New pill targets Hard-to-Treat lymphoma in early human test

NCT ID NCT05824585

Completed Disease control Sponsor: Dizal Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This early-stage trial tests an experimental oral drug called DZD8586 in adults with B-cell Non-Hodgkin lymphoma that has returned or stopped responding to standard treatments. The study aims to find a safe dose and check whether the drug can shrink tumors. Participants take the pill once daily, and researchers monitor side effects, drug levels in the body, and anti-cancer activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DZD8586
What this could lead to: If successful, this could lead to a new oral treatment option for people with B-cell Non-Hodgkin lymphoma who have not responded to other therapies.
What could go wrong: This is an early Phase 1 trial with only 17 participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for LYMPHOMA NON-HODGKIN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOMA NON-HODGKIN

Contacts and locations

Locations

Research site

New York, New York, 10065, United States
Research site

Albury, New South Wales, Australia
Research site

Ballarat, Victoria, Australia
Research site

Melbourne, Victoria, Australia
Research site

Perth, Western Australia, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.