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Genetic testing could unlock new treatments for kids with brain cancer

NCT ID NCT04859543

Completed Knowledge-focused Sponsor: Masaryk University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a detailed genetic analysis of tumor tissue could find treatment targets in 80 children with recurrent or very high-risk brain tumors. The goal was to see if this approach is practical and can help doctors choose personalized therapies. No new drugs were given; the study focused on gathering information.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could show that genetic testing helps doctors choose better treatments for children with aggressive brain tumors.
What could go wrong
This was a small, early study that only looked at feasibility, not whether the treatments actually work. The results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm central nervous system cancer central nervous system neoplasm childhood malignant neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CENTRAL NERVOUS SYSTEM NEOPLASMS GEN1 GENE MUTATION PEDIATRIC CANCER TUMOR, BRAIN

Contacts and locations

Locations

  • Medical University of Vienna

    Vienna, Spitalgasse 23,, 1090, Austria

  • Motol University Hospital

    Prague, V Úvalu 84,, 150 06, Czechia

  • University Hospital Brno

    Brno, Černopolní 9,, 613 00, Czechia

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