients aged 75 and older with relapsed diffuse large B-cell lymphoma. The study focuses not only on controlling the cancer but also on mainta…

This phase 2 trial tested two different daily doses of the drug orelabrutinib in 40 people with mantle cell lymphoma, a rare blood cancer. The goal was to see which dose works better at shrinking tumors and controlling the disease. Participants included both newly diagnosed and r…

This trial studies a combination of the investigational antibody isatuximab with the drugs carfilzomib and dexamethasone for people with multiple myeloma that has come back or stopped responding to previous treatments. The goal is to find the safest dose and see how well the body…

This phase 2 trial tested whether combining two drugs, romidepsin and lenalidomide, is safe and effective for people with peripheral T-cell lymphoma (PTCL) who haven't had treatment yet. PTCL is a rare blood cancer with no standard therapy, and current options like CHOP chemother…

This early-phase trial tested a new treatment for relapsing-remitting multiple sclerosis (RRMS) that uses a patient's own red blood cells. The cells are coated with specific peptides and given back to the patient to teach the immune system to stop attacking the body. The study in…

This study tests a new MRI technique called ENRAGED FLAIR that aims to capture two types of brain images (T2-FLAIR and T1-weighted) in a single sequence, instead of the usual two separate scans. Researchers will compare the image quality and time savings against standard MRI in 1…

This pilot study tests whether a special MRI contrast agent called ferumoxytol can highlight areas of active inflammation in the brains of people with secondary progressive multiple sclerosis (SPMS). The goal is to see if this imaging method can distinguish chronic-active lesions…

This study tests whether intestinal ultrasound can accurately detect pouchitis—inflammation of the internal pouch created after ulcerative colitis surgery. Adults who have had this surgery will receive an ultrasound, and the results will be compared to the standard pouchoscopy wi…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study tests whether an artificial intelligence system called GliomaAI-Astro23 can identify a specific type of brain tumor (IDH mutant astrocytoma) from routine MRI scans. Researchers are using existing MRI data from 1,372 patients to train and evaluate the AI. If accurate, t…

This pilot study tested a special microscope-like camera (endocytoscopy) to diagnose upper gut graft-versus-host disease (aGVHD) in 14 patients who had a stem cell transplant. The camera was used during a standard endoscopy to see cells in real time. The goal was to see if this t…

This study compares contrast-enhanced ultrasound to standard CT and MRI scans for detecting bowel inflammation in children aged 10–18 with Crohn's disease. Participants receive an ultrasound with a microbubble contrast agent alongside their regularly scheduled CT or MRI. The goal…

This study looked at nearly 500 patients who had a paracetamol (acetaminophen) allergy test over 22 years. The goal was to find the smallest dose that triggers a reaction, so future tests can be shorter and safer. By analyzing past data, researchers hope to create a simplified te…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This trial tests whether giving children with autoimmune diseases (like inflammatory bowel disease or rheumatologic conditions) an extra booster dose of the flu vaccine improves their immune response compared to a single dose. These children take immunosuppressive medications tha…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

This study compares different ways of screening pregnant women for three common sexually transmitted infections (chlamydia, gonorrhea, and trichomonas) to see if treating these infections can reduce the risk of preterm birth and low birth weight. Over 2,200 pregnant women in Sout…

This study tests whether a proven HIV prevention education program can be delivered through Facebook to reach high-risk rural women in Appalachia. Participants are women leaving jail who have a history of drug use and risky sexual behavior. The goal is to see if social media can …

This study tests whether a special silk dressing (SYLKE®) causes fewer skin problems like rashes, blisters, or redness compared to standard skin glue (Dermabond®) after ACL knee surgery. About 100 people aged 14 to 60 having ACL reconstruction will be randomly assigned to one of …

This study tests whether listening to music or metronome sounds that match your heart rate can reduce chronic pain in people with multiple sclerosis. 45 participants will be split into three groups: one does motor imagery with a heartbeat-synced metronome, one listens to relaxing…

This pilot study tests whether a transcutaneous electrical nerve stimulation (TENS) device is acceptable and helpful for people with scleroderma who experience gastroparesis symptoms like bloating and distension. Participants use the device for 45 minutes twice daily after meals …

This study tests an electronic program that combines mindfulness and music therapy for people undergoing stem cell transplants for blood cancers. The goal is to see if it improves quality of life and reduces symptoms like pain. About 60 adults will participate, and the program in…

This study looks at whether watching a short, AI-created story video at home can help children aged 4 to 10 feel less anxious and scared before their first skin prick test for allergies. About 100 kids will be split into two groups: one watches the video, the other gets standard …

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tests if progressive resistance exercise can improve arm swelling and function in people who developed lymphedema after breast cancer treatment. Fifty adults aged 18-60 who are at least 3 months past surgery will be enrolled. Participants will do supervised exercises a…

This study looked at whether the drug Acthar can reduce inflammation and improve symptoms during a rheumatoid arthritis (RA) flare. Forty adults with RA who were having a flare took part. Researchers used ultrasound and disease activity scores to measure changes after treatment.

This trial is testing whether a bio-natural moisturizing cream, called SaaTwae, can safely ease symptoms of mild-to-moderate atopic dermatitis (eczema) in children and adults. Participants will apply the cream or a placebo to affected skin twice daily, and researchers will track …

This pilot study is testing whether a low-cost, portable driving simulator can help retrain driving skills in people who have had a stroke or who live with Parkinson's disease or multiple sclerosis. Participants will be randomly assigned to train on either the portable simulator …

This study looked at whether closed kinetic chain and weight shifting exercises can improve balance and stability in women who have arm swelling (lymphedema) after a mastectomy. Sixty women aged 40-60 with moderate lymphedema participated. They did exercises designed to strengthe…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This trial tests whether combining proprioceptive neuromuscular facilitation (a type of stretching that improves flexibility and strength) with core strengthening exercises can help people with Guillain-Barré syndrome recover balance, muscle strength, and the ability to perform d…

This trial tests whether practicing tai chi can increase overall physical activity in people with spondyloarthritis, a type of inflammatory arthritis. Participants will either take tai chi sessions for two or four months or receive no tai chi (control group). The study measures c…

This trial tests whether adding mental rotation and motor imagery training to standard physiotherapy can improve upper-extremity function in people with relapsing-remitting multiple sclerosis (RRMS). Participants receive either this cognitive-motor training or an active visual-at…

This trial tests whether a 12-week ketogenic diet program, delivered entirely online, is practical and acceptable for adults with Long COVID who also have ME/CFS and dysautonomia. Participants follow a low-carb, high-fat diet with vitamin B1 and electrolyte support, plus weekly v…

This study tests whether sensory integration therapy can improve walking stability and quality of life in people with multiple sclerosis (MS). About 44 adults with relapsing-remitting MS will be randomly assigned to receive either the therapy or standard care. The therapy uses sp…

This study tested whether repeated electrical brain stimulation could improve mental health and cognitive function in people with multiple sclerosis (MS). Fifty-three adults with MS received either real or fake stimulation in a double-blind setup. Researchers measured changes in …

This trial tests whether adding a glutathione gel to microneedling improves the lightening of dark gums compared to microneedling alone. Fifteen healthy adults with gum pigmentation will receive both treatments on different sides of their mouth to compare results. The study measu…

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This early-stage study looked at whether giving two standard chemotherapy drugs (cytarabine and daunorubicin) in a different way could be safer for the heart in adults newly diagnosed with acute myeloid leukemia (AML). Researchers used heart MRI scans to monitor for damage. The g…

This trial tests whether a cream containing hyaluronic acid, peptides, and plant extracts can improve skin barrier function and ease symptoms in people with atopic dermatitis (eczema). Participants, aged 2 and older, will use the cream alongside their usual topical corticosteroid…

This trial tests whether optimizing protein intake—through dietary counseling and whey protein supplements—can reduce household work limitations and overall disability in women with rheumatoid arthritis. Participants will aim for 1.0 gram of protein per kilogram of body weight da…

This study investigates how easy or hard it is for adults with inflammatory bowel disease (IBD) to follow three different eating plans: intermittent fasting, the Mediterranean diet, and the low FODMAP diet. Researchers will interview participants to understand what helps or hinde…

This trial tests whether N-acetyl cysteine (NAC), an antioxidant supplement, can reduce fatigue in people with progressive multiple sclerosis. Participants take NAC or a placebo three times daily for four weeks, and researchers measure changes in fatigue scores and brain chemistr…

This trial tests whether sucking lemon candy and using honey mouthwash can reduce salivary gland damage caused by radioiodine therapy for thyroid cancer. About 120 adults who have had their thyroid removed and are about to receive radioiodine will be randomly assigned to the cand…

This trial compares two exercise programs—chin tuck against resistance (CTAR) and proprioceptive neuromuscular facilitation (PNF) neck stretches—for people with multiple sclerosis who have trouble swallowing. Over 8 weeks, participants perform supervised sessions three times a we…

This phase 3 trial tests whether a once-daily pill combining desloratadine (an antihistamine) and betamethasone (a corticosteroid) relieves nasal allergy symptoms better than desloratadine alone. About 70 adults with moderate-to-severe allergic rhinitis will take either the combo…

This trial tests whether a structured memory training program, called Strategy-Based Training to Enhance Memory (STEM), can improve learning and recall in people with multiple sclerosis who report memory difficulties. Participants attend eight training sessions over four weeks an…

This study tests whether a daily postbiotic supplement called PosBion® can ease symptoms and improve quality of life in adults with irritable bowel syndrome (IBS). Participants take two sachets of the supplement each day for 12 weeks. Researchers measure changes in IBS symptoms, …

This study tests whether a daily supplement called NPQ Plus can improve skin health, antioxidant status, fatigue, and well-being in healthy adults with minor skin concerns like dryness or itchiness. The supplement contains polyphenols, NMN, PQQ, CoQ10, and minerals. Participants …

This pilot study tests a digital decision aid designed for people who have experienced sexual assault and are considering HIV post-exposure prophylaxis (PEP). The tool helps patients and providers weigh risk, effectiveness, side effects, and personal priorities together. Research…

This trial investigates whether a supervised program of aerobic and strength exercises can improve or prevent lymphedema—a painful arm swelling—in women who have had breast cancer treatment. Participants are assigned to either an exercise group or a no-exercise control group. Res…

This study tests whether a small device that gently stimulates a nerve in the ear can reduce muscle and joint pain in people with lupus. The idea is to activate the body's natural 'cholinergic anti-inflammatory pathway' to lower inflammation. Participants use the device for 5 min…

This early-stage trial tests whether HL-300 ointment is safe and tolerable when applied to the skin of healthy adult volunteers. Researchers will give single or multiple doses of the ointment or a placebo to 36 participants aged 18 to 45 in China. The study monitors for side effe…

This trial investigates whether a non-invasive technique called transcranial direct current stimulation (tDCS) can help with fatigue, depression, anxiety, and cognitive problems in people with multiple sclerosis (MS). tDCS uses a weak electrical current applied to the scalp to ge…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests whether adding task-oriented training—like walking on different surfaces, climbing stairs, and reaching for objects—to standard aerobic and strength exercises can improve functional mobility, balance, and fatigue in people with relapsing-remitting multiple sclero…

This study tests whether a 9-week relaxation response mind-body program can improve quality of life and reduce symptoms in people with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Participants attend weekly group sessions that include breathing exercises, m…

This study explores whether a 9-month online mind-body exercise program is practical and acceptable for people with multiple sclerosis (MS) living in Portugal and Spain. The program combines physical fitness, Pilates, Tai-Chi, mindfulness, and relaxation in small group sessions v…

This study tested whether a supplement containing L-histidine, along with a topical oil or lotion and unscented soap, could improve mild-to-moderate eczema in children. Forty children ages 1 to 12 were split into two groups: one received a powder supplement and the other a gummy …

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps a…

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study looked at whether having a tendency toward depression affects how well people with thymoma-associated myasthenia gravis (MG) respond to psychological counseling. Nineteen adults who had surgery for thymoma and MG received eight sessions of counseling based on Gestalt t…

This study tests whether PG2, a compound from the astragalus root, can reduce fatigue and low white blood cell counts caused by chemotherapy in women with stage II or III breast cancer. Participants receive either PG2 or a placebo alongside their standard chemotherapy. The goal i…

This study tests whether a probiotic gummy containing Weizmannia coagulans BC99 can reduce symptoms of allergic rhinitis (hay fever) in children aged 4 to 14. Over 8 weeks, half the children receive the probiotic gummy and half receive a placebo. Researchers track changes in nasa…

This study compared two ways to remove tonsils in 66 people with chronic tonsillitis: using a harmonic scalpel (ultrasonic energy) versus traditional cold steel instruments. The main goal was to see if the harmonic scalpel causes less pain three days after surgery. Researchers al…

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study tested a self-guided online program for people with psoriasis. 348 adults were split into two groups: one got the app plus their regular treatment, the other got regular treatment alone. The main goal was to see if the app improved quality of life over 12 months.

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tested whether a device that gently stimulates the vagus nerve through the ear could help control rheumatoid arthritis in one patient who had their spleen removed. The patient used the device at home for 24 months and visited the clinic every two months for checkups. T…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This study tests whether a daily skincare routine using Cetaphil cleansers and moisturizers can improve skin symptoms and quality of life for people with mild-to-severe plaque psoriasis. Participants apply the products to one side of their body while continuing their usual prescr…

This study looked at whether 8 weeks of low-load leg exercises with a blood flow restriction cuff is safe and doable for people with multiple sclerosis who have moderate to severe walking problems. Sixteen adults with MS took part, doing exercises like knee extensions and hip lif…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This completed pilot study looked at whether a placebo treatment — sham TENS combined with positive verbal suggestions — could reduce fatigue in people with relapsing-remitting multiple sclerosis. 36 participants were enrolled. The main goal was to measure motor performance (numb…

This study compares core stabilization exercises to a daily physical activity program in children aged 10-18 with juvenile spondyloarthropathy, a type of arthritis. The goal is to see if targeted core training can reduce pain, fatigue, and improve quality of life better than gene…

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

This study will analyze the genetic makeup of tumors from 100 people with relapsed multiple myeloma. Researchers will use advanced DNA and RNA sequencing to find genetic changes and understand how the cancer works. The goal is to gather information that could guide more personali…

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This research program aims to deepen understanding of severe asthma by closely studying its clinical and biological features over time. Researchers will follow more than a thousand people with asthma, aged 6 and older, measuring lung function and tracking how often severe asthma …

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looks at how a simple monitor called the Pleth Variability Index (PVI) changes during laparoscopic-assisted vaginal hysterectomy. Researchers will track PVI at six key moments when the patient's body position changes, such as tilting the head down or raising the legs. …

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study looks at whether adrenaline, the body's stress hormone, triggers an immune reaction during low blood sugar (hypoglycemia) in people with and without type 1 diabetes. Researchers will lower participants' blood sugar and then give drugs that block adrenaline's effects to…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study compares levels of a protein called VISTA in immune cells from people with multiple sclerosis (MS) or clinically isolated syndrome (CIS) and healthy volunteers. Researchers will take blood samples at the first attack and again at 6 and 12 months to see if VISTA levels …

This study investigates whether disease-modifying medications for relapsing-remitting multiple sclerosis (RRMS) can reduce cognitive fatigue—the tiredness that follows intense mental effort. Researchers will use functional MRI to measure brain activation in people starting either…

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This study is testing whether an artificial intelligence system can more accurately classify small bowel Crohn's disease and predict how patients will fare over the next year. Researchers will analyze existing CT or MRI scans from 437 patients, combining imaging features with cli…

This study explores whether the medication Tysabri can reduce cognitive fatigue—the tiredness that comes after intense mental effort—in people with relapsing-remitting multiple sclerosis (RRMS). Researchers will compare brain activity, measured with functional MRI, between RRMS p…

This trial asks whether a single tablet combining three HIV medications (ACC017, emtricitabine, and tenofovir alafenamide) is absorbed by the body just as well as taking the same drugs separately. Healthy adult volunteers will receive both versions in a random order under fasting…

This study looked at how well vaccines work in adults with moderate-to-severe eczema who are taking amlitelimab, an experimental drug. About 224 participants received either amlitelimab or a placebo along with tetanus and pneumonia vaccines. The goal was to see if the drug change…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study is looking at whether a substance in the blood called LRG can help doctors tell how active ulcerative colitis or Crohn's disease is in the gut. Researchers will measure LRG levels in 300 people who might have these conditions and compare them with what is seen during a…

This study tested a new risk score that combines genetic and environmental factors to predict multiple sclerosis (MS). Researchers studied 181 people, including MS patients and their close relatives. The goal was to see if this score could identify who might develop MS in the fut…

This study looks back at the medical records of over 1,000 people hospitalized with inflammatory bowel disease (IBD) in China. The goal is to understand the features, treatments, and outcomes of patients whose IBD does not respond well to standard therapies. By analyzing real-wor…

This completed study analyzed genetic material from 1,340 patients with lymphoma, leukemia, or multiple myeloma. Researchers used DNA microarrays and other tools to find new molecular subtypes that could explain why some patients respond better to treatment than others. The goal …

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study observes 1006 adults with ulcerative colitis or Crohn's disease in Brazil who are taking or have taken vedolizumab. Researchers will look at how long patients stay on the drug and what other treatments they used before. No new treatment is given—this is just a review o…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This trial investigates whether gluten consumption affects digestive comfort, quality of life, and physical performance in non-celiac athletes who train intensively. Participants, who are healthy and free of digestive diseases, will be randomly assigned to a gluten-containing or …

This study follows people with relapsing-remitting multiple sclerosis who are starting immunosuppressant treatment. Researchers will track changes in cognitive abilities, fatigue, emotions, and overall quality of life over an extended period. The goal is to better understand how …

This study looks back at medical records of people who had an allogeneic stem cell transplant to see whether romiplostim helped their platelets recover faster. Platelets are blood cells that help clotting, and low counts are common after transplant. The researchers will compare p…

This study will use a special headband that reads brain waves to see how adults with mild to moderate atopic dermatitis (eczema) respond to a single application of a marketed cream compared to plain water. Twenty participants will have their brain activity measured for signals re…

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This study follows 66 people with primary progressive multiple sclerosis (PPMS) and healthy volunteers for two years to understand how thinking and memory change over time. Participants take cognitive tests and undergo MRI scans to see how brain tissue damage relates to mental de…

This study investigates whether a blood test can identify nerve damage in the bowel wall that may cause chronic constipation and defecation disorders. Researchers will compare blood samples and tissue from 100 adults undergoing surgery for obstructive defecation disorder to see i…

This study looks at whether Aquacel, a silver-containing wound dressing used after hip or knee replacement surgery, can cause allergic contact dermatitis—a type of skin rash. Researchers will compare patients having their first joint replacement with those who had a previous join…

This study looks at whether women with lymphedema in one leg have worse balance and body awareness compared to healthy women. Lymphedema causes swelling due to fluid buildup, which may make the limb feel heavy and affect how the body senses and controls movement. Researchers will…

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

This study tests whether a French version of the Pain Sensitivity Questionnaire (PSQ) accurately measures a person's natural sensitivity to pain. The PSQ uses 17 questions about everyday situations that might cause pain. Researchers will compare answers from healthy volunteers an…

This study examines what happens when people with multiple sclerosis (MS) experience a relapse while on a standard treatment. It compares those who switch to a stronger, high-efficacy treatment with those who stay on their current therapy, looking at how many experience further r…

This study tests whether a smartphone-based digital assessment can measure rheumatoid arthritis activity as well as a standard doctor-performed exam. Adults with rheumatoid arthritis will complete a digital questionnaire, record guided videos of their joint movements, and then ha…

This study surveys medical students to understand their attitudes toward tattoos and piercings and measure their awareness of related skin risks, such as infections, allergic reactions, and scarring. Researchers aim to see if students have adequate knowledge and how their views d…

This study looks at how type 1 diabetes affects the heart, lungs, and overall fitness of children aged 6 to 17. It also measures their physical activity levels and quality of life. Researchers will compare these results with those of healthy children of the same age. The goal is …

This study aims to find the lowest concentrations of ragweed and birch pollen that cause allergy symptoms in people with seasonal allergic rhinitis. Participants sit in a special chamber where pollen levels are carefully controlled, and their nasal symptoms are measured. The goal…

Multiple myeloma, a common blood cancer, often causes bone lesions that lead to pain, fractures, and other serious events. This study reviews medical records of patients diagnosed between 2019 and 2021 to describe how often these bone complications occur and what rehabilitation s…

This study examines a rare brain disease called anti-LGI1 encephalitis, where the immune system attacks a protein in the brain, causing memory loss, confusion, and seizures. Researchers will review medical records from 112 patients across five hospitals in Eastern China to see ho…

This study explores whether a special type of PET/CT scan, using a radioactive tracer called 18F-FDG, can accurately measure disease activity in people with granulomatosis with polyangiitis (GPA), a rare condition that causes inflammation of blood vessels. Researchers will compar…

This study looks at the features of psoriasis and how the skin condition impacts the quality of life of patients visiting Tanta University Hospitals. Researchers will collect information from 170 adults with psoriasis to understand the disease's effects on their daily lives. The …

This study tests a data visualization tool called the Trial Enrollment Diversity Dashboard (TEDD) designed to help doctors see how diverse their clinical trial enrollments are. The goal is to overcome racial and ethnic disparities in leukemia trial participation. The study enroll…

This study investigates why some aggressive B-cell lymphomas stop responding to immunotherapy. Researchers are looking at tiny particles called exosomes that are released by tumor cells and may act as decoys, soaking up therapeutic antibodies before they can reach the cancer. By …

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study looks at whether people who have had a Prineo dressing before are more likely to develop an allergic skin reaction when it is used again after joint replacement surgery. Researchers will compare first-time users with those who have had the dressing in the past, trackin…

This study investigates how women with type 1 diabetes manually adjust their automated insulin delivery (AID) systems to manage blood sugar changes during their menstrual cycle. Researchers will interview 69 women to catalog strategies like entering fake carbohydrates or changing…

This study looks at Chapman reflex points—small, palpable nodules in connective tissue thought to be linked to internal organ function—in healthy young adults. Researchers examine how often these points occur and whether they are associated with symptoms people may experience. Th…

This study compares two ways of doing colonoscopy in people with inflammatory bowel disease (IBD) who are at higher risk for colon cancer. One method takes biopsies only from visible abnormal areas, while the other also takes random biopsies from normal-looking tissue. The goal i…

This study looks back at medical records of over 300 adults with relapsed/refractory multiple myeloma to compare how well different drug combinations work in everyday practice. Researchers are analyzing outcomes like how long patients live without their cancer worsening and overa…

This study investigates whether GHB is truly the most common drug used in chemical submission (drug-facilitated assault) or if its short detection window in blood and urine hides its real prevalence. Researchers will analyze hair samples from adult victims of suspected chemical s…

This study tests whether artificial intelligence can help doctors tell the difference between drug-induced liver injury and autoimmune hepatitis, two conditions that look very similar. Researchers are building a machine learning model using data from over 2,500 patients. If it wo…

This study looks at children with eczema (atopic dermatitis) that is not well controlled by prescription creams or for whom such creams are not advised. Researchers are collecting blood and cheek swab samples to find biological markers (biomarkers) that may be linked to how the d…

This study follows thousands of people with multiple sclerosis (MS) in the UK to see how COVID-19 affects them. Researchers track infections, hospital stays, and deaths using questionnaires and national health data. The goal is to understand the risks and outcomes for this group,…

This study investigates the genetic causes of pediatric Evans syndrome, a rare autoimmune condition where the immune system attacks blood cells. Researchers analyze blood samples from affected children and their families to find known or new mutations. The goal is to better under…

This study investigates whether the ability to sense wrist position is linked to manual dexterity in people with multiple sclerosis (MS). Researchers will measure wrist position sense using a special device and assess hand skills with a pegboard test. The goal is to understand ho…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This study looks at how well existing risk models predict dangerous blood clots in people with diffuse large B-cell lymphoma (DLBCL), a common type of blood cancer. Researchers will review medical records from over 1,500 patients across multiple hospitals to see which factors are…

This study compares two simple educational tools—a written PDF and an audio podcast—to see which helps people with inflammatory bowel disease (IBD) learn more about their condition. Participants fill out questionnaires at the start and after three months to measure knowledge, sat…

This study looks back at medical records from a single hospital in Scotland to see how well the drug bosutinib works and how safe it is for people with chronic myeloid leukemia (CML) in everyday practice. Researchers will track blood cell counts, genetic responses, and side effec…

This study investigates whether exercising in the morning versus the afternoon changes how the body handles blood sugar and burns fat in people with type 1 diabetes. Twelve adults with type 1 diabetes will do one hour of moderate exercise at 9 AM and another session at 4 PM on se…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study looked at whether asking people with multiple sclerosis (MS) to do two things at once — like walking while thinking — can uncover balance problems that standard tests miss. Researchers studied 24 people with mild MS and low disability. The goal was to see if this dual-…

This completed study enrolled 6 adults with systemic lupus erythematosus (SLE) to collect blood, urine, saliva, stool, and tissue samples over time. The goal was to find biological markers that could predict when a patient's disease might flare up or how they might respond to tre…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study looked at how the drug adalimumab affects gene activity in the skin of people with chronic plaque psoriasis. Researchers compared skin samples from normal, non-lesional, and lesional areas before and after treatment. The goal was to understand the immune changes that h…

This study tests French versions of three questionnaires that measure fear of low blood sugar (hypoglycemia) in children with type 1 diabetes and their parents. The goal is to ensure these tools are reliable for French-speaking families. About 194 children aged 2 to 18 and their …

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This pilot study tested whether a rapid lab test called frozen section analysis, done during thyroid surgery, can help surgeons decide how many lymph nodes to remove from the neck. The study included 66 adults with low-risk thyroid cancer and no signs of spread before surgery. Th…

This study looked at 347 children and teens with type 1 diabetes who use the Medtronic MiniMed 780G insulin pump. Researchers tracked how much carbohydrate they ate each day and measured their blood sugar control over time. The goal was to understand the link between daily carb i…

This study looked at 107 people with severe food or insect allergies to measure the distance from skin to muscle in their thighs. The goal was to see if the needles on common epinephrine auto-injectors (like EpiPen) are long enough to deliver the medicine into the muscle, as reco…

This study looked back at the medical records of 57 children and young adults (under 25) who received CAR T-cell therapy for B-cell acute lymphoblastic leukemia (B-ALL). The goal was to understand how well the treatment worked and what side effects occurred, especially in those w…

This study tested whether children under 16 with a history of mild beta-lactam (like penicillin) allergies could safely take the drug again without first having skin tests. Researchers used a questionnaire to identify low-risk kids and then gave them an oral dose. The goal was to…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study tested a 6-week 'I Love and Protect My Environment' education program in 113 third-graders. Half the students got the program, the other half did not. Researchers measured changes in environmental attitudes and awareness using surveys. The goal is to see if early educa…

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through su…

This study looked at how the COVID-19 lockdown affected people with spondyloarthritis, a type of arthritis. Researchers surveyed 1,000 patients to see if they stopped their usual treatments during confinement and what psychological factors might have played a role. The goal was t…

This study follows children in France diagnosed with severe autoimmune cytopenia—conditions where the immune system attacks blood cells. Researchers will track their health over time to see who achieves remission and what factors influence their recovery. The goal is to better un…

This completed study looked at blood samples from 70 children and adults newly diagnosed with immune thrombocytopenic purpura (ITP), a condition that causes easy bruising and bleeding. Researchers wanted to see if certain immune and blood markers could predict whether the disease…

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This study aims to develop a standardized reference guide for pharmacists to use during initial consultations with multiple myeloma patients starting oral chemotherapy. The goal is to provide clear, consistent information that helps patients understand and follow their treatment …

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study evaluates the SF-6D, a questionnaire that measures health-related quality of life, in people with early inflammatory back pain (symptoms for 3 months to 3 years). Researchers will check if the tool is reliable, sensitive to changes over time, and how factors like age, …

This study looked at how well two drugs, azathioprine and mycophenolate mofetil, work for people with myasthenia gravis in everyday medical practice. Researchers followed 82 adults with autoimmune MG for 2-3 years, measuring quality of life and side effects. The goal was to provi…

This study checked how well two continuous glucose monitors (Dexcom G6 and FreeStyle Libre) work when oxygen levels are low. Thirty people with type 1 or type 2 diabetes took part. Researchers compared sensor readings to blood tests during controlled low-oxygen conditions to see …

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study followed 813 people with early rheumatoid arthritis in France to see how often and why doctors prescribe TNF blockers. Researchers tracked symptoms, joint damage, and treatment success over 5 years. The goal was to learn which patients benefit most and how well doctors…

This study followed 115 people with relapsing-remitting multiple sclerosis for up to 5 years to see if early damage to the spinal cord could predict later walking difficulties. Researchers used MRI scans and walking tests to track changes. The goal was to better understand how ea…

This completed study from France examined whether a specific type of immune cell (innate CD8+ T cells) is linked to how quickly resistance mutations develop in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Researchers analyzed blood…

This study followed 813 people with early rheumatoid arthritis in France to see how often doctors prescribe TNF blockers alone (without other arthritis drugs) and how well they work. Researchers tracked symptoms, joint damage, and how long patients stayed on treatment over 5 year…

This study looked at whether French doctors follow EULAR recommendations to check heart disease risk every year in patients with rheumatoid arthritis. Over 7000 patients were included. The goal was to see how often tests like blood sugar, cholesterol, and heart scans were prescri…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study looks at whether people with chronic inflammatory rheumatism (like spondyloarthritis) or lupus who still have pain despite treatment have low vitamin C levels. Researchers will measure vitamin C in the blood and ask about pain, fatigue, and quality of life. The goal is…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study investigates whether analyzing bowel sounds with a computer can help measure disease activity in children with Crohn's disease. Researchers will record bowel sounds and compare them to a standard disease activity score. The goal is to find a noninvasive, painless way t…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This study analyzed data from 500 Crohn's disease patients to create a tool that uses routine blood tests to predict the risk of needing intestinal surgery. The goal is to help doctors move from reacting to problems to preventing them. The model is still in early development and …

This completed study reviewed the medical records of 210 people with aortitis (inflammation of the aorta) or retroperitoneal fibrosis (scar tissue in the abdomen). The goal was to find patterns in symptoms, lab tests, and imaging that could help doctors tell different types of th…

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This study looked at how people with multiple sclerosis and their natural caregivers (like family members) feel about the quality of care they receive. Researchers surveyed over 1,000 participants to understand their expectations and experiences. The goal was to create a tool tha…

This study looked at 100 people with primary Sjögren's syndrome to understand how the disease affects their physical, emotional, and social well-being. Researchers used questionnaires and simple tests to measure symptoms like fatigue, pain, swallowing problems, and mood. A health…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This completed study looked at how common celiac disease is in Spain and what factors might influence it. Researchers tested nearly 5,000 people of all ages across five regions using blood tests and biopsies. They aimed to understand why earlier studies found different rates in c…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This completed study looked at 70 patients with myeloma or lymphoma who needed stem cell transplants. Researchers compared two drugs, Zarzio and Granocyte, used to stimulate stem cell production before collection. The goal was to see if one drug led to better stem cell grafts. Si…