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Bent or straight? study tests if knee angle can slow muscle loss during immobility

NCT ID NCT07690150

Knowledge-focused Sponsor: Wageningen University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study investigates whether keeping the knee bent (at a 60-degree angle) during five days of leg immobilization helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will wear a knee brace and undergo scans, blood tests, and muscle biopsies before and after. The findings could inform simple ways to protect muscles when people are unable to move, such as after surgery or illness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Knee immobilization brace
What this could lead to
If keeping the knee bent helps preserve muscle, it could lead to simple positioning strategies to protect muscles during bed rest or recovery after surgery.
What could go wrong
This is a small, short-term study in healthy volunteers, so results may not apply to sick or injured people. The intervention is only five days, and long-term effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy males and females * Aged from 18-40 years at the time of signing informed consent * 18.5 \< BMI \< 30 kg·m-2 * Must be willing and able to communicate and participate in the whole study Exclusion Criteria: * Smoking * Diabetes (Type 1, Type 2, or genetic form of diabetes) * Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic) * Chronic use of any prescribed or over the counter pharmaceuticals that may modulate muscle protein metabolism (excluding oral contraceptives and contraceptive devices). * A personal or family history of thrombosis, epilepsy, seizures or schizophrenia. * Prone to keloid forming (i.e. hyperplastic growth of scars). * Any known disorders in muscle metabolism * Regular use of dietary protein and/or amino acid supplements (\>3 times per week) * Currently involved in a structured progressive resistance training programme (\>3 times per week) * Known allergy to lidocaine * Known severe kidney problems * Allergy to one or multiple amino acids * Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture) * Having received or ingested a stable isotope tracer containing 15N in the past * Contra-indications for MRI such as incompatible metal objects in the body and claustrophobia. * Currently taking part in other scientific research * Pregnant or breastfeeding * Unable to give consent

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Conditions

The condition(s) this trial relates to.

muscular atrophy Muscular Disorders, Atrophic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Disuse atrophy Immobilization Muscle atrophy

How to take part

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  1. The official record

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