HYPERTENSION

This study tests a virtual clinic where pharmacists monitor blood pressure, adjust medications, and provide telehealth support to older adults (65+) with high blood pressure. The goal is to see if better blood pressure control can also help prevent cognitive decline. About 1,000 …

This study tests a 12-week home-based digital program called eCardiacRehab for people who have had a heart procedure (PCI). The program includes video messages, modules, and tracking to support recovery. Researchers want to see if patients will use it regularly and find it accept…

This study tests two programs—mindfulness training and a heart-healthy diet plan—to help Black women caregivers lower their blood pressure and stress. About 90 participants will join weekly group sessions online for 8 weeks, with follow-up calls. The goal is to see if these appro…

This study tests whether home visits by female community health volunteers plus regular SMS messages can help adults in Pokhara, Nepal, better control high blood pressure, type 2 diabetes, and smoking. About 2100 participants are split into two groups: one gets the home visits an…

This early-stage study tests a new drug called ADX-850 in 28 people with mild to moderate high blood pressure. The drug uses siRNA technology to target genes involved in blood pressure regulation. The main goal is to check safety and how the drug moves through the body, with a se…

This study tests a smartphone app called Liebria designed to help people manage high blood pressure. 328 adults with high blood pressure used the app at home to track and lower their readings. The goal is to see if the app can help control blood pressure and improve daily life.

This study tests a 6-month church-based program to help African Americans with uncontrolled high blood pressure. The program includes Bible study sessions led by the pastor and small group meetings focused on diet and exercise. A community health worker provides extra support if …

This study tests a program where people with slightly high blood pressure use a home monitor and get support from a community health worker. The goal is to see if this helps keep blood pressure from rising to dangerous levels. About 600 adults from 20 health centers are taking pa…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study tests a mobile app called HyperCoach that provides health coaching to help people with high blood pressure manage their condition. Thirty-seven adults with hypertension who are already on medication will use the app to track blood pressure, weight, and steps, and set p…

This study looks at whether giving low-income people with diabetes or hypertension a monthly grocery card ($80 or $120) helps them control their disease and feel less stressed about food. About 4,450 adults in California are taking part. Researchers will check changes in blood su…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests whether a church-based program led by community health workers can help Black adults in Louisiana lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 812 participants from local churches will receive either a health worke…

This study tests whether sending primary care doctors a monthly report comparing their hypertension control rates to peers can improve patient care. About 93 doctors and their patients with high blood pressure are involved. The goal is to see if this feedback leads to more medica…

This study tests an experimental drug called QCZ484, given as an injection under the skin every 6 months, for people with mild to moderate high blood pressure. About 385 adults aged 18 to 75 are taking part. The goal is to see if the drug safely lowers blood pressure compared to …

This study tests whether monthly home visits from trained health agents can help people in poor, high-altitude communities in Peru better control their high blood pressure and diabetes. Over 1,000 participants will either receive these visits for a year or get usual care. The goa…

This Phase 3 trial tests a daily pill called orforglipron in 487 adults with high blood pressure who are also overweight or obese. The study measures how well the drug lowers blood pressure and body weight compared to a placebo. It is currently active but not recruiting.

This Phase 3 trial is testing a once-daily pill called orforglipron in nearly 1,000 people with high blood pressure who are also overweight or have obesity. The study compares the drug to a placebo to see if it safely lowers blood pressure. Participants may be untreated or on sta…

This Phase 3 study tests an experimental once-daily pill called orforglipron in about 487 adults who have both high blood pressure and obesity or overweight. The main goal is to see if the drug lowers blood pressure more than a placebo. Researchers will also check for changes in …

This early-phase study tests a single injection of ART101 in 16 adults with high blood pressure. The goal is to see if it is safe and how it affects blood pressure over 24 weeks. Participants receive either 600 mg or 800 mg of the drug and are closely monitored.

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study tests whether nurse-led health coaching can help adults with high blood pressure in Huayuan County, China, better manage their condition. About 78 participants will receive either standard care or additional coaching sessions over six months. The goal is to see if coac…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This study looks at whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have had a kidney transplant. Twenty-five participants who are at least three months post-transplant will follow a plant-based diet for 16 weeks after a two-…

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study tests a mobile health system called mGlide that helps patients with uncontrolled high blood pressure monitor their BP at home and automatically share readings with their healthcare team. The system alerts doctors when BP goes off track, allowing for timely medication a…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This phase 3 trial tests a procedure called renal denervation, where a small amount of alcohol is injected around the kidney nerves to calm overactive signals that raise blood pressure. 142 people with uncontrolled hypertension will either get the real procedure or a sham (fake) …

This study tests a smartphone app called MED-AD that sends reminders and tracks medication use for people with heart disease, high blood pressure, or high cholesterol. About 1,000 adults in Oman will be randomly assigned to use the app, receive daily text reminders, or get usual …

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether the drug eplerenone works better than amlodipine for controlling high blood pressure in Black adults who carry a specific gene variant (LSD1 risk allele). About 300 participants will follow a controlled diet and take escalating doses of one of the two dru…

This pilot study tests whether checking blood pressure at home and talking to a pharmacist weekly by phone can help manage uncontrolled hypertension after an emergency department visit. Twenty-four participants will be split into two groups: one receives the home monitoring and t…

This study looks at how the timing of meals and sleep patterns influence blood sugar, heart health, and weight loss in adults with type 2 diabetes, obesity, or high blood pressure. Researchers will provide nutritional guidance and track changes in weight, lab results, and body me…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study tests a device that uses ultrasound to disrupt overactive nerves in the kidneys, which can drive high blood pressure. About 282 adults with hypertension will either get the real procedure or a sham (fake) procedure. The goal is to see if this treatment safely lowers bl…

This study is testing a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. It includes 1,000 people whose blood pressure stays high despite taking three or more medications, or who can't tolerate those drugs. Researchers …

This study tests a device called Paradise™ that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers will compare the device to a sham (fake) procedure in 154 adults with hypertension who are already taking two blood pressure …

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study tests a new app called COACH that helps patients and their doctors work together to control high blood pressure. The app connects home blood pressure readings to the patient's medical record and sends reminders based on behavioral science. About 550 adults with high bl…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study tests if a smartphone app called OptiZ can help people with high blood pressure get better control of their condition. Participants use the app to track their blood pressure, medication, and side effects, and share reports with their doctor for personalized dose adjust…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This study tests a program that helps adults with type 2 diabetes, high blood pressure, or high cholesterol address social needs like food, housing, and transportation. About 4,800 participants will be screened during primary care visits and offered support from providers, care c…

This study tests whether giving women a home blood pressure monitor plus regular pharmacist follow-up helps lower blood pressure better than usual care. 368 women with high blood pressure will be randomly assigned to either the home monitoring program or standard care. The pharma…

This study looks at whether a home blood pressure monitoring program helps people with high blood pressure get better control. About 24,000 adults from primary care clinics are taking part. The program includes support and education to help patients measure and manage their blood…

This study looks at whether a cuffless blood pressure monitor (CART BP Pro) can help manage high blood pressure better than usual care in Korean adults whose blood pressure is not well controlled. About 288 participants will either use the device to guide their treatment or recei…

This study tests a 6-month digital care program for adults aged 50+ with type 2 diabetes and at least one other chronic condition like high blood pressure or kidney disease. The program combines online education, phone support, a mobile health app, home visits, and personalized c…

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug remains s…

This study looks at the long-term safety and effectiveness of a drug called lorundrostat for people with high blood pressure. About 1,076 adults who have already taken lorundrostat in a previous study will continue taking it for up to 36 weeks. The goal is to see if the drug keep…

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study tests a special device that uses radiofrequency energy to calm overactive kidney nerves, which can help lower blood pressure. It is for adults aged 18-65 with uncontrolled high blood pressure and chronic kidney disease who are already on at least two blood pressure med…

This study tests different strategies to help people from diverse backgrounds monitor their blood pressure at home. About 330 adults with uncontrolled high blood pressure will receive training on using a blood pressure monitor and a mobile app, plus SMS reminders and education. T…

This study tests a program to help control high blood pressure in adults aged 35 and older living in rural Pakistan. The program includes regular blood pressure checks, home health education, and referrals to doctors. Researchers want to see if this approach can be effectively us…

This study tests whether providing home-delivered DASH diet groceries, with help from a dietitian, can lower blood pressure in Black adults who already take medication for hypertension and live in areas with limited access to healthy food. About 150 participants will receive week…

This study tests whether interactive storytelling modules can help adults in a large Vietnamese city better control their high blood pressure. Seven hundred participants with uncontrolled hypertension will receive the storytelling intervention or usual care. The goal is to see if…

This study tests different patient- and clinic-focused strategies to help people with high blood pressure get it under control. Researchers will compare changes in blood pressure readings from clinic and home monitoring. The goal is to find the most effective approach for English…

This study tests whether regular exercise and cognitive training, alone or together, can improve physical and mental function in adults aged 60+ who have had a stroke and also have high blood pressure or diabetes. Over 400 participants from five Chinese cities will take part in 1…

This study looks at how to best help primary care clinics adopt team-based home blood pressure monitoring. Over 5,700 patients and their care teams will use a program where patients send in their home readings and get support from doctors, nurses, and community resources. The goa…

This study compares two types of peritoneal dialysis—standard and incremental—in 100 adults starting dialysis. The goal is to see if using less dialysis solution (incremental) helps preserve remaining kidney function and reduces cell damage compared to the standard approach. Part…

This study tests whether helping people who sleep less than 6.5 hours per night extend their sleep can lower their blood pressure. Researchers will compare an 8-week sleep coaching program to general health education in 110 adults with prehypertension or mild hypertension. The ma…

This study looked at whether a 36-week program of exercise, nutrition advice, and psychoeducation could improve body composition, blood markers, and physical performance in 40 older women, some with high blood pressure and some without. The women exercised regularly and received …

This study tests whether colchicine, a drug used for gout, can improve blood vessel stiffness and heart function in people with high blood pressure. About 150 adults with hypertension and additional risks like diabetes or high cholesterol will take colchicine or a placebo daily f…

This large trial tests whether a program led by village doctors can help control high blood pressure in rural China. Over 33,000 participants will receive training, discounted medications, and a simple treatment protocol. The study aims to see if this approach improves blood pres…

This study looks at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent high blood pressure or lower it in healthy adults. Over 25,000 people are taking part, with a smaller group having their blood pressure monitored around the clock. The goal is t…

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study tests whether a powder made from haskap berries can help lower blood pressure and improve alertness in women aged 35 and older. Thirty-two participants will take either the berry powder or a placebo for six weeks, then switch after a break. The goal is to see if this n…

This study tests whether a culturally tailored telehealth coaching program led by community health workers can help South Asian adults with type 2 diabetes and high blood pressure get their blood pressure under control. About 450 participants will either receive the coaching or u…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot or will not use a CPAP machine. Researchers will measure blood pressure changes over 36 weeks in 122 p…

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This study tests whether patient- and provider-focused strategies can help more people control their blood pressure. About 540 adults with hypertension from Los Angeles County clinics will take part. Clinics are randomly assigned to receive either provider outreach, patient outre…

This study will follow 800 adults in Turkey with high blood pressure or chronic chest pain (angina) who are already taking benidipine. Researchers will track how well the drug controls blood pressure and eases chest pain symptoms over time. The goal is to see how benidipine works…

This study checks if a Withings smart scale can accurately spot signs of high blood pressure by looking at body measurements like weight and heart rate. Researchers compared the scale's results to a standard blood pressure cuff in 2,500 adults. The goal is to see if the scale wor…

This study tests whether Withings bathroom scales can accurately measure pulse wave velocity (PWV), a key indicator of vascular stiffness. Researchers will compare readings from the scales with a standard medical device in 176 adults, including those with high blood pressure, sle…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study tests a new type of MRI scan (qMT-MRI) to see if it can detect scarring in the kidneys of people with high blood pressure and narrowed kidney arteries. Researchers will compare the scan results to kidney function and injury markers. If it works, this could offer a safe…

This study looks at whether helping communities switch to cleaner cookstoves can lower indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will take part. Some families get extra support to use the new stoves, while others just receive informat…

This study tests whether a culturally tailored, skills-based program delivered by community health workers can help Latinx and Vietnamese families in Santa Ana, CA, improve their heart health and prevent high blood pressure. About 483 participants will receive either the special …

This study tests whether a program using church-based health coaches can help rural Black adults with slightly high blood pressure lower it. Participants from 30 churches in Alabama will get health education and online cooking and exercise classes. Half will also get a health coa…

This study tests whether personalized counseling, leaflets, and text messages can help 1,700 healthy adults living in Dhaka slums avoid high blood pressure. Participants receive 20 face-to-face sessions on diet, exercise, and tobacco use. The goal is to see if these lifestyle cha…

This large, phase 4 trial is testing whether berberine, a natural compound, can prevent heart disease and diabetes in over 2,000 high-risk adults in China. Participants take berberine or a placebo twice daily, plus receive lifestyle advice. The study tracks blood sugar and heart …

This study tests whether a mobile health unit program can help Black adults in Detroit lower their blood pressure and prevent stage 2 hypertension. Participants receive personalized lifestyle coaching from community health workers. The goal is to address social barriers like food…

This study tests whether a smartphone-based stress management program can help Black men with hypertension lower their blood pressure and feel less stressed. About 135 participants will either use a culturally tailored app (m-CBSMi) or take a standard online stress course. Resear…

This study looks at whether a program that combines physical activity with support from a peer is acceptable and practical for women living with both HIV and high blood pressure. About 50 women aged 40 and older will take part. The goal is to see if women stick with the program a…

This study tests whether a virtual reality (VR) wellness program can help Black women with high blood pressure reduce stress and improve heart health. Sixty Black women in South Florida will either use a five-week VR program or receive standard educational materials. Researchers …

This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual …

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study looks at which local anesthetic works better and is safer for people with high blood pressure who need a tooth pulled. Sixty adults with controlled hypertension will get either articaine with epinephrine or mepivacaine without epinephrine. Researchers will measure pain…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study tests whether changing how combination blood pressure pills appear in the electronic health record can encourage doctors to prescribe them more often. Over 12,000 patients will be included, and researchers will track whether a simple label like "(PREFERRED)" makes a di…

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study looks at whether personalized digital messages can help 12,000 adults with uncontrolled high blood pressure stick to their treatment plan. The messages are tailored using artificial intelligence to encourage doctor visits, medication adherence, and home blood pressure …

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study tests a training program that teaches doctors how to better talk with, listen to, and involve patients in their own care. About 180 doctors and their patients with high blood pressure will take part. The main goal is to see if the training is practical and acceptable, …

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study looks at whether giving extra support to community health centers helps them screen patients for non-medical needs like food or housing and refer them to community resources. Twenty health centers will be randomly assigned to get this support or not. The goal is to see…

This study looks at how a special heart device (BackBeat CNT) affects nerve activity in 15 people with high blood pressure who already have the device implanted. Researchers measure nerve signals and blood pressure with and without the device turned on. The goal is to understand …

This study looks at how common kidney injury is in newborns in intensive care and what factors increase the risk. Researchers will review medical records of about 4,000 babies from hospitals around the world. The goal is to better understand short- and long-term kidney health, bu…

This study tests whether a Learning Health System (LHS) can improve care for people with high blood pressure, diabetes, and kidney disease in Thai primary care clinics. The LHS uses electronic health records to help healthcare teams identify patients who need more active manageme…

This study looks at how exercise affects gut bacteria and blood pressure in African Americans, who face higher rates of hypertension. Researchers will measure changes in blood pressure and gut microbes in 36 sedentary adults aged 30-50. The goal is to understand if exercise impro…

This study looks at over 1,000 South African children ages 5 to 9 to understand why some develop early signs of high blood pressure and heart problems. Researchers will measure blood pressure, body fat, and fitness, and test blood for early warning markers. The goal is to find wa…

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study watches 50 people with chronic lymphocytic leukemia (CLL) who are starting a type of drug called a BTK inhibitor. These drugs can cause high blood pressure and irregular heartbeats. Participants will use a wearable device at home to track their heart rhythm and blood p…

The ALOHA study is a community-based research project for adults aged 50 and older in the Washington, D.C., Maryland, and Virginia area. Over five years, participants receive annual health assessments—including physical and cognitive tests—and get a personalized 'Health Passport'…

This study examines the links between sleep bruxism (teeth grinding during sleep) and sleep quality, heart health, thyroid function, and mood. Researchers will give some participants opipramol, a drug that may reduce grinding activity, and monitor them with sleep tests. The goal …

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study aimed to see if data from Withings devices (like smart scales and blood pressure monitors) could predict uncontrolled high blood pressure. It planned to enroll adults in the U.S. who had used Withings devices for at least two years. The study was withdrawn before any p…

This study aimed to see if telling surgery patients about their high blood pressure would lead them to get a formal diagnosis. Researchers planned to call 108 patients with elevated readings and follow up six months later. However, the study was withdrawn before enrolling anyone,…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study looks at a specific genetic change found in some people with high blood pressure. Researchers want to see if this change is linked to a condition called primary aldosteronism, which can sometimes be cured with surgery. About 76 men from a larger Swedish health study wh…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study looks at how sleep and your internal body clock influence blood pressure at night. Researchers will monitor over 1,400 participants using a constant routine protocol—staying awake in a dim room for over 24 hours—to measure melatonin, body temperature, and blood pressur…

This study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3,000 participants over time to see how the heart changes and who develops serious problems.…

This study looks at people with high blood pressure whose levels don't drop normally during sleep, a condition linked to worse health outcomes. Researchers will use wearable devices and smartphone apps to monitor blood pressure patterns over 24 hours. The goal is to understand ho…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to study immune cells called monocytes and see if they trigger a hormone that raises blood pressure. The goal i…

This study looks at whether a personalized brain-training program can improve memory and thinking in older adults (60+) who have high blood pressure but no dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo version for 12 weeks. The …

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with mild to moderate high blood pressure. Researchers will measure kidney blood flow, artery flexibility, and blood pressure after low- and high-salt diets, as well as after an infusion of a…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study looks at how the kidneys work differently in people whose blood pressure is sensitive to salt. Researchers will measure kidney oxygen levels and chemical changes in 70 adults with mild high blood pressure after low- and high-salt diets. The goal is to find new ways to …

This study tests a program to help prenatal clinics improve how they measure and treat high blood pressure in pregnant and postpartum patients. About 4,000 clinic staff from North Carolina will receive training, coaching, and practice sessions. Researchers will check if the progr…

This study gives 300 new mothers a medical-grade smartwatch that tracks blood pressure multiple times daily for 6 weeks after delivery. Researchers want to see if daily blood pressure patterns differ between low-risk, intermediate-risk, and high-risk groups. The goal is to better…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study follows over 31,000 middle-aged and older adults to see how being overweight or having high blood pressure affects their risk of heart attacks, strokes, and death. Researchers will track participants until 2026 using routine health checkups. The goal is to better under…

This study was designed to see if training residents of Boston housing developments as Community Health Ambassadors could help more people get primary care visits and screenings for diabetes and high blood pressure. The ambassadors would have led workshops and connected neighbors…

This study looks at how often children and teenagers (ages 6-18) with type 1 diabetes have pre-hypertension, or early signs of high blood pressure. Researchers will measure blood pressure carefully and also take blood samples to check for related conditions. The goal is to unders…

This study tests whether a heart failure medication called Entresto (sacubitril/valsartan) can boost a natural hormone that helps control blood sugar after meals. Researchers will give the drug or a comparison drug (valsartan) to 25 adults with type 2 diabetes or prediabetes and …

This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for t…