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Can an AI chatbot lift the spirits of advanced cancer patients?

NCT ID NCT07793084

Symptom relief Sponsor: National Yang Ming Chiao Tung University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This trial tests whether an AI emotional companion app can improve depression, anxiety, and demoralization in adults with advanced cancer. Participants use a mobile app where a virtual character holds conversations, reads emotional cues, and offers a link to a human hotline if distress spikes. Researchers compare their mental health, quality of life, and sleep against a control group, and also explore how patients experience the interaction.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AI emotional companion assistant, a mobile app with a virtual character that uses Azure OpenAI, speech synthesis, and emotion recognition to provide empathetic conversations and offer human hotline referrals when needed
What this could lead to
If it works, this could offer a convenient, always-available way to support the mental health of people with advanced cancer, easing depression, anxiety, and demoralization without needing extra clinic visits.
What could go wrong
This is a small early-stage trial with 50 participants, so results may not apply broadly. The app might not match the depth of human therapy, and some patients may not engage with a virtual companion.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Nov 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * (1) Patients diagnosed with advanced cancer; (2) A score of 6 or higher on the Brief Symptom Rating Scale (BSRS-5); (3) Aged between 20 -65 years old; (4) Ability to communicate in Chinese; (5) Ownership of a smartphone with internet access and the ability to use it; (6) Willingness to participate in the study. Exclusion Criteria: * (1) Individuals determined by a physician to have suicidal ideation or tendencies; (2) A score of 2 or higher on the last item (suicidal thoughts) of the BSRS-5 scale; (3) Unable to communicate verbally.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Advanced cancer

Contacts and locations

Locations

  • National Yang Ming Chiao Tung University

    Taipei, 155, Taiwan

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