Idiopathic disease

This Phase 1 trial tests the safety and how the body handles HRS-9813, an experimental oral drug for idiopathic pulmonary fibrosis (a lung-scarring disease). Healthy volunteers aged 18-45 take multiple doses to measure side effects and drug levels in the blood. The study does not…

This study compares different exercise programs for adolescents with idiopathic scoliosis who have undergone spinal fusion surgery. Participants are divided into three groups: one doing body awareness therapy plus core stabilization, one doing core stabilization alone, and a cont…

This study compares standard Schroth exercises with a virtual reality version of the same exercises in teens aged 10–15 with mild adolescent idiopathic scoliosis (curves of 10–30 degrees). The goal is to see if adding VR improves spinal alignment, trunk rotation, and mobility mor…

This study looked at whether tocilizumab, a drug already used for arthritis, can help people with a rare autoimmune lung condition called anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD) that hasn't responded to standard treatments. Researchers reviewed me…

This study tests an inhaled drug called AGMB-447 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. The main goal is to check safety and how the body processes the drug. 143 participants will receive either the drug or a pla…

This study looked at whether a program of core stabilization exercises could help teenagers who had surgery for scoliosis (a curved spine) have more balanced shoulders and shoulder blades. Twenty teens aged 10 to 18 who had spinal fusion surgery did the exercises and were tested …

This study looked at whether bosentan (Tracleer) can reduce the thickness of lung artery walls in people with a type of high blood pressure in the lungs (pulmonary arterial hypertension, or PAH). Eleven adults with PAH took bosentan for 6 months. Researchers measured artery wall …

This study tested an experimental drug called daxdilimab in 12 adults with dermatomyositis or anti-synthetase myositis that wasn't well controlled by standard treatments. The goal was to see if the drug could reduce disease activity and skin symptoms, and help lower steroid use o…

This study looked at whether adding virtual reality games to standard scoliosis exercises helps teenagers with curved spines. Twenty teens aged 10-15 with moderate scoliosis took part. Half did regular exercises, and the other half also played virtual reality games for balance an…

This study tested a new standing therapy device with a biofeedback mechanism in 32 children and adolescents aged 8-16 with idiopathic scoliosis. Participants used the device or received other therapies twice a week for six months. The main goal was to see if the device could redu…

This study tested an oral drug called GLPG3667 (Cadefrecitinib) in 40 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants took the drug or a placebo daily for 24 weeks to see if it improves symptoms. The trial is complete, and results w…

This study tested an experimental drug called GKT137831 in 58 people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. The drug aims to reduce lung damage caused by harmful molecules called reactive oxygen species. Researchers measured cha…

This Phase 3 trial tested whether an inhaled drug called treprostinil (Tyvaso) could slow the loss of lung function in 598 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease. Participants inhaled the drug or a placebo four times daily for 52 weeks. The ma…

This study tested a drug called luspatercept in 30 adults from China and Japan who have a bone marrow disorder (MDS) and need regular red blood cell transfusions. The goal was to see if the drug could help them go without transfusions for at least 8 weeks. The drug works by helpi…

This study tested whether specialized scoliosis exercises (PSSE-Schroth) are better than general strengthening exercises for teenagers with mild idiopathic scoliosis. Over 12 months, researchers measured changes in spine curvature and how many kids needed a brace. The goal is to …

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) works better than standard medications (Cymbalta or Lyrica) for fibromyalgia triggered by emotional trauma. 48 adults completed the trial, and researchers measured symptom improve…

This study tested the drug baricitinib, given with steroids, in 16 children aged 3-18 with newly diagnosed juvenile dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if baricitinib works better than the standard treatment (methotrexate p…

This study tested a two-step stem cell transplant for people with blood cancers like leukemia and lymphoma. First, patients received low-dose chemotherapy and radiation to prepare their bodies. Then, they got donor stem cells followed by drugs to prevent the donor cells from atta…

This early-phase study tested a purified green tea extract called EGCG in 50 people with idiopathic pulmonary fibrosis (IPF) who were already taking standard medications. The main goal was to check if EGCG is safe and how it interacts with their usual drugs. Participants took EGC…

This phase 2 trial tested an experimental tablet called HSK44459 in 186 adults with idiopathic pulmonary fibrosis (IPF), a progressive lung-scarring disease. Participants took one of three doses of the drug or a placebo twice daily for 12 weeks. The main goal was to see if the dr…

This study tested whether taking a probiotic called VSL#3, alongside standard treatment, can reduce disease activity in children with juvenile idiopathic arthritis (JIA). Fifty-one children aged 1 to 7 with specific types of JIA took either the probiotic or a placebo. Researchers…

This study looked at whether adding special breathing exercises (dynamic neuromuscular stabilization) to standard Schroth exercises helps teens with scoliosis. Twenty-six participants aged 10-18 with mild to moderate curves were enrolled. Researchers measured spine curvature, bre…

This study compared two procedures for treating achalasia, a condition where the esophagus doesn't relax properly. One is a balloon dilation (pneumodilation) and the other is a surgery called POEM done through a scope. 132 adults with achalasia were randomly assigned to one treat…

This study followed 302 children with juvenile idiopathic arthritis (JIA) who had previously taken tofacitinib in earlier studies. The goal was to see how safe the drug is over the long term, by tracking side effects, lab results, and growth. Children took tofacitinib twice daily…

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if taperi…

This study tested whether the antioxidant N-acetylcysteine (NAC) can slow lung decline in people with idiopathic pulmonary fibrosis (IPF) who have a specific gene variant (TOLLIP TT). Over 200 participants took NAC or a placebo for 24 months. The goal was to see if NAC delays wor…

This study tested a new cell therapy called REGEND001 for people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. The therapy uses special lung cells to try to repair damaged tissue. In this phase 2 trial, 23 participants received either the cell therapy or a pla…

This phase 2 trial tested an oral drug called povorcitinib in 136 adults with chronic spontaneous urticaria (hives and itching lasting months) that standard antihistamines couldn't control. Participants took either povorcitinib or a placebo for 12 weeks to see if the drug reduced…

This study tested whether adding whole-body vibration to a specific type of physiotherapy (Rigo Concept) improves spine curves, trunk rotation, and symmetry in girls with adolescent idiopathic scoliosis. Fifty girls took part in a 5-day program with daily 3-hour sessions. Some al…

This study tested a monthly dose of intravenous immunoglobulin (IVIG) for 6 months in 17 children aged 4–17 with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS), a condition marked by sudden, severe OCD or food refusal. Researchers measured changes in symptom severity and …

This study looked at two types of surgery for teens with scoliosis (a curved spine). One method, called vertebral body tethering (VBT), uses a flexible cord to straighten the spine while allowing more natural movement. The other, posterior spinal fusion (PSF), permanently fuses t…

This study tested a combination of plasma exchange, rituximab, and intravenous immunoglobulin in 82 people with a sudden, severe worsening of idiopathic pulmonary fibrosis (IPF). The goal was to see if this treatment could improve survival compared to usual care with antibiotics …

This study tested whether adding leflunomide to standard methotrexate treatment helps children with polyarticular juvenile idiopathic arthritis (JIA) that did not improve with methotrexate alone. Fifty children were randomly assigned to receive either the combination or methotrex…

This study tested whether adding nintedanib (OFEV) to standard immunosuppressant therapy can improve symptoms in people with myositis-associated interstitial lung disease, a condition where lung tissue becomes scarred and stiff. 49 adults in the U.S. participated, receiving eithe…

This study tests an experimental oral drug, BI 1819479, in 322 adults with idiopathic pulmonary fibrosis (IPF). Participants receive one of three doses or a placebo for 6 to 12 months. The main goal is to see if the drug can slow the yearly decline in lung function, measured by b…

This study tested a drug called anakinra in 24 children and young adults (ages 2-20) with severe systemic juvenile idiopathic arthritis that did not respond well to steroids. For the first month, half received anakinra and half received a placebo, then all received anakinra for 1…

This study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…

This study looked at 279 adults with worsening idiopathic pulmonary fibrosis (IPF), a serious lung disease. It compared taking two antifibrotic drugs together (pirfenidone and nintedanib) versus switching to the other single drug. The goal was to see which approach better slows l…

This Phase 2 trial tested an experimental drug called BMS-986278 in 403 adults with pulmonary fibrosis, a condition that causes lung scarring and breathing difficulty. The study compared the drug to a placebo to see if it could improve lung function and was safe. Results will hel…

This study tested whether a Chêneau spinal brace improves spine and leg alignment in 30 teens with adolescent idiopathic scoliosis. Participants wore the brace at least 18 hours daily, and researchers measured changes after 3 and 6 months using X-rays and other tests. The goal wa…

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study tested an experimental drug called MN-001 (tipelukast) in 15 people with moderate to severe idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Participants took either the drug or a placebo twice daily for six months, then everyone could take the drug for an…

This study tested whether adding rituximab (a drug that calms certain immune cells) to standard mycophenolate mofetil treatment helps people with interstitial lung disease whose lungs are not responding to initial therapy. 122 adults with various ILD types received either rituxim…

This early study tested whether injecting human umbilical cord stem cells into the lungs is safe for people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. Seventeen patients received different doses through a bronchoscope. The m…

This completed study compared two common surgeries for moderate nearsightedness: FemtoLasik and implantable collamer lens (ICL) implantation. Researchers looked at how stable the vision correction was, contrast sensitivity, and higher-order aberrations in 60 adults aged 21-40. Th…

This Phase 2 trial tested a new injectable drug called LP-003 in 202 adults with chronic spontaneous urticaria (long-lasting hives and itching) that standard antihistamines couldn't control. The study compared LP-003 to a placebo and to an existing drug (omalizumab) to see if it …

This study looks at the long-term safety and effectiveness of pitolisant in adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness. Participants had already completed a previous study. The goal is to see if pitolisant remains safe and helps control s…

This study tested an experimental oral drug called INS018_055 in 71 adults with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and makes breathing hard. The main goal was to see if the drug is safe and tolerable over 12 weeks compared to a placebo. Resea…

This phase 2a trial tested a drug called PLN-74809 in 10 people with idiopathic pulmonary fibrosis (IPF), a disease that causes progressive lung scarring. Participants took the drug or a placebo daily for 12 weeks. The study used a special PET/MRI scan to measure collagen (scar t…

This study compared two exercise programs—SEAS and BSPTS—for 30 teens with mild scoliosis (curves under 30 degrees). The goal was to see which approach better stops the curve from getting worse and improves posture and quality of life. Both methods use special exercises to streng…

This early-stage trial tested the safety and tolerability of a new drug called BI 1015550 (Nerandomilast) in 15 people with idiopathic pulmonary fibrosis (IPF). Participants took either the drug or a placebo twice daily for up to 12 weeks. The study aimed to see if the drug is sa…

This completed Phase 2 trial tested whether inhaling a green tea extract called EGCG could help cancer patients with moderate-to-severe COVID-19 pneumonia. 111 participants received either EGCG mist or a placebo three times daily for 7 days. The study looked at lung CT scan impro…

This study tested the drug dupilumab (Dupixent) in 15 children aged 2 to 12 who have chronic spontaneous urticaria (CSU), also known as long-lasting hives, that didn't get better with antihistamines. The main goals were to check how the drug behaves in the body and to see if it's…

This early-phase trial tested an experimental drug called PMG1015 in 29 people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. The main goal was to check the drug's safety and how the body processes it, not whether it works. Participants received either PMG1015…

This study tested the long-term safety and effectiveness of a drug called KZR-616 in 18 adults with active polymyositis or dermatomyositis, rare diseases that cause muscle inflammation and weakness. Participants who completed an earlier study received weekly injections of KZR-616…

This study tested a new drug, MIL62, in 94 adults with primary membranous nephropathy, a serious kidney condition. The goal was to see if MIL62 is safe and can help reduce protein in the urine better than the standard drug cyclosporine. Participants received either MIL62 or cyclo…

This Phase 2 trial tested a drug called KZR-616 (zetomipzomib) in 25 adults with active polymyositis or dermatomyositis, two rare diseases that cause muscle inflammation and weakness. Participants received either the drug or a placebo for 16 weeks, then switched to the other trea…

This study tested an intravenous drug called golimumab in 130 children with active juvenile idiopathic arthritis that did not improve with methotrexate. The main goal was to measure how the drug moves through the body over time. The study was completed and provides information on…

This study tested a mobile app called UrApp designed to help families manage childhood nephrotic syndrome, a chronic kidney disease. 58 caregivers of children with the condition were randomly assigned to use the app or receive standard care for one year. The goal was to see if th…

This study tested an oral drug called GRI-0621 in 35 adults with idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring and breathing difficulty. Participants took either the drug or a placebo daily for 12 weeks. The main goals were to check safety and m…

This large Phase 3 trial tested whether the drug BI 1015550 (nerandomilast) can help people with idiopathic pulmonary fibrosis (IPF), a serious lung disease that causes scarring and makes breathing hard. Over 1,100 adults aged 40 and older took either a low or high dose of the dr…

This study tested a drug called remibrutinib in 144 adults with chronic spontaneous urticaria (hives lasting over 6 months) that standard antihistamines couldn't control. Participants took a 25 mg tablet twice daily for up to 12 weeks. The main goal was to see if the drug affecte…

This study looked at the long-term safety and effectiveness of the drug secukinumab in children with two types of juvenile idiopathic arthritis: juvenile psoriatic arthritis and enthesitis related arthritis. Fifty-five children who had already completed a previous study continued…

This study tested an inhaled drug called ARO-MMP7 in healthy volunteers and people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs and makes breathing hard. The main goal was to check safety and how the body handles the drug. About 105 participants took p…

This completed Phase 3 trial tested whether TEV-45779, a biosimilar of the drug omalizumab (XOLAIR), works as well as the original for people with chronic hives that don't improve with antihistamines. 608 participants received either the biosimilar or XOLAIR. The main goal was to…

This Phase 2 study tested an experimental oral drug called TTI-101 in 100 people with idiopathic pulmonary fibrosis (IPF), a disease that causes lung scarring and breathing difficulty. Participants took either TTI-101 or a placebo daily for 12 weeks. The main goal was to check sa…

This study tested whether adding augmented reality (AR) to standard scoliosis exercises helps teenagers with mild to moderate curves. Thirty adolescents aged 10-18 did either regular Schroth exercises or AR-assisted versions for four weeks. Researchers measured body awareness, ho…

This early-stage study tested a new drug called HuL001 in 24 people, including healthy volunteers and patients with idiopathic pulmonary fibrosis (IPF), a lung scarring disease. The main goal was to check safety and how the body handles the drug. This is a first step to see if Hu…

This study reviews a modified transplant conditioning regimen for severe aplastic anemia in 72 patients across two hospitals. The approach uses a combination of fludarabine, melphalan, and cyclophosphamide to prepare the body for a stem cell transplant. Researchers looked at how …

This study tested a single dose of HLX6018, an experimental antibody, in 66 healthy adults to see if it is safe and how the body handles it. HLX6018 is designed to block a protein pathway involved in idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. Because thi…

This study looked at the long-term safety of the drug tocilizumab (Actemra) in 7 children with a type of arthritis called juvenile idiopathic arthritis. All children had already completed a previous study and continued to receive the drug every 4 weeks for up to 2 years. The main…

This study tested the drug adalimumab against a placebo in 34 children with juvenile arthritis and active eye inflammation (uveitis) that wasn't controlled by steroid drops or methotrexate. The goal was to see if adalimumab could reduce eye inflammation after two months. After th…

This study tested a new genetic screening approach to find cases of a rare inherited nerve disease called TTR-FAP in 130 patients with chronic neuropathy of unknown cause. The goal was to see how many of these patients actually have TTR-FAP, which is often missed due to varied sy…

This study looked at tiny molecules in the blood, called microRNAs, to see if they can help diagnose adolescent idiopathic scoliosis (AIS), a condition that causes a curved spine in teens. Researchers compared blood samples from 20 teens with AIS and 10 healthy teens to find diff…

This study tested whether a special lung MRI can replace CT scans for diagnosing idiopathic pulmonary fibrosis (IPF), a scarring lung disease. Researchers compared MRI to standard CT in 60 patients to see if MRI could spot the same key signs of IPF without using radiation. The go…

This study tested a new, noninvasive technique called magnetogastrogram (MGG) to measure the stomach's electrical activity without radiation. Researchers studied 22 people, including those with diabetes, gastroparesis, and other stomach conditions, to see if the test can tell nor…

This study examined whether the level of neutrophils, a type of white blood cell, in the blood can help predict how severe antisynthetase syndrome (ASyS) will be. ASyS is a rare autoimmune disease that can cause muscle inflammation, lung disease, and other symptoms. Researchers l…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This study tested the drug letermovir to prevent CMV infection in 15 adults who had a lung transplant for idiopathic pulmonary fibrosis (IPF). Participants took letermovir daily for 6 or 12 months depending on their CMV risk. The goal was to see if the drug could prevent CMV infe…

This study investigates whether adding dance-based exercises to standard scoliosis therapy improves physical fitness, body image, and quality of life in adolescents with mild scoliosis. Twenty-four teens aged 10–18 with a spinal curve between 10 and 30 degrees will be randomly as…

This study tests an experimental drug called EVO756 in 160 adults with moderate to severe chronic spontaneous urticaria (CSU), also known as chronic hives. Participants must have had hives for at least 3 months and not gotten enough relief from standard antihistamines. The goal i…

This study tests an oral drug called SDX (serdexmethylphenidate) to see if it safely reduces excessive daytime sleepiness in adults with idiopathic hypersomnia, a condition where people feel extremely sleepy during the day despite getting enough sleep at night. Participants will …

This study looked at whether scoliosis-specific corrective exercises, like the Schroth method, can improve physical fitness in teens with idiopathic scoliosis. Forty-two adolescents aged 10 to 19 with mild to moderate curves took part. They did either supervised exercises twice a…

This study tested whether an extended-release form of nalbuphine, a pain medication, can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF). 165 participants received either different doses of the drug or a placebo for 6 weeks. The main goal was to see if …

This study tested a 16-session web-based resistance training program for people with fibromyalgia. Researchers measured balance, muscle performance, and symptoms in 13 adults. The goal was to see if a home-based exercise program could improve physical function and ease fibromyalg…

This study tested a 24-session program for 100 adults with fibromyalgia. The program brings together nurses, doctors, physiotherapists, nutritionists, and mental health experts to teach self-management skills. Researchers measured quality of life, pain impact, and mood over 12 mo…

This study tested a one-year support program (JASP-1) for children newly diagnosed with juvenile idiopathic arthritis (JIA). The program included seven structured visits with a focus on the child and family. Researchers compared registry data from 56 children who took part in the…

This early-stage trial tested an experimental oral drug called BGB-16673 in 34 adults with chronic spontaneous urticaria (CSU), a condition causing persistent hives and itching. The study was double-blind and placebo-controlled, meaning neither patients nor doctors knew who got t…

This study tested two different exercise approaches in 34 people aged 11–24 with idiopathic scoliosis and chronic low back pain. Researchers measured changes in back muscle tissue thickness, pain levels, and daily function. The goal was to see which exercise method works better f…

This study looked at whether giving extra oxygen (40%) during exercise helps people with idiopathic pulmonary fibrosis (IPF) who do not have low oxygen at rest but do get low oxygen when active. Fifteen stable IPF patients completed exercise tests while breathing either oxygen or…

This study looked at whether adding a gentle electrical nerve stimulation (TENS) to cognitive behavior therapy (CBT) and standard medicines could reduce pain and improve quality of life in 60 postmenopausal women with fibromyalgia. Participants were split into three groups: one r…

This study tested whether sound therapy using weighted tuning forks, combined with relaxation, could reduce pain in women with fibromyalgia. Forty women aged 30 to 60 took part, attending three weekly sessions. Researchers compared pain levels before and after sessions between th…

This study tested whether giving teens extra doses of the steroid dexamethasone after scoliosis surgery could reduce inflammation, pain, nausea, and hospital stay. Forty-two adolescents with scoliosis were randomly assigned to receive either one standard dose or three extra doses…

This study tested whether a short posture training program could reduce back pain and improve body posture in middle school students. 27 students with poor posture took part in three training sessions. Researchers measured pain and posture before, right after, and at 1 and 3 mont…

This study looked at how the brain processes pain in people with fibromyalgia compared to healthy individuals. Researchers tested whether a non-invasive procedure called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate the brain, could reduce pain …

This study compares core stabilization exercises to a daily physical activity program in children aged 10-18 with juvenile spondyloarthropathy, a type of arthritis. The goal is to see if targeted core training can reduce pain, fatigue, and improve quality of life better than gene…

This study tested whether a non-invasive, FDA-approved device called cranial electrical stimulation (CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans received either real CES or a placebo treatment for several weeks. Researchers used brain scans and pain…

This study tested whether doing exercise in a virtual reality headset can improve quality of life, thinking, and mood in people with fibromyalgia. Thirty adults with fibromyalgia took part in a crossover trial where everyone tried both virtual reality exercise and regular exercis…

This study looked at whether classical massage can reduce pain and improve daily function in people with myofascial pain syndrome, a condition that causes muscle knots and radiating pain. Sixty adults aged 30–50 with active trigger points in the upper back took part. Researchers …

This study looked at whether breathing 60% oxygen during exercise helps people with idiopathic pulmonary fibrosis (IPF) who are taking nintedanib. 78 participants exercised on a bike or walked while getting either high oxygen or standard care. The goal was to see if they could ex…

This study tested whether a home-based balance therapy program is practical for children aged 4-17 with inner-ear problems that cause dizziness and balance issues. Twenty-one children did balance exercises at home for 8 weeks, with weekly check-ins from a physical therapist. The …

This study looked at whether aerobic dance exercises can improve symptoms and quality of life in women with fibromyalgia. Forty-four women were split into two groups: one did aerobic dance sessions led by a physiotherapist, and the other did standard postural exercises. Researche…

This study followed 18 people in Spain with idiopathic pulmonary fibrosis (IPF) or other progressive lung scarring who were taking nintedanib (OFEV) and had developed diarrhea. The goal was to see if the diarrhea could be controlled after 12 weeks while staying on the full dose. …

This study tested whether a daily probiotic supplement could reduce pain, fatigue, and cognitive issues in women with fibromyalgia. 97 participants took either a multi-strain probiotic or a placebo for 12 weeks. Researchers measured changes in pain, sleep, mood, and quality of li…

This study tested whether a combination of two exercise methods (proprioceptive neuromuscular facilitation and spiral muscle chain training) can improve posture, spinal flexibility, and back muscle endurance in teenagers aged 13 to 18 with spinal curvature issues like scoliosis o…

This study tested a once-nightly extended-release form of sodium oxybate (FT218) in 157 adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness despite adequate sleep. Participants were already on stable doses of stimulants or other alerting agents. T…

This study tested whether stimulating a nerve in the ear (taVNS) can help people with fibromyalgia feel better and exercise more. 90 adults with fibromyalgia were split into three groups: one-sided stimulation, both ears, or just a home exercise program. Over two weeks, researche…

This study tested whether a digital sleep therapy program called Sleepio can improve quality of life, sleep, and thinking in people with fibromyalgia. 80 participants were randomly assigned to use Sleepio or receive standard sleep advice. Researchers measured changes in symptoms …

This study tested whether low-dose morphine can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a lung-scarring disease. Forty-four participants received either morphine or a placebo for two weeks, then switched after a week off. The goal was to see if…

This study looked at whether taking creatine and coenzyme Q10 supplements, along with exercise, could help children with juvenile myositis (a disease that causes muscle weakness and fatigue). Fifteen children aged 7 to 18 took part. The goal was to see if these supplements could …

This study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could reduce pain and improve quality of life in people with fibromyalgia, compared to standard medications like Cymbalta or Lyrica. Seventy-six adults with fibromyalgia and a his…

This completed study tested whether hyperbaric oxygen therapy (HBOT) combined with creative art psychotherapy can help women with fibromyalgia who have a history of psychological trauma. Thirty women received 60 sessions of HBOT plus psychotherapy. Researchers measured pain sensi…

This study looked at whether Schroth exercises, a special type of physical therapy, can help teenagers with scoliosis. 30 teens with mild to moderate curves took part. Researchers measured muscle strength, balance, breathing, and quality of life before and after the exercise prog…

This study tested whether personalized health coaching can improve daily life for Veterans suffering from long-term pain and related symptoms. Researchers enrolled 260 Veterans with chronic multisymptom illness (like fibromyalgia) and measured changes in pain and disability. The …

This study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …

This study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…

This study tested a new drug called naronapride in 328 adults with moderate to severe gastroparesis (stomach paralysis). Participants took either 10, 20, or 40 mg of the drug or a placebo daily for 12 weeks. The goal was to see if the drug could reduce symptoms like nausea, vomit…

This study looked at whether adding dexmedetomidine to a standard nerve block (ESPB) can improve pain control after scoliosis surgery in children aged 10 to 18. The main goal was to see how long it took before patients needed opioid pain medicine. The study enrolled 60 teens and …

This study looked at whether a combination of scoliosis-specific exercises and strength training for arms and legs could improve muscle thickness, flexibility, and lung function in teens with mild scoliosis. Twenty-four adolescents aged 12 to 18 with a spinal curve between 10 and…

This study tested whether a slow, gentle back massage can help women with fibromyalgia feel less pain and fatigue. 48 women took part, receiving 30-minute massages three times a week. The goal was to see if this simple, drug-free approach could improve daily comfort.

This study tested whether playing virtual reality exercise games (like Kinect Sports) for 30 minutes twice a week over 6 weeks helps teens recover after spinal fusion surgery for scoliosis. Researchers measured fear of movement, breathing strength, spine flexibility, and quality …

This study tested two different exercise programs in 28 children and teens with rheumatic diseases like juvenile arthritis and familial Mediterranean fever. One program used external focus (thinking about the movement's effect), the other used internal focus (thinking about the b…

This study looked at whether indoor physical activity can improve symptoms in people with both fibromyalgia and irritable bowel syndrome (IBS). Researchers measured changes in gut and pain symptoms, intestinal health, and psychological well-being in 165 participants. The goal was…

This study tested two treatments for vestibulodynia, a chronic pain condition affecting the vulvar area. 209 women received either a lidocaine/estradiol cream, the antidepressant nortriptyline, both, or a placebo. The goal was to see which approach best reduces pain and improves …

This study compared two ways to fix a tight upper lip frenulum (lip-tie): using a scalpel or a diode laser. Some patients also got low-level laser therapy after surgery to help healing. The trial measured pain, speech, chewing, and quality of life in 94 adults. Results may help d…

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested whether adding a gentle manual therapy called strain counterstrain to standard physiotherapy helps women with fibromyalgia feel better. 105 women were split into three groups: one got standard care, another got standard care plus the therapy, and a control group…

This study tested whether Klapp method exercises could help breastfeeding mothers with a hunched back (kyphosis) feel less pain and stand taller. Thirty-two mothers who had given birth by C-section and were nursing did either the Klapp exercises twice a week for a month or follow…

This study tested an 8-week online mindfulness-based stress reduction program in 94 adults with fibromyalgia. Participants were randomly assigned to the online program or usual care. The goal was to see if the program could reduce pain catastrophizing and improve daily function.

This study tested a self-management program for jaw muscle pain in 107 adults with fibromyalgia. The program included online sessions on pain education, jaw exercises, and self-massage. Researchers measured changes in quality of life, pain, and fear of movement over 12 months. Th…

This study tested whether different types of sounds (natural, city, broadband, or silence) can help improve mood, stress, and anxiety in people with fibromyalgia. 72 adults with fibromyalgia listened to each sound for 20 minutes during four weekly visits. Researchers measured cha…

This study looked at how intravenous lidocaine affects sleep and quality of life in 51 people with fibromyalgia who still had pain and sleep problems despite other treatments. Researchers measured pain, sleep quality, and overall impact of the condition. The goal was to see if th…

This study looked at whether an 8-week foot exercise program could help people with fibromyalgia who have foot pain. 27 adults with fibromyalgia took part. The program focused on strengthening the small muscles in the feet. Researchers measured changes in foot pain, function, and…

This study looked at whether Xolair (omalizumab) is safe and works for Chinese teenagers with chronic spontaneous urticaria (long-term hives and itching) that doesn't get better with standard antihistamines. 55 teens took part, receiving Xolair for 12 weeks, followed by 4 weeks o…

This study tested a mobile app called SurgeryPal that teaches teens coping skills before and after major spine surgery. 433 teens aged 12-18 were randomly assigned to use the app or receive standard education. The goal was to see if the app could reduce pain and prevent pain from…

This study tested two pain relief methods after scoliosis surgery: a nerve block called MTP and morphine injected into the spine. Forty adults having scoliosis surgery took part. The goal was to see which method controls pain better in the first 24 hours after surgery.

This completed pilot study tested whether a smartphone app teaching mindfulness could help people with fibromyalgia. Fifty-four adults used the app daily for pain tracking and weekly for mindfulness lessons, while a control group only tracked symptoms. The goal was to see if the …

This study tested two different antihistamine treatments in 60 adults with chronic hives (itchy welts that keep coming back). One group took a higher dose of bilastine, the other took a mix of bilastine and levocetirizine. The goal was to see which approach better reduces itching…

This study looked at whether an antidepressant, physical therapy, or a combination of both can help people with chronic low back pain who also struggle with negative feelings. About 308 adults aged 18-75 with pain lasting over 6 months took part. The goal was to see if these trea…

This study tested whether adding home-based posture exercises to regular medication could improve pain and mobility in 55 adults with fibromyalgia. Participants did exercises at home while continuing their usual drugs. Researchers measured pain threshold, spinal flexibility, anxi…

This study tested a smartphone app designed to help people with fibromyalgia manage their condition. Researchers wanted to see if the app was easy to use and helpful. The study included 36 adults with fibromyalgia who used the app to track their symptoms and learn coping strategi…

This study tested a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve, which helps control pain and stress. Thirty adults with fibromyalgia received either real or sham stimulation for 30 minutes daily, five days a week, over four weeks…

This study tested whether an ultrasound-guided nerve block injection (stellate ganglion block) could help people with fibromyalgia who still have symptoms despite taking duloxetine. 68 adults received either the active injection or a sham (fake) injection, and researchers measure…

This study tested a drug called ligelizumab in 49 teenagers aged 12 to 17 who had chronic hives (itchy welts) that didn't get better with standard allergy pills. The goal was to see if adding ligelizumab to their current treatment could reduce the number and severity of hives. Pa…

This study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain in women with fibromyalgia. 100 women received either real or sham (fake) stimulation to see if the placebo effect plays a role. The goal is to find out who might benefit most from th…

This study looked at whether specific scoliosis exercises could improve back muscle thickness and quality of life in 70 teenagers with adolescent idiopathic scoliosis. One group did scoliosis-specific exercises, while the other did leg exercises, both for 12 weeks with a physioth…

This completed study tested whether a non-invasive brain stimulation technique called tDCS can reduce pain and improve daily function in 100 women with fibromyalgia. Researchers also looked at how a person's tendency to respond to placebo might affect results. Participants receiv…

This study tested a device called ANI that measures pain during surgery in children having scoliosis correction. The goal was to see if using this monitor to guide pain medicine during surgery would lower the amount of morphine needed in the first 24 hours after surgery. The stud…

This study tested whether a medicine called Panzyga (given through a vein) can reduce obsessive-compulsive symptoms in children aged 6 to 17 with a condition called PANS or PANDAS. These children experience a sudden, severe onset of OCD and other neuropsychiatric problems. The st…

This study looked at whether 8 weeks of strength training could improve balance, muscle performance, and symptoms in 57 adults with fibromyalgia. Participants did 16 sessions of 50-minute strength exercises twice a week. Researchers measured balance, jumping ability, and upper bo…

This study tested whether an ultrasound-guided nerve block (ESP block) given before spinal surgery for scoliosis can lower pain and the need for strong painkillers after the operation. Eleven teenagers took part, with half receiving the block plus general anesthesia and half rece…

This study tested whether a personalized exercise program can improve daily function and quality of life for people with dermatomyositis or polymyositis, two rare diseases that cause muscle weakness and inflammation. 80 adults with stable muscle impairment took part. The program …

This study tested whether injecting botulinum toxin (like Botox) into the lower esophagus can ease symptoms of nutcracker esophagus, a condition that causes chest pain and trouble swallowing. Twenty-four adults received either the toxin or a placebo in a double-blind setup. The m…

This study tested whether adding a gentle brain stimulation technique called rTMS to standard exercise therapy could reduce pain in people with fibromyalgia. Forty-two adults with long-term pain took part, receiving either real or fake rTMS alongside exercise for 14 weeks. Resear…

This study tested whether combining a gentle brain stimulation technique called tDCS with aerobic exercise could improve the body's natural pain control system in people with fibromyalgia. 116 adults with fibromyalgia received either active or sham tDCS along with exercise or a c…

This study tested whether adding telerehabilitation (remote coaching) to home exercises helps teens with mild scoliosis more than standard home exercises alone. Twenty-nine adolescents aged 10-18 with mild curves participated. Researchers measured posture, pain, body image, and q…

This study tested whether Pilates or core stability exercises better ease fibromyalgia symptoms like pain and balance. Thirty women aged 35-65 with fibromyalgia took part. Researchers used objective tests (pain sensitivity, balance) instead of just questionnaires to compare the t…

This study looked at whether adding dexamethasone to a nerve block (erector spinae plane block) can improve pain control after scoliosis surgery in children aged 10 to 18. Sixty children were randomly assigned to receive either the nerve block with dexamethasone or with a placebo…

This study looked at whether kinesiotaping (a special elastic tape) can immediately reduce pain, improve body awareness, and fix posture in people with rounded shoulders and shoulder impingement. 114 adults with neck pain took part. Researchers measured pain, posture, and joint p…

This study tested whether relaxation therapy can reduce chronic pain and improve daily life in people with fibromyalgia. Eighty adults with fibromyalgia were randomly assigned to either active relaxation sessions with a therapist or to relax alone in a quiet room (placebo) for 12…

This study tested whether different types of sounds—like birdsong, traffic noise, or white noise—can reduce pain in people with fibromyalgia, a condition causing widespread pain. 88 adults with fibromyalgia listened to four different sound environments for 20 minutes each, one we…

This study tested whether adding virtual reality to standard physiotherapy could help teenagers with chronic musculoskeletal pain. 34 teens aged 10-17 took part in up to 8 sessions over 6-12 weeks. The goal was to see if VR was practical and enjoyable, and whether it could improv…

This study tested a drug called orvepitant to see if it can reduce chronic coughing in people with idiopathic pulmonary fibrosis (IPF), a serious lung disease. About 80 adults with IPF and persistent cough took either orvepitant or a placebo in two separate periods, and researche…

This study tested whether a daily pill called ASP8062 can reduce pain and improve daily life for people with fibromyalgia. 183 adults took either the drug or a placebo for 8 weeks. Researchers measured pain scores, side effects, and overall well-being. The trial is now complete, …

This study looked at whether adding a TENS device (which uses mild electrical pulses) to regular physical therapy helps reduce pain during movement in people with fibromyalgia. Over 450 adults with fibromyalgia took part. Researchers measured pain levels and other symptoms to see…

This study tested a pure cannabidiol (CBD) solution called CardiolRx in 27 adults with recurrent pericarditis, a condition causing repeated inflammation and pain around the heart. Participants had not responded well to standard treatments or needed long-term steroids. The goal wa…

This study compared two stretching techniques—Proprioceptive Neuromuscular Facilitation (PNF) and Passive Stretching—in 28 people with mild scoliosis (ages 14-65). The goal was to see which method better improves head position and spine endurance. Participants did exercises and h…

This study tested a 12-week home exercise program for women with fibromyalgia. Sixty participants were randomly assigned to exercise or a control group. Researchers measured changes in pain, fatigue, quality of life, and mood. The goal was to see if a structured, at-home routine …

This study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…

This study tested whether giving teens extra education and coping skills through a smartphone app could help them manage pain and recover faster after scoliosis surgery. Forty adolescents aged 11 to 18 took part. The app provided videos on what to expect and how to cope, aiming t…

This study tested whether cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in women with fibromyalgia. 131 women with both conditions received either CBT-I or sleep hygiene education. Researchers measured sleep quality, pain sensitivity, and bra…

This study tested a new approach for chronic low-back pain and fibromyalgia in 48 adults. Participants received pain education plus propranolol (a blood pressure drug) to help the brain 'relearn' and reduce pain. The goal was to see if the treatment is feasible and acceptable, an…

This study tested whether using virtual reality (VR) before physical therapy sessions could help teens aged 13-18 feel less pain and need fewer opioids after scoliosis surgery. Twenty participants were split into two groups: one received VR sessions before therapy, the other did …

This study tested whether phone calls from a nurse could help people with fibromyalgia feel less pain and be more active. 44 adults were split into two groups: one got standard care, the other also received an educational booklet and three phone calls over 4 weeks covering exerci…

This study looked at 38 people with achalasia cardia, a condition where the esophagus muscle doesn't relax, making swallowing difficult. Half had laparoscopic (minimally invasive) surgery and half had open surgery. Researchers measured symptoms and quality of life before and afte…

This study tested a cognitive exercise therapy approach called BETY in 52 children with juvenile idiopathic arthritis (JIA). The program combines exercises, pain management, and group activities to improve physical function and social well-being. Researchers compared it to a home…

This study tested two exercise programs for teenagers with juvenile idiopathic arthritis (JIA): one supervised by a physiotherapist and one delivered through a personalized mobile app. Fifty-four participants aged 12-18 were split into two groups and followed for 12 weeks. The go…

This study tested whether a special suit called EXOPULSE Mollii can help adults with fibromyalgia feel less pain, fatigue, and depression. Twenty-eight participants wore either the active suit or a sham (fake) suit for two weeks, then had a washout period. After that, everyone co…

This study looked at whether 6 weeks of osteopathic treatment (gentle hands-on manipulation) could reduce pain in people with fibromyalgia. 101 adults with long-term fibromyalgia took part, comparing real osteopathy sessions to fake ones. The main goal was to track pain levels we…

This completed study tested whether adding cognitive behavior therapy (CBT) to standard physiotherapy helps adults with fibromyalgia feel less pain and have a better quality of life. 66 people took part, with one group doing gentle exercises and the other doing exercises plus CBT…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study follows 31 people with progressive fibrosing interstitial lung disease (PF-ILD) for one year. Researchers compare imaging scans (CT and MRI) with standard breathing tests to see which method best tracks lung damage over time. The goal is to find better ways to measure …

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study investigates whether a portable, affordable hand dynamometer can reliably measure trunk muscle strength in adolescents with idiopathic scoliosis. Researchers will test the device on 41 teens aged 10-18, comparing results between two evaluators and across two sessions o…

This study aims to understand why people experience pain differently and whether the body's natural ability to manage pain can be improved through training, similar to athletic performance. Researchers will enroll 180 adults, including those with widespread muscle pain and those …

This completed study examined 22 adolescents with idiopathic scoliosis to see if joint hypermobility (flexibility) and foot posture are linked to the severity of their spinal curve. Researchers measured hypermobility with the Beighton Score, foot posture with the Foot Posture Ind…

This study looked at 20 teens with scoliosis (a curved spine) to see if the position of their shoulder blades is linked to how well they can use their arms. Researchers measured shoulder blade movement and arm power using simple tests like throwing a weighted ball. The goal is to…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

This study looked at 275 adults with a lung condition called bronchiectasis, where airways are stretched and trap mucus, leading to infections. The goal was to learn more about the physical traits, lung scans, and germs in the lungs of people with the unexplained form of the dise…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This early-stage study tests a new oral drug called HRS-3095 in 66 healthy adults aged 18-55. The main goal is to check safety and how the body processes the drug, not to treat any disease. Results will help design future studies for chronic spontaneous urticaria (long-term hives…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study follows 87 women who had chronic low back pain 13 years ago to see how their pain, daily activities, and ability to work have changed. Researchers are looking for patterns that might predict who will improve or worsen over time. The goal is to better understand the lon…

This study looked at whether certain genes make people who are regularly around pigeons more likely to develop a type of lung disease called hypersensitivity pneumonitis. Researchers analyzed the DNA of 475 pigeon fanciers to find genetic markers linked to lung scarring. The goal…

This study looked at how teenagers with scoliosis sense and imagine their own bodies compared to healthy teens. Researchers tested touch sensitivity, left-right thinking, and body position awareness. The goal was to better understand how the brain might be involved in scoliosis, …

This study checks if a new balance assessment system gives consistent results in teenagers with scoliosis. Forty participants aged 12-18 with mild to moderate curves will perform balance tests twice, one week apart. The goal is to see if the tool is reliable for measuring postura…

This study looked at how a new drug called HEC585 interacts with two existing medicines for idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. Thirty-three healthy adults took part to measure drug levels and safety. The goal was to see if combining these drugs cause…

This study looked at whether hip X-rays can help doctors measure how much growing a teenager with scoliosis has left. Researchers examined 70 patients and graded the closure of the growth plate in the hip bone. The goal was to see if this method is reliable and easy to use in cli…

This study looked at how dental students hold their bodies while doing root canal work. Ten students were recorded on video for 5 minutes, and their posture and muscle fatigue were analyzed. The goal was to understand how their working positions might lead to pain or injury. This…

This completed pilot study looked at how lifestyle factors like diet, physical activity, sleep, stress, smoking, and alcohol use relate to pain sensitivity in 20 women with fibromyalgia. Participants wore a Fitbit, logged food, completed questionnaires, and had pain sensitivity t…

This study tested whether sending text messages to new mothers could help them follow recommended safe sleep practices and increase breastfeeding rates. Over 2,000 pregnant women and new moms from WIC centers took part. The approach used mobile health technology to deliver simple…

This study tested whether a new type of PET scan can measure how the supplement EGCG (found in green tea) affects collagen buildup in the lungs of people with idiopathic pulmonary fibrosis (IPF). Twelve participants who were already in a larger EGCG study received an injection of…

This completed study in France tracked over 10,000 people with idiopathic pulmonary fibrosis to see how long they continued taking antifibrotic drugs (nintedanib or pirfenidone). The goal was to measure the percentage still on treatment after 30 months and identify factors linked…

This completed study involved 280 people with various types of scoliosis. Researchers created a registry to collect data on brace treatments, with the goal of developing better, evidence-based guidelines for when and how to use braces. The study did not test a new treatment but f…

This study looked at whether levels of certain minerals (like selenium, magnesium, and zinc) in the blood are different in women with fibromyalgia compared to healthy women. It also checked if those mineral levels are linked to how severe the disease is, or to anxiety and depress…

This completed study examined whether fibromyalgia, a condition causing widespread pain, is linked to changes in eye blood vessels. Researchers compared 80 people with and without fibromyalgia using eye scans and symptom questionnaires. The goal was to see if nerve system problem…

This study followed 51 people with idiopathic pulmonary fibrosis (IPF) for 6 months to understand how their shortness of breath changes over time. Researchers measured both the physical sensation and the emotional impact of breathlessness, and looked at how these relate to lung f…

This study looked at 47 people with a rare condition called idiopathic CD4 lymphocytopenia, where the body has too few CD4 immune cells. Researchers collected blood samples and genetic data to understand what causes the condition and how it affects patients. The goal was to impro…

This study looked at how having fibromyalgia changes body measurements and sleep patterns in people with obstructive sleep apnea. Researchers measured neck, waist, and hip sizes, and used sleep tests and ultrasound to compare 77 participants. The goal was to better understand the…

This study looked at 65 people with fibromyalgia to figure out what kind of pain they have—nerve pain, tissue pain, or a mixed type. Researchers used a special checklist and simple tests like brushing the skin or pressing with a tool. The goal is to help doctors choose better tre…

This study looked at how the lungs move chloride, sodium, and bicarbonate in 42 patients with idiopathic bronchiectasis (widened airways of unknown cause). Researchers measured electrical signals in the airway lining during bronchoscopy and took nasal and bronchial samples. The g…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This study looked at whether people with fibromyalgia have early, hidden changes in heart function. Researchers used a special ultrasound technique called Global Longitudinal Strain (GLS) to measure heart muscle movement in 59 fibromyalgia patients and 59 healthy volunteers. The …

This completed lab study took blood samples from 20 adults with relapsed membranous nephropathy, a kidney condition. Researchers tested different immune-modulating drugs on the blood cells to see how they affect the balance of Th17 and Treg immune cells. The goal is to find which…

This study looked at a new way to measure muscle function in people with inflammatory myopathies (diseases that cause muscle weakness). Researchers compared a simple test called the Myositis Functional Index-3 with advanced computerised muscle testing. They also tested whether a …

This study looked at 420 people aged 80 and older to find out how many have fibromyalgia, a condition that causes widespread pain and fatigue. Researchers used standard medical criteria to diagnose fibromyalgia and also checked participants' memory, thinking, and overall health. …

People with achalasia, a swallowing disorder, have a much higher risk of developing esophageal cancer. This study tested whether spraying a special dye (Lugol) during an endoscopy could help doctors find early signs of cancer (dysplasia) in 39 patients who had achalasia for over …

This study tested a new thumb bone staging system (TOCI) to predict skeletal maturity and curve progression in 1,500 teens with idiopathic scoliosis. Researchers evaluated thumb X-rays to see if the simple index could replace complex methods like the Risser sign or Greulich-Pyle …

This pilot study tested whether a transition coach can help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult care. The coach met with each teen for 8 one-hour sessions covering self-advocacy, medication management, and …

This study tested a website designed to help teenagers with narcolepsy or idiopathic hypersomnia and their families understand and improve social relationships. Twenty-five teens and their parents reviewed the website's content, which included animations, patient stories, and exp…

This study looked at 195 adults with achalasia, a rare condition that makes it hard to swallow. Researchers checked if certain antibodies in the blood are linked to how severe the disease is and how well patients respond to a treatment called POEM. The goal was to see if these an…

This study tested a simple questionnaire to help match newly diagnosed idiopathic pulmonary fibrosis (IPF) patients to the right level of palliative care. Researchers asked 30 patients a few questions to see if the tool could predict their needs as accurately as a doctor's judgme…

This study looked at 21 adults with idiopathic pulmonary fibrosis (IPF) to see how a simple arm test (the 6-minute pegboard and ring test) relates to their exercise ability, fatigue, daily activities, and quality of life. Participants performed several physical tests, including w…

This completed study looked at how psychological resilience and body image relate to pain in people with rheumatoid arthritis or fibromyalgia, compared to healthy volunteers. Researchers measured these factors using questionnaires in 124 adults. The goal was to better understand …

This study looked at immune cells (T and B cells) in the blood of 44 people with a kidney disease called membranous nephropathy. Researchers wanted to see how these cells relate to treatment response and disease relapse. They also measured specific antibodies linked to the diseas…

This completed study looked at 128 women to see if those with fibromyalgia also have more chronic pelvic pain and pelvic floor problems. Researchers used pain questionnaires to compare the two groups. The goal was to better understand how these conditions might be related, not to…

This study looked at whether a mobile app (Biotonix Posture Assistant) can accurately measure spine curves in teenage girls with scoliosis, compared to standard X-rays. Thirty girls aged 14-17 with moderate scoliosis had one posture check using the app and one spinal X-ray. The g…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study looked at 78 teens with adolescent idiopathic scoliosis to see if the size of their spinal curve (Cobb angle) is linked to how much pain they feel and how they see their body. Participants were grouped by curve severity (mild, moderate, moderate-to-severe). Researchers…

This study looked at whether teens with idiopathic scoliosis (a spine curve) have different pelvic floor muscle activity compared to healthy teens. Researchers measured muscle activation using a special device and also checked quality of life. The goal was to better understand ho…

This completed study looked at blood samples from 66 women to find differences in small molecules (metabolites) between those with fibromyalgia, those with both fibromyalgia and possible sarcopenia (muscle loss), and healthy women. The goal was to identify potential biomarkers th…

This completed study from Turkey examined vitamin B12 and folic acid levels in 104 fibromyalgia patients before and after they started antiepileptic treatment. Researchers wanted to see if these drugs, already known to lower B12 and folate in epilepsy patients, have the same effe…

This study looked at how back muscles work in 25 teenagers with mild to moderate scoliosis (15-40 degree curves). Researchers used ultrasound to measure muscle thickness at rest and during exercise, both with and without special corrections based on the Schroth method. The goal w…

This study measured two newer blood markers (calprotectin and serum amyloid protein) alongside standard tests in 20 children with juvenile arthritis and related conditions. The goal was to see if these markers could better track disease flare-ups in everyday clinic visits. The st…

This completed study looked at 164 women with and without fibromyalgia to see if certain autoantibodies are linked to more severe symptoms. Researchers compared patients with high and low antibody levels, and healthy controls, using questionnaires, blood tests, skin biopsies, and…

This completed Phase 1 trial studied how deupirfenidone (LYT-100) and nintedanib interact in 24 healthy adults aged 18-65. Participants took both drugs over several weeks to measure drug levels and check for side effects. The goal was to understand potential drug-drug interaction…

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This study aimed to uncover what factors most affect functional capacity—like walking, standing, and daily tasks—in people with fibromyalgia. Researchers assessed 42 adults using physical tests, pain and fatigue scales, posture analysis, sleep quality, and psychological questionn…

This study looked at whether a 25-minute or 45-minute nap helps teenage soccer players run faster and feel less tired. Sixteen male players tried both nap lengths and a no-nap day. Results showed that napping improved agility and made exercise feel easier, but did not help them k…

This completed study looked at 151 children with common postural conditions like flat feet, knock knees, or scoliosis. Researchers used wearable motion sensors and clinical tests to measure balance and motor control, then compared the results to healthy children. The goal was to …

This study looked at how often doctors increase the dose or give Xolair more frequently for people with chronic hives. Researchers followed 163 adults for 3 months to see how many needed a stronger treatment plan. The goal was to understand real-world use, not to test a new drug.

This study looked at 250 people to understand why some smokers develop a rare lung condition called combined pulmonary fibrosis and emphysema (CPFE). Researchers compared telomere length and genetic mutations in patients with CPFE, those with only fibrosis or emphysema, and healt…

This observational study looked at how performing two tasks at once (like walking while carrying a tray) affects teenagers with scoliosis compared to healthy teens. Researchers measured timing and upper limb function to see if scoliosis impacts multitasking ability. The goal is t…

This study tested the safety and tolerability of a new biologic drug called LP-003 in 60 healthy volunteers. The drug is being developed for chronic spontaneous urticaria (long-lasting hives). The trial gave single or multiple doses of LP-003 or a placebo by IV to see how the bod…

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study looked at how many women with fibromyalgia at a pain clinic might have iron deficiency. 81 women completed a questionnaire about symptoms like heavy periods and past iron issues. The goal was to see if iron deficiency is common and if treating it could help their pain.

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This study looked at whether a 3D body scanner (surface topography) can measure scoliosis curves as accurately as standard X-rays in children aged 10-13. The goal is to reduce the need for repeated X-rays, which expose young patients to radiation. Researchers compared the two met…

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This study looked at how people with cervical or myoclonus dystonia perceive their own actions, known as the 'sense of agency.' Researchers used computer tasks and brain scans to measure how accurately participants felt in control of their movements. The goal was to link these fe…

This completed study reviewed the medical charts of 32 people with Still's disease who developed a serious complication called macrophage activation syndrome (MAS). The goal was to learn more about their symptoms, how long it took for lab values to return to normal, and what trea…

This study looked at whether a device that delivers rapid puffs of air (intrapulmonary percussive ventilation) can help inhaled medication reach scarred lung areas in people with idiopathic pulmonary fibrosis (IPF). Nine participants inhaled a radioactive tracer with and without …

This completed study looked at how smartphone addiction affects neck posture, muscle strength, and movement in 86 healthy young adults aged 18-30. Researchers measured neck muscle strength, range of motion, and posture, and compared results between men and women. The goal was to …

This study looked at 173 adults with fibromyalgia to see if doomscrolling—constantly reading negative news online—and social media addiction are linked to worse symptoms. Participants completed surveys about their social media habits, fear of missing out, and fibromyalgia-related…

This completed study looked at 126 children with juvenile idiopathic arthritis to find the best dose of the drug etanercept. Researchers measured drug levels in the blood and checked how well the disease was controlled. The goal is to help doctors give each child the right amount…

This study tested whether problems with brain cells that control movement cause fatigue in fibromyalgia. Researchers compared 37 women (some with fibromyalgia, some healthy) by measuring muscle signals during foot exercises, including when they were cheered on. The goal was to se…

This completed study tested deep brain stimulation (DBS) in the cerebellum's dentate nucleus to treat movement disorders like tremor, dystonia, and ataxia. Researchers used advanced MRI and electrical recordings to guide electrode placement in 20 adults. The goal was to see if th…

This study looked at how Schroth exercises, a special type of physical therapy for scoliosis, affect brain structure and body awareness in teenage girls with mild scoliosis. Researchers compared Schroth exercises to traditional exercises using brain scans and sensation tests. The…

This study followed 158 adults with chronic fibrosing interstitial lung disease (a type of progressive lung scarring) who were starting treatment with nintedanib. Researchers wanted to see if changes in lung function (measured by forced vital capacity) over 52 weeks were linked t…

This study looks at how the brains of fibromyalgia patients and their acupuncturists work together during electroacupuncture treatment. Using special MRI scans that record both people at once, researchers hope to see if matching brain activity leads to better pain relief. The goa…

This study involved 39 adults and children with autoinflammatory diseases like FMF and Still's disease. Researchers conducted interviews to understand how these conditions affect quality of life. The goal was to create a tool that doctors can use to better assess and address pati…

This early-stage study looked at whether people with pulmonary arterial hypertension (PAH) have low carnitine levels and if taking carnitine supplements could help. Ten adults with PAH kept food diaries and had blood tests to measure carnitine. The goal was to gather information …

This study looked at how different types of touch, like those used in massage, affect pain in people with fibromyalgia compared to healthy volunteers. Researchers measured pain levels, touch pleasantness, and other factors like mood and trauma history. The goal was to better unde…

This study looked at whether a Turkish questionnaire about posture habits and awareness is a valid and reliable tool for people with fibromyalgia. One hundred patients completed the scale along with other surveys. The goal was to see if the scale accurately measures what it is su…

This study looked at how focusing on negative thoughts (rumination) versus distracting yourself affects your mood after physical activity in people with fibromyalgia. 47 adults with fibromyalgia took part. Researchers gave them instructions to either ruminate on their muscle tens…

This study looked at how repetitive negative thinking (rumination) affects the emotional and mental symptoms of fibromyalgia. Researchers studied 107 adults with fibromyalgia using questionnaires. The goal was to understand if rumination plays a role in depression and anxiety oft…

This study looked at how stress changes gene activity in women with chronic widespread pain (fibromyalgia). Researchers compared 84 women with and without the condition, using mental stress tests and relaxation breathing. They measured changes in DNA methylation, a process that c…

This completed study looked at 60 people with idiopathic pulmonary fibrosis (IPF) to see how common muscle loss (sarcopenia) is and how it affects their quality of life and disease progression. Researchers measured muscle strength, walking speed, lung function, and used a questio…

This completed study took blood samples from 10 people with chronic spontaneous urticaria (long-lasting hives) to check for viral particles. The goal was to see if hidden viruses might be involved in causing the condition. Because it is a small observational study, it can only su…

This completed study looked at 143 people with two types of lung scarring diseases (IPF and hypersensitivity pneumonitis). Researchers compared three different scoring systems (GAP, ILD-GAP, and CPI) to see which one best predicts how long patients might live. The goal was to fin…

This study tested whether a computerized balance test can predict if adolescent scoliosis will get worse. Researchers measured postural control in 95 girls aged 11-14 with mild scoliosis. The goal is to help doctors decide early on who needs treatment like braces or therapy, avoi…

This completed study surveyed 65 U.S. families to understand the economic and quality-of-life impact of IVIG treatment for PANS/PANDAS. Researchers asked about medical visits, insurance, work absences, and children's school attendance. The goal is to shed light on the hidden cost…

This study looked at 20 people with long-term balance problems caused by inner-ear damage. Researchers wanted to see if fast, unconscious eye movements called 'covert saccades' help them see clearly when moving their head. Participants had their eye movements measured during quic…

This completed study used eye-tracking to explore how the brain adapts movements in people with dystonia, essential tremor, or Parkinson disease. Researchers measured eye movements before and after a task to look for signs of cerebellar dysfunction. The study included 14 particip…

This study looks at why some people with chronic balance problems develop very fast eye movements that help them see clearly when moving their head. Researchers tested 12 patients and 12 healthy volunteers using virtual reality and head movements. The goal was to understand what …