CBD drug shows promise for stubborn heart pain

NCT ID NCT05494788

Completed Symptom relief Sponsor: Cardiol Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a pure cannabidiol (CBD) solution called CardiolRx in 27 adults with recurrent pericarditis, a condition causing repeated inflammation and pain around the heart. Participants had not responded well to standard treatments or needed long-term steroids. The goal was to see if CardiolRx is safe and can help reduce pain and inflammation, and possibly allow patients to stop other medications. It was a small pilot study, so results are preliminary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CardiolRx (pharmaceutically produced cannabidiol, a CBD oral solution)
What this could lead to: If this works, it could offer a new option to reduce pain and inflammation for people with recurrent pericarditis who don't respond to standard treatments.
What could go wrong: This is a small, early pilot study with only 27 participants, so results may not apply widely. It tested safety and symptom changes, not long-term effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic recurrent pericarditis pericarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT PERICARDITIS

Contacts and locations

Locations

Cleveland Clinic

Cleveland, Ohio, 44195, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
MedStar Health Research Institute

Washington D.C., District of Columbia, 20010, United States
Minneapolis Heart Institute Foundation

Minneapolis, Minnesota, 55407, United States
Pima Heart and Vascular Clinical Research

Tucson, Arizona, 85719, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
Virginia Commonwealth University Health

Richmond, Virginia, 23298, United States

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