Brain tumor chemo delivered by pump shows promise in tiny safety trial

This early-phase study tested whether pumping the chemotherapy drug topotecan directly into the brain is safe for people with recurrent high-grade gliomas (aggressive brain tumors). Only 5 patients took part, and the main goal was to find a safe dose. The drug was delivered continuously through a small pump implanted under the skin. While the trial is too small to say if it works, it lays groundwork for future studies on this direct-delivery approach.