Muscle tissue disorder

This study tests two experimental drugs, ENTR-601-44 and ENTR-601-45, in people with Duchenne muscular dystrophy (DMD) who have already taken part in earlier studies. The goal is to see if long-term use is safe and tolerable, and whether it can help maintain muscle function. Part…

This early-stage study is testing a new treatment called C-CAR168 for people with autoimmune diseases like multiple sclerosis, lupus, and myasthenia gravis that have not improved with standard therapies. The treatment uses a patient's own immune cells, which are modified in a lab…

This phase 2 trial tests an oral drug called Aom0304 in adults with hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. The study includes people with both obstructive and non-obstructive forms. Participants receive different doses of Aom0304 for …

This study tests whether Maraviroc, a drug currently used for HIV, can reduce muscle inflammation and improve function in adults with myositis that hasn't responded to standard treatments. Ten participants will take a daily 300mg tablet for 12 weeks and undergo muscle biopsies an…

This early-phase trial tests a single infusion of universal CAR-T cells (RD06-05) in 30 children and adolescents with severe autoimmune diseases, including lupus, scleroderma, and kidney inflammation. The cells are designed to target and calm overactive immune cells. The main goa…

This study tests a surgery called total pancreatectomy with islet autotransplantation (TPIAT) in 30 adults with certain pancreatic tumors who are at high risk for a dangerous leak after standard surgery. The procedure removes the entire pancreas and transplants the insulin-making…

This study compares three different schedules of shock wave therapy for people with partial rotator cuff tears, a common cause of shoulder pain and limited movement. The goal is to see if a high-frequency, short-course treatment (daily sessions for one week) works as well as or b…

This study tests a new injectable drug called depemokimab in 30 children aged 6 to 11 with asthma that involves a specific type of inflammation. The drug is given alongside their usual asthma medicines to see how the body processes it, how well it works, and if it is safe. The go…

This early-stage trial is testing a new drug called REC-617 in 15 people with a rare type of sarcoma (leiomyosarcoma) that has spread or cannot be removed and has not responded to prior treatments. The drug targets a protein (CDK7) that helps cancer cells grow. The main goal is t…

This trial tests whether an injection of platelet-rich plasma (PRP) made from a patient's own blood can help heal partial tears of the supraspinatus tendon in the shoulder. One hundred adults with confirmed tears will receive either PRP plus standard physical therapy or therapy a…

This trial tests whether using a piece of the patient's own biceps tendon as a graft can improve rotator cuff repair and reduce the risk of re-tear. About 90 working-age adults with supraspinatus tears will be randomly assigned to either standard arthroscopic repair or repair wit…

This small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…

This study tracks people with severe eosinophilic asthma who already take Fasenra (benralizumab) every 8 weeks. Participants use electronic monitors on their regular inhalers and a study-provided rescue inhaler (AirSupra) to see if asthma control stays steady throughout the dosin…

This study tests whether semaglutide (a GLP-1 drug used for weight loss) is safe for adolescents and young adults with Duchenne muscular dystrophy (DMD) who are also overweight or obese. The main concern is that the drug might reduce muscle mass, which is already weak in DMD. Par…

This study tests whether injecting a patient's own fat-derived stem cells into the shoulder muscle, alongside standard surgery, improves healing for torn rotator cuffs. Thirty adults with a confirmed tear will be randomly assigned to surgery alone or surgery plus stem cell inject…

This study tests whether pacing the heart from a specific spot (posterosuperior bundle) can lower the chance of atrial fibrillation (AF) in people with sinus node dysfunction (a slow or irregular heartbeat). About 300 adults who need a pacemaker will be randomly assigned to get p…

This early-stage trial tests a one-time infusion of donor immune cells (CAR-γδT cells) designed to target and destroy faulty B cells in people with severe autoimmune diseases like lupus and scleroderma. The main goal is to check safety and find the right dose in 9 adults whose di…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This study tests a non-invasive radiation treatment called STAR for people with a dangerous fast heart rhythm caused by heart scarring. Instead of using medications or a catheter procedure, a single targeted dose of radiation is delivered to the scarred area. The goal is to see i…

This early study tests whether the drug CAEL-101/anselamimab can bind to and shrink abnormal protein deposits (amyloid) in people with AL amyloidoma. Five adults with measurable amyloid deposits will receive the drug and be monitored for up to 72 weeks. The goal is to see if the …

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This early-stage trial tests a single dose of a gene therapy called NVC-001 in 21 adults with a genetic form of dilated cardiomyopathy (LMNA mutation). The therapy uses a harmless virus to deliver a modified gene into heart cells, aiming to protect the heart muscle. The main goal…

This study tests whether injecting stem cells from umbilical cords can help heal partial rotator cuff tears in the shoulder. Thirty-eight adults with ongoing shoulder pain will receive either a high or medium dose of stem cells or a placebo. The main goal is to see if the tear sh…

This study tests whether adding sirolimus (a drug that calms the immune system) to ELEVIDYS gene therapy can prevent serious liver injury in boys with Duchenne muscular dystrophy. About 20 participants will receive the treatment and be monitored for side effects. The goal is to m…

This study looks at whether adding stem cells from the shoulder bursa and platelet-rich plasma (PRP) to standard rotator cuff repair helps the tendon heal better. About 200 adults with full-thickness supraspinatus tears will be followed for a year. Researchers will compare those …

This early-phase trial tests a single dose of universal (off-the-shelf) CAR-T cells in 30 adults with active autoimmune diseases like lupus, scleroderma, vasculitis, myositis, or Sjögren's. The treatment targets CD19 and BCMA on immune cells to reset the faulty immune system. The…

This study tests an experimental drug called AOC 1044 for boys with Duchenne muscular dystrophy (DMD) who have a specific genetic change (exon 44 skipping). About 70 boys aged 7 to 16 who can still walk will receive either the drug or a placebo. The main goal is to see if the dru…

This study looks at whether setting a pacemaker to a personalized rate of 75 beats per minute, instead of the usual 50-60, can improve heart function and blood flow to the brain in people with high blood pressure and a slow heart rate. About 70 patients aged 65 and older will be …

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps women with infertility have a baby. About 792 women aged 20-39 with fibroids 4-6 cm that do not distort the uterine cavity will be randomly assigned to either h…

This early-phase study tests whether injecting tiny tantalum particles directly into a recurrent soft tissue sarcoma tumor, followed by radiation, is safe and tolerable. Nine adults with a specific type of sarcoma that has come back after standard treatment will receive one of th…

This study follows 80 babies with severe congenital diaphragmatic hernia (CDH) who had a special surgery called FETO while still in the womb. Researchers want to see if these babies survive to leave the hospital more often and have fewer long-term health issues compared to babies…

This study tests a daily injection called elamipretide in 48 people with genetically confirmed Barth syndrome, a rare condition that causes muscle weakness and heart problems. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see if the drug…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests whether using a piece of the patient's own biceps tendon as a patch during rotator cuff repair helps the torn tendon heal better. 80 adults with medium to large tears will be randomly assigned to standard repair or repair with the patch. Researchers will measure …

This Phase 2 trial tests a new drug called QLS4131, given under the skin, in combination with other medications for people with malignant plasma cell neoplasms like multiple myeloma. The study will compare different drug combinations to see which works best at shrinking tumors an…

This study compares a newer pacing method called Left Bundle Branch Area Pacing (LBBAP) with the standard coronary sinus pacing for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if LBBAP better imp…

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

This study tests a medicine called surlorian in 28 adults with a rare genetic muscle disease (RYR1-related myopathy) that causes weakness. The goal is to see if surlorian improves muscle strength and function, like standing from a chair or walking. Participants will be randomly a…

This study tests whether a 12-week program of exercise and personalized diet counseling can help preserve muscle mass in obese adults taking GLP-1 medications like Wegovy. Twenty participants aged 40-55 will be followed to see if these lifestyle changes prevent the muscle loss of…

This study tests a new pacing method called anodal biphasic pacing (ABP) in 108 adults who need a heart procedure or have a pacemaker. ABP uses a different electrical waveform that may improve how the heart pumps and reduce problems from standard pacing. Researchers will compare …

This study tests an experimental drug called elranatamab in people newly diagnosed with AL amyloidosis who have not yet had treatment. The drug helps the body's immune cells find and destroy the abnormal cells causing the disease. Researchers want to see if it can produce deep re…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This phase 2 trial tests whether adding the drug bevacizumab (Onbevzi) to standard chemotherapy (gemcitabine and docetaxel) can shrink tumors better than chemo alone in people with advanced soft tissue sarcoma. About 92 adults who have already had 1-2 prior chemotherapies will be…

This study will test whether sildenafil, a drug often used for erectile dysfunction, can improve heart function in children aged 1-18 with dilated cardiomyopathy, a condition where the heart is enlarged and weak. Researchers will measure changes in the heart's pumping ability ove…

This phase 3 trial tests whether injecting a concentrate of your own bone marrow (BMAC) into the jaw joint during arthroscopy reduces pain and damage better than a standard steroid shot. Twenty adults with long-lasting TMJ pain will be randomly assigned to one of the two treatmen…

This study tests whether a 12-month digital program with health coaching and a wearable device can reduce scarring in the heart muscle caused by high blood pressure. Researchers will enroll 200 adults aged 40-70 with early signs of heart thickening. The goal is to see if lifestyl…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study compares two methods to control bleeding during laparoscopic myomectomy (surgery to remove fibroids from the uterus). One method uses a temporary tourniquet to block blood flow, and the other injects a medicine called epinephrine into the uterus to narrow blood vessels…

This early-phase study tests a new treatment called CAR19-BCMA CAR-T for people with certain blood cancers (plasma cell neoplasms or lymphomas/leukemias) that have returned or not responded to at least three prior treatments. The therapy uses a patient's own immune cells, modifie…

This study gives ongoing access to benralizumab (Fasenra) for people with asthma, eosinophilic granulomatosis with polyangiitis (EGPA), or hypereosinophilic syndrome (HES) who completed a prior benralizumab trial and still benefit from the drug. About 230 participants will receiv…

This early-stage trial tests UX016, a drug designed to help people with GNE myopathy, a rare genetic muscle-weakening disease. Researchers will give the drug or a placebo to 24 adults to see if it is safe and improves muscle strength. The study is not yet recruiting.

This study looks at three ways to treat a specific type of shoulder fracture (greater tuberosity fracture) that also involves a rotator cuff injury. The three options are: non-surgical care, surgery right away, or surgery after a delay. The goal is to see which approach leads to …

This study tests a new treatment for people with a rare disease called light-chain cardiac amyloidosis that has come back or not responded to other treatments. The treatment uses specially engineered immune cells (CAR-NK cells) from donated umbilical cord blood to target and atta…

This study compares a newer pacing method (HIS or left bundle branch pacing) to the standard biventricular pacing in 1100 heart failure patients across Nordic countries. The goal is to see if the new approach reduces death or unplanned heart failure hospitalizations. Participants…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests whether routinely placing a small tube in the leg artery (distal perfusion catheter) is better than waiting until a problem arises in patients on mechanical heart pumps. About 500 adults with severe heart failure or shock will be randomly assigned to one of the t…

This study tests a new, small pacemaker that doesn't need wires (leads) to help people with a slow heartbeat. About 15 adults with certain heart rhythm problems will get the device to see if it's safe and works well. The pacemaker is placed directly in the heart to keep the beat …

This study looks at whether estradiol patches can improve shoulder healing after rotator cuff repair in post-menopausal women. About 58 women will receive either an estradiol patch or a placebo patch for three months after surgery. The goal is to see if the hormone helps reduce p…

This Phase 2 trial tests a new drug, belantamab mafodotin, combined with standard chemotherapy in 60 adults newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins damage organs. The goal is to see if the combination improves blood and organ responses. The stu…

This study tests the safety of a drug called rituximab in 5 boys aged 6-10 with Duchenne muscular dystrophy (DMD) who can still walk. The drug aims to lower certain immune proteins to possibly slow muscle damage. Researchers will monitor side effects and measure changes in walkin…

This phase 2b trial tests AVTX-801, a D-galactose supplement, in 8 adults with PGM1-CDG, a rare genetic disorder affecting sugar metabolism. Participants currently on D-galactose will receive either the study drug or a placebo to see if it reduces disease-related events like low …

This study tests whether a person's own stem cells, processed and given by IV, can safely help with multiple system atrophy (MSA) — a rare, worsening brain disease that affects movement and automatic body functions like blood pressure. Fifty adults aged 35 to 65 will receive eith…

This early study tests a new, wire-free pacemaker (ALPS) in 10 people with bradycardia (slow heart rate). The goal is to see if it is safe and works well. Participants will be monitored for device-related problems and how well the pacemaker controls their heart rhythm.

This Phase 2 study tests a drug called apitegromab in 60 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. Participants will receive either the drug or a placebo every 4 weeks for a year. The main goal is to see if the dru…

This early-stage trial will test a new cell therapy called YTS109 in 12 children aged 5 to 17 with severe autoimmune diseases like lupus or scleroderma that have not responded to standard treatments. The children will receive a single infusion of these cells, and researchers will…

This study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …

This very early trial will test whether injecting a patient's own lab-grown muscle cells under the skin is safe for people with muscle atrophy from long-term bed rest. Only 6 participants will receive the transplant and be closely monitored for side effects and signs of muscle re…

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This study looks at whether an implantable defibrillator (ICD) can reduce the risk of sudden cardiac death in people with non-ischemic dilated cardiomyopathy, a type of heart muscle disease not caused by blocked arteries. Researchers will use MRI scans to find heart scarring (fib…

This early trial tests whether baricitinib, an immune-calming drug already used for arthritis, can reduce heart inflammation in people with cardiac sarcoidosis. Ten adults will take the drug for 16 weeks alongside their usual steroid-sparing medication. Researchers will use PET s…

This study compares a telerehabilitation system called Band Connect to standard in-person physical therapy for people recovering from rotator cuff repair surgery. The Band Connect uses smart handles and resistance bands that connect to a phone app to guide exercises and track pro…

This trial tests two different heart pacing leads—one without a hollow core (lumenless) and one with a stylet—to see which works better for left bundle branch pacing. About 288 people with slow heart rhythms will take part. Doctors will use continuous monitoring to guide the lead…

This Phase 3 trial tests whether the anti-inflammatory drug anakinra can help children with acute myocarditis (heart inflammation) recover heart function faster. About 110 children in intensive care will receive either anakinra or a placebo for 7 days, alongside standard care. Th…

This study tests whether a herbal medicine called Danhong injection can help protect the heart in people with sepsis, a life-threatening infection. Researchers will give 140 patients either the injection or a placebo for 7 days and check heart function and survival rates. The goa…

This early-phase trial tests a new type of immune cell therapy called GPRC5D CAR-T in 18 people with relapsed or treatment-resistant plasma cell disorders, such as multiple myeloma. The therapy involves giving patients a single infusion of their own modified immune cells designed…

This study tests a drug called telitacicept in 30 adults with inflammatory myopathy, a condition where the immune system attacks muscles, causing weakness. The goal is to see if the drug is safe and can control the disease. Participants must have not responded well to standard tr…

This study tests a drug called mavacamten in 132 people with hypertrophic cardiomyopathy (thick heart muscle) that blocks blood flow in the middle or tip of the heart's main pumping chamber. The goal is to see if mavacamten can reduce the pressure difference across the blockage a…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that haven't responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the di…

This early-phase trial will test whether injecting lab-grown heart muscle cells (made from stem cells) into the heart can safely help people with severe heart failure. Fourteen participants with weak hearts will receive the cells via a catheter. The main goal is to check for side…

This phase 2 trial tests a drug called sonrotoclax, combined with dexamethasone and sometimes daratumumab, in 39 people with a specific genetic form of AL amyloidosis (t(11;14)). The goal is to see if the treatment can quickly reduce harmful protein levels and improve organ funct…

This study tests whether adding melatonin (a natural sleep hormone) to standard heart failure treatment can improve heart function in women with peripartum cardiomyopathy, a rare heart condition that develops during or after pregnancy. 25 women will receive either melatonin, sele…

This early-phase trial tests whether tendon stem cells can help rotator cuff tears heal better after surgery. About 107 adults with small to medium tears will receive either standard repair or repair plus stem cells placed at the injury site. The study will check for side effects…

This study tests whether a new Fast Fix suturing system works better than the usual method for repositioning the jaw joint disc in people with TMJ internal derangement. About 50 adults who need surgery after other treatments failed will be randomly assigned to one of the two tech…

This early-phase trial will test BCT301, a type of immune cell made from stem cells, in 10 people with severe autoimmune diseases like lupus and scleroderma. Participants receive a single infusion of these cells after a short course of chemotherapy. The main goal is to check safe…

This study tests whether henagliflozin, a drug currently used for diabetes, can reduce scarring in the heart muscle of people with a type of hypertrophic cardiomyopathy (non-obstructive HCM). The trial will enroll 150 adults and use special PET scans to measure changes in scar ti…

This early study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The therapy uses modified immune cells to target and calm the overactive immune system. The main goals are to check safety and see i…

This early study tests whether high-dose vitamin B3 (nicotinamide) can help preserve or improve vision in people with Leber's hereditary optic neuropathy (LHON), a rare genetic disease that causes sudden vision loss. Researchers will give 13 participants 2 grams of vitamin B3 dai…

This study tests whether a gel placed inside the uterus after robotic fibroid removal can reduce scarring (adhesions) that may harm fertility. About 62 women having fibroid surgery will be randomly assigned to receive the gel or standard care. Researchers will check for adhesions…

This early-phase trial tests a new drug called BOLD-100 combined with standard chemotherapy (doxorubicin) in 32 people with advanced soft tissue sarcomas that cannot be removed by surgery or have spread. The goal is to find the safest dose and see if the combination can shrink tu…

This study compares two procedures for treating atrial fibrillation (AF) in people with heart failure: catheter ablation to restore normal heart rhythm, or a pacemaker plus ablation to control heart rate. About 1056 adults with both conditions will be followed for several years t…

This Phase 2 trial tests AD17002, a nasal spray that aims to calm the immune system in people with moderate to severe eosinophilic asthma that is not well controlled by current treatments. About 126 adults will receive either the spray or a placebo for 3 months. Researchers will …

This study looks at whether inhaled nitric oxide can help newborns with a hole in their diaphragm (congenital diaphragmatic hernia) who also have high blood pressure in their lungs. About 40 babies will receive the gas, and doctors will check if their oxygen levels improve within…

This study tests a minimally invasive treatment called microwave ablation for uterine fibroids. It uses heat to shrink fibroids and reduce symptoms like heavy bleeding and pelvic pressure, while preserving the uterus. The study will enroll 20 premenopausal women with fewer than f…

This study compares two heart failure medications—sacubitril/valsartan (a newer combo drug) and captopril (an older drug)—in 70 children aged 1 month to 18 years with dilated cardiomyopathy (an enlarged, weak heart). The goal is to see which drug better improves the heart's pumpi…

This study will test whether adding a special breathing exercise (inspiratory muscle training) to standard cardiac rehab helps heart patients recover better. About 80 adults who have been hospitalized for a heart condition will take part. The main goal is to see if the training i…

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

This phase III trial tests a procedure called FETO for severe congenital diaphragmatic hernia (CDH), where the diaphragm is incomplete and organs move into the chest. Doctors place a temporary balloon in the baby's windpipe before birth to help the lungs grow. The study will comp…

This study tests a special radioactive tracer called [68Ga]Ga-FAPI-46 for PET scans in 40 people with transthyretin cardiac amyloidosis (ATTR-CM), a condition where abnormal proteins build up in the heart. The goal is to see if this scan can measure scar-like activity in the hear…

This study explores whether a painless ultrasound technique, called shear wave elastography, can detect early signs of muscle weakness in critically ill patients on breathing machines. About 98 adults will have their nerves scanned on days 1, 4, and 7 in the ICU. The goal is to s…

This study will check if an AI system can accurately measure eye movements from smartphone videos. About 1,000 adults with suspected eye movement issues will record a short video while following a moving target. The AI's measurements will be compared to expert ratings to see if i…

This study explores whether a PET/MR scan using a radioactive tracer called 18F-Florbetaben can detect amyloid deposits—abnormal protein clumps that can damage organs—in people with certain blood disorders. Participants receive a single injection of the tracer followed by a whole…

This study will test whether a faster type of bone scan (CZT-SPECT) can accurately diagnose transthyretin cardiac amyloidosis, a serious heart condition. Researchers will compare the new scan with the standard method in 200 patients. If it works, it could make diagnosis quicker a…

This study will check if a muscle ultrasound can reliably detect muscle loss (sarcopenia) in 140 adults getting a kidney transplant. Researchers will compare ultrasound results with a standard body-composition test before and up to one year after transplant. If it works, this cou…

This study aims to see if a new radioactive dye can detect early signs of a heart condition called amyloidosis in people who carry a TTR gene mutation but have no heart failure symptoms. About 80 adults aged 30-80 will receive an injection of the dye and then have a PET/CT scan t…

This study tests whether a computer model can find signs of a heart condition called cardiac amyloidosis in bone scans that were done for other reasons. Researchers will look back at 57 patients' scans to see if the model can correctly identify those with the disease. If it works…

This early-phase study tests whether a special ultrasound with a targeted contrast agent (Sonazoid) can quickly diagnose heart inflammation caused by immune checkpoint inhibitor cancer drugs. About 30 adults who recently received these drugs and show signs of heart inflammation w…

This study tests whether a special PET-CT scan using a drug called evuzamitide can detect signs of cardiac amyloidosis in people whose standard heart scans were unclear but who have high levels of a blood marker called TAD1. About 25 adults with heart failure or a genetic risk fo…

This study will check if a new physical exam called Said's test can accurately diagnose biceps tendon injuries in the shoulder. Researchers will test 144 adults, including those with shoulder injuries and healthy volunteers. Two doctors will perform the new test and standard test…

This early study tests a new radioactive tracer called 64Cu-GRIP B that targets a protein released by immune cells during heart inflammation. Researchers will scan 10 people with acute myocarditis to see if the tracer can clearly highlight inflamed areas of the heart. If it works…

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This study will check if an artificial intelligence (AI) model can accurately tell the difference between common, non-cancerous uterine fibroids and a rare but serious cancer called uterine sarcoma using MRI scans. Researchers will enroll 500 women who are scheduled for surgery o…

This study tests whether a drug called sotagliflozin can prevent heart, muscle, and fat damage caused by a common type of chemotherapy (anthracycline) in people with newly diagnosed lymphoma. About 60 adults who are scheduled to receive high-dose anthracycline will take either th…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether two types of diabetes medications—SGLT2 inhibitors and DPP-4 inhibitors—can prevent heart damage caused by the chemotherapy drug doxorubicin in women with breast cancer. About 150 Egyptian women will be randomly assigned to receive one of the drugs or sta…

This study tests whether telmisartan, a blood pressure medication, can prevent heart damage caused by the chemotherapy drug doxorubicin in breast cancer patients. Researchers will enroll 36 newly diagnosed women and measure changes in heart function and injury markers. If effecti…

This study tests whether taking rosuvastatin, a cholesterol-lowering drug, can prevent heart damage caused by anthracycline chemotherapy in women with breast cancer. Four hundred participants will receive either rosuvastatin or a placebo daily for 12 months. The main goal is to s…

This study looks at whether a gel called Hyalosem can prevent scar tissue from forming inside the uterus after surgery. Researchers will review the medical records of 80 women who had uterine surgery and then received the gel. The goal is to see if the gel reduces adhesions and i…

This study will compare two types of nerve blocks for pain relief after shoulder surgery. One is a standard block that can sometimes weaken breathing; the other is a newer block that may avoid that side effect. 120 adults having shoulder arthroscopy will be randomly assigned to o…

This study tests whether adding cyclobenzaprine, a muscle relaxant, to standard pain medicines (ibuprofen, acetaminophen, and short-term narcotics) improves pain control and reduces narcotic use after minimally invasive hysterectomy. About 36 women undergoing laparoscopic hystere…

This pilot study tests whether focused shockwave therapy can reduce pain and improve function in people with chronic neck and shoulder muscle pain. Sixty adults will be randomly assigned to receive either three weekly shockwave sessions or a home exercise program. Researchers wil…

This study compares task-oriented occupational therapy to standard rehab for people recovering from rotator cuff surgery. Thirty participants will be randomly assigned to one of two groups, attending 40-minute sessions twice a week for 10 weeks. The goal is to see if focusing on …

This study looks at whether adding a specific hands-on technique called Mobilization With Movement (MWM) to standard exercises can better reduce pain and improve shoulder function in people with rotator cuff tendinopathy. About 60 adults with chronic shoulder pain will be split i…

This study tests whether a gentle neck mobilization technique can improve jaw movement and reduce pain in people with chronic jaw muscle pain (TMD myalgia). 48 adults with jaw pain will receive either the neck treatment or a placebo. Researchers will measure jaw motion, muscle ac…

This study compares two manual therapy techniques—myofascial trigger point release and the Neil Asher Technique—for treating rotator cuff syndrome, a common cause of shoulder pain and limited movement. Thirty-six adults aged 40 to 60 with mild to moderate rotator cuff syndrome wi…

This study tests whether taking at least 4 tablespoons of extra-virgin olive oil daily for 12 weeks, alongside standard cardiac rehab, is feasible and helpful for people with heart failure with reduced ejection fraction. Researchers will measure changes in diet, exercise capacity…

This study compares two brain-training programs for adults with ME/CFS who experience brain fog. Both programs include computer games and a mild nerve stimulation device, but one focuses on processing speed and daily tasks while the other emphasizes relaxation and healthy habits.…

This study tests whether adding deep breathing exercises to a massage routine can quickly reduce neck pain and stiffness in operating room nurses after surgery. Thirty-eight nurses will receive either massage alone or massage plus breathing exercises in a single session. Research…

This study looks at whether 4 weeks of low-intensity shoulder exercises, done with or without a blood flow restriction cuff, can reduce pain and improve function in people with rotator cuff-related shoulder pain. 34 adults with long-lasting shoulder pain will be randomly assigned…

This study tests whether shining specific light wavelengths (635, 940, or 1064 nm) on the jaw muscles can reduce pain and improve jaw function in people with chronic jaw muscle disorder (TMD). About 45 adults with moderate-to-severe jaw pain lasting over 3 months will receive sev…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with mild to moderate chronic fatigue syndrome. 74 participants will receive either real treatment or a sham (placebo) for 60 sessions over 3 months. Researchers wi…

This study tests two different manual therapy techniques—Active Release Technique and Myofascial Release—each paired with eye exercises, to see which better reduces eye strain, improves sleep quality, and lowers stress in people with neck pain. 44 adults aged 18-40 with neck pain…

This study compares two non-invasive treatments—high-intensity laser therapy and shock wave therapy—for people with chronic shoulder pain from supraspinatus tendinitis. Researchers will measure pain and disability in 48 adults over several weeks to see which approach works better…

This study looks at two treatments for a jaw joint condition called disc displacement without reduction, which causes pain and trouble opening the mouth. Fifty-two adults who haven't gotten better with standard care will be randomly assigned to get either arthroscopic surgery alo…

This study tests whether applying local heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults with TMD will receive heat therapy and report their pain levels daily for 8 days. Researchers will com…

This study tests a new combination of nerve blocks for elderly patients (65 and older) having surgery for a broken shoulder. The goal is to see if the new approach provides better pain relief during surgery and lowers the risk of temporary diaphragm paralysis, which can cause bre…

This study tests a new type of nerve block (PENG block) for people with chronic shoulder pain that hasn't improved with other treatments. 45 adults will get an ultrasound-guided injection of numbing medicine and steroid. Researchers will measure pain, shoulder function, and satis…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests whether myofascial release therapy, a type of hands-on treatment that loosens tight connective tissue, can improve body posture and facial symmetry in healthy adults. Sixty participants will be randomly assigned to receive the therapy twice a week for six weeks o…

This study tests whether injections of platelet-rich plasma (PRP) can reduce pain and improve jaw function in people with chronic jaw muscle pain (myogenous TMD). Fifty women aged 20–50 with at least 3 months of pain will receive either PRP or a saltwater shot, then be followed f…

This study tests a treatment called Intermittent Hypoxia-Hyperoxia Treatment (IHHT) for people with ME/CFS or long COVID. The therapy uses a mask to deliver short cycles of low and high oxygen, aiming to improve energy and reduce inflammation. 104 patients will be randomly assign…

This study tests whether modafinil, a drug used for sleep disorders, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, starting at 100 mg daily with possible dose increases. …

This study tests whether cauterizing the uterine artery at its origin before removing the uterus via laparoscopy reduces blood loss and surgery time compared to the standard technique. It will involve 44 women over 35 with non-cancerous conditions like fibroids or abnormal bleedi…

This study tests which injection mixture works better for people with a displaced jaw joint (TMJ) that still clicks and moves. Twenty adults will receive either a mix of hyaluronic acid and steroids or hyaluronic acid and platelet-rich plasma after a joint washout. The goal is to…

This early study tests whether a low-level magnetic therapy device, used at home, is safe and practical for people with cognitive issues from brain injury, Long COVID, or Alzheimer's. About 30 adults will use the device regularly and complete computer-based thinking tests. The go…

This study tests two treatments—trigger point activator and shock wave therapy—for people with painful knots in the upper neck muscle. One hundred adults aged 25–40 with active trigger points will be randomly assigned to one of the two therapies. Researchers will measure pain and…

This study tests if a newer ultrasound-guided needle works better than a standard needle to treat gluteal tendinosis—a painful tendon condition in the buttock area. About 110 adults who haven't improved after 3 months of other treatments will be randomly assigned to one of the tw…

This study compares two types of full can exercises—concentric and eccentric—for people with partial rotator cuff tears. Sixty participants will do one type of exercise plus standard physiotherapy for 6 weeks. Researchers will measure changes in shoulder muscle structure, pain, a…

This study tests a hands-on technique called Integrated Neuromuscular Inhibition (INIMT) for people with painful muscle knots in the upper neck. 60 adults with trigger points will receive either INIMT plus standard therapy or standard therapy alone for four weeks. Researchers wil…

This study tests whether adding shockwave therapy or platelet-rich plasma (PRP) injections to a standard exercise program helps people with long-term Achilles tendon pain. One hundred active adults aged 18-65 with symptoms lasting over 3 months will be randomly assigned to exerci…

This study tests whether a low dose of naltrexone can reduce fatigue in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will enroll 75 adults from Alabama and track their fatigue levels weekly through online surveys. The goal is to find the be…

This study tests whether cycling while using a virtual park app can slow the loss of motor function in children and teens with neuromuscular diseases like muscular dystrophy. Twenty-two participants will first receive standard care for 3 months, then use the virtual park bike 3 t…

This study will test different types of strengthening exercises in 45 children aged 6 to 10 with Duchenne muscular dystrophy (DMD). The goal is to see if these exercises can improve muscle strength, walking distance, and chemical markers in the blood. The results could help guide…

This study tests whether tele-rehabilitation—guided video sessions with self-massage, stretches, and posture tips—can reduce pain and improve neck movement in people with rhomboid trigger points. Thirty-six adults with neck and upper back pain will be randomly assigned to either …

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study tests whether adding high-intensity laser therapy to standard physical therapy helps people recover better after arthroscopic rotator cuff repair. 46 adults aged 30-70 with shoulder pain will be randomly assigned to receive either real laser therapy or a sham treatment…

This study tests whether adding dual-task exercises (combining physical movements with mental tasks) to standard physiotherapy, delivered via telerehabilitation, can reduce pain and improve jaw function in young adults with temporomandibular joint (TMJ) dysfunction. Thirty partic…

This study tests whether a mobile app with AI-guided exercise videos and reminders helps people recover better after arthroscopic rotator cuff repair compared to standard paper instructions. About 102 adults who need surgery will be randomly assigned to use the app or follow pape…

This study looks at whether a special breathing exercise (threshold inspiratory muscle training) can make the diaphragm thicker and move better in people with stable COPD. Fifteen participants aged 40-59 with moderate COPD will do the training. The goal is to see if this exercise…

This study looks at whether adding famotidine (an acid-reducing drug) to standard painkillers (paracetamol and ibuprofen) helps people with calcific tendinitis of the shoulder feel less pain and move better. About 200 adults with shoulder pain and calcium deposits will be followe…

This study tests whether a stronger laser (high-intensity) works better than a standard low-level laser for reducing pain and improving jaw movement in people with chronic jaw muscle pain. Forty adults will receive 12 laser sessions over one month and be followed for six months. …

This study tests two methods of injecting platelet-rich fibrin (PRF) into the jaw joint for people with a displaced disc that causes pain and limited mouth opening. One method uses ultrasound to guide the needle, the other uses a tiny camera (arthroscope). The goal is to see whic…

This study tests whether adding a gentle back-mobilization technique to standard shoulder therapy can improve pain, movement, and function in people with rotator cuff injuries. Forty adults with chronic shoulder pain will receive either shoulder mobilization alone or combined wit…

This study tests whether a supervised exercise program combining resistance training and walking can improve physical function, fitness, and quality of life in women with stage IV breast cancer. 78 women currently on medical treatment will be randomly assigned to either the exerc…

This study compares two exercise programs for people with rotator cuff-related shoulder pain. One group gets a standard, fixed program, while the other gets the same exercises but with personalized touches like preferred music, choice of exercises, and motivational feedback. Rese…

This study tests whether a game-based biofeedback therapy can improve quality of life and sleep in people with dyssynergic defecation, a condition where pelvic floor muscles don't relax properly during bowel movements. Thirty-six adults will either receive the game-based therapy …

This trial tests a new single-channel bag used during keyhole surgery to remove uterine fibroids. The bag holds the fibroid while it is cut into smaller pieces, and the goal is to see if it makes the surgery faster and simpler than the current two-channel bag. About 78 women aged…

This study tests whether a special device called H-Wave can help people recover faster and with less pain after rotator cuff repair surgery. About 80 adults aged 18-64 will either receive standard care or standard care plus the H-Wave device. Researchers will track pain, medicati…

This study tests whether a structured 5-week cardiac rehabilitation program can improve exercise ability and quality of life in 40 adults with cardiac amyloidosis. Participants will undergo supervised aerobic and strength training five days a week, with tests before and after the…

This study tests a device called TUNES, which delivers gentle electrical stimulation through a menstrual disc to nerves near the uterus. The goal is to see if it can reduce pain and the need for pain medication in 60 women after uterine fibroid embolization. Participants will be …

This study tests whether a supervised exercise program can help women who have had breast or gynecological cancer and now suffer from muscle loss (sarcopenia). The 78 participants will do resistance, aerobic, balance, and stretching exercises. Researchers will measure changes in …

This study tests two types of nerve blocks for shoulder surgery to see which one is less likely to temporarily paralyze the diaphragm, the main muscle for breathing. About 70 adults having elective shoulder surgery will be randomly assigned to receive either a standard interscale…

This study tests whether a mental exercise program called graded motor imagery can reduce pain and improve shoulder function after surgery for a massive rotator cuff tear. The program includes tasks like recognizing shoulder positions, imagining movements, and using a mirror to t…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study compares two treatments for buttock pain caused by piriformis syndrome and related muscle pain. Researchers will use ultrasound to guide either a sugar-water injection or a dry needle into the affected area. The goal is to see which method provides better pain relief o…

This study tests whether taking a supplement called HMB, along with a standard rehab program, can reduce pain and improve knee function in athletes with patellar tendinopathy (jumper's knee). Thirty athletes will receive either HMB or a placebo for 8 weeks. Researchers will measu…

This study tests whether a special light therapy (photobiomodulation) can reduce pain and improve jaw function in people with myofascial temporomandibular disorder (TMD), a condition causing muscle pain in the face and jaw. About 140 adults will be split into three groups: light …

This study tests three treatments for myofascial pain in the upper trapezius muscle: dry needling alone, dry needling plus a lidocaine injection, and a sham needling plus lidocaine. All groups also do stretching exercises. Ninety adults aged 18–65 with active trigger points will …

This study tests whether a mix of two drugs (triamcinolone and lidocaine) injected into jaw muscle trigger points can reduce pain in people with TMJ disorders. About 30 adults will receive either the active injection or a placebo. The main goal is to see if it lowers pain intensi…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests whether increasing the pacemaker's lower rate from 60 to 80 beats per minute improves quality of life and daily function in people with ATTR cardiac amyloidosis. The heart in this condition is stiff and depends on a faster heart rate to pump blood. Thirty-four pa…

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from their hormone therapy. The program includes exercise, education, symptom tracking, and follow-up. Eighty-eight patients in Ethiopia will be randomly assigned to the program…

This study tests whether a home-based exercise program combined with nutritional supplements can improve walking ability and muscle strength in people aged 70 and older with transthyretin cardiac amyloidosis, a heart condition that causes weakness and frailty. About 102 participa…

This study compares two hands-on treatments—Integrated Neuromuscular Inhibition and Active Release Technique—for people with neck pain caused by trigger points in the upper trapezius muscle. About 64 adults with active trigger points and forward head posture will receive one of t…

This study tests whether a home-based virtual reality (VR) exercise program is practical and helpful for people with shoulder pain lasting more than three months. Thirty adults aged 16 and older with rotator cuff syndrome, frozen shoulder, or shoulder instability will use a VR he…

This study compares two surgical techniques for the biceps tendon—tenotomy (cutting the tendon) and tenodesis (reattaching it)—in 50 adults aged 50-70 undergoing rotator cuff repair. The goal is to see which method leads to less pain, better shoulder function, and stronger grip a…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40 to 70 will choose whether to use the pillow or not. Their pain, sleep quality, and shoulder function will be checked …

This study looks at whether teaching people with rotator cuff syndrome the best sleeping positions can improve their sleep quality while they undergo physical therapy. Researchers will compare two groups: one getting standard physical therapy, and another getting physical therapy…

This study tests whether a gamified mobile app can help 46 boys aged 6–12 with Duchenne muscular dystrophy stay motivated with their home physiotherapy. The app includes rewards, levels, and feedback to make exercise more engaging. Researchers will measure physical function, endu…

This study tests whether a long-hold isometric exercise can reduce pain and improve function in competitive weightlifters with patellar tendinopathy (jumper's knee). About 24 athletes will either do the supervised exercise or follow routine training. Researchers will measure pain…

This study tests whether acupuncture can improve thinking and memory problems (brain fog) in people with chronic fatigue syndrome (ME/CFS) that started after COVID-19. About 99 adults will be randomly assigned to real acupuncture, fake acupuncture, or a waiting list for 8 weeks. …

This study tests whether hypnotherapy can reduce pain and anxiety in children aged 6 to 18 during needle procedures like injections or blood draws. About 70 kids with conditions like juvenile arthritis or lupus will be randomly assigned to receive either hypnotherapy or standard …

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether high-intensity laser therapy can reduce pain and improve neck movement, daily function, and mood in people with trapezius myofascial pain syndrome. About 104 adults with neck pain for at least 4 weeks will receive either real or sham laser treatment. Rese…

This study tests whether inhaled salbutamol, a drug used for asthma, can reduce breathing distress in newborns with transient tachypnea of the newborn (TTN). TTN is a common lung condition after birth where fluid stays in the lungs, causing fast breathing. The trial will enroll j…

This study tests whether a multicomponent support group can improve the confidence (self-efficacy) of primary caregivers of children with Duchenne muscular dystrophy or spinal muscular atrophy in Pakistan. Thirty caregivers will join group sessions with doctors, therapists, and o…

This study looks at whether starting gentle shoulder exercises soon after rotator cuff repair leads to better recovery than waiting six weeks. About 86 adults who have surgery for a torn rotator cuff will be randomly assigned to either early or delayed rehabilitation. Researchers…

This study compares two methods of injecting medicine into the jaw joint to relieve pain and improve function: one using a tiny camera (arthroscopy) and the other using ultrasound guidance. About 50 adults with long-term jaw pain will take part. The goal is to see which approach …

This study tests whether applying an ozonated gel with ultrasound (phonophoresis) can reduce pain and improve shoulder function in people with chronic supraspinatus tendinitis. Forty adults aged 30-60 with mild to moderate tendon issues will receive either the ozone gel treatment…

This study looks at whether TECAR therapy, a type of energy treatment, can reduce pain and improve shoulder movement in people with chronic supraspinatus tendinitis (a common tendon injury). About 46 adults with grade II tendinitis will receive the therapy. Researchers will measu…

This study looks at whether doing extra tissue release during arthroscopic rotator cuff repair can prevent shoulder stiffness after surgery. About 50 adults with small-to-medium rotator cuff tears will be randomly assigned to get either the standard repair or the repair plus extr…

This study tests four different virtual reality (VR) exercises in 30 adults who have had rotator cuff-related shoulder pain for at least 6 months. Participants will do weekly VR sessions for four weeks and complete questionnaires about their arm function, pain, and fear of moveme…

This early-stage trial tests amlodipine, a calcium channel blocker used for high blood pressure, in 20 adults with myotonic dystrophy type 1. The goal is to see if the drug is safe and can improve muscle strength, reduce stiffness, and help with daily function. All participants w…

This study compares two needle-based treatments—electrolysis and dry needling—against standard physiotherapy for whiplash pain from car accidents. Thirty-six adults with neck pain and active trigger points will receive one of the three approaches. The goal is to see which method …

This study tests whether adding core-strengthening exercises to standard physical therapy can reduce pain and improve function in people with temporomandibular joint (TMJ) disorders. Fifty adults with jaw pain will be randomly assigned to either standard TMJ therapy or standard t…

This study tests whether a digital tool called MSCopilot Boost can reduce the impact of fatigue in people with multiple sclerosis better than standard care. The tool includes remote monitoring of walking, dexterity, vision, and cognition, plus a personalized telerehabilitation pr…

This study tests a special brace with a built-in pillow to see if it helps people sleep better after rotator cuff surgery. About 100 patients will either use the pillow brace or a standard brace. The goal is to reduce nighttime pain and improve sleep quality, which may help recov…

This study looks at whether hands-on myofascial release or a tool called Graston can improve flexibility, balance, and agility better than home exercises in people with tight hamstrings. About 45 adults with hamstring shortness will be randomly assigned to one of three groups and…

This study compares two advanced, minimally invasive hysterectomy techniques—TU-LESS (through the belly button) and vNOTES (through the vagina)—in 210 women with an enlarged uterus. The goal is to see which method leads to faster recovery, less pain, and shorter hospital stays. P…

This study tests whether a personalized exercise program based on muscle structure works better than a standard eccentric heel-drop program for people with chronic Achilles tendinopathy. Twenty adults with mid-tendon pain for at least 3 months will be randomly assigned to one of …

This study compares total laparoscopic hysterectomy (removing the whole uterus including the cervix) with subtotal laparoscopic hysterectomy (keeping the cervix) in 500 women with benign conditions like fibroids or endometriosis. The main goal is to see which surgery leads to bet…

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study investigates whether measuring blood flow in the heart's smallest blood vessels (microcirculation) can help predict serious health events within a year after a person is hospitalized for acute myocarditis. Researchers will use a special technique during a standard hear…

This study compares three types of nerve blocks used for pain relief during shoulder surgery. The goal is to see which block is least likely to temporarily paralyze the diaphragm, the main muscle used for breathing. Seventy-five adults having shoulder surgery will be randomly ass…

This study will follow 50 adults having arthroscopic rotator cuff repair to see if a condition called central sensitization—where the nervous system is overly sensitive to pain—affects their recovery. Before surgery and 3 months after, researchers will measure pain and shoulder f…

This study tests whether a wearable sensor (Syde device) can reliably measure arm and hand function in boys with Duchenne muscular dystrophy who can no longer walk. Current tests are done in clinics and may miss small changes. The goal is to see if home-based digital monitoring i…

This study looks at whether the way your jaw and teeth fit together (called malocclusion) is related to your body posture. Researchers will use a 3D scanner to measure the spine's curves and alignment in people with different types of jaw misalignment. The goal is to better under…

This study will use portable ultrasound to measure the thickness of forearm muscles and tendons in 90 adults with rotator cuff-related shoulder pain. Researchers want to see if these measurements change based on how long someone has had shoulder pain. They will also measure hand …

This study looks at whether 'central sensitization' — a condition where the nervous system is overly sensitive to pain — affects how well physical therapy works for people with partial rotator cuff tears. Researchers will follow 60 adults aged 18-65 who have had shoulder pain for…

This observational study monitors the long-term safety of eplontersen, a treatment for transthyretin amyloidosis, in patients who have had a liver transplant or have severe liver impairment. Researchers will track side effects, lab changes, and serious health events in about 320 …

This early-stage study will give a small dose of a radioactive-labeled drug called HRS-1893 to 6 healthy men. Researchers will track how the drug is absorbed, broken down, and eliminated through urine and feces. The goal is to understand the drug's path in the body, which is a ke…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study follows 10 Chinese adults who have a specific gene mutation (BAG3) linked to dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Researchers will track changes in heart function, symptoms, and biomarkers over time to better understand how the…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study looks at whether a digital tool called Luscii is practical and acceptable for people with a rare heart condition called ATTR-CM. About 60 adults in Austria, Germany, and Italy will use a smartphone app and home devices to share health information with their care team. …

This study will collect health information from 3000 people with hypertrophic cardiomyopathy (HCM) across multiple hospitals in China. The goal is to build a comprehensive database to understand how the disease is currently diagnosed and treated, and to identify factors that affe…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study aims to better understand and treat myofascial pelvic pain, a common cause of long-term pelvic pain in women. Researchers will use a noninvasive imaging technique to measure pelvic floor muscle function before and after three different treatments: education with relaxa…

This study will collect blood samples from 115 adults with cardiac sarcoidosis to look for tiny particles called exosomes that might show whether the disease is active or quiet. The goal is to develop a simple blood test that could help doctors monitor the condition without needi…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will follow 200 people with suspected or confirmed cardiac amyloidosis, a condition where abnormal proteins build up in the heart and cause heart failure. Over two years, participants will undergo heart MRI scans, exercise tests, and blood work at regular visits. The g…

This study looks at whether the LASMAR scoring system can predict how well hysteroscopic myomectomy works for women with submucous fibroids. Researchers will check if the score matches surgery time, number of sessions, fluid use, and complications. The goal is to help doctors pla…

This study looks at how stress on the shoulder bone (acromion) changes after reverse shoulder replacement surgery. Researchers will use CT and MRI scans from 13 patients to create computer models that show where bone stress is highest. The goal is to better understand and prevent…

This study looks at two different ways to perform reverse total shoulder replacement in 130 people aged 60-85 with severe shoulder arthritis and torn rotator cuffs. The goal is to see which technique leads to better muscle activity and arm movement. Participants will have their s…

This study will measure hormone levels in 100 children aged 1 to 12 who have dilated cardiomyopathy, a condition where the heart is enlarged and weakened. Researchers will collect blood samples to check hormones like thyroid, cortisol, and growth factors, and compare them to heal…

This study looks at whether a specially trained physical therapist can diagnose jaw disorders (like TMJ) as accurately as an oral surgeon. 70 people with jaw pain will be checked by both a physical therapist and a surgeon, and their diagnoses will be compared. The goal is to see …

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study tests a new imaging technique called full-field OCT to see if it can spot muscle inflammation faster than the usual method, which takes weeks. Researchers will compare both methods on muscle samples from 20 healthy adults and people with suspected myositis. The goal is…

This study will use ultrasound to check for tendon inflammation (tenosynovitis) in children with two types of juvenile idiopathic arthritis (JIA): polyarticular and oligoarticular. Researchers will examine 106 children under 16 at Assiut University Hospital, comparing physical ex…

This study looks at whether metabolic syndrome (a cluster of conditions like high blood pressure and excess belly fat) makes it harder to recover from a rotator cuff injury. Forty adults with rotator cuff tears will be split into two groups—those with and without metabolic syndro…

This observational study looks at how daily coffee consumption might influence balance in healthy university students aged 18–25. Researchers will group participants by their usual caffeine intake and measure their static and dynamic balance using simple tests like standing on on…

This study aims to understand if diet influences muscle health and daily function in adults with inclusion body myositis (IBM), a rare muscle disease. Researchers will compare 47 adults with IBM to healthy volunteers aged 40 and older. Participants will track their diet and activ…

This observational study will enroll 1,000 pregnant women and their fetuses to establish normal ranges for heart sounds and ECGs. The goal is to develop early warning systems for serious heart events in mothers, progression of fetal heart defects, and autoimmune-related fetal hea…

This study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …

This study will follow 500 boys aged 1 to 18 with Duchenne or Becker muscular dystrophy for several years. Researchers will track their muscle function, body composition, lab tests, and heart and lung imaging to map how the disease changes over time. The goal is to create a model…

This study will check children under 18 with chronic liver disease for hidden heart problems. Doctors will use simple tests like ECG and ultrasound to look for issues such as abnormal heart rhythms or weakened heart muscle. The goal is to better understand how liver disease affec…

This study looks back at medical records of 1500 adults hospitalized for acute myocarditis (heart muscle inflammation). The goal is to find out how often dangerous heart rhythms occur and what factors predict them. No new treatments are tested—researchers will use existing data t…

This study aims to better understand a condition called multilocus imprinting disorder (MLID), where multiple genes are affected by abnormal chemical marks. Researchers will test a new technique to detect these marks in 96 people, including those with known imprinting disorders a…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This study follows up to 10 people of any age with nemaline myopathy, a rare muscle disease, for three years. Researchers will collect information during regular hospital visits to understand how the disease changes over time. The goal is to find better ways to measure disease pr…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study watches how dilated cardiomyopathy (a weakened heart muscle) progresses in adults with specific BAG3 gene changes. Researchers will track heart function and health events over time in 30 participants. No treatment is given—the goal is to better understand the disease.…

This study will observe 300 people with long-term jaw and face muscle pain (TMD) to see how psychological factors relate to their physical symptoms. Participants will fill out questionnaires about their pain and other body symptoms. The goal is to better understand the role of me…

This study looks at how a person's genes affect their response to the heart drug mavacamten for obstructive hypertrophic cardiomyopathy. Researchers will collect DNA samples from 300 patients to see which genetic types respond best. The goal is to improve dosing safety and effect…

This study looks back at medical records of 220 patients who had a procedure called radiofrequency ablation for heart rhythm issues. The goal is to compare how well the procedure works for two types of abnormal heart connections. Researchers hope to find which type is easier to t…

This study gathers information from 5,000 adults with hypertrophic cardiomyopathy, a condition where the heart muscle is too thick. Researchers will use heart MRI scans to look for scarring and build a better way to predict who is at risk of dying from the disease. The goal is to…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This study looks at how taking caffeine in different ways—daily low doses, gradually increasing doses, or only on workout days—affects muscle growth and strength in 180 young men who don't normally drink caffeine or exercise with weights. Participants will follow two 4-week super…

This study is creating a registry for people with Duchenne and Becker muscular dystrophy, as well as symptomatic female carriers. The goal is to collect health data and quality-of-life information to monitor how new therapies work in real-world settings. Up to 1,500 participants …

This study aims to find out why the heart medication mavacamten works better for some people with hypertrophic cardiomyopathy (a condition where the heart muscle is too thick) than for others. Researchers will look at participants' genes, including the specific gene causing their…

This study looks at how athletes at risk for patellar tendinopathy (jumper's knee) move during jumps. Researchers will use a camera system to track knee, hip, and ankle angles in 60 male athletes over 12 months. The goal is to find early movement changes that could lead to better…

This study aims to see if artificial intelligence can predict serious heart rhythm problems, like atrial fibrillation, after high-risk surgeries. Researchers will record ECGs from 300 adults before surgery and analyze over 200 heart cycle parameters to find the best prediction me…

This study compares two types of nerve blocks used during shoulder surgery to see which one causes less diaphragm paralysis (temporary trouble breathing). Sixty adults scheduled for shoulder surgery will receive either a standard interscalene block or a combination block. Researc…

This study will collect data from 5,000 adults with acute myocarditis (heart muscle inflammation) across France. Researchers will analyze heart MRI scans to see if certain patterns can predict who is at risk for serious complications like death, heart failure, or dangerous heart …

This observational study will measure how well the upper neck moves and how that relates to jaw motion in 50 adults with temporomandibular disorders (TMD). Participants will have their neck and jaw movements measured with simple tools. The goal is to understand if limited neck mo…

This study aims to identify the many factors that influence how physically active children with Duchenne Muscular Dystrophy (DMD) are. Researchers will look at muscle strength, balance, thinking skills, sleep, behavior, and family environment. The goal is to gather information th…

This study tests a more sensitive ultrasound method called speckle tracking echocardiography (STE) to check heart function in newborns. Researchers will scan healthy babies and those with conditions like lung disease or oxygen deprivation to establish normal values and track chan…

This study will observe 143 older adults with severe aortic stenosis who are scheduled for a minimally invasive valve replacement procedure called TAVR. Researchers want to find out how many also have cardiac amyloidosis, a condition where abnormal proteins build up in the heart.…

This study will follow 1,550 adults with various neurological autoimmune diseases—like multiple sclerosis, myasthenia gravis, and autoimmune encephalitis—to see how these conditions progress and respond to treatments in everyday medical practice. Researchers will measure disabili…

This study compares two common gym exercises—lat pulldown and lat row—to see if the angle of your shoulder affects muscle growth. Twenty healthy adults aged 19-30 will train each arm with a different exercise for 12 weeks. Researchers will measure muscle size and strength changes…

This study looks at whether using artificial intelligence (AI) can help physical therapists make better treatment choices for people with myofascial pain syndrome (a type of muscle pain). About 70 adults with chronic muscle pain will be split into two groups: one gets therapy dec…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at whether a new medication (mavacamten) can improve the energy levels of the heart muscle in people with obstructive hypertrophic cardiomyopathy, a condition where the heart wall thickens and blocks blood flow. Researchers will use a special MRI scan to measure …

This study will follow 100 people who have had their stomach removed (gastrectomy) to see how their muscles change over time. Researchers will measure muscle thickness in the arms and legs to understand the pattern of muscle loss and how nutrition plays a role. The goal is to gat…

This study looks at how energy production inside cells (mitochondria) works in people with cystinosis, a rare disease that causes cystine buildup and early aging. Researchers will measure cell energy activity in 25 patients and compare it to healthy people. The goal is to underst…

This study will test if simple, bedside heart tests (ultrasound, EKG, and blood tests) can accurately detect heart problems in pregnant women who regularly use methamphetamine. Researchers will compare these quick tests to a full heart ultrasound. The goal is to find a faster, ea…

This study will follow 386 critically ill patients on breathing machines to see if losing 10% or more of thigh muscle within the first week in the hospital is linked to a higher chance of dying within 28 days. Researchers will use ultrasound to measure muscle size. The goal is to…

This study will follow 500 people with dual-chamber pacemakers to see how the pacemaker's programming affects the development of permanent atrial fibrillation (AF), a common heart rhythm problem. Researchers will track AF episodes, quality of life, hospitalizations, and deaths ov…

This study checks if a special ultrasound technique (shear-wave elastography) can accurately measure diaphragm pressure without needles or tubes. Twelve healthy adults will perform breathing exercises while researchers compare ultrasound readings to standard pressure measurements…

This pilot study will test whether it is safe and effective to remove uterine fibroids and retrieve eggs in a single surgical step for infertile women aged 18–45. The researchers will track pregnancy, miscarriage, and live birth rates after frozen embryo transfer. Only 20 women w…

This study looks at why people with Noonan syndrome often bleed easily, especially from the skin, mouth, or nose. Researchers will compare a simple questionnaire about bleeding history with blood tests in 100 patients. The goal is to find better ways to predict serious bleeding, …

This study looks at whether people with certain heart rhythm disorders also carry genetic variants linked to a rare muscle condition called non-dystrophic myotonia. Researchers will review medical records of 570 participants and invite some for a neurological exam and electromyog…

This study will check if certain blood markers can predict heart damage in children and teens who had anthracycline chemotherapy for cancer. Researchers will compare blood tests and heart imaging results from 40 survivors and healthy volunteers. The goal is to find early warning …

This study tests a new AI-powered software that helps doctors see, in real time, how well a minimally invasive fibroid treatment (uterine artery embolization) is working. The goal is to make the procedure more accurate and consistent. The study will involve 250 women with symptom…

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…

This study looks at 50 adults with AL amyloidosis who achieved complete remission after initial chemotherapy. It checks if tiny amounts of remaining disease (called minimal residual disease, or MRD) affect organ recovery and survival. Researchers also test whether a stem cell tra…

This study looks at how long-term use of a BiPAP machine affects the diaphragm—the main breathing muscle—in people with advanced COPD. Researchers will use ultrasound to measure diaphragm thickness and movement over 6 weeks and 12 months in 30 patients. The goal is to learn wheth…

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study checks how often doctors can accurately needle specific hip muscles using only touch and landmarks, without ultrasound guidance. Forty adults with hip pain will receive dry needling, and a second doctor will use ultrasound to see if the needle hit the right spot. The g…

This study looks at whether biologic therapy can reverse long-term lung damage in adults with severe asthma. Researchers will follow 150 patients and 50 healthy volunteers for two years, using advanced imaging and lung function tests. The goal is to see if treatment leads to 'cli…

This study will follow 100 children aged 1 to 18 with myocarditis (inflammation of the heart muscle) to see how different types of the disease progress. Researchers will track symptoms, treatments, and outcomes over one year. The goal is to better understand which children recove…

This study will test a computer model that predicts infertility risk in women with uterine fibroids. Researchers will follow over 7,000 women aged 20-50 who want to conceive and have fibroids. The goal is to see if the model can accurately identify who might struggle to get pregn…

This study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…

This study will collect health information, samples, and data from 100 people in Luxembourg (800 total across Europe) who have rheumatoid diseases and are starting or changing treatment. Researchers hope to find patterns that can predict which treatments work best for each person…

This study looks at 100 adults with frequent extra heartbeats (PVCs) to see if hidden heart inflammation (myocarditis) is the cause. Participants will get advanced heart scans and lab tests. The goal is to better understand the link and see if anti-inflammatory therapy helps thos…