HYPERTENSION

This study tests a 9-month program for women who had preeclampsia in their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and lifestyle coaching. Researchers want to see if it lowers blood pressure and helps w…

This study is testing whether getting healthy, DASH-diet groceries delivered to your home, along with help from a dietitian, can lower blood pressure in adults with high blood pressure. About 150 people in Florida, Georgia, and Tennessee will take part. Participants will eat only…

This study tracks 1,000 Medicare patients with hard-to-control high blood pressure to see if a procedure called renal denervation (RDN) plus standard care works better than standard care alone. Researchers will compare blood pressure changes and heart events over two years using …

This study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will enroll 100 adults aged 18-60 who speak English or Spanish and have poorly controlled blood pressure or diabetes. The goal is to see if home visits lead…

This study follows 1,000 adults with high blood pressure that remains high despite lifestyle changes and medication. Participants receive a one-time procedure using the Paradise System, which uses ultrasound to calm overactive kidney nerves. The goal is to see if the device safel…

This study tests whether a daily pill called empagliflozin, originally used for diabetes, can improve heart function in 80 older adults with high blood pressure and obesity who are at risk for heart failure. Participants take either the drug or a placebo for 9 months, and doctors…

This study looks at whether a 12-week exercise program with support from a peer is something women with HIV and high blood pressure will stick with and find helpful. About 50 women aged 40 and older will take part. The goal is to see if the program is easy to follow and if it hel…

This study tests a wearable cuffless blood pressure monitor (CART BP Pro) in 400 Korean adults with uncontrolled hypertension. Participants are randomly assigned to use the device to guide their treatment or to receive usual care. The goal is to see if the device helps lower bloo…

This study tests a program to help 800 adults in Africa control their high blood pressure. The program includes support for patients, healthcare providers, and the health system. The goal is to lower blood pressure and reduce the risk of heart disease, stroke, and kidney disease.

This study looks at different methods to help people with high blood pressure get it under control. It involves nearly 17,000 adults from nine community health centers in Boston. The goal is to find which approaches work best for patients, especially those from diverse background…

This study compares managing chronic high blood pressure during pregnancy using telehealth visits and home blood pressure monitoring versus standard in-person clinic visits. Pregnant women aged 18-45 with chronic hypertension can join. The goal is to see if this approach is safe,…

This study tests a new medicine called tonlamarsen in 100 adults who were recently hospitalized for dangerously high blood pressure. The goal is to see if the drug can safely lower blood pressure and reduce a protein linked to hypertension. Participants will receive either tonlam…

This study looks at how long new mothers with high blood pressure should monitor their blood pressure from home after giving birth. Researchers will compare a 2-week program with a 6-week program to see which leads to better blood pressure control at the 6-week checkup. About 400…

This study looks at whether a 12-week digital diet program, including extra vegetables and soy foods, can lower blood pressure and improve heart health in 300 adults with obesity, high blood pressure, and often type 2 diabetes. Participants will either follow the diet with highly…

This study tests whether a single pill containing three blood pressure medications can quickly control resistant hypertension better than taking several separate pills. About 142 adults with hard-to-treat high blood pressure will be randomly assigned to either the triple-combinat…

This study tests whether trained community health workers can help refugees with high blood pressure stick to their medication and lower their blood pressure. About 250 adult refugees will either receive extra support sessions or just standard information and a home blood pressur…

This study looks at whether older adults (65+) with high blood pressure and other health problems can better control their blood pressure by measuring it at home. Some participants will get extra support from a clinical pharmacist. The goal is to see if this approach lowers blood…

This study tests a new medicine called ALN-AGT01 RVR in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely lowers blood pressure and reduces a protein linked to hypertension. About 93 part…

This study is testing a smartphone app that gives personalized exercise plans to people with high blood pressure, high blood sugar, high cholesterol, and high uric acid (the 'Four Highs'). About 100 adults will use the app for six months to see if it helps them walk more and impr…

This study tests a program that helps adults with uncontrolled high blood pressure plus diabetes or kidney disease. Participants use a home blood pressure monitor that sends readings to a care team, including a community health worker and a pharmacist. The goal is to see if this …

This study tests whether an AI-powered smartphone app can help people who have had heart bypass surgery or stents better control their blood pressure, diabetes, and cholesterol. About 536 adults who already have these conditions will use the app or receive standard care. The goal…

This study tests whether using focused ultrasound to modify fat around the kidney can lower blood pressure in people with essential hypertension. About 30 adults with mild high blood pressure despite medication will be randomly assigned to the ultrasound treatment or a sham proce…

This study tests a 12-month church-based program to help African Americans with uncontrolled high blood pressure lower their numbers. About 312 adults from churches with mostly African American members will join. The program focuses on healthy eating, medication adherence, and li…

This study tests whether a combination of three drugs (THP-00101, THP-00102, and THP-00103) works better than taking just one or two of them for people with both type 2 diabetes and high blood pressure. About 221 adults will take the pills daily for 12 weeks. The goal is to see i…

This study tests whether coaching from community health workers through telehealth can help people with dangerously high blood pressure avoid major heart problems like heart attacks and strokes. About 3,620 adults with severe hypertension will be randomly assigned to receive eith…

This study tests whether combining graphic health warnings with personalized advice from pharmacists helps people quit smoking and prevent diseases like high blood pressure and diabetes. About 3,400 adult smokers in Bangladesh and Pakistan will be split into three groups: some ge…

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 24 doctors and 48 patients will take part. The goal is to see if the tool is easy to use and…

This study looks at whether taking melatonin for 12 weeks can improve blood pressure in women going through menopause who also have high blood pressure. Researchers will measure nighttime blood pressure and markers of oxidative stress. The goal is to find a simple way to help con…

This early-stage study tests a new drug, KN060, for people with high blood pressure (hypertension). About 60 adults will receive either KN060 or a placebo by IV every two weeks for 12 weeks. The goal is to see if KN060 safely lowers blood pressure compared to placebo.

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and mild hypertension to stop taking daily blood pressure pills. About 60 participants will either receive the weight l…

This study tests whether trained community health workers can help people in Nepal manage their high blood pressure. Over 3,500 participants will receive regular home visits or group meetings for one year. Researchers will compare their blood pressure to those who only get standa…

This study tests whether a telemedicine system can safely replace regular doctor visits for people with well-controlled high blood pressure. About 364 participants will either use a home blood pressure monitor and get automatic medication refills, or continue seeing their doctor …

This study tests whether thiazide diuretics (water pills) can lower blood pressure in people on peritoneal dialysis for end-stage kidney disease. About 40 participants with high blood pressure will take the medication and have their blood pressure, weight, and body fluid levels m…

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study tests whether an upgraded smartphone app helps people follow their bariatric surgery plan better than the standard app. About 200 adults having weight-loss surgery will use either the regular or an enhanced version of the "Get Ready" app. Researchers will track weight …

This study tests whether a smartphone app that offers daily rewards and helps plan when to take pills can improve medication adherence in 600 adults with high blood pressure. Participants will take surveys, submit blood pressure readings, and some will send photo proof of taking …

This study tests an experimental drug called zilebesiran in 11,000 adults whose high blood pressure is not well controlled despite taking at least two standard medications. Participants must have heart disease or be at high risk for it. The goal is to see if adding zilebesiran to…

This study tests a program to help people with high blood pressure and high cholesterol lower their risk of heart disease. About 1,980 adults from Penn Medicine primary care will be assigned to either the program or usual care. The program uses tools and behavior change support t…

This study looks at two ways to help people who have had a stroke lower their blood pressure. One way is checking blood pressure at home. The other adds group medical visits where people learn together. The goal is to see if combining both methods works better to prevent another …

This study tests whether a natural compound called inorganic nitrate can help control high blood pressure in pregnant women with chronic hypertension. About 144 women will receive either nitrate or a placebo from the second trimester onward. The goal is to see if nitrate can safe…

This study tests whether adding vicadrostat to the standard medicine empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and existing heart disease. About 11,800 participants will be randomly assigned to receive either vicadros…

This study tests whether dietary nitrate from beetroot juice can lower blood pressure and improve kidney function in people with hypertension and early-stage chronic kidney disease. About 14 to 20 adults will receive either nitrate-rich beetroot juice or a placebo for two weeks, …

This study looks at whether the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. R…

This study tests a pharmacist-led program to help adults with uncontrolled high blood pressure in underserved Chicago communities. Over 3 months, a mobile team provides blood pressure checks, medication management, and health education. The goal is to lower blood pressure and imp…

This study tests whether smartphone apps and text messages can help African American adults aged 50 and older better manage their blood pressure. Participants will use a medication reminder app and receive health tips. The goal is to see if these tools improve blood pressure cont…

This study tests whether a smartphone app called FAITH! can help African-American adults with uncontrolled high blood pressure lower their numbers and improve heart-healthy habits. About 100 participants will use the app or receive standard care, and their blood pressure will be …

This study tests whether patiromer, a drug that lowers potassium levels, allows people with moderate-to-severe chronic kidney disease to safely increase their dose of a common blood pressure medication (irbesartan). The goal is to see if this leads to better kidney protection and…

This study tests a new way to program pacemakers to help lower blood pressure in people who have both high blood pressure and a slow heart rate. About 30 adults who already have or need a special pacemaker will try two different setup sessions. Researchers will check if the new s…

This study tests whether a dietary supplement made from omega-3 and omega-6 fats (called SPMs) can reduce inflammation and improve blood vessel function in 60 adults with obesity and high blood pressure. Participants will take the supplement or a placebo for 12 weeks. The goal is…

This study tests whether combining remote blood pressure monitoring with support from community health workers helps Latinx patients better control their hypertension. About 300 adults with uncontrolled high blood pressure will be enrolled. The goal is to see if this approach low…

This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys that can raise blood pressure. The goal is to see if the quicker approach works as well as the standard method for lowering blood pressure in peop…

This study is testing a program called PILI 'Āina for Native Hawaiians with type 2 diabetes, high blood pressure, high cholesterol, or overweight. The program promotes traditional Hawaiian diets and cooking to improve health and social connections. About 210 adults will take part…

This study tests a program called PILI 'Āina that helps Native Hawaiians manage type 2 diabetes, high blood pressure, and weight by returning to traditional diets and cooking methods. About 1,780 adults who are overweight and have these conditions will take part. The goal is to i…

This study tests whether taking two medications together (JW0104 and C2402) is safe and effective for people with both high blood pressure and high cholesterol. About 162 adults will receive either the combo or a placebo. The goal is to see if the combo lowers blood pressure and …

This study tests an investigational drug called iloperidone for people whose high blood pressure remains high despite taking one or more standard medications. About 240 adults will receive either iloperidone or a placebo for 4 weeks to see if it safely lowers blood pressure furth…

This study tests a once-daily pill called orforglipron to see if it can safely lower blood pressure in people who are overweight or have obesity. About 974 adults with high blood pressure will take either the study drug or a placebo. The goal is to manage blood pressure, not to c…

This study tests whether a community-based lifestyle program can help adults with or at risk for high blood pressure lower their numbers. Participants get coaching on diet, exercise, sleep, and self-management from experts. The program is meant to work alongside regular medicatio…

This study looks at whether a type of blood pressure medication (mineralocorticoid receptor antagonist) can improve blood flow and energy use in the heart better than a standard diuretic. It involves 75 adults with high blood pressure and left ventricular hypertrophy (thickened h…

This study tests whether a drug called engagliflozin (an SGLT2 inhibitor) can improve heart function in people with pre-heart failure and high blood pressure who do not have diabetes. About 120 participants will receive either the drug or a placebo for 6 months. The main goal is …

This study is observing how well the drug dapagliflozin works and how safe it is for people with type 2 diabetes who also have high blood pressure. Researchers will track blood sugar and blood pressure control in 9,000 participants over time. The goal is to see if this medication…

This study looks at how a 20-week exercise program combining endurance and resistance training affects heart health, body composition, and menopause symptoms in 60 physically active postmenopausal women. Researchers will compare different ways of combining exercises to find the b…

This study tests whether a special pharmacist-led program helps people with type 2 diabetes control their blood sugar better than usual doctor care. About 600 adults with uncontrolled diabetes will join. The goal is to see if easier access to pharmacists can lower A1C levels and …

This study tests whether providing healthy food and lifestyle coaching can help adults with high blood pressure and type 2 diabetes living in areas with few grocery stores. About 80 participants will be randomly assigned to receive either standard diet advice or extra coaching an…

This study looks at whether taking ketone supplements can help older adults (ages 60-85) avoid the negative effects of a high-salt diet, such as higher blood pressure, blood vessel problems, and kidney stress. Researchers will give 30 healthy volunteers a high-salt diet with or w…

This study tests an experimental drug called QCZ484, given as a shot under the skin every 6 months, to see if it can safely lower blood pressure in people with mild to moderate hypertension. About 380 adults aged 18 to 75 who are not on blood pressure meds or are on up to two med…

This pilot study gives free produce boxes to 20 Veterans with kidney disease who also struggle to get enough healthy food. Researchers will check if the boxes help lower blood pressure and improve kidney function. They will also interview participants to learn about their experie…

This study tests whether a mobile health program that helps children sleep longer can lower their blood pressure. Ten children recently diagnosed with essential hypertension who sleep 7.5 hours or less on school nights will use a sleep tracker and receive coaching. The goal is to…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will do weekly physical activity and health education, and work with a coach and community health worker. The goal is to see if the program improves heart health and r…

This study tests whether a technique called remote ischemic preconditioning (RIPC) can help lower blood pressure in people with mild hypertension. RIPC involves briefly restricting blood flow to a limb using a cuff, which may trigger protective effects. The study will enroll 400 …

This study tests whether the IV drug clevidipine can lower blood pressure quickly and keep it stable in people having a bleeding stroke. About 1,000 adults with high blood pressure and a recent intracerebral hemorrhage will receive either clevidipine or another IV blood pressure …

This study looks at whether taking ketone supplements can prevent the negative effects of eating too much salt, like high blood pressure and blood vessel damage. Researchers will give 35 healthy young adults a high-salt diet with or without ketone supplements and measure changes …

This study tests whether a church-based program led by community health workers can help Black adults in New Orleans lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 800 participants aged 40 and older with at least three heart risk fac…

This study tests a 24-month program to help African Americans aged 55 and older better control their high blood pressure. Participants get counseling from a pharmacist and support from a community health worker. The goal is to lower blood pressure and reduce the risk of heart dis…

This study tests whether a program led by community health workers can help migrant farmworker women ages 18-45 reduce stress, feel less isolated, and improve heart health. Participants will either receive peer support and help finding community resources, or just basic health in…

This study tests whether home visits from female community health volunteers, combined with regular text messages, can help adults in Pokhara, Nepal, better manage high blood pressure, type 2 diabetes, and smoking. About 2,070 participants will be split into two groups: one recei…

This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, bedside delivery, and health coaches to address common barriers like cost and t…

This study tests a special pacemaker setting that may help lower blood pressure in people with hypertension. About 500 adults who already have or need a dual-chamber pacemaker will take part. The setting adjusts the timing between heartbeats and is compared to a standard setting …

This study looks at whether taking blood pressure medication in the morning or evening can help restore the natural day-night blood pressure rhythm in people with obesity. Obese individuals often have high nighttime blood pressure, which increases heart risks. Researchers will co…

This study tests whether a type of diabetes medication (SGLT2 inhibitors) can improve the heart's upper chamber function and help prevent heart failure in people with intermittent atrial fibrillation, high blood pressure, and abnormal blood sugar. About 66 adults will receive eit…

This study tests whether a mobile health app can help people who have had a bleeding stroke (intracerebral hemorrhage) manage their high blood pressure. About 140 participants will use the app to track and control their blood pressure at home. The goal is to see if the app helps …

This study looks at whether giving people healthy prepared meals and education helps them eat better compared to just getting physical activity coaching. About 120 adults in Anson County who have or are at risk for chronic diseases like obesity, diabetes, or heart disease will ta…

This study tests a new device that uses ultrasound to treat high blood pressure. About 261 adults with high blood pressure will either get the real treatment or a fake procedure. The goal is to see if the ultrasound can safely lower blood pressure without needing lifelong medicat…

This study tests a once-daily pill called orforglipron to see if it can lower blood pressure in people who have both high blood pressure and obesity or overweight. About 487 adults will take either the study drug or a placebo. The goal is to manage blood pressure and weight, but …

This study is for adults aged 65 and older whose high blood pressure is not well controlled with medication. It uses a procedure called ultrasound renal denervation, which quiets overactive kidney nerves that can raise blood pressure. Researchers will track blood pressure changes…

This study tests a team of pharmacists and community health workers (CHWs) to help people with high blood pressure take their medications as prescribed. The goal is to improve medication adherence and lower blood pressure. The study includes 217 adults who identify as African-Ame…

This study aims to help 2,000 adults in Chicago's South Side better control their high blood pressure. The program brings proven heart-health strategies into local churches and clinics, led by community health workers. The goal is to make blood pressure management easier and more…

This study looks at whether delivering healthy food and teaching kitchen skills at home can improve blood pressure and nutrition in adults who have high blood pressure and struggle to afford enough food. About 200 people aged 35-75 will take part. Researchers will compare those w…

This study tests whether community health workers in rural Guatemala, using a mobile health app and remote doctor support, can manage high blood pressure as effectively as a physician. About 460 adults with high blood pressure will be randomly assigned to either a community healt…

This study looks at whether continuing GLP-1 medications (like Ozempic or Wegovy) after bariatric surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity, some with diabetes, will be randomly assigned to keep o…

This study looks at what helps or hinders people with high blood pressure from cutting salt and boosting potassium. Researchers will test a new educational tool in 190 adults from two Singapore clinics. The goal is to see if the tool can lower sodium intake and improve blood pres…

This study looks at whether eating only during the early part of the day (early time-restricted eating) can help improve heart health and daily body rhythms in older adults with high blood pressure. Researchers will monitor blood sugar, heart rate variability, and blood pressure …

This study tests a 12-week program for Black women who have had breast cancer and also have high blood pressure or obesity. The program includes grocery delivery, cooking classes, and nutrition education to help them eat healthier and control blood pressure. The goal is to see if…

This study tests whether having a peer deliver blood pressure medication directly to patients' homes, combined with health technology, can help people take their pills regularly and lower their blood pressure. About 1,140 adults with uncontrolled high blood pressure in western Ke…

This study tests if doing wall squats (a type of isometric exercise) can lower blood pressure in people with hypertension. About 390 adults who do not exercise much will be randomly assigned to do wall squats or stretching exercises for 24 weeks. Their blood pressure will be trac…

This study tests whether taking one of two new single drugs (HL1113R1 or HL1113R2) works as well as a combination pill for people with both high blood pressure and type 2 diabetes. About 228 adults will join this Phase 3 trial to compare blood pressure and blood sugar control ove…

This study looks at whether eating baked potatoes (with the skin) as part of a Mediterranean diet can improve blood sugar, cholesterol, and heart health in adults with pre-diabetes. Sixty people aged 45-80 will either follow the Mediterranean diet alone or add baked potatoes for …

This study tests a program called Inspire HER, designed to help Black women improve their heart health through education, physical activity, and social support. Researchers will enroll 90 Black women aged 30-79 with heart, kidney, or metabolic conditions in the Birmingham, AL are…

This study aims to see if giving overweight adults a specific daily step count, based on their body fat, can help them lose weight and lower risks for heart disease and diabetes. Researchers will track 200 adults aged 20 and older over 8 months as they walk while eating normally.…

This study tests a once-daily pill called orforglipron to see if it can lower blood pressure in people who have hypertension and are also overweight or have obesity. About 487 participants will receive either the study drug or a placebo. The main goal is to measure changes in blo…

This study tests whether training religious leaders to measure and educate about blood pressure can lower average blood pressure in their communities. Researchers will compare communities where leaders receive training to those that do not. About 24,000 adults aged 35 and older a…

This early-stage study tests a new tablet called VB19055 in 86 healthy Chinese adults to see if it is safe and how the body processes it. The goal is to gather initial safety data for a potential new high blood pressure treatment. Participants will be randomly assigned to receive…

This study tests whether gentle shockwave therapy to the kidneys can help lower blood pressure and improve kidney function in people with chronic kidney disease and high blood pressure. 30 adults will receive either real or sham treatments over three weeks. The goal is to see if …

This study tests a new way to remove fluid during dialysis by using a patient's recent blood pressure patterns to guide how much fluid is taken out. The goal is to reduce dangerous low blood pressure episodes during treatment while still controlling fluid buildup. About 69 vetera…

This study compares two programs designed to reduce heart disease risks in Black women after pregnancy. Researchers will track changes in blood pressure and body weight at 6 weeks and 12 months after delivery. The goal is to find the best way to support heart health and reduce he…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication. About 100 participants will use either the full app with reminders or just an education portal for 16 weeks. …

This study tests a device that uses energy to calm overactive nerves in the kidney and liver, which may help lower blood pressure. It is for adults aged 18 to 80 with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The goal is to…

This study tests whether taking low-dose aspirin for 6 months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple tr…

This study tests whether a computer program that learns from patient data can help doctors choose the most effective blood pressure medications. About 2,160 adults with high blood pressure will be enrolled across 51 clinics in China. Some clinics will use the computer tool, while…

This study looks at whether adding Pilates breathing or diaphragmatic breathing to moderate cycling training can lower blood pressure, improve lung function, and boost quality of life in people with hypertension. About 45 adults aged 20–55 with stage 1 or 2 high blood pressure wi…

This study is tracking about 5000 people with high blood pressure who have a procedure called renal denervation, which uses energy to calm overactive kidney nerves. The goal is to see how safe and effective the procedure is over 1 to 5 years in real-world settings. Participants m…

This study tests whether dotinurad is better than febuxostat at improving blood vessel health in people with both high uric acid and high blood pressure. About 360 adults will take one of the two drugs for 24 weeks. The main goal is to see changes in a measure of artery stiffness…

This study looks at whether adding stair climbing to daily routines can lower blood pressure more than brisk walking alone. About 450 adults with high blood pressure, overweight, and a sedentary lifestyle will be split into three groups: stair walking plus brisk walking, brisk wa…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This study tests whether a simple, 5-minute daily breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve blood vessel health in postmenopausal women aged 50 and older with high blood pressure. It compares this breathing exercise to standard…

This study compares a team-based program that addresses both medical and social needs to standard care for managing high blood pressure. It will enroll 200 African American and Latinx adults with uncontrolled hypertension. The main goal is to see if more people can lower their sy…

This study tests a new steroid-based blood test to see if it can more accurately identify Primary Aldosteronism (a common, curable cause of high blood pressure) in people who continue taking their usual blood pressure medications. About 406 adults with high blood pressure will ha…

This study will test if the Oura Ring's new Blood Pressure Profile algorithm can accurately identify signs of high blood pressure (hypertension). Researchers will compare the ring's readings to what participants report about their own blood pressure. Up to 2 million Oura Ring use…

This study tests whether using a smartwatch and a digital health coach can help people at risk for chronic diseases like high blood pressure, diabetes, and obesity become more active. Researchers will enroll 1,700 adults aged 21-75 who have risk factors or early signs of these co…

This study looks at whether combining the MIND diet (a mix of Mediterranean and DASH diets) with aerobic exercise can help prevent memory and thinking problems in Black adults aged 35-75 who have high blood pressure. Participants will either receive food delivery, cooking lessons…

This study looks at whether telling people their genetic risk for high blood pressure can help them make healthier choices and lower their blood pressure. Researchers will give some participants a special genetic test result plus counseling, while others get standard care. The go…

This study tests whether helping older adults (70+) with high blood pressure get better control of their numbers can also protect their memory and thinking skills. Researchers will compare a special care program (using decision-support tools and a team approach) against usual car…

This study aims to reduce heart-related health problems in Detroit and Cleveland by using community health workers to coach people on managing blood pressure and other risk factors. About 364 adults with high blood pressure or early signs of heart failure will receive support to …

This study tests whether a smartphone game that responds to your activity can help Native American adults with high blood pressure get more exercise and better manage their condition. Half of the 220 participants will use the game plus an activity tracker, while the other half wi…

This study tests whether a telephone-based mindfulness program can help Black women with high blood pressure lower their numbers and feel less stressed. Researchers will compare the mindfulness program to a support group, both delivered over Zoom. The goal is to see if learning t…

This study looks at whether a beetroot supplement can help older women (ages 60-70) with high blood pressure during a single exercise session. Researchers will measure blood pressure, muscle oxygen levels, and markers of oxidative stress. The goal is to see if beetroot extract of…

This early-stage study is testing a new injectable drug called LY3971297 to see if it is safe and how the body processes it. The trial includes healthy volunteers, people with obesity and high blood pressure, and those with reduced kidney function. Researchers will monitor side e…

This study is testing a new wearable device that uses light to measure blood pressure, comparing it to standard home monitors. About 35 adults with high blood pressure will wear the device while taking medication. The goal is to see if the optical monitor is accurate and easy to …

This study tests whether a medication given as a nose spray (dexmedetomidine) can help keep blood pressure stable in older adults with high blood pressure who are having cataract surgery. About 126 people aged 65 and older will take part. The goal is to see if the spray reduces d…

This study looks at whether exercising in the morning or early evening makes a difference in lowering blood pressure and improving blood vessel health in postmenopausal women with high blood pressure. Researchers will track blood pressure changes over 24 hours. Participants must …

This study tests whether applying gentle heat to the belly overnight can safely lower high blood pressure in people with autonomic failure who also have high blood pressure when lying down. About 20 adults with conditions like Parkinson's or Multiple System Atrophy will be monito…

This study tests whether an 8-week mindfulness program, adapted for African American adults, can improve depressive symptoms and blood pressure control. About 60 participants from Chicago's South Side will learn stress management techniques like deep breathing and meditation. The…

This study tests whether a structured 8-week program of physical and cognitive exercises can improve daily function, thinking skills, and quality of life in adults with Long COVID and chronic conditions like high blood pressure or diabetes. About 374 participants will be randomly…

This study tests whether a time-saving, joint-friendly muscle stimulation technology (whole-body electromyostimulation) can lower resting blood pressure and improve other heart-related risk factors in people with mild high blood pressure and overweight. Researchers will compare t…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will use a new, non-invasive method to measure stiffness caused by blood pressure itself versus long-term changes in the artery wall.…

This study aims to find the genes that cause high blood pressure in children and teens. Researchers will study 2300 people, including those with childhood-onset high blood pressure and their healthy relatives. Participants will have yearly checkups, blood and urine tests, and opt…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cylindrical cuff on the upper arm in pregnant women. High blood pressure during pregnancy can lead to serious decisions like early delivery or C-section…

This study looks at how a park-based afterschool program affects the mental health, resilience, physical fitness, and violence prevention of 1000 teens aged 12-17 in Miami-Dade County. Researchers will measure changes in weight, blood pressure, fitness, anxiety, depression, and o…

This study will use wearable digital health devices to collect heart data from 5,000 adults with chronic heart conditions like heart failure, high blood pressure, and aortic stenosis. The goal is to observe how these conditions progress over time. No new treatments or medications…

This study is creating a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to study genetic links to heart disease, diabetes, and obesity. The goal is to support future studies, not to test a treatment directly.

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This early-phase study tests a new radioactive tracer called [18F]FNP-59 to see how well it can image cholesterol in the adrenal glands using PET scans. Six healthy adults will receive a tiny, safe dose of the tracer to measure its uptake in the adrenal glands. The goal is to imp…

This study looks at whether taking a single 1 mg dose of dexamethasone at bedtime can make screening for primary aldosteronism more accurate in people already taking blood pressure medications. Primary aldosteronism is a condition where the adrenal gland makes too much aldosteron…

This study looks at how the body controls blood pressure and heart rate in healthy adults and older adults with high blood pressure. Researchers will measure heart activity and artery stiffness during standing and exercise. The goal is to better understand these processes and hel…

This study looks at whether adding a heart ultrasound to routine check-ups helps doctors better manage high blood pressure in young adults aged 18 to 40. Researchers will collect data from 750 participants over up to 10 years to find patterns that improve risk prediction. The stu…

This study looks at whether screening for social needs (like housing or food) with a focus on antiracism can help reduce chronic diseases such as high blood pressure, diabetes, and asthma. About 68,000 adults and children in primary care will take part. The goal is to see if this…

This study looks at whether blocking certain nerve signals for two weeks can improve how the body produces and uses sugar in people with obesity and high blood pressure. Twelve adults will be randomly assigned to receive either a placebo, a blood pressure drug (amlodipine), or a …

This study is tracking 30,000 people aged 60 and older in rural China to see if a comprehensive program—combining medication, lifestyle advice, education, and heart monitoring—can lower the risk of heart attacks, strokes, and heart-related deaths. Participants will be followed fo…

This study aims to understand why some hospitalized patients have side effects from eye drops (tropicamide/phenylephrine) given before eye surgery. Researchers will check vital signs and ask patients about side effects at several time points after the drops are given. The goal is…

This early study aims to understand how stimulating nerves in the kidney affects the body's response before and after a procedure that quiets those nerves (renal denervation). About 19 adults with high blood pressure will take part. The goal is not to treat the condition directly…

This study is following 2,500 adults aged 30-75 in Puerto Rico to learn how stress, diet, and where they live affect chronic diseases like heart disease, diabetes, and obesity. Researchers will collect health data and survey participants over two years, including before and after…

This study looks at how early menopause affects the body's ability to control blood pressure. Researchers will measure nerve activity and blood pressure in 160 women aged 35-70. The goal is to understand why some women develop high blood pressure after early menopause. No treatme…

This study will enroll 8,000 adults who are already getting a routine health checkup. Researchers want to learn how a person's environment, genes, and proteins interact to cause conditions like high blood pressure, diabetes, and other metabolic problems. The goal is to create an …

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure or diabetes. Researchers use repeated MRI scans over 15 months to watch how small blood vessel damage in the brain gets worse. The goal is to learn more about how this damage …

This study looks at whether pregnant women with high-risk conditions like diabetes or high blood pressure can use a home device to monitor their baby's health instead of going to the clinic. Fifty participants will try the device for three 30-minute sessions each week starting at…

This study aims to find the genes that cause primary aldosteronism, a condition where an adrenal gland tumor leads to high blood pressure and low potassium. Researchers will study 1150 Black, African American, or Caribbean individuals aged 18-70 with hard-to-control blood pressur…

This study follows 300 people having metabolic (weight-loss) surgery to see how their gut bacteria change over time and how those changes relate to improvements in heart health, diabetes, and cholesterol. Participants provide stool, blood, and tissue samples before and up to 3 ye…

This study follows 220 adults aged 75 and older who have high blood pressure. Researchers want to see if brief episodes of very low daytime blood pressure are linked to serious events like falls, hospital stays, or heart problems. Participants wear a 24-hour blood pressure monito…

This study looks at why people with chronic conditions like high blood pressure, diabetes, and high cholesterol often struggle to stick with healthy behaviors. Researchers will test a program designed to boost motivation and help patients take charge of their health. The study in…

This study will screen over 22,000 children aged 5 to 18 across South Africa to find out what normal blood pressure is for kids in the country. Right now, doctors use standards from the US and Europe, which may not fit South African children and can lead to wrong diagnoses. The g…

This study looks at how sleep and the body's internal clock influence blood pressure in people with hypertension. Researchers will monitor 32 adults aged 25-64 to understand why some have 'non-dipping' blood pressure that stays high overnight. The goal is to uncover mechanisms, n…

This study is enrolling 20,000 adults in Taining County, China, to better understand common chronic diseases like high blood pressure, diabetes, and frailty. Researchers will collect health data and samples over three years to find patterns and risk factors. The goal is to create…

This study tests whether a simple educational session can help hospital doctors feel more confident when adjusting diabetes and blood pressure medications for older adults (65+). About 150 clinicians will attend a one-time training and complete surveys before and after. Researche…

This study follows about 4,000 adults from Shanghai communities to see how heart, kidney, and metabolic diseases develop over time. Researchers will compare current health data with information collected between 2016 and 2017. The goal is to understand how risk factors change and…

This study tests a new wrist-worn device that measures blood pressure without a traditional arm cuff. It compares the readings to standard cuff devices in healthy volunteers and people with high blood pressure. The goal is to see if the cuff-less method is accurate and comfortabl…

This study looks at whether customizing digital health messages can help people with uncontrolled high blood pressure keep doctor visits, take medications, and check their blood pressure at home. Researchers will enroll 12,000 adults from Cone Health who have high readings. The g…

This study looks at whether two types of strength training can help older adults (60+) with high blood pressure improve their heart health, mental well-being, and physical fitness. Sixty participants will be randomly assigned to either dynamic or isometric strength training for s…

This study looks at why women who had high blood pressure during pregnancy are more likely to develop high blood pressure and heart disease later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to bett…

This study looks at sleep issues in healthy Somali Americans and how they might affect blood pressure. Researchers will measure sleep quality and blood pressure in 240 adults. The goal is to find hidden sleep problems that could raise hypertension risk in this community.

This study tests a 12-week education and support program for African American adults with advanced chronic kidney disease. Participants will either receive the program or standard care. The goal is to see if the program helps patients learn more about their condition, manage it b…

This study looks at how high blood pressure, diabetes, and high cholesterol change the tiny blood vessels in the back of the eye. Researchers will use a special, non-invasive eye scan called OCTA to measure these changes in 300 adults. Participants will be followed for five years…

This study is testing a new MRI technique that uses a special substance called hyperpolarized pyruvate to take pictures of the heart's energy use. Researchers want to see if this method can show how heart cells are working in people with high blood pressure, thickened heart muscl…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict problems like bleeding, infection, or frailty. Researchers want to understand how pump readings relate to patients' quality of life and health outcomes. The goal is to h…

This study will look at health records from 15,000 adults with high blood pressure in Brazil's public health system. The goal is to understand how doctors treat the condition and whether they adjust medications when blood pressure stays high. No new treatments are being tested; i…

This study tests whether nurses using an AI tool can provide care that is as good as a doctor's for common issues like high blood pressure, diabetes, fever, and breathing problems. About 672 adults in rural and semi-urban India will see both a nurse with AI and a doctor, and rese…

This study looks at 500 women who recently gave birth—250 with preeclampsia and 250 without—to see if exercise stress tests can spot early signs of heart failure with preserved ejection fraction (HFpEF). Researchers will track heart function and blood markers over a year. The goa…

This study tests a special PET scan tracer to see how cholesterol moves in the adrenal glands. About 24 adults will take part, including healthy volunteers and people with adrenal conditions. The goal is to learn more about cholesterol trafficking, not to treat any disease.

This study looks at how certain natural chemicals in the body, like angiotensin-(1-7), affect high blood pressure and damage to the heart and kidneys in children. Researchers will follow 125 children with newly diagnosed high blood pressure and healthy kids for two years, collect…

This study follows 5,000 children in a park-based afterschool program to see if it improves their physical fitness, weight, and mental health. Researchers will measure changes in body measurements, fitness tests, and questionnaires about anxiety and well-being. The goal is to und…

This study looks at why people with rheumatoid arthritis often have trouble controlling high blood pressure, which raises their risk of heart disease. Researchers will work with 25 adults to test a program that helps them monitor their blood pressure and share results with their …

This study looks at how a park-based fitness program affects the health of adults aged 50 and older in Miami-Dade County. Researchers will measure changes in weight, blood pressure, strength, and mobility in 1,000 participants. The goal is to see if community park programs can he…

This study looks at 100 living kidney donors to see if the amount of fat around the kidney (called PRAT) is linked to worse blood pressure and kidney function after donation. Researchers will compare donors with high and low PRAT by testing blood, urine, and fat samples. The goal…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already taking these drugs as part of their regular care, or have had a recent CO…

This study looks at how three common blood pressure medications (beta-blockers, ACE inhibitors, and calcium channel blockers) affect balance and fall risk in adults newly diagnosed with high blood pressure. About 186 participants will be randomly assigned to one of the three drug…

This study is testing a simple food questionnaire called EvalSel to see how accurately it measures salt intake in hospitalized patients with high blood pressure or kidney disease. Researchers will compare the questionnaire results with a 24-hour urine test, the gold standard for …

This study looks at how taking multiple medications affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older in Shaanxi Province, China, over two years. The goal is to…

This study is working with community groups to adapt a program called Staying Healthy After Childbirth (STAC) so it better meets the needs of Black women and birthing persons. The goal is to improve blood pressure monitoring and overall health after pregnancy. Researchers will in…

This study partners with community organizations and trusted local members to improve health research participation among Black, Latino, and Native American communities in Colorado. It focuses on understanding and addressing health issues like mental health, high blood pressure, …

This study is like a big health check-up for 600 U.S. Army soldiers. Researchers will look at what they eat, their heart health, body composition, mental well-being, and physical fitness. The goal is to gather information to help improve soldier health and readiness, not to test …

This study is testing an experimental drug called angiotensin-(1-7) to see if it can improve how blood vessels and nerves work in people who have both obesity and high blood pressure. Researchers will measure nerve activity and artery size during a short infusion of the drug comp…

This study looks at how blood flow to muscles changes as people age or have conditions like COPD, pulmonary hypertension, or heart failure. Researchers will measure blood flow and blood pressure in up to 420 volunteers, including healthy young and older adults, as well as patient…

This study aims to uncover the genetic and lifestyle factors that contribute to type 2 diabetes in African populations, particularly the Yoruba people in Nigeria. Researchers will compare 300 people with diabetes to 300 without, using blood samples and health data. The goal is to…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women aged 18-70. Researchers will measure body fat, blood fats, and insulin function to find out why heart disease risk factors differ between African Americans and C…

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…