HYPERTENSION

This pilot study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can safely help regulate blood pressure. Researchers will enroll 25 adults with either mild untreated hypertension or hard-to-control high blood pressure. Participan…

This study tests whether a pharmacist can encourage patients and their doctors to switch to a single pill that combines multiple blood pressure medicines. About 720 adults with high blood pressure will take part. The goal is to see if this simpler approach helps lower blood press…

This study will give 1,500 veterans in North Carolina who struggle to afford healthy food a 'produce prescription' — money to buy fruits and vegetables. The goal is to see if this helps lower their blood pressure and reduces hospital visits. Participants will be split into groups…

This study tests whether an AI-powered tool can help community doctors better manage patients with high blood pressure plus diabetes or high cholesterol. About 6,800 adults will be split into two groups: one gets standard care, the other gets AI-assisted care. The goal is to see …

This study tests whether group care—where patients meet together with healthcare providers for education and check-ups—can help control high blood pressure and diabetes in Nepal. About 1,110 adults from 37 health facilities will take part. The goal is to see if group visits impro…

This study tests whether a special clinic with heart, kidney, diabetes, and liver doctors working together can help people with type 2 diabetes and heart disease better control their blood pressure and cholesterol. About 150 participants will be randomly assigned to either usual …

This study tests whether regular phone counseling can help people with high blood pressure improve their self-care, take their medications correctly, and avoid emergency hospital visits. About 320 adults in Ethiopia will either receive usual care or usual care plus 10-15 minute p…

This study looks at whether giving blood pressure medicine (enalapril) to women after a pregnancy complicated by preeclampsia can help protect their hearts. Researchers want to see if 60 women are willing to try different medicines and how their blood pressure responds over 4 mon…

This study tests an investigational drug called IBI3016 for people with mild to moderate high blood pressure. The drug is given as an injection under the skin every 3 or 6 months, aiming to lower blood pressure more conveniently than daily pills. The trial will compare different …

This study looks at whether using a low sodium salt substitute is safe for adults with high blood pressure who are already on medication. About 607 participants in Bangladesh will replace regular salt with the substitute and be monitored for dangerous potassium levels. The goal i…

This study tests a new way to manage care for older adults (ages 60-74) who have both high blood pressure and type 2 diabetes in rural China. About 960 participants from community health centers will receive either the new integrated care package or standard care. The goal is to …

This study tests whether a mobile app that tracks blood pressure readings and provides feedback can help people with hypertension stick to their treatment and make healthier lifestyle changes. About 40 adults with high blood pressure will use either a Bluetooth-enabled monitor th…

This study tests a technology-based program to help women aged 18-44 with high blood pressure lower their blood pressure before pregnancy. Participants will use remote monitoring and support through their primary care clinic. The goal is to improve heart health and reduce pregnan…

This study tests whether a 12-month digital program combining a mobile app, wearable device, and health coaching can help reverse scarring of the heart muscle (myocardial fibrosis) and improve blood pressure in people with hypertensive heart disease. The trial will enroll 200 phy…

This study tests a new medicine called VCT220 for people with high blood pressure who are also overweight or obese. About 160 adults will receive either the drug or a placebo for 20 weeks to see if it safely lowers blood pressure. The goal is to find a better treatment option for…

This study tests a digital tool called "Smart Family Doctor" that uses artificial intelligence to help patients manage high blood pressure, diabetes, and high cholesterol after heart surgery or stenting. About 951 adults who have had bypass surgery or a stent placed will use the …

This study tests whether shining a special light on blood vessels (photobiomodulation) can improve blood pressure and blood vessel health in people with high blood pressure who are already taking the medication losartan. About 80 adults aged 18 to 65 will receive either the activ…

This study tests whether a special tool in the electronic medical record can help doctors lower blood pressure more effectively in patients whose hypertension is not well controlled. About 168 adults with high blood pressure will have their pressure checked 4 weeks after a clinic…

This early-stage study tests a single injection of IBI3016 in 30 Chinese adults with mild to moderate hypertension who are not currently on medication. The main goal is to check safety and how the drug moves through the body, with a secondary look at blood pressure changes over a…

This study will test a community-based program that combines exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. About 1000 adults will take part to see if the program improves heart and lung function and muscle …

This study tests whether a personalized approach using blood tests and computer programs can help doctors choose the right blood pressure medication for each patient. It involves 400 adults with high blood pressure across four European countries. Participants will use a home bloo…

This study tests whether Songling Xuemaikang capsules can help people with high blood pressure who also have cerebral small vessel disease, a condition that damages tiny blood vessels in the brain and can lead to dementia or movement problems. About 90 adults aged 55-75 will rece…

This study tests a new medicine called TCA108 for people whose high blood pressure is not controlled by current treatments. About 400 adults aged 18 and older will take part. The main goal is to see if TCA108 lowers blood pressure more than a placebo after 10 weeks.

This study gives children with high blood pressure, high cholesterol, or obesity a free debit card to buy fruits and vegetables, plus virtual nutrition classes. Researchers want to see if this program helps kids eat more produce and improves their heart health over 6 to 12 months…

This study tests whether a 30-day treatment called remote ischemic conditioning (using a blood pressure cuff to briefly restrict blood flow) can help lower blood pressure in adults with hypertension who have moved to high-altitude areas (above 2,500 meters). About 184 participant…

This study looks at 200 women who have high blood pressure after giving birth. It compares two drug pairs—nifedipine with enalapril versus nifedipine with labetalol—to see which controls blood pressure better and reduces hospital stays or readmissions within six weeks after deliv…

This study will test a new way to manage heart disease risk using a digital, nurse-led remote monitoring program. About 750 adults with heart disease or related conditions will use home devices to track their cholesterol and blood pressure. The goal is to see if this approach hel…

This study tests if a short digital education program can help people aged 50 and older with high blood pressure improve their self-care and health literacy. Participants will watch videos, read brochures, and listen to podcasts about managing blood pressure and using online heal…

This study tests a new care package for adults aged 65 and older who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support. Researchers will compare this approach to usu…

This study tests whether giving people with high blood pressure personalized advice based on their daily habits helps lower blood pressure more than standard guidance. About 64 adults aged 18-65 with high blood pressure will be split into two groups: one gets routine advice, the …

This study will give 4,450 low-income adults with diabetes or hypertension a monthly food card of either $80 or $120. Researchers want to see if the extra grocery support helps people control their blood sugar and blood pressure, and reduces food insecurity. The goal is to find o…

This study tests a drug called osilodrostat in 63 adults with Cushing's syndrome who also have high blood pressure. The goal is to see if the drug can bring stress hormone levels back to normal and help lower blood pressure. Participants will take the drug or a placebo for 30 wee…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs of people with heart failure. The treatment aims to reduce serious heart events like hospitalizations or death. About 750 adults with stable heart failure will be randomly assigned…

This study tests a program called iTHRIVE for 100 Black or Hispanic adults with high blood pressure living in areas with limited healthy food options. Participants get access to a digital food marketplace, personalized dietitian coaching, and a home blood pressure monitor. The go…

This study tests a new way to help Black and Hispanic women with high blood pressure by bringing health services right into beauty salons. Stylists will be trained to check blood pressure, and participants will get home monitoring, coaching, and pharmacist support. The goal is to…

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This study will check if a newer blood pressure medicine called ARNi works better than standard treatments in adults with high blood pressure living in the United Arab Emirates. About 500 people will take either ARNi or a standard drug for up to 12 weeks. The main goal is to see …

This study tests a community-based exercise program for adults aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, or arthritis. The goal is to see if personalized exercise can improve heart and muscle fitness, mobility, and overall well-b…

This study tests whether providing healthy food and cooking lessons can help adults with high blood pressure and obesity lower their blood pressure and weight. About 150 adults will either receive the food and lessons or continue their usual care for 24 weeks. The goal is to see …

This study tests a procedure called renal denervation, which uses energy to calm overactive kidney nerves, to see if it can safely lower diastolic blood pressure (the bottom number) in people with isolated diastolic hypertension. About 124 adults who have never taken blood pressu…

This study tests whether a probiotic supplement containing Bifidobacterium can reduce blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 10 weeks, and their blood pressure will be measured at the start and end. Th…

This study tests whether choosing blood pressure drugs based on a person's unique heart function (using a simple body scan) works better than the usual guideline-based method. About 240 adults with mild to moderate high blood pressure who have never taken medication will be assig…

This study tests a 12-month program to help adults with high blood pressure in Bangladesh control their condition. The program includes group classes, one-on-one counseling, and tools like blood pressure monitoring stations and reminder calendars. About 480 people from 12 communi…

This study tests whether a supplement called Nigella sativa (Nisatol®) can lower blood pressure in women who have borderline high readings or a nighttime blood pressure pattern that doesn't dip. About 106 women will take either the supplement or a placebo for 12 weeks, followed b…

This small pilot study will test whether a pharmacist-led program to manage high blood pressure and high cholesterol can help protect brain health in 10 people aged 50-75 who carry the APOE ε4 gene, a known risk factor for dementia. Participants will take standard medications (AR…

This study aims to help primary care doctors use data from wearable fitness trackers to counsel patients with high blood pressure. Researchers will create easy-to-read activity reports and guides for doctors. The study will involve 330 patients and their doctors at UC San Diego H…

This study tests a workplace-based program to help adults aged 18-60 who are newly diagnosed with high blood pressure. Over 500 participants will either get the special program or standard workplace health management. The goal is to see if the program improves blood pressure cont…

This study looks at two types of birth control pills (drospirenone and norethindrone) to see which one helps control blood pressure better after a pregnancy complicated by preeclampsia. About 50 women who recently gave birth and want a progestin-only pill will take one of the two…

This study compares a new combination drug (sacubitril/allisartan) with a standard medicine (amlodipine) to see which lowers blood pressure better in overweight or obese adults. About 104 participants aged 18-75 with high blood pressure and a BMI of 24 or higher will be randomly …

This study will test if a 1-3 minute facial scan using artificial intelligence can accurately measure health indicators like heart rate, blood pressure, and blood sugar. 1,000 adults in urban areas will have their scan results compared to standard medical tests. The goal is to de…

This study will test a wrist-worn device that uses light to measure blood pressure without a traditional arm cuff. About 200 adults aged 22 to 59 will wear the device for a week, and its readings will be compared to standard blood pressure measurements. The goal is to see if the …

This study tests whether a powder containing potassium, magnesium, and citrate can help prevent or treat high blood pressure in African Americans. About 45 participants with pre- or early-stage hypertension will take the supplement daily. The goal is to see if it works like the D…

This study tests whether one session of laser acupuncture can lower blood pressure in people with hypertension who are on hemodialysis. Sixty adults aged 18 to 65 will receive the treatment, and their blood pressure will be measured before and after. The goal is to see if this ne…

This study looks at whether a single dose of beetroot juice can improve how the heart and blood vessels respond and recover after light cycling exercise in adults with type 2 diabetes. About 20 people aged 40 to 65 will take part, each trying beetroot juice and a placebo on separ…

This study will test if combining the Mediterranean diet with intermittent fasting can lower blood pressure in people with newly diagnosed hypertension. About 48 adults aged 40-65 with high blood pressure and a healthy weight will follow one of three eating plans: a low-salt Medi…

This study tests whether laser acupuncture can improve arterial stiffness in people with cardiorenal metabolic syndrome (CRMS), a condition linking heart, kidney, and metabolic problems. 35 adults with at least two related conditions (like high blood pressure, diabetes, or chroni…

This study will screen over 7,000 adults aged 40 and older living in affordable housing in New York City for undiagnosed or uncontrolled high blood pressure and glaucoma. Participants will receive free screenings and be referred to follow-up care. The goal is to see if a virtual …

This study looks at how drinking coffee versus hibiscus tea changes blood pressure and heart rate when you sit for a long time. Thirty healthy adults (15 men, 15 women) will try both drinks on different days. Researchers will measure heart health using monitors and questionnaires…

This early-stage study will test two experimental drugs, AD-2321 and AD-2322, in 41 healthy adults aged 19 to 64. The goal is to see how the drugs interact in the body and whether they are safe. Participants will take both drugs in a set order, and researchers will measure drug l…

This study tests whether giving primary care doctors regular feedback on how well they follow treatment guidelines can improve care for patients with high blood pressure and diabetes. About 324 healthcare providers in Nepal, Mozambique, Tanzania, and China will be randomly assign…

This observational study will follow 100,000 elderly Chinese adults to see how conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide health data through clinic visits a…

This study collects basic health information like blood pressure, heart rhythm, and weight from 50 adults aged 18-64. The data will help researchers develop a new device that can monitor blood pressure continuously without needles or cuffs. Participants do not receive any treatme…

This study looks at how mothers and babies respond to stress together after birth, and whether that affects their future heart health. Researchers will measure heart activity in 40 mother-infant pairs during a mild stress task. Some mothers took a mindfulness class during pregnan…

This study looks at how two different exercise programs—moderate steady walking versus short bursts of brisk walking—affect a protein called Sestrin-2 and overall heart health in women with obesity and high blood pressure. About 42 women aged 30-65 will follow an 8-week exercise …

This study looks at how a 12-week cardiac rehabilitation exercise program affects the heart and blood proteins in 42 older adults with high blood pressure who don't currently exercise. Participants will have heart tests, fitness tests, and blood draws before and after the program…

This early-stage study tests whether a new single tablet (ATB-U101) that combines two common drugs for type 2 diabetes and high blood pressure works the same as taking the two drugs separately. About 36 healthy Caucasian adults will receive each treatment once, with blood samples…

This study aims to find better ways to deliver health services to women Veterans, especially those in midlife. Researchers will test two different strategies at 18 VA sites to see which one helps more women get the care they need. The study focuses on improving engagement with pr…

This study looks at how everyday mouthwashes change the natural bacteria in your mouth and whether that affects your heart health. Researchers will test different mouthwashes in 200 adults, some with healthy gums and some with gum disease. The goal is to find out which mouthwashe…

This study looks at how metabolic health (like insulin resistance) relates to artery stiffness and daily blood pressure changes in 800 adults. Participants will have routine tests and monitoring, but no extra treatments. The goal is to find better ways to identify people at highe…

This study tests whether community health workers (CHWs) can help people with two or more chronic conditions like diabetes, high blood pressure, or heart disease better manage their health. CHWs will work one-on-one with participants to create personalized health plans and teach …

This study will examine 100 adults on hemodialysis to see how traditional heart risk factors (like high blood pressure and diabetes) and dialysis-specific factors (like treatment length) relate to the thickness of the carotid artery wall. The goal is to better understand why hear…

This study aims to understand why people with HIV who have controlled their virus sometimes struggle to take their blood pressure medications. Researchers will interview patients and providers, then design and test a nurse-led support program. The goal is to improve heart health …

This study looks at how changes in blood pressure during sleep affect the heart's electrical signals in people with high blood pressure. Researchers will compare those whose blood pressure dips at night to those whose does not. The goal is to better understand heart risks and imp…

This study tests if a contactless camera technology (rPPG) can accurately measure heart rate, blood pressure, and heart disease risk just by scanning your face for 30-60 seconds. Researchers will compare these results with standard medical tests in 300 adults aged 30 and older in…

This study tests whether a personalized computer model, called a digital twin, can predict which patients with high blood pressure will respond to a procedure called renal denervation. Researchers will enroll 60 people, including those with hard-to-treat hypertension, those start…

This study looks at people whose high blood pressure stays high even when taking two or more medications. Researchers will follow 100 participants for about 3 months, collecting information on their health and blood pressure changes. The goal is to figure out which patients might…

This study aims to see how well a new optical blood pressure monitor (the Hilo band) works compared to standard monitors over a full day. About 330 adults with high blood pressure will wear both devices for 24 hours. The goal is to collect data and check how comfortable and easy …

This study looks at how to make it easier for doctors to screen patients who don't get enough physical activity and refer them to local exercise programs. Researchers will work with 35 clinics and track how many patients get referred and whether their health improves. The goal is…

This early-stage study looks at how three experimental drugs (AD-231A, AD-231B, and AD-231C) interact in the body. It involves 55 healthy adults aged 19 to 64. The goal is to measure drug levels and check for safety, not to treat any condition.

This study compares three methods of measuring pulse wave velocity, a key indicator of artery stiffness and heart disease risk. Researchers will enroll 350 adults with high blood pressure to see if a simple arm-cuff device or a mathematical formula works as well as the standard n…

This study looks at whether different types of exercise (like aerobic or isometric) and timing (morning vs. evening) can safely lower blood pressure in people with glaucoma and high blood pressure. Researchers will measure blood pressure over 24 hours after each exercise session.…

This study is testing a new computer-based decision aid designed to help cancer survivors and their heart doctors. The tool, accessed through electronic health records, aims to improve decisions about heart-protective medications and monitoring tests. Researchers want to see if b…