Could a faster pacemaker setting help heart amyloidosis patients feel better?

NCT ID NCT07413081

Not yet recruiting Symptom relief Sponsor: Region Skane Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether increasing the pacemaker's lower rate from 60 to 80 beats per minute improves quality of life and daily function in people with ATTR cardiac amyloidosis. The heart in this condition is stiff and depends on a faster heart rate to pump blood. Thirty-four participants will try both settings in a crossover design to see which works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pacemaker rate adjustment
What this could lead to: If it works, this could point toward a simple way to improve daily function and well-being for people with cardiac amyloidosis who have a pacemaker.
What could go wrong: This is a small, early-stage trial with only 34 participants, so results may not apply to everyone. The benefit seen in similar conditions may not hold true for amyloidosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Amyloid Neuropathies, Familial amyloidosis wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC AMYLOIDOSIS PACEMAKER

Contacts and locations

Locations

Aarhus University Hospital

Aarhus, Denmark
Academic University Hospital

Uppsala, Sweden
Karolinska University Hospital

Stockholm, Sweden
Linköping University Hospital

Linköping, Sweden
Norrland University Hospital

Umeå, Sweden
Rigshospitalet

Copenhagen, Denmark
Sahlgrenska University Hospital

Gothenburg, Sweden
Skane University Hospital

Lund, Sweden
Skellefteå Hospital

Skellefteå, Sweden

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