Can a Two-Drug combo outsmart childhood cancers that resist treatment?

This early-stage trial is testing whether combining two chemotherapy drugs, temozolomide and topotecan, is safe and tolerable for children and adolescents with malignant tumors that have returned or not responded to standard treatments. The study aims to find the highest safe dose of each drug when used together, while also checking how the body processes them and whether the combination shows any signs of shrinking tumors. Participants must have a confirmed cancer with no curative options available and be healthy enough to undergo treatment.