Bent or straight? study tests if knee angle can slow muscle loss during immobility

NCT ID NCT07690150

Not yet recruiting Knowledge-focused Sponsor: Wageningen University Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study investigates whether keeping the knee bent (at a 60-degree angle) during five days of leg immobilization helps prevent muscle loss compared to keeping the knee straight. Thirty healthy adults will wear a knee brace and undergo scans, blood tests, and muscle biopsies before and after. The findings could inform simple ways to protect muscles when people are unable to move, such as after surgery or illness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Knee immobilization brace
What this could lead to: If keeping the knee bent helps preserve muscle, it could lead to simple positioning strategies to protect muscles during bed rest or recovery after surgery.
What could go wrong: This is a small, short-term study in healthy volunteers, so results may not apply to sick or injured people. The intervention is only five days, and long-term effects are unknown.

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Conditions

The condition(s) this trial relates to.

muscular atrophy Muscular Disorders, Atrophic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DISUSE ATROPHY IMMOBILIZATION MUSCLE ATROPHY

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