Ketone supplements may shield your body from too much salt

NCT ID NCT05545501

Recruiting now Disease control Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking a ketone supplement can prevent the negative effects of eating too much salt, like high blood pressure and kidney strain. Researchers will give 35 healthy young adults either a high-salt diet with a ketone supplement or a placebo, then measure changes in blood pressure, blood vessel function, and kidney health. The goal is to find a simple way to reduce the health risks of a high-salt diet without requiring people to change their eating habits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketone supplement (beta-hydroxybutyrate)
What this could lead to: If it works, this could point toward a simple supplement to help counteract the harmful effects of a high-salt diet on blood pressure and kidney health.
What could go wrong: This is a small, early-stage study with only 35 participants, so results may not apply to everyone. It's also a short-term trial, so long-term benefits or risks are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION SALT; EXCESS

Contacts and locations

Locations

Indiana University, School of Public Health
RECRUITING

Bloomington, Indiana, 47405, United States

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