New inhaled drug for lung scarring enters early human testing

NCT ID NCT07344558

Completed Disease control Sponsor: Mannkind Corporation Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This early-stage trial is testing an inhaled form of nintedanib (called MNKD-201) in 24 people with idiopathic pulmonary fibrosis (IPF), a disease that scars the lungs. The study aims to see if the drug is safe and tolerable when breathed in, and how the body processes it. Participants will receive either the inhaled drug or a placebo, and researchers will monitor for side effects like wheezing or chest tightness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nintedanib dry powder for inhalation
What this could lead to: If successful, this could lead to a new, inhaled form of nintedanib that may be easier for IPF patients to take than the current oral pill.
What could go wrong: This is a very early, small Phase 1b trial with only 24 people, focused on safety and dosing. It is not designed to prove the drug works, and side effects like bronchospasm are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic pulmonary fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC PULMONARY FIBROSIS (IPF)

Contacts and locations

Locations

Innova Pharma Research

Doral, Florida, 33172, United States
Low Country Research

Charleston, South Carolina, 29406, United States
Metroplex Pulmomary & Sleep Center

McKinney, Texas, 75069, United States
New Access Research and Medical Services

Miami, Florida, 33186, United States
New Life Medical Research

Hialeah, Florida, 33012, United States
Palmtree Clinical Research

Palm Springs, California, 92262, United States
Pulmonary Medicine Consultants

McKinney, Texas, 75071, United States
Southeastern Research Center

Winston-Salem, North Carolina, 27103, United States
VALDI

Fresno, California, 93720, United States

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