New drug combo aims to slow lung damage in rare muscle disease

NCT ID NCT05799755

Completed Disease control Sponsor: Rohit Aggarwal, MD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding nintedanib (OFEV) to standard immunosuppressant therapy can improve symptoms in people with myositis-associated interstitial lung disease, a condition where lung tissue becomes scarred and stiff. 49 adults in the U.S. participated, receiving either nintedanib or a placebo alongside their usual medications. The main goal was to measure changes in breathing-related quality of life using a questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nintedanib (also known as OFEV)
What this could lead to: If it works, this could provide a new treatment option to slow lung scarring and improve breathing in people with myositis-related lung disease.
What could go wrong: This is an early exploratory trial with only 49 participants, so results may not be conclusive. Nintedanib can cause side effects like diarrhea and liver issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

antisynthetase syndrome interstitial lung disease myositis disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOSITIS ASSOCIATED INTERSTITIAL LUND DISEASE (MA-ILD)

Contacts and locations

Locations

Columbia University Irving Medical Center

New York, New York, 10032, United States
Mayo Clinic Arizona

Scottsdale, Arizona, 85259, United States
National Jewish Health

Denver, Colorado, 80206, United States
Northwell Health

New York, New York, 11021, United States
University of Alabama

Birmingham, Alabama, 35294, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15216, United States
University of South Florida

Tampa, Florida, 33612, United States
University of Utah Health Sciences Center

Salt Lake City, Utah, 84112, United States