HYPERTENSION

This study aims to find the best ways to help people from diverse backgrounds manage their high blood pressure in Los Angeles County clinics. Researchers are testing different outreach approaches focused on either healthcare providers or patients to see which works better. The go…

This study is testing whether eating wild blueberries daily can help lower blood pressure and improve artery function in middle-aged and older adults with mildly elevated blood pressure. Researchers are enrolling 58 men and postmenopausal women aged 45-70 to measure changes in bl…

This study is testing whether providing patients with special home blood pressure cuffs and a remote monitoring program helps control high blood pressure during virtual doctor visits. Researchers want to see if this approach helps people manage their condition better when they ca…

This study is testing different support methods to help people with high blood pressure use home monitoring devices more effectively. Researchers will compare basic training against more comprehensive support that addresses digital literacy and social factors. The goal is to find…

This study is testing a medical device procedure called renal denervation for people whose high blood pressure remains uncontrolled despite medications. The procedure uses a catheter to deliver energy to nerves around the kidney arteries, aiming to lower blood pressure long-term.…

This study is testing whether a special brain training program on tablets can help improve thinking skills in older adults who have high blood pressure and are at risk for memory problems. 120 participants aged 60+ will be randomly assigned to either the active brain training pro…

This study is testing the long-term safety and effectiveness of a new high blood pressure medication called lorundrostat. It follows over 1,000 people who have already taken the drug in a previous trial for up to a year. The goal is to see if the drug continues to lower blood pre…

This study continues testing ralinepag, an experimental medication for pulmonary arterial hypertension (PAH), to understand its long-term safety and effectiveness. It enrolls 1,000 participants who have already taken ralinepag in previous studies and are already on standard PAH m…

This study is testing a community-based program to help adults in a Vietnamese city better manage their high blood pressure. The program combines digital storytelling, home blood pressure monitoring, and extra support from local health workers. Researchers will compare this appro…

This study is testing if a heart failure medication might also help people with type 2 diabetes or pre-diabetes. Researchers want to see if the drug helps the body keep more of a natural hormone that lowers blood sugar after eating. The trial involves 25 adults and compares the e…

This study is testing a healthy lifestyle program delivered through a patient's online medical record. It aims to see if a video-based program alone, or with remote coaching, helps adults aged 50-74 lose weight and improve their health to lower the risk of chronic diseases like d…

This study is testing if a non-invasive brain stimulation treatment called TMS can help lower high blood pressure in young women who also have PTSD. Researchers want to see if treating PTSD symptoms with TMS also improves heart health over time. The study involves 30 women who wi…

This study is testing whether providing hospital-level medical care in a patient's own home is a safe and effective alternative to a traditional hospital stay. It will involve nearly 10,000 adults with conditions like heart failure, infections, or COPD who qualify for hospital ad…

This study is testing whether helping people with basic life needs—like getting enough food, stable housing, or transportation—can improve their health. It focuses on adults with type 2 diabetes and high blood pressure or cholesterol. Doctors will screen patients for these social…

This study is testing if personalized text message reminders can help people who have both high blood pressure and a mood disorder (like depression or bipolar disorder) remember to take their blood pressure medicine. Researchers are comparing two groups: one gets text reminders p…

This study is testing a medical device that uses radiofrequency energy to calm overactive nerves near the kidneys. The goal is to see if this one-time procedure can safely lower blood pressure in adults whose high blood pressure is not well-controlled by multiple medications and …

This study tests whether training local female health workers to monitor blood pressure and provide health education can help adults in rural Pakistan better manage hypertension. The program involves regular check-ups, home visits, and referrals to doctors when needed. Researcher…

This study tests a new program designed to improve teamwork between cancer specialists and primary care doctors (PCPs) for patients who have both cancer and a heart-related condition like high blood pressure or diabetes. The goal is to see if better coordination helps manage the …

This study aimed to see if a smartphone app could help people better manage their high blood pressure. The app was designed to help patients track their daily blood pressure readings, remember to take their medication, and share reports with their doctor for personalized dose adj…

This study is testing whether a low dose of the anti-inflammatory drug colchicine can improve heart and blood vessel function in people with high blood pressure. About 150 adults already taking blood pressure medication will take either colchicine or a placebo pill daily for six …

This study is testing whether a one-year course of a dietary supplement called spermidine can help older adults with heart disease. Spermidine is a natural compound found in foods like whole grains and nuts. Researchers will check if it improves heart function, muscle mass, physi…

This study is testing whether improving sleep habits can help control high blood pressure. It involves 110 adults with prehypertension or mild stage 1 hypertension who regularly sleep 6.5 hours or less per night. Participants will either follow an 8-week program to extend their s…

This study is testing whether a daily powder made from Canadian haskap berries can help lower blood pressure and improve mental alertness in women. It involves 32 women aged 35+ with mildly elevated blood pressure. Participants will take either the berry powder or a look-alike co…

This study is testing whether a medication chosen based on a specific gene works better than a standard blood pressure drug for Black patients with high blood pressure. About 300 participants with a particular genetic marker will take either the gene-targeted drug or the standard…

This large study is testing whether a supported home blood pressure monitoring program can help people with high blood pressure get better control of their condition. The program is being rolled out across many primary care practices serving diverse patient populations. Researche…

This study is testing whether a smartphone app called mGlide can help people better control their high blood pressure. About 450 people with uncontrolled blood pressure will use the app to send daily home readings to their doctors, who get alerts if numbers go outside a safe rang…

This small pilot study is testing if a simple telehealth program can help people better manage their high blood pressure after a trip to the emergency room. The program involves checking blood pressure at home and having weekly phone check-ins with a pharmacist to adjust medicati…

This study is testing different remote monitoring strategies to help people with high blood pressure better manage their condition. Researchers will enroll 2,500 English- and Spanish-speaking adults with hypertension to compare patient-focused and clinic-focused approaches. The g…

This study tests a training program called ACHIEVE that helps prenatal care clinics improve how they handle high blood pressure in pregnant and postpartum patients. The program provides coaching, simulations, and educational materials to clinic staff across 20 clinics in North Ca…

This study is testing if adding nutrition education to an existing high blood pressure support program helps people eat healthier and better control their blood pressure. It involves 60 adults with high blood pressure who also struggle to afford healthy food. Participants are ran…

This study is testing whether a wearable, cuffless blood pressure monitor helps doctors manage high blood pressure better than usual care. It involves 288 Korean adults whose blood pressure is still high despite medication. Doctors will use the device's 24-hour readings to guide …

This study is testing whether taking potassium supplements can help protect kidney function in people with moderate to advanced chronic kidney disease (CKD) and high blood pressure. It involves 532 participants who have CKD and are at risk of their kidney function getting worse. …

This study is testing a 6-month digital community support program to help older adults with type 2 diabetes and other chronic conditions like high blood pressure manage their health better. The program uses a smartphone app, online education, phone calls, and trained community vo…

This study is testing whether online group doctor visits help people better manage type 2 diabetes and related heart conditions. Researchers are comparing virtual group visits to regular individual care for 720 patients across Chicago health systems. The goal is to see if this ap…

This study aims to see how well the blood pressure medication benidipine works for Turkish patients who already take it for high blood pressure and/or stable chest pain from heart disease. It will observe about 800 adult patients across Turkey to see if the drug helps them reach …

This study is testing whether a smartphone app called Elfie can help people with high blood pressure lower their readings. About 930 adults will either use the app alongside their usual care or just receive usual care. The app aims to help people manage their condition better by …

This study is testing whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have received a kidney transplant. Researchers are helping 25 participants follow the diet for at least 16 weeks, with training and support. They will meas…

This study is testing two different wellness programs delivered through video calls to help Black women who are caregivers for family members with dementia. The programs combine mindfulness exercises with a heart-healthy eating plan tailored for Black Americans. Researchers want …

This study is testing if a simple monthly message to primary care doctors, showing how their blood pressure control rates compare to their peers, leads to better patient care. The goal is to see if this 'nudge' encourages doctors to start or adjust medications more often for thei…

This study is testing whether a culturally tailored telehealth program, where community health workers coach patients remotely, can help South Asian immigrants better control their diabetes and high blood pressure. It will compare this coaching approach to usual medical care over…

This large study is testing whether a structured treatment program led by local village doctors can help people in rural China better control their high blood pressure. It involves nearly 34,000 adults with uncontrolled blood pressure across 326 villages. The goal is to see if th…

This study is testing whether exercise training, brain training, or a combination of both can help older adults who have had a stroke and also have high blood pressure or diabetes. Over 400 participants in several Chinese cities will be assigned to one of four groups for a year t…

This study aims to find the best ways for doctor's offices to use team-based home blood pressure monitoring. It involves 5,760 patients with high blood pressure who will regularly send their home readings to their care team. Researchers will test different support strategies to s…

This study is testing a new coaching program to help nurses better manage high blood pressure in patients who are also living with HIV. It involves 830 adults with uncontrolled blood pressure across 30 primary health clinics in Nigeria. The goal is to see if providing nurses with…

This study is testing whether a simple, 5-minute daily breathing exercise can help lower high blood pressure and improve heart health in adults aged 50 and older who have moderate to severe obstructive sleep apnea. Researchers are comparing a high-intensity breathing training pro…

This study is comparing two ways of doing peritoneal dialysis to see which one is better at protecting a patient's remaining natural kidney function and reducing harmful stress on the body. It involves 100 new dialysis patients in Mexico who will be randomly assigned to receive e…

This early-stage study is testing a new medication called ADX-850 for people with high blood pressure. Researchers will check if the drug is safe and how it affects blood pressure in 28 participants. This is the first time this medication is being tested in humans, so the main go…

This study is collecting real-world data on a device-based treatment for high blood pressure. It is for patients whose blood pressure remains high despite taking multiple medications or who cannot tolerate those drugs. The treatment uses a catheter to deliver radiofrequency energ…

This study is testing if a game-like program can help Veterans with obesity and high blood pressure become more physically active. Over 700 Veterans will try programs that use teamwork or friendly competition, tracked with wearable devices, to encourage daily steps. The goal is t…

This study aims to see if a specific eating plan is better than a prescription medication for reducing liver fat and scarring. Researchers will compare a Mediterranean diet combined with intermittent fasting against the weight-loss drug naltrexone/bupropion (Mysimba®). The goal i…

This large, long-term study is analyzing health records to see if effectively treating both obstructive sleep apnea and high blood pressure can prevent serious heart problems or death. It will follow 10,000 patients to compare outcomes between those who use their sleep apnea mach…

This study is testing whether delivering healthy groceries directly to homes can help Black adults better control their high blood pressure. Researchers are comparing 150 participants who receive 12 weeks of free DASH diet groceries with those who get a shopping stipend instead. …

This study is testing whether portable ultrasound and blood glucose monitoring devices can help doctors detect chronic conditions like diabetes and heart disease earlier than standard care. 200 participants at risk for these conditions will use the devices at home for 6 months wh…

This study is testing a new type of MRI scan to see if it can accurately detect and measure scarring (fibrosis) in kidneys. The research involves 24 adults with high blood pressure and kidney artery narrowing. The goal is to see if this non-invasive scan can reliably predict whet…

This study aimed to see if checking blood pressure before outpatient surgery could help find people with undiagnosed high blood pressure. It planned to enroll adults having elective surgery who had high readings but no prior diagnosis. Researchers would then follow up to see if t…

This VA study aims to improve how 20 VA medical centers provide virtual health programs to women Veterans. It's testing two different support strategies to help these facilities successfully offer proven programs for preventing heart disease, diabetes, and depression. The goal is…

This study is testing a community-based program to help prevent high blood pressure and heart disease in Latino and Vietnamese families in Santa Ana, California. For three years, some families will work with community health workers who provide personalized coaching, educational …

This study aimed to see if training and paying residents as Community Health Ambassadors could help more people in Boston public housing get primary care visits and screenings for diabetes and high blood pressure. The ambassadors would run workshops and connect their neighbors to…

This large study is testing whether berberine, a compound from plants, can help prevent heart disease and type 2 diabetes in adults at high risk. Over 2,000 participants in China will take either berberine or a placebo pill for three years, alongside lifestyle advice. Researchers…

This study tests whether church-based health coaching can help prevent high blood pressure in rural Black adults in Alabama. Participants with slightly elevated blood pressure receive education, tablets for online cooking and exercise classes, and some get additional phone coachi…

This study is testing whether providing home-delivered healthy groceries based on the DASH diet can help lower blood pressure in Black adults living in Boston-area neighborhoods with limited access to fresh food. 150 participants with untreated elevated blood pressure will either…

This study is testing whether personalized counseling sessions can help prevent high blood pressure in adults living in slums in Dhaka, Bangladesh. Researchers will work with 1,700 healthy adults who have not been diagnosed with hypertension, providing them with 20 short counseli…

This large study is checking if taking daily vitamin D or fish oil (omega-3) supplements can help prevent high blood pressure in healthy adults. It involves over 25,000 U.S. men and women without a history of high blood pressure. Researchers will track participants for two years …

This study tests a program to help prevent serious high blood pressure. It combines home blood pressure monitors, a smartphone app for tracking, and regular support from community health workers. The goal is to see if this extra support helps people with slightly elevated blood p…

This study tests whether bringing healthcare directly to neighborhoods through mobile health units can help prevent high blood pressure in Black adults. Community health workers provide personalized lifestyle coaching to 330 participants with slightly elevated blood pressure who …

This study aimed to see if adding game-like challenges to a patient's daily step goals could help them be more active while in the hospital. It planned to use wearable devices and text messages with older adults who had heart or metabolic conditions. The goal was to see if more w…

This study aims to find which of two common numbing medicines works better and is safer for pulling upper teeth in people with controlled high blood pressure. It will compare how well they control pain and how much they affect heart rate and blood pressure during the procedure. T…

This remote study aimed to provide holistic education and pastoral counseling to help people manage stress and improve wellness in daily life. It was designed for specific unmarried Alaska Medicaid recipients who met religious and lifestyle criteria. The study was withdrawn befor…

This study aims to better understand how often two effective leukemia drugs cause high blood pressure and irregular heartbeats. Researchers will give 50 patients smartwatches and home blood pressure monitors to track their heart health during treatment. The goal is to gather real…

This study aims to better understand a condition called 'non-dipping hypertension,' where a person's blood pressure doesn't drop at night as it normally should. Researchers are enrolling 150 adults with high blood pressure to track their daily patterns using wearable devices and …

This study aims to understand why some people develop high blood pressure and heart disease by looking at how their genes and body respond to different amounts of salt. Researchers will enroll 120 adults with mild to moderate high blood pressure, temporarily adjust their medicati…

This study is checking back with 317 people who have type 2 diabetes to see how their liver health has changed over several years. Researchers are not testing a treatment; instead, they are using scans and blood tests to understand why some people develop serious liver disease an…

This study aims to better understand blood pressure changes in the 6 weeks after childbirth. Researchers will give 300 new mothers a special smartwatch that continuously monitors blood pressure to see how patterns differ between low-risk, medium-risk, and high-risk women. The goa…

This study aims to find out how common pre-hypertension (slightly elevated blood pressure) is among children and teenagers with type 1 diabetes. Researchers will measure the blood pressure of 60 young patients to see what factors might be linked to this early sign of high blood p…

This study aims to understand if lowering blood pressure can help manage chronic pain. It involves 36 adults who have both chronic back pain and high blood pressure, and who already have a permanent spinal cord stimulator. Participants will take a standard blood pressure pill (a …

This study aims to use advanced heart scans to better understand early heart failure in people with conditions like diabetes, high blood pressure, or obesity. It will enroll 3,000 participants who have these risk factors but whose hearts still pump normally. The goal is to find p…

This research project is analyzing thousands of existing medical studies to understand a puzzling problem: why do some patients with high blood pressure who are on medication and have their blood pressure under control still die from heart attacks, strokes, or kidney failure? The…

This long-term study followed nearly 5,900 adults aged 65 and older to identify what factors predict heart disease and stroke in the elderly. Researchers tracked participants' health over decades, using exams and tests to understand how risk factors like high blood pressure and c…

This study aims to understand how common heart disease and its risk factors are among adults in Port-au-Prince, Haiti. Researchers will follow about 3,000 people for several years, tracking their health, lifestyle, and diet. The goal is to gather information to help plan better h…

This study aims to understand how a specific genetic variant is linked to high blood pressure and a condition called primary aldosteronism. Researchers are following up with 76 people from a larger Swedish health study who have both the genetic variant and high blood pressure. Th…

This study aims to understand how sleep habits and your body's natural daily rhythm affect blood pressure during the night. Researchers will observe over 1,400 people and, for a smaller group, conduct a special 30-hour test to measure their internal body clock. The goal is to gat…

This study aims to understand how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will take blood samples from 40 participants to examine a specific type of white blood cell. They want to see if these cells from people with low vit…

This study is observing over 31,000 middle-aged and older adults to better understand how being overweight or having obesity, combined with high blood pressure, affects the long-term risk of heart attacks, strokes, and other serious heart problems. Researchers are not testing a t…

This study aims to understand why some people's blood pressure rises with high salt intake while others' does not. Researchers will have 70 participants with varying blood pressure levels follow high-salt and low-salt diets for two weeks each. They will use special MRI scans and …

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This study is testing a new online platform called CONNECT, designed to help more women, Black, and Latino adults join heart disease research. The program sends educational text messages about heart health and clinical trials for one year and helps connect interested people to on…

This study aims to collect and store biological samples from 500 people with obesity. The goal is to build a repository of blood, urine, and tissue to help researchers understand why weight loss treatments sometimes work or fail, and why weight is often regained. This is an obser…

This is a long-term observational study that began in 1985 to understand how heart disease risk factors develop in young adulthood. It follows over 5,000 Black and White men and women who were 18-30 years old when they joined. The goal is to identify which lifestyle habits and ch…

This study aimed to see if data from Withings smart devices (like watches and scales) could help predict when a person's high blood pressure is not well controlled. It planned to look at data from US adults who had used Withings devices for at least two years. The study was withd…

This project is not a new treatment trial, but a large-scale analysis of past research. Researchers are compiling and reviewing results from many existing diet studies to understand if replacing animal protein (like meat and dairy) with plant protein (like beans and nuts) leads t…

This study aims to understand the complex links between sleep bruxism (nighttime teeth grinding) and other health issues like sleep apnea, heart disease risk, thyroid problems, and stress. Researchers will observe 100 adults who grind their teeth during sleep, using sleep studies…

This study aims to understand how high blood pressure affects a patient's heart and blood flow during spine surgery, which is performed lying face down. Researchers will closely monitor 70 adults scheduled for back surgery to see if their blood pressure drops more dangerously if …

This study aims to understand how older adults can maintain their health and independence as they age. It will follow 500 adults aged 50 and older in the Washington D.C. area for up to five years, giving them a detailed annual health check-up and a personalized 'Health Passport' …