New shot could stop chemo sickness in its tracks

NCT ID NCT00343460

Completed Symptom relief Sponsor: Heron Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested a drug called APF530, given as a shot, to prevent nausea and vomiting caused by chemotherapy. Over 1,400 cancer patients took part, comparing APF530 with the standard drug Aloxi. The goal was to see if APF530 could keep patients from vomiting or needing rescue medicine during the first day and the following days after chemo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: APF530 (a drug given as a shot under the skin)
What this could lead to: If it works, this could give cancer patients a new option to prevent nausea and vomiting during chemotherapy, improving their quality of life.
What could go wrong: This is a completed phase 3 trial, but results may not show a clear advantage over the existing drug Aloxi. The benefit may be modest and not apply to all chemotherapy types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer Nausea Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAUSEA AND VOMITING UNSPECIFIED ADULT SOLID TUMOR, PROTOCOL SPECIFIC

Contacts and locations

Locations

Advanced Research Management Services, Incorporated

Los Angeles, California, 90057, United States
Anniston Oncology, PC

Anniston, Alabama, 36207, United States
Arizona Clinical Research Center, Incorporated

Tucson, Arizona, 85715, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
Boice Willis Clinic, PA

Rocky Mount, North Carolina, 27804, United States
Cancer Center of Indiana

New Albany, Indiana, 47150, United States
Cancer Outreach Associates - Abingdon

Abingdon, Virginia, 24211, United States
Cancer Treatment Centers of America at Southwestern Regional Medical Center

Tulsa, Oklahoma, 74133-4564, United States
Center for Cancer and Blood Disorders at Suburban Hospital

Bethesda, Maryland, 20817, United States
Center for Clinical Research at Washington County Hospital

Hagerstown, Maryland, 21740, United States
Charleston Hematology Oncology Associates, PA

Charleston, South Carolina, 29403, United States
Clintell, Incorporated

Skokie, Illinois, 60077, United States
Columbus Clinic, PC

Columbus, Georgia, 31901, United States
Compassionate Cancer Care Medical Group Incorporated - Corona

Corona, California, 92882, United States
Compassionate Cancer Care Medical Group Incorporated - Fountain Valley

Fountain Valley, California, 92708, United States
Comprehensive Cancer Center at Pardee Hospital

Hendersonville, North Carolina, 28791, United States
Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States
Eastern North Carolina Medical Group, PLLC

Rocky Mount, North Carolina, 27804, United States
Falck Cancer Center at Arnot Ogden Medical Center

Elmira, New York, 14905, United States
Family Medicine of Vincennes Clinical Trial Center

Vincennes, Indiana, 47591, United States
Gabrail Cancer Center - Canton Office

Canton, Ohio, 44718, United States
Gabrail Cancer Center - Dover Office

Dover, Ohio, 44622, United States
Hematology-Medical Oncology Associates at Central Maine Comprehensive Cancer Center

Lewiston, Maine, 04240, United States
Hudson Valley Hematology-Oncology Associates - Poughkeepsie

Poughkeepsie, New York, 12601, United States
Innovative Medical Research of South Florida, Incorporated

North Miami Beach, Florida, 33179-4709, United States
Investigative Clinical Research, LLC

Indianapolis, Indiana, 46254, United States
Julie and Ben Rogers Cancer Institute at Memorial Hermann Baptist Beaumont Hospital

Beaumont, Texas, 77701, United States
Kansas City Cancer Centers - South

Kansas City, Missouri, 64131, United States
Kenmar Research Institute

Los Angeles, California, 90057, United States
Kentuckiana Cancer Institute, PLLC

Louisville, Kentucky, 40202, United States
Kentucky Cancer Clinic - Hazard

Hazard, Kentucky, 41701, United States
Mary Babb Randolph Cancer Center at West Virginia University Hospitals

Morgantown, West Virginia, 26506-9300, United States
McDowell Cancer Center at Akron General Medical Center

Akron, Ohio, 44302, United States
MedCentral - Mansfield Hospital

Mansfield, Ohio, 44903, United States
Medical Center Vincennes

Vincennes, Indiana, 47591, United States
Medical Oncology Care Associates - Orange

Orange, California, 92868, United States
Mercy Medical Center

Baltimore, Maryland, 21202-2165, United States
MultiCare Regional Cancer Center at Tacoma General Hospital

Tacoma, Washington, 98405, United States
Northern Michigan Hospital

Petoskey, Michigan, 49770, United States
Pacific Cancer Medical Center, Incorporated

Anaheim, California, 92801, United States
Palo Verde Hematology Oncology - Glendale

Glendale, Arizona, 85304, United States
Pasco Pinellas Cancer Center - New Port Richey

New Port Richey, Florida, 34689, United States
Pottsville Cancer Clinic

Pottsville, Pennsylvania, 17901, United States
Providence Hospital

Washington D.C., District of Columbia, 20017, United States
Regional Cancer Center at Singing River Hospital

Pascagoula, Mississippi, 39581, United States
Signal Point Hematology Oncology Incorporated

Middletown, Ohio, 45042, United States
Southbay Oncology / Hematology Medical Group

Campbell, California, 95008, United States
Star Hematology & Oncology

Phillipsburg, New Jersey, 08865, United States
Texas Cancer Clinic

San Antonio, Texas, 78240, United States
Veterans Affairs Medical Center - Buffalo

Buffalo, New York, 14215, United States
Virginia Oncology Care, PC

Richlands, Virginia, 24641, United States
Western Washington Oncology, Incorporated, PS at Western Washington Cancer Center

Lacey, Washington, 98503, United States

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