Could breathing different oxygen levels ease chronic fatigue?

This study tests a treatment called Intermittent Hypoxia-Hyperoxia Treatment (IHHT) for people with ME/CFS or long COVID. The therapy uses a mask to deliver short cycles of low and high oxygen, aiming to improve energy and reduce inflammation. 104 patients will be randomly assigned to receive either the real treatment or a placebo over eight weeks. Researchers will measure changes in fatigue, mental clarity, pain, and quality of life.