Brain stem glioma

This study tested whether a personalized vaccine could be safely made and given to 25 adults with advanced cancers that cannot be cured. The vaccine was custom-made for each person. The main goal was to check for side effects and see if the approach is feasible.

This early-stage trial tests an experimental cell therapy called IBR854 in people with advanced solid tumors that cannot be surgically removed or have spread. The main goals are to check the treatment's safety and find the right dose. Participants receive the cells by infusion tw…

This study tests an experimental drug called XmAb24306, given alone or with another cancer drug (atezolizumab), in people with advanced solid tumors that cannot be cured. The main goal is to check the drug's safety and how the body processes it. About 195 participants will take p…

This early-phase trial tests an experimental tablet called YZJ-5053 in people with advanced solid tumors who have no standard treatment options left. The main goals are to find a safe dose and check for side effects. Researchers will also look at how the drug moves through the bo…

This early-phase study tested the safety of combining two drugs—pembrolizumab (an immunotherapy) and AMG386 (which targets blood vessel growth)—in 62 people with advanced solid tumors like melanoma, ovarian, renal, or colorectal cancer. The main goals were to find the safest dose…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This early-stage trial tested a new drug called BGB-15025, alone or with another drug (tislelizumab), in 157 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the best dose. The study is now complete, …

This early-phase trial tested an experimental drug called IOS-1002, given alone or with the immunotherapy pembrolizumab, in 47 adults with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. Research…

This phase 2 study tested a combination of two drugs—olaparib and pembrolizumab—in 333 adults with advanced solid tumors that have specific DNA repair problems (HRR mutations or HRD). The goal was to see if the combo could shrink tumors or slow their growth. Participants had alre…

This study tested a new drug called CT7001, alone or with other cancer treatments, in 124 people with advanced solid tumors like breast and prostate cancer. The main goal was to check safety and side effects. The drug is taken by mouth and aims to control the disease, not cure it…

This early-phase trial tested an experimental drug called IBI129 in 36 adults with advanced solid tumors that could not be removed by surgery or had spread. The main goals were to find a safe dose and check for side effects. Researchers also looked for any signs that the drug mig…

This Phase 1 trial tested an investigational oral drug called CFI-402257 in 52 people with advanced solid tumors, including breast cancer, that had stopped responding to standard treatments. The main goal was to find a safe dose and check how the drug moves through the body. It w…

This early-phase study tested a method called convection-enhanced delivery to pump the chemotherapy drug topotecan directly into brain tumors in 16 patients with recurrent malignant brain tumors. The goal was to see if this approach is safe and to find the best dose, while also m…

This study tested a fixed-dose combination of two immunotherapy drugs, tiragolumab and atezolizumab, given together as a single infusion every three weeks. The trial enrolled 64 people with advanced solid tumors that express a protein called PD-L1. The main goal was to check the …

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tested a drug called PF-06801591 in 155 people with advanced solid tumors or non-small-cell lung cancer. The drug works by blocking a protein that stops the immune system from attacking cancer cells. The goal was to check safety, how the drug moves through the body, an…

This pilot study tested whether combining high-dose radiation therapy with the immunotherapy drug pembrolizumab (Keytruda) could boost the immune system's ability to fight advanced solid tumors. Twenty-one patients with various advanced cancers received the combination either at …

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This phase 1 trial tested the combination of dasatinib (a pill) and bevacizumab (an infusion) in 50 adults with advanced solid tumors that no longer respond to standard treatments. The goal was to find the safest dose and see how well the two drugs work together to slow cancer gr…

This study tested two experimental drugs (AK104 and AK117) together, sometimes with chemotherapy, in 128 people with advanced solid tumors. The goal was to see if the combination is safe and can shrink tumors. It focused on patients with stomach, esophageal, or other advanced can…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This study tested a new oral drug called BGB-43395 in 33 Chinese patients with advanced or metastatic HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. The goal was to find a safe dose and see if it can shrink tumors wh…

This early-phase study tested a new drug called BGB-C354, alone or with an immunotherapy (tislelizumab), in 63 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check safety and find the right dose. Researchers also looked for…

This study tested a new under-the-skin shot version of the cancer drug pembrolizumab (Keytruda) in 142 people with advanced solid tumors. The goal was to see how well the body absorbs the drug compared to the standard IV infusion. Researchers also checked for side effects and how…

This early-phase study tested whether adding the experimental drug ruxolitinib to standard radiation and chemotherapy (temozolomide) is safe for people with newly diagnosed high-grade gliomas or glioblastoma. Ruxolitinib targets proteins that help cancer cells grow. The study enr…

This study tested a special vaccine made from the child's own immune cells (dendritic cells) to fight aggressive brain tumors like high-grade glioma and DIPG. Ten children received the vaccine alongside standard treatments. The goal was to see if the vaccine was safe, possible to…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This study looked at the long-term safety of several cancer drugs, including tislelizumab and pamiparib, in 404 people with advanced cancers. Participants had already been in an earlier trial of these drugs. The goal was to track serious side effects and see if patients could kee…

This study tested a new drug called XTX202 in 95 people with advanced solid tumors that had not responded to standard treatments. The goal was to check safety, find the right dose, and see if the drug could shrink tumors. The trial is now complete.

This early-phase study tested a combination of two drugs, cabozantinib and 13-cis-retinoic acid, in 15 children whose solid tumors had come back or were not responding to standard treatments. The main goal was to find the safest dose and understand side effects. The study did not…

This early-stage trial tested a new drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and tolerable, and to find the best dose. Researcher…

This early-stage trial tested an experimental drug called LVGN6051, which activates immune cells by targeting CD137, both alone and combined with the approved immunotherapy Keytruda. The study involved 105 adults with advanced or metastatic cancers that had spread. The main goal …

This early-stage study tested a new drug called LVGN7409, which boosts the immune system to fight cancer. It was given alone or with other immune-boosting drugs to 66 adults with advanced cancers that had stopped responding to standard treatments. The main goal was to find the sa…

This early-phase trial tested an experimental drug called NEV801 in 78 adults with advanced solid tumors that had stopped responding to standard treatments. The drug was given by IV in increasing doses to find the safest dose and to see if it had any anti-cancer effects. The stud…

This study tested a new drug called TJ004309, either alone or combined with another drug called Toripalimab, in 225 adults with advanced solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and see early signs of effectiveness. The…

This study tested a new drug called LBL-033 in 26 adults with advanced malignant tumors that had not responded to other treatments. The main goals were to find a safe dose and check for serious side effects. Researchers also looked at how the drug moves through the body and wheth…

This early-phase study tested a daily combination of two oral drugs, axitinib and everolimus, in 19 people with advanced solid tumors, particularly kidney cancer. The main goal was to find the safest dose by monitoring side effects in the first month. Researchers also tracked how…

This study tested a new oral drug called HMPL-453 tartrate, either alone or combined with chemotherapy or an immunotherapy (toripalimab), in 190 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and see if th…

This early-stage study tested two drugs, cabozantinib and pamiparib, together in 44 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and understand side effects. The drugs work by blocking certain enzymes t…

This early-phase study tested a new drug called CCT3833 in 31 adults with advanced solid tumours, including melanoma. The main goal was to find a safe dose and check for side effects. Researchers measured how the drug moves through the body and looked for the best dose to use in …

This early-phase trial tested a new drug called PM14 in 126 people with advanced solid tumors that had no standard cure. The main goals were to find a safe dose and check for early signs of tumor shrinkage. The drug was given by IV infusion on different schedules. This is a first…

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This early-phase trial tested a new drug called KL340399, which is injected directly into tumors to activate the immune system. It involved 6 adults with advanced solid tumors who had no other treatment options. The main goals were to check safety, find the right dose, and see if…

This early-phase trial tested a new drug called KL340399 in 21 adults with advanced solid tumors that had stopped responding to standard treatments. The drug works by activating the STING pathway to help the immune system fight cancer. The main goals were to check safety, find th…

This study tested pegloticase, a drug used for gout, in 10 cancer patients with high uric acid from tumor lysis syndrome. The goal was to see if it could quickly lower uric acid levels and protect kidney function. It was a small pilot trial to gather early data.

This phase 2 study tested the drug erdafitinib in 316 adults and children with advanced solid tumors that have specific FGFR gene mutations or fusions. The main goal was to see if the drug could shrink tumors. Participants took erdafitinib tablets daily. The study is now complete…

This early-phase study tested a new drug, HBM1020, in 17 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. The drug was given by IV every three weeks. Because this is a Phase 1 trial, i…

This study tested a new drug called PRL3-ZUMAB in 14 people with advanced solid tumors (like stomach or liver cancer) that stopped responding to standard treatments. The drug was given every two weeks to see if it could shrink tumors or stop them from growing. Researchers also lo…

This study tested a new oral drug called ensartinib (X-396) for the first time in humans. It involved 131 people with advanced solid tumors, including those with ALK-positive non-small cell lung cancer. The goal was to find the safest dose and see if the drug could shrink tumors.…

This study tested a new radioactive drug, 177Lu-NeoB, in 35 adults with advanced solid tumors that have a specific marker (GRPR). The goal was to check safety, find the best dose, and see if it shrinks tumors. It is an early-stage trial, so it focuses on safety and dosing, not a …

This early-phase trial tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard therapy. The main goal was to find the safest dose and check for s…

This early-stage trial tested a new drug, ProAgio, in 46 people with advanced solid tumors, including pancreatic cancer, who had already tried other treatments. The main goal was to find a safe dose and check for side effects. The study did not aim to cure the disease, but to con…

This early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…

This early-stage trial tested an experimental drug called HH-101 in 12 people with advanced solid tumors that had not responded to standard treatments. The main goal was to check the drug's safety and find the right dose. Participants received HH-101 as an IV infusion every three…

This study tested three flavors of Supportan® drink (Tropical Fruits, Cappuccino, and Pineapple-Coconut) in 123 cancer patients undergoing chemotherapy, radiotherapy, immunotherapy, or targeted therapy. Patients drank two bottles daily for four weeks alongside their normal diet. …

This completed phase I/IIb trial tested a personalized vaccine made from each patient's unique tumor mutations. Eight adults with advanced solid tumors or high recurrence risk received the vaccine alongside an immune booster and later checkpoint inhibitors. The goal was to see if…

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This study tested a new drug called FF-10502-01 in 106 adults with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drug could shrink tumors or slow disease progression. While not a cure, th…

This early-phase study tested whether pumping the chemotherapy drug topotecan directly into the brain is safe for people with recurrent high-grade gliomas (aggressive brain tumors). Only 5 patients took part, and the main goal was to find a safe dose. The drug was delivered conti…

This early-phase trial tested a new drug called NOV140101 in 32 adults with advanced solid tumors that had spread or could not be removed by surgery. The main goals were to find the safest dose and check for side effects. The study is complete, but it was too small to determine i…

This early-phase study tested a new drug called TQB2210 in 16 people with advanced cancers that had not responded to other treatments. The drug is a lab-made antibody that targets a specific protein (FGFR2b) on cancer cells to block their growth. The main goals were to find a saf…

This phase 2 trial tested an experimental drug called HX009 in 20 adults with advanced solid tumors that had stopped responding to standard treatments. HX009 is a bifunctional antibody designed to block two proteins (CD47 and PD-1) that help tumors hide from the immune system. Th…

This phase II trial tested whether a newer antibiotic combination (imipenem-relebactam) works better than standard antibiotics for treating fever caused by low white blood cell counts in cancer patients. About 100 adults with cancer or who had a stem cell transplant took part. Th…

This early-phase trial tested whether combining the experimental drug relatlimab with other immunotherapies (nivolumab plus either BMS-986205 or ipilimumab) is safe and can shrink tumors in people with advanced solid cancers. A total of 229 participants with various incurable, ad…

This phase 2 trial tests the drug utidelone in 126 people with advanced solid tumors (excluding breast, lung, and colorectal cancers) that have not responded to standard treatments. The study aims to see if the drug can shrink tumors and how safe it is. Participants receive utide…

This study tested combinations of three immunotherapy drugs—tislelizumab, surzebiclimab, and alcestobart—in 147 adults with advanced solid tumors that had not responded to prior treatments. The goal was to find safe doses and see if the drugs could shrink tumors. The trial is now…

This completed trial tested an online Tai Chi program to help cancer survivors stop smoking. Sixty-eight participants practiced slow movements and breathing exercises over 8 weeks, with their progress tracked via carbon monoxide tests and surveys. The goal was to see if this gent…

This early-phase trial tested the safety of combining pioglitazone (a diabetes drug) with carboplatin (a chemotherapy) in 14 people with advanced solid tumors that could not be cured with standard treatments. The goal was to find the best dose and see if the combination is safe. …

This early-phase study tested a new drug called BAT4706 in 28 adults with advanced solid tumors or melanoma who had no other good treatment options. The main goal was to find a safe dose and check for side effects. This was not a cure study; it aimed to gather safety information …

This study tested a combination of two drugs, LBL-007 and tislelizumab, in 98 adults with advanced solid tumors. The goal was to see if the combo is safe, tolerable, and effective at shrinking tumors. Researchers also looked at how the drugs move through the body and whether they…

This study tested a weight management program for young adult cancer survivors (ages 18-39) who have obesity and are within 5 years of finishing cancer treatment. The program combined healthy eating, physical activity, and symptom management to help reduce cardiovascular disease …

This study tested a new cancer drug called brigimadlin (BI 907828) in 266 adults with advanced solid tumors that had spread or stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors. Brigimadlin is an MDM2 inhibitor tak…

This study checked if a generic version of the cancer drug trifluridine/tipiracil works the same as the brand-name drug Lonsurf in 76 patients with solid tumors. Participants took the drug under fasting and fed conditions to compare how the body absorbs it. The goal was to show t…

This early-stage study tested an experimental drug called JCXH-211, which is injected directly into tumors. It involved 19 adults with advanced solid tumors that had not responded to standard treatments. The main goals were to check safety and find the right dose, while also watc…

This study looked at whether a sedative called dexmedetomidine can protect the brain during surgery to remove a brain tumor. 56 adults having brain tumor surgery received either the drug or a placebo. The goal was to see if the drug reduces brain damage and inflammation, helping …

This study tested whether a hydrochloric acid lock can help treat central line infections in 212 cancer and blood disease patients. The acid solution was placed in the line for 10 minutes, repeated three times, alongside standard antibiotics. The goal was to see if it reduces tre…

This study tested whether a device called ExAblate, which uses focused ultrasound, can safely open the blood-brain barrier in 20 people with high-grade glioma (a type of brain cancer). The goal was to allow standard chemotherapy to reach the tumor more effectively. Researchers ch…

This early-stage study tested a new drug called DF6215, alone or with another drug (pembrolizumab), in 35 adults with advanced solid tumors that could not be removed by surgery or had spread. The main goals were to find the safest dose and check for side effects. The study is com…

This early-phase study tested a new drug called ZN-c3 (Azenosertib) in 274 adults with various solid tumors. The main goals were to find a safe dose and check for side effects. Researchers also looked for signs that the drug could shrink tumors. This is a first step to see if the…

This early-phase trial tested an experimental drug called DF6002, either alone or combined with the approved immunotherapy nivolumab (Opdivo), in 170 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find th…

This study tested a new drug called DF1001 in 270 adults with advanced solid tumors that have spread or cannot be removed. The drug works by helping the body's immune cells attack cancer cells. The trial first found the safest dose, then tested it alone or with other cancer drugs…

This study tested a new drug called BI 3706674 in 47 adults with advanced stomach or esophageal cancer that had not responded to prior treatment. The drug is a tablet that blocks growth signals in cancer cells. The main goals were to find a safe dose and see if the drug could shr…

This study tested two treatments for people with advanced cancer who cannot have standard therapy. One group took a low-dose chemotherapy pill (cyclophosphamide) daily, and the other took a hormone pill (megestrol). The goal was to see which treatment could slow cancer growth for…

This early-phase study tested a combination of two chemotherapy drugs—weekly paclitaxel given through a vein and daily oral cyclophosphamide—in 28 adults with advanced cancer who had no other treatment options. The goal was to find the safest dose of paclitaxel when used with a f…

This early-phase study tested whether adding the drug cilengitide to standard radiation is safe for children and young adults with a rare, aggressive brain tumor called DIPG. The main goal was to find the highest safe dose. 32 participants were enrolled. The study did not aim to …

This early-phase study tested a new drug called HRS7415 in 38 people with advanced cancers that had spread. The main goals were to check safety, find the right dose, and see if the drug could help control the disease. Researchers monitored side effects and measured drug levels in…

This early-phase trial tested a new drug called RS-0139 in 16 people with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to target tumors specifically, and the main goals were to find a safe dose and understand how the body processe…

This study tested a combination of two drugs—NT-I7 (efineptakin alfa) and pembrolizumab (Keytruda)—in 215 people with advanced solid tumors that had stopped responding to treatment. The goal was to check safety, find the right dose, and see if the combo could shrink tumors. The t…

This early-stage trial tested a modified virus called TILT-123 in 32 people with advanced solid tumors that had not responded to standard treatments. The virus is designed to infect and kill cancer cells while releasing immune-boosting proteins. The main goal was to check safety …

This early-phase study tested the safety of combining two drugs—AZD1775 (a pill) and durvalumab (an IV infusion)—in 56 adults with advanced solid tumours that had stopped responding to standard treatments. The goal was to find safe doses and watch for side effects. While not a cu…

This phase 2 trial tested whether taking iohexol by mouth can treat chylous ascites, a leak of lymphatic fluid that can happen after abdominal or pelvic cancer surgery. The study enrolled 42 patients who developed this condition after surgery. The goal was to see if oral iohexol …

This completed Phase 2 trial tested whether combining an immunotherapy drug (durvalumab) with an epigenetic drug (tazemetostat) can control advanced solid tumors like pancreatic, colorectal, and soft-tissue sarcoma. The study enrolled 164 adults and measured how well the combo sh…

This study tested a combination of two experimental drugs, AK112 and AK117, with or without chemotherapy, in 154 people with advanced solid tumors. The goal was to see if the combo could shrink tumors and control the disease. The trial has finished, and researchers are now lookin…

This study tested the safety and effectiveness of the drug abemaciclib combined with other cancer medicines in 47 children and young adults whose solid tumors (including neuroblastoma) had stopped responding to standard treatments. The goal was to find the best dose and see if th…

This early-stage trial tested a new drug called PN20 in 24 adults with lymphoma or solid tumors who were getting chemotherapy. The goal was to see if a single injection before chemo could safely prevent a drop in platelets, which can cause bleeding. Researchers checked safety and…

This early-phase trial tested a new treatment for aggressive brain tumors called high-grade glioma. Sixteen patients received a drug (5-ALA) plus focused ultrasound to activate the drug inside the tumor, a few days before standard surgery and chemo-radiation. The main goal was to…

This study tested a new oral drug called RLY-4008 in 490 adults with advanced bile duct cancer or other solid tumors that have specific FGFR2 gene changes. The drug is designed to block the FGFR2 protein, which can drive cancer growth. The trial aimed to find the safest dose and …

This study tested an experimental drug (BMS-986253) combined with standard immunotherapy drugs (nivolumab with or without ipilimumab) in 281 people with advanced cancers like melanoma. The main goals were to check safety and see if tumors shrank. This is a disease-control approac…

This early-phase trial tested a new drug called BGB-10188, alone or combined with other cancer drugs (zanubrutinib for blood cancers, tislelizumab for solid tumors), in 97 patients whose cancers had returned or stopped responding to treatment. The main goals were to find safe dos…

This study looked at whether reducing the use of strong, broad-spectrum antibiotics in cancer patients with sepsis or septic shock is as safe as continuing them. The goal is to lower the risk of creating drug-resistant bacteria. Researchers compared a de-escalation strategy to st…

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goal was to find the safest dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 we…

This early-phase study tested an oral drug called AG-881 in 95 adults with advanced solid tumors, including brain tumors (gliomas), that have specific IDH gene mutations. The main goals were to check safety, find the best dose, and see how the drug works in the body. While not a …

This early-phase study tested a new drug called AMG 305 in 37 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety and find the best dose for future studies. Participants received the drug and were mo…

This study tested a program called CareConnect that uses automated phone calls to help cancer patients stop smoking. About 400 cancer patients who smoked took part. The program gave them educational messages and connected them to resources like quitlines or websites. The goal was…

This study tested combinations of the immunotherapy drug durvalumab with other drugs (danvatirsen, AZD5069, or tremelimumab) in 340 adults with advanced solid tumors or head and neck cancer. The goal was to find safe doses and see if the combinations shrink tumors. The trial has …

This early-phase study tested a new drug called CUDC-907 in 26 children and young adults (ages 1-21) with cancers that had come back or stopped responding to treatment, including solid tumors, brain tumors, and lymphoma. The main goal was to find a safe dose and check for side ef…

This early-phase trial tested two experimental drugs, FdCyd and THU, taken by mouth for advanced solid tumors that had not responded to standard treatments. Fifty-nine adults received the drugs in 21-day cycles to see if they were safe and tolerable. The goal was to find a dose f…

This study tested a new pill called larotrectinib in 75 adults with advanced cancers that have a specific gene change (NTRK fusion). The main goals were to check the drug's safety, find the best dose, and see how the body processes it. Participants had no other good treatment opt…

This early-stage trial tested a new oral drug, MSP008-22, in 7 adults with advanced solid tumors (breast, ovarian, prostate, head and neck cancers) that had spread or could not be removed. The main goal was to find a safe dose and check for side effects. This is a first step to s…

This early-phase trial tested a new drug called LBL-019, given alone or with another immunotherapy, in 26 adults with advanced cancers that no longer responded to standard treatments. The main goal was to check safety and find the right dose. Researchers also looked at whether th…

This early-phase trial tested a new immunotherapy drug called BI 754091 in 110 people with advanced solid tumours that had spread or could not be removed surgically. The main goals were to find the safest dose and check for side effects. Researchers also looked for early signs th…

This early-phase trial tested a new drug called SNB-101 in 21 people with advanced solid tumors (like colorectal, breast, and lung cancers) that had stopped responding to standard treatments. SNB-101 is a nanoparticle version of SN-38, the active part of a common chemotherapy dru…

This early-stage trial tested an experimental drug called CyPep-1, injected directly into tumors, either alone or with the immunotherapy pembrolizumab. The study involved 60 adults with advanced solid cancers that had stopped responding to standard treatments. The main goals were…

This early-phase trial tested an experimental drug called VS-6766, given alone or with everolimus, in 104 adults with advanced solid tumors or multiple myeloma that had stopped responding to standard treatments. The goal was to find a safe, tolerable dosing schedule and measure h…

This study tested a new immunotherapy drug, ezabenlimab, combined with other cancer medicines in 211 adults with advanced solid tumors that had spread. The goal was to see if the tumors shrank or disappeared. Participants received different drug combinations, and doctors monitore…

This early-stage study tested the drug revumenib in 42 adults with colorectal cancer or other solid tumors that had spread or come back after at least one prior treatment. The goal was to see if the drug is safe and can slow tumor growth. Researchers measured side effects, how th…

This study tested two experimental drugs (BI 754111 and BI 754091) that help the immune system attack cancer. It included 172 adults with advanced solid tumors, including non-small cell lung cancer that had returned after prior treatment. The first part found the safest dose, and…

This completed Phase 1 trial tested whether a dye called indocyanine green (ICG) can make brain tumor cells glow during surgery, helping surgeons see and remove them more completely. 363 adults with brain tumors received an ICG injection before surgery, and special cameras captur…

This pilot study tested a new type of immune cell therapy called anti-ALPP CAR-T cells in 5 patients with advanced solid tumors that have a specific marker (ALPP). The goal was to see if the treatment is safe and can shrink tumors. Patients first received chemotherapy to prepare …

This early-phase study tested a new type of immunotherapy called ALPP CAR-T cells in 5 adults with advanced solid tumors that had not responded to standard treatments. The therapy involves genetically modifying a patient's own immune cells to recognize and attack cancer cells tha…

This early-phase study tested an experimental drug called BMS-986288, both by itself and combined with the immunotherapy nivolumab (Opdivo), in 219 people with advanced solid tumors that had worsened after standard treatments. The main goal was to check safety and tolerability, a…

This early-phase trial tested whether adding two chemotherapy drugs (6-mercaptopurine and 6-thioguanine) to an immunotherapy drug (Atezolizumab) could help treat advanced solid tumors that have stopped responding to standard treatments. The study enrolled 18 adults with metastati…

This study tested a drug called avapritinib in 29 children aged 2 to 18 with advanced solid tumors that have specific genetic changes (KIT or PDGFRA). The goal was to see if the drug is safe and can shrink or control the tumors. Participants took the drug by mouth, and researcher…

This study tested a new drug called ALRN-6924 in 142 people with advanced solid tumors or lymphomas that have a normal p53 gene. The goal was to see if the drug is safe and can shrink tumors. Participants had cancers that did not respond to standard treatments or had no standard …

This early-phase study tested a new drug called JAB-8263 in 41 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects. The study is now complete.

This early-stage trial tested a new drug called MRX-2843 in 42 adults with advanced solid tumors that had spread or come back after other treatments. The main goal was to check safety and find the right dose. Researchers monitored side effects and how the drug moved through the b…

This early-phase trial tested an experimental drug called ADG116, which helps the immune system attack cancer cells. The study included 72 adults with advanced solid tumors that had stopped responding to standard treatments. Some participants received ADG116 alone, while others g…

This early-phase study tested a new drug called RC108-ADC in 67 people with advanced solid tumors that have a specific protein (c-Met). The drug is designed to deliver a toxin directly to cancer cells. The main goals were to check safety and find the best dose. Researchers also l…

This early-phase study tested an experimental drug called INCB7839 in 13 children whose high-grade gliomas (aggressive brain tumors) had come back or worsened after standard treatment. The main goals were to find a safe dose and check for side effects. The drug works by blocking …

This early-phase trial tested a new drug called FL115 in 18 adults with advanced solid tumors that had stopped responding to standard treatments. FL115 is designed to strengthen the body's immune cells to fight cancer. The main goal was to check safety and find the right dose, wh…

This study tested a new drug called IBI334 in 28 people with advanced solid tumors that could not be removed by surgery or had spread. The main goals were to check the drug's safety and see if it helps control the cancer. The study is now complete.

This early-stage trial tested a new biologic drug called ZGGS15 in 22 adults with advanced solid tumors who had no standard treatment options left. The main goals were to check safety, find the right dose, and look for early signs that the drug might control tumor growth. Partici…

This early-phase study tested an experimental drug called JAB-BX102, alone or with the immunotherapy pembrolizumab, in 21 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose, while also …

This early-phase study tested a new drug called BAT8006 in 216 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the best dose for future studies. This is not a cure, but a step toward better control…

This early-phase study tested an experimental oral drug called Q702 in 51 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects, while also looking at whether the drug could shrink …

This trial tested a two-step treatment for people with advanced solid tumors that no longer respond to standard therapies. First, a laser heats and destroys part of the tumor. Then, a drug called IP-001 is injected directly into the treated area to help the immune system recogniz…

This early-stage trial tested an oral drug called JAB-3312 in 40 adults with advanced solid tumors (like lung, colon, or breast cancer) that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects. Researchers also looked …

This early-phase study tested a new oral drug called LP-118 in 68 people with advanced solid tumors or lymphomas that had stopped responding to standard treatments. LP-118 works by blocking two proteins that help cancer cells survive. The main goals were to find a safe dose and c…

This phase 1 study tested an experimental drug called LY3039478 in 247 people with advanced or metastatic cancer, including lymphoma. The main goal was to find a safe dose and see how the drug affects the body. Researchers also looked for signs that the drug might shrink tumors.

This early-phase trial tested a new drug called NB003 in 258 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety, find the right dose, and see if it could shrink tumors. The study is now complete, an…

This study tested an injectable drug called RC88 in 41 people with advanced solid tumours who had no other good treatment options. The main goal was to check the drug's safety and find the right dose. The study is now complete, and results will help guide future research.

This study tested a new drug called RP903 in 69 people with advanced solid tumors (like ovarian, breast, or cervical cancer) who had run out of standard options. The main goals were to check safety, find the best dose, and see if the drug shrinks tumors. It is an early-phase tria…

This early-phase study tested a new daily pill, ASC61, in 18 adults with advanced solid tumors that had stopped responding to standard treatments. The goal was to check the drug's safety and how the body processes it. Researchers looked for side effects and measured tumor respons…

This early-stage trial tested a new oral drug, JNJ-64619178, in 114 people with advanced cancers (including solid tumors, lymphoma, and myelodysplastic syndromes) that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effect…

This early-phase trial tested an experimental drug called ezabenlimab, alone or combined with another drug (BI 754111), in 146 Asian patients with advanced solid tumors. The main goals were to check safety, find the right dose, and see if the combination shrinks tumors in cancers…

This early-phase study tested a new drug called RO7623066, given alone or with other treatments, in 116 adults with advanced solid tumors that had not responded to prior therapies. The main goals were to find the safest dose and check for side effects. While not a cure, the study…

This early-phase study tested an experimental drug called E7090 in 40 adults with advanced solid tumors that had not responded to standard treatments. The goal was to find the safest dose and check for early signs of effectiveness, especially in patients whose tumors have certain…

This early-phase study tested a new drug called ABBV-155, given alone or with standard chemotherapy (paclitaxel or docetaxel), in 168 adults with advanced solid tumors that had come back or stopped responding to treatment. The main goal was to find a safe dose and check for early…

This study tested a drug called 5-ALA in 78 children with brain tumors. The drug makes tumor cells glow under a special light during surgery, helping surgeons remove more of the tumor while avoiding healthy brain. The main goal was to check if the drug is safe for children. Resea…

This early-phase trial tested a new drug called BAT6026 in 30 adults with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check the drug's safety and find the best dose. Researchers also looked at how the drug moves through the body …

This early-stage study tested a new drug called BAT1308 in 59 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find a safe dose and check for side effects. Researchers also looked at how the drug moves through the body. Th…

This early-stage study tested a fixed-dose combination of two immunotherapy drugs (relatlimab and nivolumab) in 24 Chinese patients with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, how the drugs move through the b…

This pilot study tested whether a structured exercise program is feasible for young cancer survivors (ages 18-45) who have mild heart dysfunction after cancer treatment. The program, called CORE, is like cardiac rehab and aims to improve heart health, fitness, and quality of life…

This early-phase study tested a combination of two experimental drugs (AK127 and AK104) in 67 people with advanced or metastatic solid tumours that had stopped responding to standard treatments. The main goals were to check safety and find the right dose, while also looking for s…

This early-stage trial tested a new drug called BAT7104 in 86 people with advanced cancers that had stopped responding to standard treatments. The drug is a bispecific antibody designed to block two proteins (PD-L1 and CD47) that help tumors hide from the immune system. The main …

This completed Phase 2 trial tested whether inhaling a green tea extract called EGCG could help cancer patients with moderate-to-severe COVID-19 pneumonia. 111 participants received either EGCG mist or a placebo three times daily for 7 days. The study looked at lung CT scan impro…

This early-stage trial tested a new drug, GEN1056, in 26 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check the drug's safety and find the best dose. Researchers also looked for signs that the drug might shrink tumors.

This early-phase trial tested a new drug called BR101 in 15 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check the drug's safety, find the right dose, and see if it shows any signs of shrinking tumors. Participants receiv…

This study tested an experimental drug called BMS-986249, either alone or combined with the immunotherapy nivolumab (Opdivo), in 356 people with advanced solid tumors. The main goals were to check safety and find the right dose. Researchers also looked at whether the tumors shran…

This early-phase trial tested a combination of three drugs—afuresertib, sintilimab, and chemotherapy—in 22 adults with solid tumors (including lung, cervical, and stomach cancers) that had stopped responding to prior immunotherapy. The goal was to find a safe dose and see if the …

This early-phase trial tested a new immunotherapy drug called BDB001, alone or combined with atezolizumab (Tecentriq), in 40 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the best dose, and see if t…

This early-phase trial tested a new immunotherapy drug called BDB001, both alone and combined with pembrolizumab, in 87 adults with advanced solid tumors that had progressed after standard treatments. The main goals were to check safety and find the best dose. The study is comple…

This early-phase study tested a new immunotherapy drug called BDB018, given alone or with pembrolizumab, in people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to check safety and find the right dose. Only one person took part, …

This early-phase trial tested a new drug called CHS-388 in 145 people with advanced solid tumors (kidney, liver, or lung cancer) that had stopped responding to standard treatments. CHS-388 is an antibody that blocks a protein called IL-27, which may help the immune system fight c…

This early-phase study tested a new drug called boserolimab (MK-5890), either alone or combined with the immunotherapy pembrolizumab (KEYTRUDA), in 182 adults with advanced solid tumors, including lung and breast cancers. The main goals were to check safety and how the drug moves…

This early-phase trial tested a new drug called HCW9218 in 18 people with advanced solid tumors that had not responded to at least two prior treatments. The drug is designed to both activate immune cells and block signals that help tumors grow. The main goal was to find a safe do…

This study offers continued access to tazemetostat for 58 people with various cancers who already benefited from the drug in earlier trials. The main goal is to monitor long-term safety and side effects. Participants must have shown clinical benefit from tazemetostat before joini…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight. The app tracked diet and activity as part of a behavioral weight loss program. The goal was to see if this approach was practical and well-liked by participants. The study involved 6…

This study tested a new drug called DF9001, which helps the body's natural killer cells attack cancer cells. It was given alone or with another immunotherapy (pembrolizumab) to 24 adults with advanced solid tumors that have the EGFR protein. The goal was to check safety and find …

This study tested two different smoking cessation treatments in 52 adult cancer patients who had been diagnosed within the past 3 years. One group received a 12-week course of the medication varenicline plus 7 counseling calls tailored to cancer patients. The other group received…

This early-phase study tested an experimental drug (MK-1454) injected directly into tumors, either alone or with pembrolizumab (Keytruda), in 156 people with advanced solid tumors or lymphomas. The main goals were to find the safest dose and check for side effects. The study also…

This early-phase trial tested a combination of two drugs, vandetanib and everolimus, in 151 people with advanced or metastatic cancer that had stopped responding to standard treatments. The goal was to find the safest dose and see if the combination could slow or stop cancer grow…

This study tested a quick finger-prick blood test to see if cancer patients had been infected with COVID-19 in the past. Researchers enrolled 214 adults being treated for cancer. The goal was to find out how many had antibodies, including those without symptoms, to help clinics k…

This early study tested a radioactive imaging agent called [99mTc]Tc(CO)3-(HE)3-Ec1 in 10 adults with solid tumors. The agent is designed to attach to EpCAM receptors on cancer cells, making them visible on SPECT scans. Researchers aimed to see where the agent goes in the body, m…

This study tested a handheld device that uses a single wave to measure how well the heart pumps blood and how stiff the arteries are. Researchers compared it to standard echocardiography in 159 cancer patients. The goal was to see if the device could also help identify patients a…

This study tested whether a special dye called fluoroethyltyrosine (FET) can improve PET scans for detecting brain tumors that have come back. 143 people with suspected recurrent brain tumors received an injection of FET before their PET scan. The goal was to see if FET-PET could…

This study tested whether a simple checklist and blood test (the YEARS algorithm) can safely rule out pulmonary embolism (a blood clot in the lungs) in people with active cancer, compared to the standard approach of doing a CT scan on everyone. About 700 cancer patients with susp…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study looked at whether a type of PET scan called FDOPA-PET can help doctors tell the difference between brain tumors and non-cancerous brain lesions. Researchers reviewed scans from 74 patients with suspected brain tumors. They measured how much of the tracer the lesions to…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested whether a taurolidine-citrate solution (TauroLock) placed in the catheter between treatments can prevent bloodstream infections in adults with solid tumors receiving IV anti-cancer therapy. 162 patients were randomly assigned to get either the TauroLock solution…

This phase 3 trial tested whether a biologic called IMM-101 could reduce severe respiratory infections, including COVID-19, in cancer patients at higher risk. 195 participants either received three doses of IMM-101 or were simply observed. The goal was to see if the treatment cou…

This study tested whether a 12-week physical activity program could improve memory and attention in children who had radiation for brain tumors. Thirty-six kids aged 8–17 who finished radiation at least a year ago took part. Half started the program right away, while the other ha…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study tested whether Benson relaxation exercises can improve sleep quality in cancer patients. 72 adults with cancer were randomly assigned to do relaxation exercises or receive a sleep hygiene booklet. The goal was to see if this simple, non-drug method could help with slee…

This study tested whether young cancer survivors (ages 15-39) could learn to do acupressure on themselves to reduce fatigue. 42 people who had finished cancer treatment at least three months ago and still felt tired took part. They used a special tool and a phone app to apply pre…

This study tested three non-drug methods to reduce pain, fear, and anxiety during subcutaneous injections in 45 children aged 6–12 with cancer. The approaches were Buzzy® (a device that vibrates and cools the skin), a cognitive-behavioral coaching package, and a kaleidoscope for …

This study tested whether a one-week physiotherapy program could improve movement, walking, and daily independence in 32 advanced cancer patients receiving palliative care. The program included exercises, mobility training, and breathing therapy tailored to each patient. Research…

This study looked at whether teaching cancer patients about their portable chemotherapy pump (elastomeric pump) can make them feel more comfortable and less anxious. 70 adults receiving 5-FU treatment were split into two groups: one got extra education and a booklet, the other go…

This pilot study tested whether a 12-week exercise program designed for Punjabi-speaking South Asian cancer patients and their support persons is practical and well-liked. Twelve participants did twice-weekly exercise sessions and filled out questionnaires. The goal was to see if…

This phase 3 trial tested whether giving a continuous, slow infusion of ondansetron (a common anti-nausea drug) plus dexamethasone (a steroid) could better control nausea and vomiting in children undergoing chemotherapy. The study enrolled 28 children aged 1 day to 18 years with …

This study tested a one-month program designed to build inner strength in elderly cancer patients who were feeling demoralized. 66 patients took part, with half receiving the program plus standard care and the other half receiving standard care alone. The goal was to see if the p…

This study tested whether using virtual reality goggles during the insertion of a port needle (a common procedure for chemotherapy) can improve comfort and satisfaction in cancer patients. 92 adults with stage I-III cancer were randomly assigned to either standard care or standar…

This study tested whether a yoga program taught by a Black instructor could help Black cancer survivors feel better and improve their quality of life. 13 adults who had cancer in the last 5 years took part. The goal was to see if this approach was acceptable and helpful for manag…

This study tested a low-dose fentanyl patch in 14 cancer patients in Taiwan to see if it is safe and tolerable for managing pain. The patch delivers pain medicine through the skin over 28 days. The main goal was to see how many patients dropped out due to side effects, with the h…

This study tested whether naldemedine, a drug already used for opioid-induced constipation, can also prevent nausea and vomiting when cancer patients start strong painkillers. 120 adults with cancer who were beginning opioid therapy took either naldemedine or a placebo for up to …

This study tested whether the drug benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. The goal was to lower the number of high-grade rashes to milder ones, which could improve quality of life and help patients stay on their cancer t…

This study tested whether a gentle, non-invasive brain stimulation technique called tDCS could help cancer survivors who smoke feel less distressed and smoke fewer cigarettes. 43 participants used the device at home via telehealth. The main goal was to see if people found the dev…

This study tested a Spanish adaptation of Meaning-Centered Psychotherapy for 92 adults who completed cancer treatment. The therapy aims to help patients find meaning in life and reduce anxiety. Participants attended eight group sessions focused on sources of meaning, facing the f…

This study looked at 2,000 adults with solid tumors to find the best dose of olanzapine for preventing nausea and vomiting caused by strong chemotherapy. Researchers compared 2.5 mg, 5 mg, and 10 mg doses to see which works best with the fewest side effects like daytime sleepines…

This study tested a program called Bright IDEAS-YA that teaches young adults with cancer a step-by-step approach to solving problems. The goal was to see if it could reduce symptoms of depression and anxiety and improve quality of life. 344 young adults (ages 18-39) newly diagnos…

This study tested a music therapy program called Meraki for cancer patients receiving palliative care. The goal was to see if three music sessions could improve emotional well-being, reduce anxiety and depression, and boost quality of life. Researchers enrolled 80 patients and me…

This study looked at whether laughter yoga could help cancer patients going through chemotherapy. 55 patients were split into two groups: one did weekly 40-minute laughter yoga sessions for four weeks, while the other received standard care. After four weeks, the laughter yoga gr…

This study tested a 3-week program that helps cancer patients identify their personal strengths (like hobbies, social support, or personal qualities) and use them to cope better. 32 adults with different cancers took part in card-sorting sessions, phone calls, and home exercises.…

This study tested a 6-session therapy called Acceptance and Commitment Therapy (ACT) for cancer patients at risk of opioid misuse. 40 adults with cancer and a high score on an opioid risk tool participated. The goal was to see if the therapy was feasible and acceptable, not yet t…

This study tested whether a simple at-home writing program could help teens and young adults (ages 15-39) who finished cancer treatment feel less distressed about their body image and reduce anxiety. Thirty survivors participated in a four-week expressive writing program. The goa…

This study tested whether coloring mandala patterns can reduce nausea, vomiting, and fatigue, and improve psychological well-being in cancer patients receiving chemotherapy. 85 patients were split into a coloring group and a control group. The coloring session lasted 20-30 minute…

This study tested a special pain coping skills program for people with advanced solid tumor cancer who have pain that interferes with daily activities. 211 patients were randomly assigned to either the program or standard care. The program taught ways to manage pain and find mean…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This pilot study tested whether taking a green tea extract (EGCG) plus vitamin C daily for 12 weeks is safe and feasible for older cancer survivors who are frail or pre-frail. The study enrolled 24 people aged 65 and older who had completed cancer treatment. The main goal was to …

This study looked at whether a structured nutrition education program can improve how much and how well cancer patients eat. 80 adults on active cancer treatment were split into two groups: one received personalized nutrition advice, the other did not. Researchers measured their …

This study tested whether using a virtual reality headset during chemotherapy can reduce distress, anxiety, and pain. 68 cancer patients were randomly assigned to either use VR for 15–30 minutes or receive standard care. Researchers measured changes in distress and pain scores be…

This study looked at whether video doctor visits (telehealth) work as well as in-person visits for people with brain tumors (gliomas) who are taking oral chemotherapy. 30 patients took part, alternating between telehealth and in-person checkups. The goal was to see which type of …

This study tested a mobile app called SyMon-SAYS that lets children with cancer report their symptoms weekly to their doctors. The goal was to see if using the app helps manage symptoms and improve quality of life. 216 children and their parents took part, with some using the app…

This study tested whether a computer-based cognitive training program could help children with brain tumors who had radiation therapy. 45 children were randomly assigned to either an adaptive or non-adaptive training program. The goal was to see if the training could improve thin…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested an experimental oral drug called Trichomylin® in 11 adults with advanced cancer who had moderate to severe pain despite taking strong opioids. The goal was to see if the drug is safe and can provide additional pain relief. Participants took the drug twice daily,…

This study tested a system that helps cancer patients manage fatigue. Patients used a phone app to report their tiredness and wore a smartwatch to track activity. Based on their fatigue level, they received personalized exercise advice. The goal was to see if this approach could …

This study tested whether a gentle, light-touch therapy (therapeutic touch) could help advanced cancer patients in palliative care sleep better and feel less tired. Sixty-one patients were randomly assigned to receive either 5 days of 10-15 minute touch sessions or standard care.…

This study tested a 9-session virtual mind-body program (SMART-3RP) to see if it helps caregivers of cancer survivors feel less stressed and more resilient. It compared the program to a standard online support group. The trial enrolled 94 participants and focused on whether the p…

This study tested a sleep improvement program for people with cancer and their intimate partners who also have sleep problems. The goal was to reduce insomnia and improve sleep quality. Only 2 couples took part, so results are very limited.

This study tested an online program to help cancer patients with insomnia. It included 348 adults with cancer who had trouble sleeping. The program used cognitive-behavioral techniques and aimed to see who might need extra help from a professional.

This completed Phase 1 trial tested a smartphone app that uses mindfulness exercises to help cancer survivors quit smoking. Twelve participants used the app daily for three weeks, completed surveys, and received nicotine patches. The goal was to see if people liked the app and fo…

This study tested whether mild electrical pulses on specific acupoints could reduce nausea and vomiting caused by cisplatin chemotherapy. Thirty-four cancer patients received the stimulation during treatment. The goal was to see if this drug-free approach could ease these common …

This study tested a device that delivers pain medicine directly to the spinal cord for cancer patients with severe pain not controlled by oral opioids. Researchers compared the pump to standard medical management in 30 adults. The goal was to see if the pump reduces pain intensit…

This study tested whether using a low-frequency laser on an acupuncture point (P6) can help prevent nausea and vomiting caused by chemotherapy in children aged 2 to 20. The 30 participants received the laser treatment alongside standard anti-nausea drugs. The goal was to see if a…

This pilot study tested whether a 10-minute virtual reality mindfulness program could help cancer patients relax before their radiation simulation. 25 adults scheduled for radiation planning used a VR headset to practice breathing exercises in a calming virtual environment. The m…

This study tested whether a pharmacist-led program could safely reduce the number of unnecessary medications taken by older adults (65+) with curable cancers starting chemotherapy. 51 patients participated, with oncologists randomly assigned to either a pharmacist review or a sim…

This study tested a program called YATAC, designed to help young adults (ages 18-39) recover from cancer and return to everyday life. The program covers goal-setting, managing daily life, staying active, coping with emotions, education, work, finances, relationships, and peer sup…

This study tested whether a 12-week virtual exercise program could help rural cancer survivors improve their physical function and quality of life. One hundred adults who had completed cancer treatment and lived in rural areas took part. The program focused on cardiovascular endu…

This study tested a 6-month program called CancerPEP that sends daily emails to cancer patients and survivors with tips on exercise, yoga, stress reduction, and healthy eating. The goal was to see if the program is practical and helps improve mental and physical health. 104 adult…

This study tested whether family-focused grief therapy (FFGT) helps families cope when a member has advanced cancer. 700 families were randomly assigned to standard care, 6 therapy sessions, or 10 sessions. The goal was to prevent depression and improve communication during palli…

This study tested an online educational program for cancer patients receiving chemotherapy. The program included video sessions, peer discussions, and digital materials to help with symptom management and emotional coping. Researchers compared 212 patients who used the program to…

This study tested whether a pickleball program is practical and enjoyable for cancer survivors and their family or friends. The goal was to increase physical activity and improve overall wellness. 28 participants joined the program, which involved learning and playing pickleball …

This study looked at whether cancer patients prefer doing yoga online or in a studio during their treatment. 163 people with cancer chose their preferred setting and attended weekly group yoga for 12 weeks. Researchers measured quality of life and interviewed participants about t…

This study tested a new way to help cancer patients quit smoking before their surgery. 282 adults with cancer or suspected cancer who smoked daily took part. Half received standard counseling and nicotine patches, while the other half also got extra rewards for staying smoke-free…

This phase 3 trial tested a drug called APF530, given as a shot, to prevent nausea and vomiting caused by chemotherapy. Over 1,400 cancer patients took part, comparing APF530 with the standard drug Aloxi. The goal was to see if APF530 could keep patients from vomiting or needing …

This phase 3 trial tested whether a new drug called APF530, given as a shot under the skin, works better than the standard drug ondansetron for preventing nausea and vomiting after strong chemotherapy. About 942 cancer patients took part. The study compared both drugs when combin…

This study tested a program that mixes traditional Chinese medicine with standard Western hospital care to help reduce cancer-related fatigue. 86 adults with cancer took part while in the hospital. The main goal was to see if their fatigue levels improved from their worst point t…

This study tested an online sleep education program for young adult cancer survivors (ages 20-39) who have trouble sleeping. Participants took a single online session, with some also getting extra coaching. The goal was to see if it could reduce insomnia and improve mood. The stu…

This study tested an implantable pump that delivers pain medicine directly into the spinal fluid for people with hard-to-treat cancer pain. Eight patients with advanced cancer and severe pain despite strong opioids took part. The goal was to see if the pump could provide better p…

This study tested a smartphone app called Compas-Y, designed to help people with cancer manage emotional distress through self-compassion exercises. 28 adults who had finished cancer treatment and felt low well-being used the app for 6 weeks. Researchers measured changes in self-…

This study tested a smartphone app called POSTHOC that helps cancer survivors manage symptoms and track healthy behaviors after finishing treatment. Fifty-one adults who recently completed cancer therapy used the app or received standard care for 12 weeks. The goal was to see if …

This study looked at whether using a person's DNA to pick an antidepressant works better than usual care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Half got a DNA-guided choice of medication, and the other half got standard care. Resear…

This study tested whether a single online education session can help cancer survivors with insomnia sleep better. 70 survivors took part, learning either behavioral changes to improve sleep or relaxation techniques. The goal was to see if a simple, accessible program could ease i…

This study tested two phone-based programs for cancer survivors and their caregivers to help manage physical and emotional symptoms after treatment ends. 555 survivors and their caregivers took part. The programs provided information and counseling to reduce distress and improve …

This study tested whether asking cancer patients to complete a symptom questionnaire online before their doctor visit could help identify who might benefit from a palliative care referral. Forty adults with advanced cancer participated. The goal was to see if this approach is pra…

This study looked at whether a 12-week adapted physical activity program could help cancer patients feel less tired and improve their quality of life. 37 adults with different cancer types and treatments took part. Researchers measured fatigue, quality of life, and fear of moveme…

This study looked at whether taking statins (cholesterol-lowering drugs) can reduce hearing loss caused by platinum-based chemotherapy in people with solid tumors. 56 adults who were about to start chemotherapy took part. The goal was to see if statins could protect their ears fr…

This study tested whether wearing virtual reality glasses to visit a museum during chemotherapy could help reduce pain, fatigue, and anxiety. 64 patients were split into two groups: one received routine care, while the other also took a 20-minute virtual museum tour each week for…

This study tested if playing an augmented reality game called SpellBound can help children with cancer feel less pain and need fewer opioids after surgery. 29 kids aged 5-15 who had never taken opioids before took part. The game was used alongside standard care to see if it impro…

This study tested an 8-week phone- and app-based program designed to increase hope and reduce life disruption in young adults who have finished cancer treatment. 155 survivors participated in a randomized trial comparing the hope program to a control group. The goal was to see if…

This study tested whether using creams with niacinamide and shea butter can prevent or reduce skin itching in cancer patients receiving immunotherapy. 130 adults with solid tumors starting checkpoint inhibitor treatment were randomly assigned to use either the test cream or a con…

This study tested a program called CAFÉ, where financial navigators helped cancer patients with money concerns after diagnosis. The goal was to reduce financial hardship and improve quality of life. 371 patients from two Kaiser Permanente regions took part. The program provided p…

This study tested whether adding manual acupuncture to standard anxiety treatments (medication and talk therapy) helps cancer patients feel less anxious and improves their quality of life. Thirty-eight cancer patients with moderate to severe anxiety received either real acupunctu…

This study tested whether a telemonitoring app called Cureety could reduce the number of phone calls hospital staff receive from cancer patients starting oral or IV treatment. 86 adults with cancer were randomly assigned to standard care or standard care plus the app. The goal wa…

This study tested a simple, drug-free method called WASPE to help children aged 0-4 years stay still during radiation therapy for cancer. The method uses activities like watching videos, playing, and eating snacks to keep the child awake and calm. 48 children took part, and the g…

This study tested whether a mobile app that lets cancer patients report their symptoms to their doctor can reduce unplanned hospital visits. 166 adults with solid cancers on systemic therapy participated. Half used the app before clinic visits, while the other half had usual care…

This study tested a dietary supplement containing ingredients like palmitoylethanolamide, alpha lipoic acid, and several B vitamins to see if it could reduce nerve pain in cancer patients receiving chemotherapy. 71 newly diagnosed patients who had not yet started treatment took e…

This study tested a 4-week online mindful compassion program for women who had finished cancer treatment and were in hospice care at home. The goal was to see if it could improve sexual function, well-being, and quality of life. Twenty-two women took part, and the program include…

This study tested whether inhaling geranium essential oil during chemotherapy can reduce pain and blood pressure in cancer patients. 90 Indonesian patients under 65 with normal weight took part. The treatment group breathed in geranium oil for 15 minutes during chemo, while the c…

This study tested whether inhaling geranium essential oil can reduce nausea and vomiting in cancer patients receiving chemotherapy. 90 participants were randomly assigned to either inhale geranium oil during chemo or receive no aromatherapy. Nausea and vomiting were measured befo…

This study tested whether an 8-week sleep coaching program delivered through a smartphone app is practical and acceptable for cancer survivors and their bedroom partners. Forty participants were enrolled to see if they would stick with the program and find it helpful. The goal wa…

This study tested a short-term talking therapy (psychodynamic psychotherapy) for 24 adults with advanced solid tumors and high psychological distress. The goal was to see if the therapy is safe, acceptable, and feasible, not to cure the cancer. Results will help design larger stu…

This study looked at whether a walking platform with fall protection and support is practical for older cancer patients (over 70) during hospital stays. 45 patients were enrolled to see if they would use it at least twice for 6 minutes or more. The goal was to help them stay acti…

This study tested a mobile app called HopeMove designed to help teenagers with cancer stay physically active and reduce fatigue. Fifteen adolescents aged 13 to 18 who were receiving cancer treatment used the app for four weeks, doing guided exercises at least three times a week. …

This study tested a program called PRISM that teaches stress management, goal-setting, and coping skills to adolescents and young adults (ages 12-24) with advanced cancer. Researchers wanted to see if it could improve quality of life and reduce anxiety and depression. The program…

This study looked at whether listening to relaxing Turkish music for 30 minutes could help cancer patients in palliative care feel less pain and anxiety. 32 patients took part, with half listening to music and the other half resting quietly. The researchers measured pain, anxiety…

This study tested a program to help older cancer patients get stronger before and after surgery. 148 patients aged 70+ (or 60+ with other health issues) took part. The program included exercise, nutrition advice, and education to reduce complications and improve recovery.

This completed trial tested whether virtual clinics offering exercise sessions and psychological support could help cancer patients maintain physical and mental health while following COVID-19 social distancing rules. Over 1,100 adults with suspected or confirmed cancer took part…

This study tested whether a nasal spray made from rose geranium in sesame oil can improve symptoms of nasal vestibulitis—like dryness, discomfort, bleeding, and scabbing—in cancer patients receiving chemotherapy. Over 100 participants were randomly assigned to use either the rose…

This study tested if the drug Akynzeo can prevent nausea and vomiting in cancer patients getting moderate chemotherapy who are at high risk based on a special prediction tool. Over 400 adults took part. The goal was to see if Akynzeo works better than standard care over three rou…

This study looked at whether a program called expressive helping—where people write or record their feelings—is helpful for Chinese-speaking cancer patients and survivors. About 60 adults with any type of cancer took part. The goal was to see if the program was easy to use and if…

This study tested a nurse-led program to help adults with cancer who are taking part in early-phase clinical trials feel better day-to-day. The program included regular check-ins on symptoms and well-being, plus team meetings to address concerns. Researchers wanted to see if the …

This study tested a financial navigation program for cancer patients in rural and non-rural North Carolina. The program helped patients find financial assistance to reduce the burden of cancer costs. Researchers measured changes in financial toxicity and quality of life in 258 pa…

This study tested a telehealth program called Dyadic Life Review (DLR) for older adults (65+) with advanced cancer and mild cognitive impairment, along with their caregivers. The program involved 8 weekly video sessions where patients and caregivers shared memories from different…

This study tested whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely relieve constipation caused by opioid painkillers in people with cancer. 92 patients took part in a single-blind trial where some received real electroacupuncture and others …

This study tested whether mangafodipir, an MRI contrast agent with antioxidant properties, could reduce nerve damage caused by oxaliplatin chemotherapy. Researchers enrolled 23 cancer patients who already had moderate nerve problems from oxaliplatin but needed to continue treatme…

This study tested Sujok therapy, a technique where seeds are placed on specific points on the hands, to see if it reduces pain and anxiety in cancer patients getting a port catheter for chemotherapy. 90 patients were split into three groups: one received real Sujok, one received …

This study tested a new drug called HR20013 to see if it works better than an existing drug (palonosetron) at preventing nausea and vomiting caused by moderate-risk chemotherapy. Over 700 cancer patients who had never had chemo before took part. The main goal was to see how many …

This study tested a new medicine called QLM2010 to see if it can prevent nausea and vomiting caused by strong chemotherapy. 665 adults with solid tumors who had never had chemo before took part. The goal was to see if QLM2010 works better than current standard drugs at stopping v…

This 12-week home study tested whether a Fitbit tracker and health coaching could help 64 older cancer survivors become more active. Participants did light activities like walking or stretching. The goal was to see if this approach is practical and can improve physical function a…

This study tested whether Reiki, a relaxation therapy where a practitioner places hands on or near the body, could help cancer patients with symptoms like pain and fatigue. Ten adults with cancer who had at least three bothersome symptoms received up to six Reiki sessions. Resear…

This study tested a mobile app called STAMP+CBT for advanced cancer patients with chronic pain. The app helps patients track their pain, mood, and opioid use while providing tailored education and cognitive behavioral therapy (CBT) exercises. Fifty-two patients used the app for 4…

This study tested a new program called SMILE that helps teens and young adults (ages 15-29) with advanced cancer manage symptoms like pain, fatigue, and emotional distress. The program includes four video sessions at home, teaching relaxation and coping skills. Researchers checke…

This study tested a 30-week walking program for cancer survivors who had been hospitalized with COVID-19. The goal was to see if the exercise was safe and caused few side effects. Only 3 people took part, so the results are very early and not conclusive.

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looks at whether a 12-week program of cooking demonstrations, recipe cards, and free fruit and vegetable bundles can help cancer survivors eat healthier. Only 11 people are taking part, and the main goal is to see if such a program is practical and keeps people interes…

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study collects and analyzes health records from 10,000 cancer patients across multiple sites. Researchers will use this real-world data to better understand patient populations, improve clinical trial design, and support drug development. No new treatments are tested—the goa…

This completed study enrolled over 1,200 people with brain or spinal cord tumors to collect medical information, blood samples, and tumor tissue. The goal was to better understand these cancers and identify promising areas for future research. Participants also received guidance …

This study tested whether a smartphone app called QuestOnco can reliably track side effects in 134 adult cancer patients receiving active treatment. Patients used the app to report symptoms, and researchers compared those reports to standard paper questionnaires. The goal was to …

This completed study collected tongue images and clinical data from 4,100 people—both cancer patients and healthy individuals—to build a database. Researchers plan to use artificial intelligence to analyze tongue features for early cancer screening and diagnosis. The study did no…

This completed study surveyed 100 adults with brain tumors (gliomas) to understand how social factors like income, education, housing, and community support affect their health. Participants answered questionnaires about their neighborhoods, access to food and transportation, and…

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

This study looks at the DNA of 100 children (and young adults up to age 17) who have cancer, along with the DNA of their healthy parents. The goal is to find genetic changes that may have caused the cancer. By comparing the child's DNA to both parents', researchers hope to discov…

This pilot study tested whether a heart MRI could be done safely and effectively in children with cancer who recently had sepsis. The goal was to see if the MRI could find hidden heart inflammation or weakness that standard tests might miss. Only 7 children took part, and the foc…

This study tested whether letting patients move freely between the injection of a radioactive tracer and the PET scan affects image quality. Normally, patients must rest for an hour to avoid muscle uptake that can blur results. The trial involved 284 adults with cancer or needing…

This study looks at whether it's possible for people diagnosed with solid tumors to have a follow-up visit with their general practitioner within 15 days of learning their diagnosis. Researchers will track how many patients actually attend this visit and why some might not. The g…

This study looked at whether an informational video could help parents and teens better understand genetic testing after a new cancer diagnosis. About 355 families from a children's hospital took part. The goal was to see if the video was acceptable and improved knowledge about g…

This study looked at brain tumors (gliomas) in 128 patients under 25 treated at one French hospital. Researchers compared the genetic and imaging features of tumors in children (0-14 years) versus adolescents and young adults (15-25 years). The goal was to see if these groups hav…

This study observed 255 cancer patients receiving immunotherapy to understand why some develop skin side effects. Researchers measured immune markers and lipids in the skin and blood. The goal is to identify patterns that could predict or explain these reactions.

This study tested a nutrition program for cancer survivors who are overweight or have obesity. The program included one-on-one counseling with a dietitian, behavioral skills training, and group support. The goal was to see if the program was easy to run and acceptable to particip…

This completed study reviewed medical records of 200 adults with cancer who received the drug nivolumab (Opdivo) either as an intravenous infusion or as a subcutaneous injection (Opdivo Qvantig) in community oncology clinics across the United States. The goal was to describe the …

This study investigates which parts of the brain help us judge when a moving object will reach us, a skill used in daily life. Researchers test patients during awake brain surgery for tumor removal, using a simple task where they estimate when a disappearing object would have mad…

This study looked at medical records of 938 adults with solid tumors who received immunotherapy. Researchers compared how well the treatment worked when cancer had spread to different organs like the liver, brain, lung, or bone. The goal is to understand why some metastatic sites…

This study tested a program that lets recently hospitalized cancer patients recover at home with remote monitoring of symptoms, vital signs, and weight. The program includes home visits and close communication with the oncology team. Researchers wanted to see if this approach is …

This pilot study tested whether it's possible to adjust proton radiation plans each day while the patient is on the treatment table. Ten adults with solid tumors took part. The goal was to see if this approach is safe and practical enough to study in a larger trial.

This study tested whether providing grocery delivery (via Instacart) and weekly nutrition coaching calls helps cancer survivors who struggle to afford healthy food. Forty survivors who had finished active cancer treatment took part. The goal was to see if this support was practic…

This study measured how two common blood thinners (rivaroxaban and apixaban) behave in 193 adults with active cancer who also had blood clots or atrial fibrillation. Researchers aimed to understand factors like age, weight, and kidney function that affect drug levels. The goal wa…

This completed study at Sohag Oncology Center tested whether a quality-of-life survey could help match cancer patients' needs with the right supportive care, like pain management or nutrition counseling. Over 4,400 adult cancer patients completed the EORTC QLQ-C30 questionnaire, …

This study tested whether machine learning can detect cancer pain by analyzing facial expressions, voice, and speech. 83 people with cancer recorded videos at clinic visits and at home over 3 months. The goal was to see if this technology could classify pain levels in a diverse g…

This completed registry followed nearly 8,000 adults with solid tumors who had next-generation sequencing (NGS) genetic testing. The goal was to collect real-world data linking test results, treatments, and survival. No new drug or intervention was tested; instead, the registry a…

Researchers tested a new online tool called PIPO that helps doctors estimate how long a cancer patient might live. This information can guide decisions about which patients to enroll in early-phase clinical trials. The study included 586 people who had already joined phase 1 or p…

This study tested a machine learning model that uses electronic health records to predict which cancer patients receiving infusion therapy are at risk of needing emergency care or hospitalization within 30 days. Researchers analyzed data from over 4,700 patients at UCSF. The goal…

This study looked at whether a virtual reality (VR) education program could help first-time radiation therapy patients understand their treatment better and reduce anxiety and depression. 84 cancer patients were split into two groups: one received VR education, the other standard…

This pilot study tested a program called GUIDE, which uses a trained navigator to help cancer patients overcome social and financial barriers to joining clinical trials. The study included 100 adults with cancer who were eligible for a trial and had at least one health-related so…

This study created and tested an educational website to help Black and African American cancer patients learn about personalized cancer treatments and clinical trials. Researchers interviewed 48 patients and caregivers, then tested the website with 33 patients. The goal was to se…

This completed study looked at whether adding a warning prompt above cancer misinformation posts on social media encourages people to flag them. Researchers recruited 294 US adults who had either been diagnosed with cancer or cared for someone with cancer. Participants saw fake s…

This study tested whether a special MRI scan (31P-MRS) can detect early signs of damage to heart and muscle cells caused by chemotherapy drugs like doxorubicin. Twelve cancer patients scheduled for chemo underwent three scans over time. The goal was to see if the scan could measu…

This study tested a new on-couch imaging system called HyperSight, which takes 3D X-ray pictures (CBCT) of cancer patients right before their radiation treatment. 46 adults with head/neck, chest, abdomen, or pelvic cancers received both the new HyperSight scan and a standard scan…

This study tested a co-designed nutritional training program for 20 oncology nurses in Vietnam. The program included a three-day workshop with theory and hands-on practice, focusing on managing diet-related side effects of cancer treatment like nausea and diarrhea. Researchers me…

This study tested whether a detailed genetic analysis of tumor tissue could find treatment targets in 80 children with recurrent or very high-risk brain tumors. The goal was to see if this approach is practical and can help doctors choose personalized therapies. No new drugs were…

This study looked at whether it's possible to measure muscle mass and physical function in children (ages 8-21) with newly diagnosed solid tumors or lymphoma during cancer treatment. Researchers used simple tests like a 6-minute walk and a special drink to measure muscle, along w…

This study looked at how cancer treatment changes patients' ability to stick with a Mediterranean diet. Researchers followed 116 patients starting chemotherapy or immunotherapy, checking their diet adherence and sensory changes (taste and smell) at the start and after 9 weeks. Th…

This study looked at how cancer patients, the general public, and healthcare professionals use and feel about large language models (like ChatGPT) for making cancer treatment decisions. Over 7,000 people from 30 countries completed a survey. The goal was to understand current usa…

This study looked at how trust and communication (called a therapeutic alliance) between Latino/a advanced cancer patients and their oncologists might affect care. Researchers interviewed 4 doctors and held focus groups with 10 patients to understand barriers and what helps build…

This study looked at 330 older adults (65+) who had cancer surgery to see if low albumin levels before surgery led to more complications. Researchers compared patients with low albumin to those with normal levels, tracking problems like infections, hospital stay length, and ICU n…

This study tested whether a tool called the ARISCAT score can predict lung complications (like pneumonia or collapsed lung) after major abdominal cancer surgery. Researchers followed 410 adults who had surgery under general anesthesia. The goal was to see if the score could help …

This study aimed to improve how we measure quality of life in cancer patients whose disease is progressing. Researchers interviewed 20 patients, their carers, and healthcare professionals to learn their preferences on how often and in what way to collect this information. The goa…

This study looked at how cancer patients feel about returning to work while undergoing treatment. Researchers interviewed 20 patients to understand their needs and how work affects their sense of normalcy. The goal is to help nurses provide better support for work-related challen…

This study looked at whether analyzing the DNA of a patient's tumor can help doctors pick a targeted therapy for advanced or metastatic cancer. Researchers enrolled 550 adults with various solid tumors that had spread. They took biopsy or blood samples to search for genetic chang…

This study looked at 135 people with advanced lung cancer, lymphoma, or other tumors treated with immunotherapy drugs called checkpoint inhibitors. Researchers collected blood and tumor samples over time to measure immune cells and molecules that might predict whether the treatme…

This study looked at the needs and challenges of family caregivers who help older adults (70+) with cancer. Researchers interviewed 78 caregivers to understand their social and personal situations, and tested a personalized support program with phone follow-ups. The goal was to s…

This study looked at how the drug tuvusertib is absorbed, broken down, and removed from the body in 12 people with advanced solid tumors. Participants received a tiny radioactive tracer to track the drug. The main goal was to understand the drug's path in the body, not to treat t…

This completed study enrolled 84 people with brain tumors, meningioma, or high-grade sarcoma who received proton beam therapy. Researchers analyzed tumor and blood samples to find biomarkers that might predict how well the cancer responds to treatment. The goal is to eventually h…

This study tested whether an 18F-FDOPA PET scan changes treatment decisions for people with high-grade gliomas (aggressive brain tumors) when standard MRI results are unclear. Researchers enrolled 110 patients and compared treatment plans before and after the scan. The goal was t…

This completed study followed 360 adults and children with chronic respiratory and other medical conditions to see how their immune systems responded to COVID-19 vaccines over 18 months. Researchers measured antibody, T cell, and B cell levels before vaccination and every 3 month…

This study tested two different PET-CT scanners to see which one is better at finding very small cancer spots (less than 1 cm) in patients. Twenty-four people with cancer each had two scans, one on each machine. The researchers then added virtual lesions to the images to compare …

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

This study looked at whether children with cancer who watch mukbang (eating shows) have better appetite during hospital treatment. Researchers tracked 179 children's eating habits and video watching over several days. The goal was to see if there's a link that could help improve …

This completed study looked at how re-irradiation affects the quality of life and symptoms of 20 children with diffuse intrinsic pontine glioma (DIPG) or recurrent brain tumors, as well as their caregivers. Researchers used surveys to track physical, emotional, and social well-be…

This completed study looked at 300 cancer patients treated with immune checkpoint inhibitors to see if measuring troponin levels could help detect serious heart problems early. The goal was to prevent major cardiovascular events like heart attack or stroke without unnecessarily s…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This completed study tested a new tool called Life S-Can that quickly checks diet, exercise, sleep, and mental health in cancer survivors. 105 survivors used the tool and some received extra coaching from health experts. The goal was to see if the tool helps doctors give better s…

This study tested whether having a clinical pharmacist review medications for cancer patients before they start treatment could prevent drug-related problems. Researchers observed 440 adults with solid tumors who were about to receive chemotherapy, immunotherapy, or oral targeted…

This study looked at 460 people with HIV to see what types of cancer they have and why some choose to join cancer clinical trials. Researchers tracked cancers like Kaposi sarcoma, lymphoma, and HPV-related tumors. They also used surveys to learn how HIV and cancer treatments affe…

This study looked at skin problems caused by targeted cancer therapies. Researchers followed 141 cancer patients starting these treatments, recording any skin reactions through exams and photos. The goal was to better understand why these side effects happen and how to manage the…

This study gathered information from nearly 3,000 cancer patients aged 65 and older to learn more about their health, living situations, and the care they receive. No new treatments were tested. The goal was to create a database that helps doctors and researchers better understan…

This completed study involved 633 participants and aimed to develop two clinical tools to identify and measure stigma experienced by children with cancer and their caregivers. Researchers worked in the United States, Guatemala, and Jordan to ensure the tools are culturally releva…

This study looked at the emotional and practical challenges faced by patients with incurable cancer and their caregivers when planning to return home for end-of-life care. Researchers measured how each person perceived the burden, using surveys and statistical analysis to find fa…

This study looked at how often a muscle enzyme called CPK increases in people with solid tumors who are taking a type of targeted therapy called tyrosine kinase inhibitors (TKIs). Researchers measured CPK levels in routine blood tests from 154 patients and checked if high levels …

This study aimed to understand and address financial stress in teens and young adults (ages 15-39) recently treated for cancer. Researchers tested a financial education and navigation program to see if it was helpful and practical. The study involved 26 participants and focused o…

This study looked at how common frailty is in people aged 70 and older with solid tumors who visited a cancer center. Researchers used a short questionnaire called VES-13 to screen patients before their doctor visit. They also compared the test results with the doctor's own judgm…

This study compared anxiety, depression, and quality of life between 125 cancer patients who joined clinical trials and those who received standard treatment. Researchers used questionnaires to measure stress and emotional well-being. The goal was to understand how trial particip…

This study looked at how patients with advanced cancer respond to being offered a conversation about their future care preferences. Researchers invited 71 patients to discuss their wishes and tracked who took part. The goal was to learn more about what helps patients feel ready t…

This study looked at 42 adults with advanced solid tumors who were already on or about to start checkpoint inhibitor immunotherapy and also needed palliative radiotherapy for symptom relief. Researchers wanted to see if the combination was safe (less than 30% severe side effects)…

This study tested a program called FinFit to help adolescent and young adult cancer survivors deal with money problems caused by their illness. Researchers interviewed 16 people from community cancer clinics to design and improve the program. The goal was to figure out the best w…

This Mayo Clinic study tested whether 3D surface images can replace standard CT scans for planning electron radiation therapy. Researchers used plastic models to compare dose accuracy between virtual CTs from 3D scans and real CTs. The goal is to reduce radiation exposure and spe…

This study watched 225 people with solid tumors who got a drug called G-CSF during chemotherapy. G-CSF can cause bone pain. Researchers measured pain levels and tracked what treatments (like pain relievers or other methods) helped. They also checked quality of life, fatigue, mood…

This study looked at 232 adult cancer patients with sepsis and low blood pressure to see if adding a type of antibiotic called aminoglycosides helps them recover faster. The main goal was to see how quickly their blood pressure returned to normal without needing strong blood pres…

This study looked at how financial problems affect the well-being of hospitalized cancer patients and their caregivers in Turkey. Over 750 patients filled out surveys about their finances, mood, and quality of life. The goal was to understand the link between money stress and car…

This completed study looked at 90 adults with glial brain tumours to see if their quality of life and thinking abilities (like memory and focus) could help predict how long they live. Researchers used questionnaires and cognitive tests to track changes over time. The goal is to h…

This study looked at 3820 adults with cancer who also had COVID-19. Researchers collected routine medical data to describe symptoms and identify factors affecting survival. The goal was to learn more about how COVID-19 affects cancer patients, not to test a new treatment.

This study looked at 30 cancer patients with COVID-19 pneumonia to see if lung ultrasound could work as well as CT scans for diagnosis. Researchers compared the imaging results and checked if they matched the patients' symptoms and lab tests. The goal was to find a cheaper, easie…

This study looked at whether using a Spiritual Needs Questionnaire helps identify and address the spiritual needs of patients in palliative care. About 100 patients with cancer, heart failure, COPD, or ALS took part. The goal was to see if this approach is practical and beneficia…

This study looked at over 1,100 critically ill cancer patients in the ICU to see if iron levels in the blood could help predict who would survive for 30 days. Researchers used artificial intelligence to combine iron markers with other routine lab results. The goal was to create a…

This study explored whether a nutritional index (PNI) can predict death and other complications after brain tumor surgery. Researchers analyzed data from over 3,200 adults who had surgery at a major hospital in South Korea. The goal was to see if this simple blood-based score cou…

This study tested whether showing cancer survivors real-time glucose data from a wearable sensor can encourage them to be more physically active. 60 cancer survivors at high risk for type 2 diabetes wore a Fitbit and some also wore a continuous glucose monitor for 4 weeks, receiv…

This study looked at leftover tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors who were having surgery. The goal was to measure cell counts and viability to help scientists design better treatments for brain cancer and other solid tumors in t…

This study looked at how children who survived brain tumors interact with others. Researchers tested their thinking and social skills to see what helps or hurts their friendships. The goal was to learn more, not to test a new treatment.

This completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…

This study looks at how two common drugs—rifampicin (an antibiotic) and itraconazole (an antifungal)—affect the levels of a new cancer drug called BI 907828 in the blood. It involves 33 adults with advanced solid tumors who have not responded to previous treatments. Participants …

This study looked at 103 diabetic adults starting chemotherapy for cancer. Researchers used a continuous glucose monitor (Freestyle Libre) to track blood sugar changes. The goal was to see how often blood sugar went too low or too high during treatment, since chemotherapy and rel…

This study tested a website designed to help people with advanced cancer and their family caregivers talk about advance care planning. Researchers worked with 36 patient-caregiver pairs to see if the website was easy to use and helpful. The main goal was to gather feedback to imp…

This study looked at how Chinese Americans talk about advance care planning—decisions about end-of-life care—with their families. Researchers interviewed religious leaders, patients with chronic diseases, and family caregivers in Chicago to understand their needs and readiness. T…

This study looked at 33 adults who had both immune thrombocytopenia (ITP) — a condition where the immune system destroys platelets — and cancer. Researchers wanted to see if treating the cancer could also improve ITP. They also investigated whether cancer cells might mimic platel…

This study tested a web-based program called GIFT that helps cancer patients share information about inherited cancer risks with their relatives. Over 3,000 patients and their family members took part. The goal was to see if the tool encourages more relatives to get genetic testi…

This study looked at whether measuring elastin fragments in blood or urine can help assess frailty in people aged 65 and older with cancer. Frailty is hard to measure with current methods, which can be slow and subjective. The researchers hope that a biological marker could provi…

This study looked at two ways to help people with advanced cancer plan their future medical care: one-on-one talks with a trained nurse or social worker (in person or by phone), or using a website on their own. Over 600 patients took part to see which method helped them think abo…

This French study asked 49 cancer patients how they felt about switching from hospital to home-based immunotherapy. The goal was to see if home treatment improved their satisfaction with care. It was an observational study, meaning no new treatments were tested—just patient exper…

This study tested two new methods to measure pressure and stiffness inside solid tumors in 27 patients. One method uses a thin catheter to measure pressure directly, and the other uses sound waves like an ultrasound to check stiffness. The goal was to see if these measurements co…

This study tested whether a machine learning model could predict kidney injury caused by platinum chemotherapy more accurately than doctors. Researchers followed 77 cancer patients receiving cisplatin or carboplatin, tracking their kidney function over time. The goal was to see i…

This study looked at whether sending reminders to cancer patients and alerts to their nurses helps them complete regular symptom questionnaires. Over 476 patients starting a new cancer therapy were split into three groups: usual care, reminders plus nurse alerts during clinic vis…

This pilot study tested whether a mobile program could help young adult cancer survivors (ages 18-39) increase physical activity and improve their diet. The program included behavioral lessons, an activity tracker, and simplified diet monitoring using a traffic-light approach. Th…

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This study tracked 300 cancer patients receiving their first round of chemotherapy to see how often nausea and vomiting still happen, even with standard anti-nausea medicines. Participants filled out questionnaires about their symptoms in the first 24 hours and up to 4 days after…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study tested whether giving cancer patients a list of questions to ask their doctors helps them feel more empowered and less anxious. About 96 patients, along with nurses and doctors, took surveys and shared their experiences. The goal is to improve communication and make pa…

This completed study enrolled 200 cancer patients aged 40-85 who were about to start chemotherapy. Researchers tracked symptoms like numbness, daily activity, and falls using surveys, activity monitors, and even smart socks. The goal was to find simple ways for doctors to predict…

This completed study followed 183 cancer patients starting checkpoint inhibitor therapy to see how often they develop autoantibodies—proteins that can mistakenly attack the body's own tissues. Researchers collected blood samples to track changes in several types of autoantibodies…

This pilot study tested a personalized program to help teens and young adults (ages 15-24) with cancer take their oral chemotherapy or preventive medications as prescribed. 70 participants were randomly assigned to either the tailored program or standard care. The main goal was t…

This study tested whether an electronic diary app helps cancer patients take their oral medications more consistently than a traditional paper diary. A total of 124 adults with solid tumors or blood cancers were randomly assigned to use either the app or a paper diary to track th…

This study looked at health-risk behaviors like smoking, alcohol use, diet, and exercise among 46 cancer survivors in France. The goal was to see how common these behaviors are so doctors can better help survivors avoid future health problems. The study found that many survivors …

This completed study looked at how well early COVID-19 antiviral therapies work in cancer patients. Researchers tracked 112 patients with solid tumors who received these treatments to see how many needed hospitalization within 14 days. The goal is to fill knowledge gaps and impro…

This study tested whether eating at least two eggs daily can help cancer survivors restore lost muscle and improve their quality of life after treatment. Only 2 people took part, making it a very small feasibility trial. Researchers measured protein intake, body weight, and overa…

This study followed 272 people with brain tumors who received Gliadel Wafer, a chemotherapy implant placed during surgery. Researchers tracked how long patients lived and whether the tumor came back, as well as any side effects. The goal was to see how the treatment works in real…

This study tested whether a wearable device and smartphone app can monitor cancer patients' vital signs and symptoms as well as standard in-clinic checks. About 100 patients with various cancers participated, either after CAR-T cell therapy or during radiation treatment. The goal…