New antibody combo takes on advanced cancers in first human trial
NCT ID NCT04130542
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tested an experimental drug called LVGN6051, which activates immune cells by targeting CD137, both alone and combined with the approved immunotherapy Keytruda. The study involved 105 adults with advanced or metastatic cancers that had spread. The main goal was to find a safe dose and check for side effects, not yet to measure how well it fights cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LVGN6051 (an experimental antibody) and pembrolizumab (Keytruda, an approved immunotherapy)
What this could lead to
If successful, this could lead to a new treatment option for people with advanced cancers that have not responded to other therapies.
What could go wrong
This is a very early (Phase 1) trial focused on safety and dosing, not on proving effectiveness. Many experimental cancer drugs fail in later stages. Side effects from immune activation could be serious.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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MD Anderson Cancer Center
Houston, Texas, 77030-3722, United States
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NYU Langone Health
New York, New York, 10016, United States
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Nebraska Cancer Specialist
Omaha, Nebraska, 68130, United States
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The Johns Hopkins University
Baltimore, Maryland, 21205, United States
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UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, 94115, United States
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University of California Irvine Health
Orange, California, 92868, United States
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Verdi Oncology Research
Lafayette, Indiana, 47905, United States