Study pits two MG drugs Head-to-Head in everyday practice

NCT ID NCT03490539

Completed Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how well two drugs, azathioprine and mycophenolate mofetil, work for people with myasthenia gravis in everyday medical practice. Researchers followed 82 adults with autoimmune MG for 2-3 years, measuring quality of life and side effects. The goal was to provide real-world evidence to help patients and doctors choose the best treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mycophenolate mofetil (Cellcept) and azathioprine (Imuran)
What this could lead to: If successful, this study could help doctors and patients choose between these two drugs based on real-world effectiveness and side effects.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by patient differences. It is also relatively small (82 participants) and completed, so it provides information but not a definitive answer.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

autoimmune disease myasthenia gravis nervous system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DISEASES NEUROLOGICAL DISORDER

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Duke University

Durham, North Carolina, 27710, United States
London Health Sciences Centre

London, Ontario, N6A5A5, Canada
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
St. Elizabeth's Medical Center

Brighton, Massachusetts, 02135, United States
Stanford University

Palo Alto, California, 84303, United States
University at Buffalo, SUNY

Buffalo, New York, 14202, United States
University of Alberta Hospital, Faculty of Medicine

Edmonton, Alberta, T6G2G3, Canada
University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Medical Center

Rochester, New York, 14642, United States
University of Vermont - Larner College of Medicine

Burlington, Vermont, 05401, United States
Unversity of Miami

Miami, Florida, 33136, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.