HYPERTENSION

This study tests whether colchicine, a common anti-inflammatory drug, can improve blood vessel stiffness and heart function in 150 adults with high blood pressure who also have diabetes, high cholesterol, or take multiple blood pressure medications. Participants take colchicine o…

This study tests whether a personalized smartphone app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression and high blood pressure take their medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditio…

This study tests a program to help people living with HIV in Nigeria also control high blood pressure. 830 adults with both conditions will get care from specially trained HIV nurses. The goal is to see if this approach lowers blood pressure and improves health.

This study compares different patient- and clinic-focused strategies to help control high blood pressure in English- and Spanish-speaking adults. Researchers will enroll 2,500 participants to see which approach works best for lowering blood pressure. The goal is to find more effe…

This study tests whether a smartphone app called MED-AD helps people with heart disease take their medications as prescribed. About 1,000 adults in Oman will either use the app, get daily text reminders, or receive usual care. The goal is to see if the app improves medication adh…

This study tests a special catheter that uses radiofrequency energy to calm overactive kidney nerves, which can help lower blood pressure. It is for adults aged 18-65 with uncontrolled hypertension despite taking 2 or more medications, and who also have chronic kidney disease. Th…

This study tests new ways to help doctors and patients manage high blood pressure more effectively. Researchers will compare three approaches: focusing on doctors, focusing on patients, or usual care. The goal is to find the best strategies to control blood pressure in a diverse …

This study tests a device that uses energy to calm overactive nerves in the kidneys, which can help lower blood pressure. It included 282 adults with high blood pressure, some on medication and some not. Participants were randomly assigned to get the real procedure or a sham (fak…

This study looks at how changing when you eat and improving sleep can help people with type 2 diabetes, high blood pressure, or obesity better control their blood sugar, heart health, and weight. About 40 adults will receive personalized nutrition advice and education. The goal i…

This study tests whether spermidine, a natural substance found in foods like wheat germ and soy, can improve heart and muscle health in people aged 65 and older with coronary artery disease. About 180 participants will receive either spermidine or a placebo for a period, and rese…

This study looks at whether a treatment tailored to a specific gene (LSD1) can better control high blood pressure and protect the kidneys in Black adults who carry a certain risk version of that gene. About 300 participants will follow a controlled diet and have their blood press…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits. About 49 adults who had a kidney transplant in the past year and have high blood pressure, hi…

This study looks at whether a home blood pressure monitoring program helps people with high blood pressure get it under control. About 24,000 adults from primary care clinics will use home monitors and receive support. The goal is to see if this approach lowers blood pressure ove…

This study tests whether providing home-delivered DASH diet groceries (low salt, rich in fruits and veggies) can lower blood pressure in Black adults who live in Boston-area food deserts and have mildly elevated blood pressure but are not on medication. About 150 participants wil…

This study tests two approaches—one focused on patients and one on clinics—to help people from diverse backgrounds monitor their blood pressure at home. About 330 adults with uncontrolled high blood pressure will take part. The goal is to see which strategy works best to safely i…

This study looks at whether sending doctors monthly feedback comparing their performance to peers can improve how they manage patients with high blood pressure. About 93 primary care providers and their patients are involved. The goal is to see if this feedback leads to more pres…

This study tests a new way to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one heart-related condition will be enrolled. Their primary care doctors will work more cl…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. About 25 adults who are at least 3 months post-transplant will follow a plant-based diet for 16 weeks. Researchers will track c…

This study looks at whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 participants will receive potassium or a placebo for several years. The goal is to see if …

This study tests a program to help adults aged 35 and older in rural Pakistan control high blood pressure. Community health workers will provide regular blood pressure checks, home education, and referrals to doctors. The goal is to see if this approach works when used on a large…

This study tests a procedure called renal denervation, where a small amount of alcohol is injected into nerves near the kidneys to lower blood pressure. About 142 adults with high blood pressure will receive either the real procedure or a fake (sham) one, and stop taking their bl…

This pilot study tests whether checking blood pressure at home and talking with a pharmacist weekly can help manage high blood pressure. Twenty-four patients from an ER follow-up clinic will take part; half will use home monitors and get phone check-ins, while the other half rece…

This study tests whether combining home blood pressure monitoring with support from community health workers helps adults with early high blood pressure keep it under control. About 600 adults from community health centers will either get a home monitor alone or the monitor plus …

This study tests whether a smartphone app called Elfie can help people with high blood pressure lower their numbers better than standard care. About 930 adults with uncontrolled hypertension who already take at least one blood pressure pill will use the app to improve medication …

This study tests whether giving stroke patients a more thorough exam—looking at hidden causes like artery stiffness, hidden heart issues, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people admitted to a Swedish hospital for a str…

This study is tracking 1,000 people with high blood pressure that is hard to control with medication or who cannot tolerate blood pressure drugs. The treatment uses a special catheter to deliver radiofrequency energy to nerves in the kidney arteries, which can help lower blood pr…

This study looks at whether exercise can help lower blood pressure and improve gut health in African Americans, a group that often has high blood pressure. Researchers will measure changes in blood pressure and gut bacteria in 36 sedentary adults aged 30-50. The goal is to unders…

This study tests whether virtual group visits can help people with type 2 diabetes and at least one heart-related condition (like high blood pressure or obesity) improve their blood sugar control. About 720 adults with high A1C levels will take part. The main goal is to see if th…

This study looks at whether helping adults with type 2 diabetes, high blood pressure, or high cholesterol meet their social needs (like food, housing, or transportation) can improve their health. About 4,800 participants will be screened during clinic visits and offered support f…

This study tests whether a telehealth coaching program led by community health workers can help South Asian adults with both type 2 diabetes and high blood pressure better control their conditions. About 450 participants will either receive the coaching or usual care. The main go…

This study tests whether exercise, brain training, or both can improve physical and mental abilities in adults 60 and older who have had a stroke and also have high blood pressure or diabetes. About 444 participants from community health centers in five Chinese cities will take p…

This study tests a procedure called renal denervation, which uses a device to calm overactive nerves in the kidneys that can raise blood pressure. About 1,900 adults with uncontrolled high blood pressure will be followed for years to see if the treatment safely and durably lowers…

This study tests whether a program led by village doctors can help people with high blood pressure in rural China get their blood pressure under control. Over 34,000 adults aged 40 and older are taking part. The program includes regular check-ins and treatment plans to lower bloo…

This study tests a smartphone app called COACH that helps patients and doctors work together to manage high blood pressure. About 550 adults with high blood pressure will use the app to track their home readings and share them with their care team. The goal is to see if the app h…

This study looks at the long-term safety and effectiveness of a drug called lorundrostat for people with high blood pressure. About 1,076 adults who completed a previous lorundrostat study will take the drug for up to 36 weeks. The goal is to see if it keeps blood pressure under …

This study tests whether a time-efficient breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve heart health in adults aged 50 and older with moderate to severe obstructive sleep apnea. Participants who cannot or will not use a CPAP machin…

This study tests whether fun, game-like challenges and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will either compete or work together to increase their daily steps over 9 months. The goal is to see if th…

This study looks at whether a cuffless blood pressure monitor can help people with uncontrolled high blood pressure manage their condition better. About 288 Korean adults will either use the device to guide their treatment or receive usual care. The main goal is to see if the dev…

This study tests two programs—mindfulness exercises and a heart-healthy diet (DASH)—to help Black women who care for a loved one with Alzheimer's or memory problems. Participants are 40 or older, have high blood pressure, and provide unpaid care. The goal is to lower blood pressu…

This study compares two ways of doing peritoneal dialysis—standard (full dose) versus incremental (lower dose tailored to the patient's remaining kidney function)—in 100 adults starting dialysis. The goal is to see which approach better preserves residual kidney function and redu…

This study tests a digital care program for adults aged 50 and older with type 2 diabetes and at least one other chronic condition like high blood pressure or kidney disease. The program includes online tools, educational sessions, phone support, and home visits to help participa…

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who have already been in earlier ralinepag studies will take the drug and be monitored f…

This study tests whether women with high blood pressure can better control it by measuring their blood pressure at home and sharing results with a pharmacist every four weeks. About 368 women will either receive a home monitor and regular pharmacist follow-up or standard care. Th…

This early-stage study tests a new medicine called ADX-850 in 28 adults with mild to moderate high blood pressure. The main goal is to check if the drug is safe and how the body processes it. Researchers will also measure changes in blood pressure over time.

This study tests a smartphone-based program called mGlide to help people with high blood pressure manage it better. About 395 participants, including stroke survivors and others at high risk, will use a wireless blood pressure monitor and phone to track their readings. If their n…

This study tests whether a storytelling program can help adults in a large city in northern Vietnam better control their high blood pressure. Researchers will enroll 700 adults with uncontrolled hypertension and compare those who receive the storytelling intervention to those who…

This study looks at whether sleeping longer (over 7 hours a night) for 8 weeks can lower blood pressure in people with prehypertension or mild hypertension who usually sleep 6.5 hours or less. About 110 adults aged 18 to 65 will either get sleep coaching or general health educati…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight, type 2 diabetes, or other heart-related risks and moderate liver fibrosis will …

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, diabetes, or high blood pressure. Participants use a tablet and fitness tracker at home, and some get extra support from a coach by video or …

This study tests whether delivering DASH diet groceries to the homes of Black adults with high blood pressure can help lower their blood pressure. Participants live in Boston-area food deserts and are already on blood pressure medication. The goal is to see if better access to he…

This study looks at whether a smartphone app called OptiZ can help people with high blood pressure get better control of their condition. The app helps patients track their blood pressure, remember to take their medication, and report side effects to their doctor, who can then ad…

This study tests a device that uses ultrasound to calm overactive kidney nerves, which can help lower blood pressure. About 154 adults with high blood pressure who are already taking two medications will receive either the ultrasound treatment or a fake procedure. The goal is to …

This study looks at whether eating wild blueberries can help lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. About 58 participants will eat blueberries and have their artery function and…

This study looks at how well the drug benidipine controls blood pressure and reduces chest pain in people with high blood pressure or chronic heart disease. About 800 adults in Turkey will be followed to see if their blood pressure drops below 130/85 and if their angina symptoms …

This study tests whether portable devices like handheld ultrasound and blood glucose monitors can help doctors find chronic diseases earlier than standard care. Two hundred adults aged 18 to 75 with conditions like prediabetes or high blood pressure will use the devices or receiv…

This study tests a culturally tailored program to help Latinx and Vietnamese families in Santa Ana, CA, improve their heart health and prevent high blood pressure. About 483 adults and children will work with community health workers to set healthy goals, learn about risk factors…

This study tests whether berberine, a natural compound, can prevent heart disease and diabetes in 2024 adults with prediabetes, obesity, and other risk factors. Participants take berberine or a placebo for one year, and researchers track changes in blood sugar and cholesterol. Th…

This study tests whether personalized counseling can help prevent high blood pressure in adults living in slums in Dhaka, Bangladesh. 1,700 healthy adults will receive 20 counseling sessions focused on exercise, diet, and avoiding tobacco and alcohol. Researchers will measure cha…

This study tests whether bringing a mobile health unit (MHU) to underserved Detroit neighborhoods can help Black adults with slightly elevated blood pressure lower it and avoid full-blown hypertension. Participants receive personalized lifestyle coaching from community health wor…

This study looks at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent high blood pressure in healthy adults. Over 25,000 men and women across the U.S. who have never had high blood pressure are taking part. Researchers will measure changes in bloo…

This study tests a program to prevent high blood pressure in 528 rural Black adults in Alabama who have slightly elevated blood pressure. Participants from 30 churches will receive health education and online cooking and exercise resources. Half of the churches will also get a he…

This study looks at whether helping families switch to cleaner cookstoves can reduce indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will take part, with some getting extra community support to use the new stoves. Researchers will track sto…

This study tests whether a non-invasive brain stimulation technique called TMS can lower blood pressure and reduce PTSD symptoms in women aged 18-44 who have both conditions. Thirty participants will receive TMS and have their blood pressure monitored for 24 hours. The goal is to…

This study aims to find which local anesthetic works better and is safer for people with high blood pressure who need a tooth pulled. It compares two common dental numbing drugs, articaine with epinephrine and mepivacaine without epinephrine, by measuring pain levels and changes …

This study looks at whether a powder made from Canadian haskap berries can help lower blood pressure and improve alertness in women aged 35 and older. The trial involves 32 women who will take either the berry powder or a placebo for six weeks, then switch after a break. The goal…

This study tests whether fun challenges (gamification) and personal coaching can help older adults become more active after leaving the hospital. About 350 people aged 50+ with conditions like high blood pressure or heart failure will wear a Fitbit to track steps. The goal is to …

This study looks at how sleep and your body's internal clock affect your blood pressure at night. Researchers will measure melatonin, body temperature, and blood pressure in 1,427 adults. No treatment is given—the goal is simply to understand these connections better.

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers measured known risks like high blood pressure and diabetes to see how they affect older people's health over time. The goal was to …

This study looks at how the kidneys work differently in people whose blood pressure is sensitive to salt. Researchers will measure kidney oxygen levels and metabolism in 70 adults with elevated or stage 1 high blood pressure after low- and high-salt diets. The goal is to uncover …

This study aimed to see if holistic pastoral counseling could help people manage stress at work and in daily life. It was designed for unmarried Alaska Medicaid recipients aged 22 and older who had internet access and a Bible. However, the study was withdrawn before any participa…

This study looks at how blood pressure changes affect chronic pain in people who already have a spinal cord stimulator. About 36 adults with chronic low back pain and high blood pressure will take a standard blood pressure drug for 2 weeks and a placebo for 2 weeks. Researchers w…

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to track heart disease risks like high blood pressure, diabetes, and smoking. Researchers will measure how common these risks are and how they lead to heart attacks, strokes, or heart failure. The g…

This study looks at whether a 'Learning Health System' can help clinics in Thailand better manage high blood pressure, diabetes, and kidney disease. About 419 people from 16 primary care units will take part. The approach uses electronic health records to give care teams real-tim…

This study looks at 100 adults with sleep bruxism (teeth grinding during sleep) to understand how it relates to sleep quality, heart health, thyroid function, and mental well-being. Participants will undergo sleep monitoring and fill out questionnaires. No treatment is given; the…

This study looks at how often pre-hypertension (higher than normal blood pressure) occurs in children and teens aged 6 to 18 who have type 1 diabetes for at least one year. Researchers will carefully measure blood pressure using a standard device on multiple visits. The goal is t…

This study reviews over 2,500 medical records to understand why some people with treated and controlled high blood pressure still die from heart attacks, strokes, kidney failure, or sudden death. It aims to find overlooked factors beyond blood pressure numbers that may lead to fa…

This study aimed to see if using wearable step counters and smartphone games could encourage hospital patients with heart conditions to walk more. It planned to enroll adults aged 50 and older admitted to medicine or cardiology floors. However, the study was withdrawn before any …

This study looks at how combat injuries impact the long-term health of U.S. service members, focusing on sleep problems, heart issues, and stress. About 200 participants will wear heart and sleep monitors and provide blood and urine samples. The goal is to understand connections …

This study looks at a specific genetic variant that may cause high blood pressure in some people, especially men. Researchers will test about 76 participants from a larger Swedish study to see if this gene is linked to a treatable condition called primary aldosteronism. The goal …

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This study looks at whether a special computer-based brain training program can improve memory and thinking in older adults (60+) who have high blood pressure but no dementia. 120 people in Beijing will be randomly assigned to either the adaptive training or a placebo version. Th…

This study is a review of many smaller studies that looked at what happens when people replace animal proteins (like meat, dairy, and eggs) with plant proteins (like beans, nuts, and seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressu…

This study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3000 participants over time to see how these scans can help predict who might develop worsen…

This study looks at people with high blood pressure whose levels don't naturally fall at night, a condition linked to worse health outcomes. Researchers will use wearable devices and smartphone apps to track blood pressure and daily rhythms in 150 adults. The goal is to better un…

This study planned to see if training residents of Boston housing developments as Community Health Ambassadors could help more people get regular doctor visits and screenings for high blood pressure and diabetes. The ambassadors would lead workshops and connect neighbors to clini…

This study looks at how a specific gene (Caveolin-1) and salt intake affect blood vessel function in people with high blood pressure. About 120 adults with mild to moderate hypertension will follow low- and high-salt diets while researchers measure heart and blood vessel response…

This study follows 50 people with chronic lymphocytic leukemia who are starting treatment with acalabrutinib or zanabrutinib. Participants use wearable devices at home to monitor their heart rhythm and blood pressure. The goal is to learn how often these drugs cause high blood pr…

This study follows 500 adults aged 50 and older in the Washington, D.C. area for up to 5 years. Participants receive a personalized 'Health Passport' with tips to manage risks for Alzheimer's, heart disease, and frailty. The goal is to see how these recommendations affect health …

This study looks at whether treating patients at home, instead of in a hospital, can lead to better health outcomes and happier patients. About 9,654 adults with conditions like heart failure, infections, or diabetes will receive hospital-level care in their own homes. Researcher…

This study aims to better understand how blood pressure changes in the six weeks after childbirth. Researchers will give 300 new mothers a medical-grade smartwatch to continuously monitor their blood pressure. The goal is to learn how to predict and prevent serious complications …

This study looks at over 1,000 South African children aged 5 to 9 to understand how high blood pressure and obesity start early in life. Researchers measure blood pressure, body composition, and fitness, and analyze blood samples for early warning signs. The goal is to find bette…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyles and risk factors affect heart disease later in life. Researchers measure things like blood pressure, cholesterol, and weight to understand what leads to heart attacks, stro…

This study is testing a program called CONNECT that helps more women and Black and Latino adults learn about and join heart health research. About 1,000 people with heart disease or risk factors like high blood pressure or diabetes will receive text messages with heart health inf…

This study looks at how a special heart device (Moderato IPG) changes nerve activity in 15 people with high blood pressure. Researchers measure nerve signals and blood pressure while the device is on and off. The goal is to understand how the device works, not to test a new treat…

This study looks at how people with high blood pressure respond to being placed face down during spinal surgery. Researchers will measure heart function and blood pressure in 70 patients to see if those with hypertension are at higher risk for dangerous drops in blood pressure. T…

This study planned to check if notifying ambulatory surgery patients with undiagnosed high blood pressure would help them get a formal diagnosis. Researchers would call patients with elevated readings (over 160/90) and follow up after 6 months. However, the study was withdrawn be…

This study follows over 31,000 middle-aged and older adults to see how being overweight or having high blood pressure impacts their risk of heart attacks, strokes, and death. Researchers will track participants until 2026 using routine health checkups. The goal is to better under…

This study looks at whether training and coaching for clinic staff can improve how they measure blood pressure and educate patients about hypertension during and after pregnancy. About 4,000 providers and staff from prenatal clinics in North Carolina will take part. The goal is t…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will examine immune cells (monocytes) from 40 participants to see if they trigger a hormone that raises blood pressure. The goal is to better understand the co…

This study looks at 10,000 people who have both sleep apnea and high blood pressure. Researchers will track them over many years to see how well they use their sleep apnea machine (PAP) and blood pressure medicines, and whether that affects their risk of heart attacks, strokes, h…

This study aimed to see if data from Withings devices (like smart scales or blood pressure monitors) could predict uncontrolled high blood pressure. It planned to include adults in the U.S. who had used a Withings device for at least two years. However, the study was withdrawn be…

This study tests whether a nurse-led health coaching program helps women aged 45 to 64 in Hong Kong use medical services more wisely and feel more in control of their health. About 1,728 women will either receive the nurse coaching or general health advice. The goal is to see if …

This study looks at whether giving extra support to care teams at community health centers helps them better screen patients for non-medical needs—like food, housing, or transportation—and connect them to community services. About 20 health centers will take part. The goal is to …

This study tests a new MRI method to see if it can measure scarring in narrowed kidneys. Researchers will scan 24 people with high blood pressure and narrowed kidney arteries. The goal is to see if this MRI technique is reliable and can predict kidney recovery.

This study re-examines 317 adults with type 2 diabetes who were first checked for fatty liver disease a few years ago. Researchers will use advanced scans and blood tests to see if their liver condition has improved, worsened, or stayed the same. The goal is to find patterns and …

This study looks at how to help primary care clinics set up a program where patients with high blood pressure send their home readings to their doctor's office. The goal is to see which strategies work best to improve blood pressure control and reduce differences in care between …

This study looks at whether a medication used for heart failure can also help treat diabetes by increasing a hormone that boosts insulin after meals. Researchers will measure GLP-1, insulin, and blood sugar levels in 25 adults with type 2 diabetes or pre-diabetes and high blood p…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, not individual patients. The goal is to see which strategies work best to get women to sign …

This study looks back at medical records of about 4,000 newborns in intensive care to understand how common kidney injury is and what factors increase the risk. Researchers want to update old data and include more hospitals around the world. No new treatments or drugs are given; …

This study looks at whether moving combination blood pressure pills to the top of the doctor's prescription list (and adding "PREFERRED") makes doctors prescribe them more often. These pills combine two medicines into one, making it easier for patients to take. Over 12,000 adults…

This long-term study aims to understand how early, hidden signs of heart disease develop and predict future heart attacks, strokes, and heart failure. It follows over 6,400 adults from four different ethnic groups who started the study with no known heart disease. Researchers use…