New pill could ease rare muscle disease

NCT ID NCT05695950

Completed Disease control Sponsor: Lakefront Biotherapeutics NV Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested an oral drug called GLPG3667 (Cadefrecitinib) in 40 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants took the drug or a placebo daily for 24 weeks to see if it improves symptoms. The trial is complete, and results will show if the drug is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

GLPG3667 (also known as Cadefrecitinib)

What this could lead to

If successful, this could point toward a new oral treatment option for dermatomyositis, potentially reducing symptoms and improving quality of life.

What could go wrong

This is a small Phase 2 trial with only 40 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

dermatomyositis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DERMATOMYOSITIS

Contacts and locations

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Locations

Altoona Center for Clinical Research, P.C.

Duncansville, Pennsylvania, 16635, United States
Augusta University

Augusta, Georgia, 30912, United States
Azienda Ospedaliero Universitaria Pisana U.O. Reumatologia Universitaria

Pisa, 56100, Italy
Azienda Ospedaliero Universitaria Policlinico. PO San Marco

Catania, 95100, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili) Medicina Interna

Brescia, 25123, Italy
BioMedica Research Group Psicomedica Clinical and Research Group

Santiago, 7500710, Chile
CHU Strasbourg - Hôpital Hautepierre service de rhumatologie

Strasbourg, 67091, France
CHU de Nice Hôpital Pasteur 2 Centre de Réf des Maladies Neuromusculaires et SLA

Nice, 06001, France
Centro de Alta Especialidad en Reumatología e Investigación del Potosí S.C.

San Luis Potosí City, 78213, Mexico
Centro de Investigacion Clínica GRAMEL S.C

México, 03720, Mexico
Centro de Investigacion Medico Asistencial S.A.S

Barranquilla, 80020, Colombia
Centrum Medyczne Plejady

Krakow, 30-363, Poland
Charité - Campus Charité Mitte - Klinik für Dermatologie, Venerologie und Allergologie

Berlin, 10117, Germany
Clinica de la Costa S.A.S

Barranquilla, 080020, Colombia
Consultorio de Reumatologia Hospital Angeles Lindavista

México, 07760, Mexico
Enroll SpA

Santiago, 7500587, Chile
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, 00168, Italy
Framingham Centro Medico

La Plata, B1902, Argentina
Fundacion Respirar Consultorios Médicos Dr. Doreski

Buenos Aires, C1426ABO, Argentina
Groupe Hospitalier Pitie-Salpetriere service de médecine interne et immunologie cliniqu

Paris, 75651, France
Healthy Medical Center

Zipaquirá, 250252, Colombia
Helios Fachklinik Vogelsang-Gommern

Gommern, 39245, Germany
HonorHealth Neurology

Scottsdale, Arizona, 85251, United States
Hospital Clinic de Barcelona Servicio de Medicina Interna

Barcelona, 08036, Spain
Hospital Cordoba

Córdoba, X5004CDT, Argentina
Hospital Italiano de La Plata

La Plata, B1900, Argentina
Hospital Universitari Vall d'Hebron Internal Medicine Dept.

Barcelona, 08035, Spain
Hospital Universitari de Bellvitge Servicio de Cardiologia

L'Hospitalet de Llobregat, 08907, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Inland Rheumatology Clinical Trials, Inc.

Upland, California, 91786, United States
Instituto Medico CER

Quilmes, B1878DVB, Argentina
Istituto Clinico Humanitas U.O. Reumatologia

Rozzano, 20089, Italy
King's College Hospital Dept of Rheumatology

London, SE5 9RS, United Kingdom
Klinika Ambroziak ESTEDERM

Warsaw, 02-953, Poland
Medical Care & Research SA de CV

Mérida, 97070, Mexico
New Access Research and Medical Center

Kendall, Florida, 33186, United States
Northwell Health, LLC PRIME

Lake Success, New York, 11042, United States
Nova Reuma Domysławska i Rusiłowicz, Spółka Partnerska Lekarza Reumatologa i Fizjoterapeuty

Bialystok, 15-707, Poland
Omega Research Orlando, LLC

Orlando, Florida, 32808, United States
Ospedale San Giovanni Bosco

Torino, 10154, Italy
Ospedale San Raffaele U.O. di Medicina Gen. Ind. Immunologico-Clinica

Milan, 20132, Italy
Polyclinic Bonifarm

Zagreb, 10000, Croatia
Revmatologicky Ustav

Prague, 12850, Czechia
Salford Care Organisation Dept of Rheumatology

Salford, M6 8HD, United Kingdom
Sc Medaudio-Optica SRL

Râmnicu Vâlcea, 240762, Romania
Solmed Polyclinic

Zagreb, 10000, Croatia
Spitalul Clinic 'Sf. Maria' Clinica de Medicina Interna si Reumatologie

Bucharest, 11172, Romania
Spitalul Clinic Colentina parent

Bucharest, 020125, Romania
St. Paul Rheumatology

Eagan, Minnesota, 55121, United States
St. Peter´s Hospital Dept of Rheumatology

Chertsey, KT16 OPZ, United Kingdom
UZ Leuven

Leuven, 3000, Belgium
Universitätsklinikum Tübingen - Universitäts-Hautklinik

Tübingen, 72076, Germany
Western General Hospital Dept of Rheumatology

Edinburgh, EH4 2XU, United Kingdom
Zespol Poradni Specjalistycznych Reumed

Lublin, 20-582, Poland