Cure My Disease

Don't miss your cure!

 Log in / Sign up

New oral drug could offer hope for Tough-to-Treat eczema

NCT ID NCT05018806

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This phase 2 study tests whether rilzabrutinib, an oral medication, can reduce eczema severity in adults with moderate-to-severe atopic dermatitis who do not respond well to or cannot tolerate topical corticosteroids. Participants receive either rilzabrutinib or a placebo for 16 weeks. The main goal is to measure changes in the Eczema Area and Severity Index (EASI) score from the start to week 16.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
rilzabrutinib
What this could lead to
If successful, rilzabrutinib could offer a new oral treatment option for people with moderate-to-severe eczema who do not get enough relief from topical steroids.
What could go wrong
This is an early-phase proof-of-concept study with a small number of participants. The drug may not prove effective or could have side effects that outweigh benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ATOPIC DERMATITIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC DERMATITIS

Contacts and locations

Locations

  • Antelope Valley Clinical Trials Site Number : 8400001

    Northridge, California, 91325, United States

  • Asthma and Allergy Associates, PC Site Number : 8400008

    Colorado Springs, Colorado, 80907, United States

  • DS Research of Kentucky, LLC Site Number : 8400004

    Louisville, Kentucky, 40241, United States

  • E.P.I.M.R.D dba Western Sky Research, Inc. Site Number : 8400009

    El Paso, Texas, 79903, United States

  • Florida International Research Center Site Number : 8400002

    Miami, Florida, 33173, United States

  • Integrative Skin Care of MS/SKYCRNG Site Number : 8400011

    Ridgeland, Mississippi, 39157, United States

  • Investigational Site Number : 1240001

    London, Ontario, N6A2C2, Canada

  • Investigational Site Number : 1240002

    Markham, Ontario, L3P 1X3, Canada

  • Investigational Site Number : 1240004

    Québec, G1V 4T3, Canada

  • Investigational Site Number : 1240007

    Toronto, Ontario, M3H 5Y8, Canada

  • Investigational Site Number : 1240008

    Red Deer, Alberta, T4P 1K4, Canada

  • Investigational Site Number : 1240011

    Toronto, Ontario, M2N 3A6, Canada

  • Investigational Site Number : 1240013

    Greater Sudbury, Ontario, P3E 5M4, Canada

  • Investigational Site Number : 1520001

    Santiago, Reg Metropolitana de Santiago, 7640881, Chile

  • Investigational Site Number : 1520002

    Santiago, Reg Metropolitana de Santiago, 8420383, Chile

  • Investigational Site Number : 1520004

    Santiago, Reg Metropolitana de Santiago, 7580206, Chile

  • Investigational Site Number : 2030001

    Prague, 160 00, Czechia

  • Investigational Site Number : 2030002

    Pilsen, 30599, Czechia

  • Investigational Site Number : 2030003

    Pardubice, 53002, Czechia

  • Investigational Site Number : 2030004

    Olomouc, 779 00, Czechia

  • Investigational Site Number : 2760001

    Bad Bentheim, 48455, Germany

  • Investigational Site Number : 2760002

    Friedrichshafen, 88045, Germany

  • Investigational Site Number : 5280001

    Utrecht, 3584 CX, Netherlands

  • Investigational Site Number : 6160001

    Lodz, Lódzkie, 90-436, Poland

  • Investigational Site Number : 6160002

    Lodz, 93-530, Poland

  • Investigational Site Number : 6160004

    Warsaw, 00-215, Poland

  • Investigational Site Number : 6160005

    Gdansk, Pomeranian Voivodeship, 80-546, Poland

  • Investigational Site Number : 6160008

    Chojnice, 89600, Poland

  • National Allergy and Asthma Research, LLC. Site Number : 8400007

    North Charleston, South Carolina, 29420, United States

  • Orion Clinical Research Site Number : 8400003

    Austin, Texas, 78759, United States

  • Skin Sciences, PLLC Site Number : 8400005

    Louisville, Kentucky, 40217, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.