CBD drug shows promise for stubborn heart pain
NCT ID NCT05494788
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a pure cannabidiol (CBD) solution called CardiolRx in 27 adults with recurrent pericarditis, a condition causing repeated inflammation and pain around the heart. Participants had not responded well to standard treatments or needed long-term steroids. The goal was to see if CardiolRx is safe and can help reduce pain and inflammation, and possibly allow patients to stop other medications. It was a small pilot study, so results are preliminary.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CardiolRx (pharmaceutically produced cannabidiol, a CBD oral solution)
What this could lead to
If this works, it could offer a new option to reduce pain and inflammation for people with recurrent pericarditis who don't respond to standard treatments.
What could go wrong
This is a small, early pilot study with only 27 participants, so results may not apply widely. It tested safety and symptom changes, not long-term effectiveness.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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MedStar Health Research Institute
Washington D.C., District of Columbia, 20010, United States
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Minneapolis Heart Institute Foundation
Minneapolis, Minnesota, 55407, United States
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Pima Heart and Vascular Clinical Research
Tucson, Arizona, 85719, United States
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University of Vermont Medical Center
Burlington, Vermont, 05401, United States
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Virginia Commonwealth University Health
Richmond, Virginia, 23298, United States