HYPERTENSION

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested whether lowering blood pressure more aggressively than standard care reduces the risk of rupture or growth of unruptured brain aneurysms. 577 Chinese adults with small, unruptured aneurysms and high blood pressure were randomly assigned to keep their blood press…

This study tests whether a 10-week program of balance and multicomponent exercises can improve muscle strength, flexibility, balance, and endurance in adults over 50 who have high blood pressure. Participants will do exercises like sit-to-stand, bicep curls, and walking tests. Th…

This study tested a program where HIV nurses were trained to also manage high blood pressure in people living with HIV. The goal was to see if this approach could lower blood pressure over 12 months. The study involved 830 adults at 30 primary health centers in Lagos, Nigeria.

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…

This study tested whether community health workers (CHWs) could help adults with high blood pressure who also struggle with food insecurity. 75 participants were assigned to either CHW education alone or CHW education plus extra support like grocery transportation and cooking cla…

This study follows about 1,100 Japanese adults with high blood pressure who are prescribed Entresto tablets. Researchers track side effects like low blood pressure, high potassium, and kidney issues over 52 weeks. The goal is to see how safe and effective Entresto is in everyday …

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This study looked at whether giving extra help to clinics (called practice facilitation) improves how well they follow a program to help patients take their blood pressure medicine. The study included 652 Latino adults with uncontrolled high blood pressure who were not taking the…

This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood…

This study tested whether providing home-delivered DASH diet groceries, with help from a dietitian, could lower blood pressure in Black adults living in urban areas with limited access to healthy food. 180 participants with elevated blood pressure but not on medication took part.…

This study looked at whether eating a plant-based diet for 12 weeks could lower blood pressure and change gut bacteria in 102 kidney transplant recipients. Participants either followed a plant-based diet or their usual diet. The goal was to see if this diet could help manage hear…

This study tests whether a personalized mobile health app (iTAB-CV) plus self-monitoring helps people with bipolar disorder or major depression take their blood pressure medication more regularly and lower their blood pressure. About 176 adults aged 21-80 with both conditions and…

This study tested a procedure called renal denervation, which uses radiofrequency energy to calm overactive nerves in the kidneys, to see if it can safely lower blood pressure in people whose hypertension is not controlled by up to three medications. The study involved 337 partic…

This small study tested whether transcranial magnetic stimulation (TMS) can lower blood pressure and ease PTSD symptoms in women aged 18-44 who have both conditions. Four participants received 30 TMS sessions over 6 weeks. Researchers measured changes in 24-hour blood pressure an…

This study tested whether a stricter blood pressure goal (below 135/85) after a pregnancy complicated by high blood pressure is better than the usual care (below 150/100). About 60 new mothers were enrolled and followed for six months. The goal is to see if tighter control is pos…

This study tested a smartphone app called Elfie to help people with high blood pressure lower their numbers. 930 adults with uncontrolled high blood pressure used the app alongside their usual care or just usual care alone. The goal was to see if the app could help bring down sys…

This study looked at whether high-intensity interval training (short bursts of intense exercise) combined with the DASH diet (a heart-healthy eating plan) can reduce artery stiffness in people with high blood pressure. 66 adults aged 35-50 with controlled hypertension took part. …

This study looked at whether a progressive resistance training program could help older adults with sarcopenia (age-related muscle loss) control their high blood pressure. 77 sedentary adults aged 60 and older participated. The goal was to see if building muscle strength could be…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study looked at whether bread made from watermelon rind could improve heart health in 120 adults with mild to moderate heart issues. Participants were between 35 and 65 years old and had conditions like high blood pressure, unhealthy cholesterol levels, or pre-diabetes. The …

This study looked at whether practicing tai chi—a slow, gentle exercise with deep breathing—could lower blood pressure and improve thinking skills in older adults with high blood pressure. Nineteen participants tried a single session and then a 12-week online tai chi program. Res…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This completed Phase 3 trial tested whether a single pill combining ezetimibe, rosuvastatin, and amlodipine can safely lower both cholesterol and blood pressure in 163 Korean adults with hypertension and high cholesterol. Participants took the combination pill or a control for 8 …

This Phase 3 trial tested whether adding a second drug (DWC202314) to an existing one (DWC202404) helps people whose high blood pressure isn't controlled by the first drug alone. 192 adults with essential hypertension took part. The study is now complete, and results will show if…

This study tested a comprehensive intelligent system (CHESS) to help manage high blood pressure in primary care clinics. Over 1,600 people took part, and the system aimed to lower blood pressure over 12 months. The approach used technology to support doctors and patients in bette…

This study tested a remote telehome monitoring program for 100 people with high blood pressure who receive virtual care. Participants used a special blood pressure cuff and a monitoring platform to share readings with their doctors. The goal was to see if this approach improves b…

This Phase 3 trial tested a new drug called lorundrostat in over 1,000 adults whose high blood pressure remained uncontrolled despite taking 2 to 5 other medications. Participants received either lorundrostat or a placebo daily for 12 weeks. The main goal was to see if the drug l…

This study tested an experimental drug called SLx-2101 in 38 adults with moderate to severe high blood pressure. Participants took either 5 mg or 10 mg of the drug daily for 14 days to see how it affected their blood pressure and heart rate. The goal was to check if the drug is s…

This study tested whether taking two drugs (DWC202206 and DWC202207) together is safe and effective for people with both high blood pressure and high cholesterol. 214 adults aged 19 to 80 took part. The goal was to see if the combination lowered blood pressure and LDL ("bad") cho…

This study tested a new drug called SLx-2101 in 26 adults with moderate to severe high blood pressure. Participants took the pill once daily for up to 12 days to see how well it lowers blood pressure and if it is safe. The goal is to find the right dose for future studies.

This completed Phase 4 trial tested a single pill containing three medicines (telmisartan, amlodipine, and rosuvastatin) in 252 Korean adults with both high blood pressure and high cholesterol. Participants took either the triple pill or a two-drug pill for 8 weeks. The study mea…

This study tested whether a structured phone call teaching patients about home blood pressure monitoring would increase the number of people who bring their blood pressure logs to doctor visits. 170 adults with uncontrolled high blood pressure took part. The goal was to see if th…

High blood pressure affects nearly half of Americans, but only half have it under control. This study tested whether a digital program—including personalized health coaching and a connected blood pressure cuff used via smartphone or website—could improve blood pressure control co…

This study looked at whether giving people home blood pressure monitors and teaching them to use online portals and texting with their doctors can help them better control their high blood pressure. Over 500 adults with uncontrolled hypertension took part for 12 months. The goal …

This study tested a 4-month program where community health workers provided nutrition education and support to 60 primary care patients with high blood pressure and food insecurity. The goal was to see if adding nutrition help to existing blood pressure coaching was feasible and …

This completed study tested whether combining valsartan and hydrochlorothiazide works better than valsartan alone for people with hypertensive heart disease. 118 adults aged 18-70 took part over 8 weeks. Researchers measured blood pressure, heart changes on ECG, and symptoms to s…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This study tested whether a peanut-based nutritional supplement could improve health in adults aged 60 and older living in peri-urban Ghana. Over 12 weeks, 81 participants either took the supplement daily or served as a control group. Researchers measured weight, blood pressure, …

This study looked at whether visits from parish nurses (faith community nurses) can help people with high blood pressure lower their numbers. Researchers recruited 100 adults from church health fairs in Los Angeles and randomly assigned them to either nurse visits or regular doct…

This study tested whether support from a significant other—like a spouse or family member—can help people with hypertension follow their medication and lifestyle recommendations. 133 participants and their significant others took part. The significant others used strategies like …

This study tested a 12-week food as medicine program for 159 adults with high blood pressure and food insecurity. Participants received either a $100 monthly grocery card or 5 medically tailored frozen meals per week. Researchers measured changes in blood pressure and diet to see…

This study tested a new robotic surgery technique that protects the vagus nerve during spleen removal and blood vessel disconnection in 60 cirrhosis patients with portal hypertension. The goal was to see if it reduces common side effects like diarrhea and delayed stomach emptying…

This study tested a monthly injection called tonlamarsen in 206 adults whose blood pressure stays high even after taking two or more daily medications. The goal was to see if the shot can safely lower blood pressure and reduce a protein linked to hypertension. Results will show w…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease improve their blood pressure. 320 adults with moderate to severe kidney disease and uncontrolled high blood pressure took part. The goal was to see if the coachin…

This study tested whether eating dark chocolate (72% cocoa) daily for two weeks could lower blood pressure and a heart risk marker in men with mild hypertension. Fifty-three Thai men ate either dark or white chocolate each day, then switched after a week off. The goal was to see …

This pilot study tested whether using central blood pressure (measured near the heart) instead of the usual arm cuff leads to better outcomes in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central BP target or a standard arm BP…

This study tested a mobile app called Collabree to see if it helps people over 50 with high blood pressure take their medication more regularly. 144 participants used the app for 90 days and were followed for another 90 days. The app sent reminders and used behavioral tricks to e…

This study tested whether a mobile app called Collabree could help people with high blood pressure take their medication more regularly. 181 adults in Switzerland who took at least 4 blood pressure pills daily participated. They were randomly assigned to use the app or receive st…

This study looked at whether giving medically tailored meals, grocery vouchers, or both to low-resource families can improve health. It included 56 adults and children living with food insecurity and either type 2 diabetes or high blood pressure. Researchers measured changes in w…

This completed study tested whether community health workers (CHWs) and home blood pressure monitoring could help adults in rural South Africa control their high blood pressure. Over 770 participants were assigned to different levels of CHW support. The goal was to see if this ap…

This study tested two different blood pressure tracking systems on smartphones to see if they help older adults take their medication regularly. About 200 people aged 65 and older with high blood pressure used one of the systems for six months. The goal was to see if one system i…

This completed pilot study tested whether a very low-carbohydrate diet could lower blood pressure in 64 lower-income African American adults with high blood pressure. Participants followed either a low-carb or standard low-fat diet for 10 months. Researchers measured changes in b…

This study tested a new drug called zilebesiran in 375 adults with high blood pressure that wasn't controlled by their current medications. Participants received either zilebesiran or a placebo as an add-on to their usual pills. The goal was to see if zilebesiran could lower bloo…

This study tested a mobile app called USeeBP in 31 African American adults with poorly controlled high blood pressure. Participants used the app alongside their usual remote monitoring program to track blood pressure readings at home. The goal was to see if the app could help imp…

This study tested a low-cost tool to help health workers in Mozambique better diagnose and manage high blood pressure in people with HIV. The tool uses cycles of evaluation and improvement to streamline care. Researchers worked with 18 health facilities to see if this approach co…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This completed trial tested a new, noninvasive device that uses focused ultrasound to destroy a small amount of fat around the kidney. The goal was to lower blood pressure in people with mild hypertension who were not taking medication. 79 participants were randomly assigned to r…

This study tested a personalized education program called 'Mi Propio Camino' (My Own Way) to help Hispanic adults with uncontrolled high blood pressure stick to their medication. Over 500 participants received either the tailored program or standard care. The goal was to see if p…

This study looked at whether adding paced or diaphragmatic breathing to mat Pilates can improve heart and lung fitness, reduce shortness of breath, lower stress and anxiety, and boost quality of life in people with stage II high blood pressure. Sixty-three adults aged 40 to 50 to…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This completed trial tested whether giving a low-sodium salt substitute to 309 households in rural Bangladesh could lower blood pressure. Community health workers delivered the salt and provided education on high blood pressure and salt intake. The study measured changes in blood…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study looked at whether a combination drug (sacubitril/valsartan) can stop atrial fibrillation from returning after a heart procedure called catheter ablation. The study included 320 older adults (ages 55-80) with high blood pressure and atrial fibrillation. Participants too…

This study looked at whether community health workers can help people with HIV and high blood pressure in northern Tanzania manage their condition. About 100 participants received counseling, doctor visits, and phone calls over 6 months. The goal was to see if this approach helps…

This study tested two common blood pressure medications—amlodipine and metoprolol—in 50 adults with heart failure with preserved ejection fraction (HFpEF) and hypertension. Participants took each drug for a period, and researchers measured their home blood pressure readings. The …

This study tested a culturally-tailored program called HARMONY for African American women at risk for heart disease, stroke, and diabetes. Over 8 sessions plus monthly boosters, participants learned stress management, exercise, and healthy eating. The goal was to see if the progr…

This study tested an experimental drug called lorundrostat in 285 adults whose high blood pressure remained uncontrolled despite taking 2 to 5 other medications. The drug works by blocking a hormone that raises blood pressure. Researchers measured how much it lowered blood pressu…

This study tested whether 10 weeks of stationary bike exercise could improve brain health and lower blood pressure in adults aged 35-65 with hypertension and a BMI of 25 or higher. Participants were assigned to moderate or high-intensity exercise sessions. The main goal was to se…

This completed pilot study tested whether a special diet made from tartary buckwheat could help lower blood pressure in 130 adults with mild hypertension. Participants added the buckwheat formulation to their regular meals and were compared to those receiving standard care. The s…

This study looked at two strategies to help Ugandans living with HIV and high blood pressure get better care. One strategy provided free blood pressure medicines and equipment, while the other added extra staff and support. Over 87,000 patients took part. The goal was to see whic…

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This phase 2 trial tested a drug called lorundrostat in 48 adults with moderate-to-severe obstructive sleep apnea and high blood pressure. Participants took either the drug or a placebo for four weeks to see if it improved breathing during sleep and lowered blood pressure. The st…

This study tested whether adding amlodipine to the blood pressure drug LCZ696 works better than LCZ696 alone. About 718 adults with mild-to-moderate high blood pressure that wasn't well controlled by LCZ696 took part. The goal was to see if the combination lowers blood pressure m…

This study tested whether training female community health volunteers (FCHVs) to lead group meetings and support can help people with high blood pressure in rural Nepal. 520 adults aged 30-75 with high blood pressure took part across 12 health facilities. The volunteers were trai…

This completed study tested two different blood pressure treatments in 59 adults under 60 who were newly diagnosed with hypertension. One group took bisoprolol alone, while the other took a combination pill containing valsartan and amlodipine. The goal was to see which approach b…

This study looked at whether it is safe to reduce blood pressure medication in frail older adults living in long-term care. Researchers enrolled 522 residents with low blood pressure and tested a gradual medication reduction plan. The goal was to see if this approach could lower …

This study tested a new drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose blood pressure was still high despite treatment. Participants took either a low or high dose of the drug or a placebo daily for 84 days. The main goal was to see if the…

This study looked at whether adding community health workers to regular care helps people with type 2 diabetes and high blood pressure in rural Mexico take their medicines as prescribed. 168 adults from local clinics took part. Researchers measured changes in blood sugar and bloo…

This study looked at 19 people with sleep apnea and mild high blood pressure. It compared a drug called bosentan to the standard CPAP machine to see if the drug could lower blood pressure just as well. The goal was to find a simpler way to manage heart risks in sleep apnea patien…

This study tested a new medicine called ALN-AGT01 in 394 adults with mild-to-moderate high blood pressure. The goal was to see if it could safely lower blood pressure over three months. Participants received either the drug or a placebo, and blood pressure was measured continuous…

This study tested whether doing wall squat exercises can help lower blood pressure in Chinese adults with hypertension. 50 participants who were not very active were randomly assigned to either a wall squat group or a stretching group for 24 weeks. The main goal was to see how ea…

This study tested whether stroke patients over 60 with high blood pressure benefit from extra nurse-led education and follow-up, compared to standard care. About 290 patients took part, each bringing a family member or friend to help. The main goal was to see if this approach low…

This study tested whether a special exercise program could help people with high blood pressure, especially those whose blood pressure doesn't drop enough during sleep (a condition linked to higher heart risks). 198 Chinese adults who did little exercise were split into two group…

This study tested whether having patients with uncontrolled high blood pressure monitor their own blood pressure at home could help lower it. 70 adults with hypertension were split into two groups: one group used a home monitor for 5 days each month, while the other group did not…

This study tested whether providing medically tailored meals, with or without weekly group support sessions, helps Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome improve their health. 75 participants received either meals alone, meals plus …

This study tested whether a grape seed extract supplement called Enovita can lower blood pressure in adults with elevated blood pressure or stage 1 hypertension. Eighty participants took either the supplement or a placebo twice daily for 8 weeks. Researchers measured changes in b…

This study tested whether a device that gently stimulates a nerve in the ear (vagus nerve) can help control blood pressure during heart stent placement. 480 adults with coronary artery disease and high blood pressure were randomly assigned to receive either real or sham stimulati…

This study tested whether doing simple isometric exercises (pulling a band at 30% effort for 2 minutes) 1, 2, or 3 times a week can lower blood pressure in people with borderline or high blood pressure. 30 adults who were not on medication participated. The goal was to find the s…

This study tested whether training healthcare teams to share tasks can help people living with HIV better control their high blood pressure. It involved 960 adults across 30 clinics. The approach included measuring blood pressure, providing lifestyle advice, and starting medicati…

This study tested whether a smartphone app called LowSalt4Life can help people with high blood pressure reduce their sodium intake and improve blood pressure. The app provides tips and reminders to eat less salt. 410 participants with high blood pressure used the app, and researc…

This study tested whether using mobile monitoring devices along with nurse support can help people better manage type 2 diabetes and high blood pressure. 220 adults with poor diabetes control took part. The program focused on teaching self-management skills like tracking blood su…

This pilot study tested a program called THRIVE in 80 Black adults with high blood pressure. Participants received personalized dietitian coaching, culturally tailored messages, free produce from a mobile market, and help connecting to social services. The goal was to see if this…

This study tested a new medicine called zilebesiran in 663 adults whose high blood pressure was not well controlled by their current pills. Participants received either zilebesiran or a placebo added to their usual treatment. The goal was to see if the new drug could lower blood …

This study tested whether a nurse-led program could help veterans with HIV lower their blood pressure and reduce their risk of heart disease. 305 veterans with HIV and high blood pressure took part. The program used video visits and care coordination to help manage blood pressure…

This study tested a new way to deliver HIV and chronic disease care by bringing services into community microfinance groups in rural Kenya. About 1,200 adults with HIV took part, with some receiving care in the community and others at usual clinics. The goal was to see if combini…

This study tested whether text messages could help homeless adults with uncontrolled high blood pressure lower their numbers and stay on track with medications and clinic visits. About 120 participants received either standard healthy-living texts or extra texts focused on blood …

This study tested a 3-month lifestyle program, delivered by Pasifika community health workers, to help Native Hawaiians and Pacific Islanders with conditions like diabetes, high blood pressure, and obesity. The program included healthy eating and activity tips plus support for so…

This study tested whether minocycline, an inexpensive antibiotic, can lower blood pressure in people whose hypertension doesn't respond to standard treatments. 34 adults with resistant high blood pressure took low or high doses of minocycline. The goal was to see if it could calm…

This study tested a program called ENACTS to help Native Hawaiian and Pacific Islander adults with high blood pressure or type 2 diabetes lower their blood pressure. The program included support for healthier eating, more physical activity, and working with grocery stores to labe…

This completed trial tested whether a cellular-enabled blood pressure cuff, used at home, could help cancer patients on the drug bevacizumab better track and manage high blood pressure. Twenty participants were randomly assigned to use the smart cuff or a standard cuff. The goal …

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

This study tested a program called Walk Together, which helps African American adults with high blood pressure and their family members work as a team to manage the condition. The program included training on using a blood pressure cuff, setting health goals, and improving commun…

This completed study tested a 12-week program that gave African American and Latinx patients with high blood pressure a home blood pressure cuff and regular calls from a community health worker, nurse, pharmacist, and social worker. The goal was to see if this support could help …

This pilot study tested a telehealth program combining mindfulness, relaxation, and dietary advice (MIM-DASH) in 28 African American women over 40 who care for a family member with Alzheimer's and have high blood pressure. The goal was to see if the program could reduce stress an…

This study tested whether adding a muscle relaxation technique to aerobic exercise improves heart and lung health more than exercise alone in people with stage 1 hypertension. Forty adults aged 18-45 participated. The relaxation group did 15 minutes of progressive muscle relaxati…

This trial tested a program where community health workers used a tablet app to screen pregnant women in rural India for anemia, high blood pressure, and diabetes. Over 3,400 women took part. The goal was to see if this screening and referral system could lower anemia rates and i…

This study looked at how safe and effective the blood pressure drug azilsartan is for children aged 6 to 16 with high blood pressure. Only 5 children took part, and doctors monitored them for side effects and blood pressure changes for up to 12 months. The goal was to gather real…

This study tested whether a specially trained nurse (Advanced Practice Nurse) could help people with high blood pressure get it under control. Over 480 adults with essential hypertension received either usual care or an extra nurse visit that included health education, medication…

This study tests whether a new device called VicorderCS can measure blood pressure accurately. The device uses a standard arm cuff and is designed to be faster and more portable than older models. Researchers will compare its readings to those taken with a traditional stethoscope…

This study checked how well the Withings BPM Pro 2, an automatic blood pressure cuff, measures blood pressure compared to a standard manual device. 89 adults had their blood pressure taken with both devices. The goal was to see if the Withings cuff is accurate enough for home use…

This study tested whether an automatic blood pressure machine (WatchBP Office) gives more accurate readings than the traditional manual method in 149 Chinese adults with high blood pressure. The automatic machine takes several readings and averages them, which may reduce the 'whi…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This pilot study tested whether ready-to-eat meals based on the DASH diet could help lower blood pressure and reduce heart disease risk. Twenty adults ate the prepackaged meals daily for 4 weeks while researchers monitored their blood pressure and weight. The goal was to see if a…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study trained community health workers to screen Black men for early signs of high blood pressure. Participants received lifestyle advice and were connected to doctors and social services. The goal was to prevent hypertension from getting worse.

This study tested whether keeping blood pressure in a lower, healthier range could prevent a painful bone condition called osteonecrosis in children and young adults being treated for leukemia. Fifty-one participants were randomly assigned to either intensive or standard blood pr…

This large, completed phase 3 trial tested whether a single pill containing three low-dose blood pressure medicines (telmisartan, amlodipine, and indapamide) could prevent another stroke in 1,671 people who had previously had a bleeding stroke (intracerebral haemorrhage) and had …

This study tested whether a slow, rhythmic breathing technique called resonant breathing can help lower blood pressure, heart rate, and stress in adults with mild hypertension. Fifty adults aged 30-65 with stage I hypertension and no serious health issues practiced this breathing…

This study compared two types of nerve blocks—erector spinae plane block and paravertebral block—for pain control after open kidney surgery. 72 adults were randomly assigned to one of the two blocks. Researchers measured pain scores, opioid use, and vital signs during the first 2…

This study looked at whether giving a sedative called dexmedetomidine before placing a breathing tube can prevent sudden rises in blood pressure and heart rate in patients with controlled high blood pressure. 70 adults having planned surgery under general anesthesia took part. Th…

This completed pilot study looked at whether yoga can help African American adults with high blood pressure manage stress and remember to take their medication. Eight participants attended weekly yoga sessions for 8 weeks. Researchers measured blood pressure, stress levels, and t…

This study looked at whether giving magnesium sulfate and fentanyl before intubation (placing a breathing tube) can prevent sudden spikes in blood pressure and heart rate in patients aged 50 and older. 76 participants were split into three groups: magnesium alone, fentanyl alone,…

This study tested whether a digital program could help adults with high blood pressure who have limited access to healthy food. 67 participants received a grocery delivery membership, personalized meal lists, dietary tracking, text message feedback, and health coaching over 4 mon…

This study tested two drugs, lignocaine and dexmedetomidine, to see which better prevents sudden rises in heart rate and blood pressure when a breathing tube is inserted during anesthesia. 62 adults having elective surgery took part. The goal is to find a safer way to protect pat…

This study looked at 40 men over 45 with high blood pressure and heart disease to compare two types of exercise: interval training and continuous training, both including aerobic and resistance exercises. The goal was to see which better improves heart function and blood pressure…

This study tested two ways of doing exercise at home for people with high blood pressure. One group exercised with a live physiotherapist on video calls, while the other followed pre-recorded videos. Over 8 weeks, researchers measured changes in exercise capacity, blood pressure,…

This study tested whether taking peppermint oil by mouth can improve heart health in people with mild to moderate high blood pressure. 40 adults aged 18-65 with systolic blood pressure between 120-139 mmHg and not on blood pressure medication participated. Researchers measured ch…

This study looked at whether exercising in the morning or early evening makes a difference in blood pressure and blood vessel health for postmenopausal women with high blood pressure. Sixty-eight women did walking and handgrip exercises at different times of day. The goal was to …

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This study tested a program that sends text reminders and uses social support and game-like features to encourage people with chronic kidney disease, diabetes, and high blood pressure to check their blood pressure regularly. 70 adults from a University of Pennsylvania clinic part…

This study looked at 558 adults with mild to moderate sleep apnea who also don't get enough sleep. Researchers compared two programs: one focused on improving use of a PAP machine, and another on sleep education. The goal was to see which works better for reducing daytime sleepin…

This early study tested a new way to deliver a substance that helps blood vessels relax, potentially lowering blood pressure. Fourteen healthy adults took a mixture placed under the tongue. Researchers measured changes in blood pressure and related chemicals in the blood to see i…

This study looked at whether playing recreational beach tennis twice a week for 12 weeks could lower blood pressure and improve fitness in people with hypertension. 42 adults with high blood pressure who were not already exercising took part. The researchers measured their blood …

This study tested whether listening to educational podcasts can help people with high blood pressure follow their treatment plan and manage their own health better. 94 adults with hypertension were randomly assigned to either listen to podcasts or receive routine care. The goal w…

This study tested whether a short, calming virtual reality (VR) experience could reduce blood pressure and anxiety in adults with suspected white coat hypertension—where blood pressure spikes due to clinic stress. Seventy-nine participants used a VR headset for 5 minutes during a…

This completed pilot study tested a 12-week home-based exercise program for cancer survivors who also have diabetes or hypertension. The program used a wearable device and smartphone app to track activity and provide feedback, with options like walking, yoga, or strength exercise…

This pilot study tested whether giving patients weekly cash payments encourages them to check their blood pressure at home more often. Fifty adults with uncontrolled high blood pressure from Louisiana health centers were given home monitors and randomly assigned to receive either…

This study looks at whether the neck-to-waist ratio can help identify patients with high blood pressure and a specific type of heart attack. Researchers measured body shapes of 238 adults arriving at the emergency room with chest pain. The goal is to see if simple body measuremen…

This study looks at how high blood pressure and its medications affect blood flow and blood pressure when patients lie face-down for spinal surgery. Researchers will monitor 70 adults to see if those with hypertension have different changes in heart function compared to healthy p…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study looked at how moderate aerobic exercise affects blood pressure in people with hypertension living in cold regions. Researchers measured changes in blood pressure, heart rate variability, and stress-related markers after 16 weeks of exercise. The goal was to understand …

This completed study looked at 670 African American adults to understand how genetics, lifestyle, and social factors like stress and neighborhood affect heart disease risk. Researchers collected blood samples, medical tests, and surveys to find links between ancestry-related DNA …

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looks at whether special pacing signals from a pacemaker can improve heart function and lower blood pressure in people who need a pacemaker and also have high blood pressure. Researchers will measure heart pressure and volume using a thin catheter inside the heart. The…

This study looks at whether the position of a pacemaker lead in the right ventricle can improve how well the BackBeat Moderato system controls blood pressure. Five people with hypertension who already have a pacemaker will have their heart pressures and volumes measured with the …

This study looked at how sleep, body clocks, and daily habits affect nighttime blood pressure in Black adults. Researchers monitored 30 participants in a lab for a week to measure blood pressure changes. The goal is to find better ways to treat high blood pressure by targeting sl…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study tested whether helping people sleep longer (through sleep hygiene and extending sleep time) could lower their blood pressure during sleep. 66 adults who slept less than 7 hours per night took part. Researchers measured blood pressure during sleep and awake periods at t…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This early-stage trial tested two experimental oral drugs, HL1113-R1 and HL1113-R2, in 35 healthy adults to see if they are safe and how the body processes them. The drugs are being developed for high blood pressure and type 2 diabetes. Participants took the drugs alone and toget…

This early-stage study tested a new drug (HL1113) in 37 healthy adults to see how the body processes it. The drug combines two existing medicines for high blood pressure and type 2 diabetes. Participants took the drug in different ways to compare safety and drug levels. The resul…

This study looked at 125 African American adults with high blood pressure to understand what helps them stick to their treatment and stay resilient. Researchers measured blood pressure, quality of life, and self-management behaviors over 6 months. The goal is to find new ways to …

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study looked at how two different ways of doing resistance exercise (short vs long sets) affect the heart and blood vessels of postmenopausal women, both with and without high blood pressure. Sixty women participated, and researchers measured things like blood pressure, hear…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study examined how Ramadan fasting changes blood pressure in 150 healthy adults and people with stable hypertension. Participants had their blood pressure monitored around the clock during the fasting period. The goal was to see if fasting affects blood pressure variability,…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This study tested whether taking a synbiotic (a mix of probiotics and prebiotics) for 30 days could improve gut bacteria, weight, and heart health in 47 healthy adults aged 18-60. Participants were randomly assigned to receive the supplement or a placebo. The goal was to gather i…

This study reviewed medical records of 901 infants who had surgery for aortic coarctation (a narrowed aorta) before age one. Researchers wanted to find out how many later developed high blood pressure or re-narrowing of the aorta. The goal is to better understand these risks and …

This completed study in Syria examined whether certain genetic variations in the apelin system are linked to coronary artery disease and high blood pressure. Researchers analyzed blood samples from 223 participants, including healthy controls and patients with heart disease and h…

This study tested whether a series of five one-minute educational videos, shared through community WeChat groups, could improve what people know and do about secondary hypertension. Over 1,000 adults from eight communities in suburban Beijing took part. Researchers measured chang…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study looked at whether giving African American adults with high blood pressure early access to genetic testing for a kidney disease risk gene (APOL1) could improve their care. Over 6,700 participants were randomly assigned to get their genetic results right away or later. T…

This small pilot study looked at whether aprepitant, a drug used for nausea, can reduce aldosterone (a hormone that raises blood pressure) in people with type 2 diabetes and low-renin hypertension. Five participants took either aprepitant or a placebo for two weeks, then switched…

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This study looked at whether having new mothers check their blood pressure at home for three weeks after leaving the hospital is a practical way to catch high blood pressure early. Over 1,600 women participated, and researchers tracked how many readings they took, whether they fo…

This study checked if a Samsung smartwatch can accurately measure blood pressure over a long period. Researchers compared the smartwatch's readings to a standard medical device in 42 healthy adults. The goal was to see if smartwatches could be a reliable tool for tracking blood p…

This small, early study tested whether drinking beetroot juice (which is rich in natural nitrates) could improve artery stiffness and brain blood vessel function in adults aged 50 to 79. Sixteen participants were randomly given either nitrate-rich or nitrate-depleted beetroot jui…

This study looked at 10 men to understand why androgen deprivation therapy (ADT) for prostate cancer can lead to high blood pressure. Researchers checked if problems with the nervous system or kidneys were to blame. The goal is to find ways to prevent heart disease in prostate ca…

This small pilot study looked at whether a short exercise program could help older adults (ages 55-75) with high blood pressure improve their thinking skills. Researchers measured changes in fitness, eye blood vessels, and blood markers. The goal was to see if exercise might reve…

This study looked at whether a planned awareness program could improve knowledge about preventing hypertensive crises in people already diagnosed with high blood pressure. Thirty-five patients took part, and their knowledge was measured before and two weeks after the program. The…

This study looked at 149 adults with high blood pressure and insomnia to understand how poor sleep might raise the risk of heart disease. Researchers used a sleep therapy called CBT-I to see if improving sleep could lower nighttime blood pressure. The goal was to learn more about…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This completed study looked at how physical activity, life satisfaction, and medication adherence are related in 82 older Turkish adults (65+) with chronic conditions like high blood pressure or diabetes. Researchers used surveys to measure each factor. The goal was to understand…

This completed study from Tunisia looked at 120 people with high blood pressure who were scheduled for minor abdominal surgery. Researchers checked their blood pressure on the day of surgery and noted how often it was high enough to cancel the procedure. They also measured anxiet…

This study looked at how salt in the diet affects blood pressure in 130 adults with chronic kidney disease. Researchers measured a protein called uromodulin in urine to see if it predicts salt sensitivity. The goal was to understand why some patients' blood pressure rises more wi…

This study looked at how Chinese Americans talk about advance care planning—decisions about end-of-life care—with their families. Researchers interviewed religious leaders, patients with chronic diseases, and family caregivers in Chicago to understand their needs and readiness. T…

This study created a registry of 200 overweight children and young adults with high blood pressure to track their heart health over time. Researchers collected medical information from clinic visits to understand how weight affects the heart. No treatments or interventions were g…

This completed study tested a web-based tool called PedsBP CDS that helps doctors identify and manage high blood pressure in children aged 6-17. The tool was used in 45 primary care clinics across three rural states, involving over 41,000 youth. The goal was to see if the tool im…

This study looked at the gut bacteria of 192 people, including those with untreated high blood pressure, treated high blood pressure, and healthy individuals. Researchers analyzed stool samples to find differences in bacteria types and functions. The goal was to understand how gu…

This study tested whether a youth-led digital education program could help adults with high blood pressure lower their numbers. Adults and teens (ages 14-24) worked together in pairs: teens learned about hypertension from online modules and then taught the adults. The study enrol…

This completed study in 49 veterans with early chronic kidney disease (CKD) tested whether diuretics (water pills) can reduce fluid overload and improve heart health. Researchers measured changes in heart stress markers and symptoms like fatigue after 4 weeks of treatment. The go…

This study looked at 139 adults with high blood pressure to find out why some blood pressure medicines work better for certain people. Researchers checked things like diet, body size, and genetics to see how they affect drug response. The goal was to learn more about high blood p…

This study tested whether an AI teaching tool (GPT) helps medical students learn about high blood pressure better than traditional methods. Fifty-two students took part, either using the AI system or standard materials. The goal was to see if the AI improved test scores and how s…

This study aimed to understand the barriers to treating high blood pressure in people living with HIV in South Africa and to design a better care program. Researchers gathered input from healthcare workers and patients at nine clinics to create a practical intervention. The goal …

This study looked at data from over 1,600 African Americans aged 30-55 with severe high blood pressure. Researchers examined genetic, behavioral, and social factors to find out why this group is more affected by hypertension. No new participants were enrolled; the goal was to lea…

This study looked at 110 people with high blood pressure who were having surgery with spinal anesthesia. Researchers used ultrasound to measure blood vessel features before the anesthesia to see if they could predict a dangerous drop in blood pressure. The goal is to help doctors…

This pilot study tested a smartphone-based tool called SMART-HABITS in 47 adults with chronic kidney disease and high blood pressure. The tool provided reminders, feedback, and educational resources through text messages or an app, and linked to wearable devices like Fitbits and …

This study looked at health records from over 800,000 older adults to see if certain blood pressure drugs (propranolol or carvedilol) are linked to a lower risk of dementia compared to other similar drugs (atenolol, bisoprolol, or sotalol). The goal was to find if repurposing exi…

This study analyzed health records from over 163,000 older adults with high blood pressure to see if one type of medication (dihydropyridine calcium channel blockers) was linked to a lower risk of developing dementia compared to another (hydrochlorothiazide). The goal was to find…

This completed study looked at medical records from over 155,000 older adults with high blood pressure. Researchers compared two types of diuretics (amiloride and triamterene) to see if one was linked to a lower risk of developing dementia or Alzheimer's disease. The goal was to …

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This study looked at whether tiny cell parts called mitochondria contribute to higher blood pressure and worse blood vessel health in Black adults. Researchers gave 31 middle-aged and older adults a supplement called MitoQ or a placebo for 8 weeks. The goal was to understand the …

This study looked at gut tissue from 35 people with and without high blood pressure to see if there are differences in how gut cells work. Researchers used samples taken during routine colonoscopies to compare gene activity and cell growth. The goal was to better understand how g…

This pilot study tested a quality improvement process called CUSP to help community mental health staff deliver better care for cardiovascular risk factors like high blood pressure, diabetes, and high cholesterol. The study included 85 staff and patients from psychiatric rehabili…

This small study looked at whether drinking a KETO5 XOGenius beverage every day could improve markers of heart health, thinking skills, and body measurements like weight and waist size. Six healthy adults aged 18 to 50 took part. The goal was to gather early information, not to t…

This study tested whether a training program called CONSULT-BP, which teaches healthcare trainees to recognize bias and communicate better, could improve blood pressure in their patients with hypertension. The study included 118 patients, mostly from minority or low-income backgr…

This study looked at how high-intensity (80% max) versus low-intensity (40% max) strength training affects heart rate and blood pressure in people with hypertension. Twenty-eight participants completed supervised sessions of squats, rows, deadlifts, and bench presses. The goal wa…

This completed study looked at how blood pressure changes over 12 weeks in 1,729 adults with hypertension who used the Aktiia 24/7 optical blood pressure monitor. The device is a wristband that measures blood pressure continuously without a cuff. Researchers also asked participan…

This study looked at 72 adults with high blood pressure to see if the concentration of their urine is linked to stiffness in their arteries. Researchers measured urine concentration, blood pressure, and arterial stiffness during a one-day hospital visit. The goal was to better un…

This study looked for genetic differences that might make some people more likely to develop high blood pressure. Researchers analyzed data from nearly 9,000 African American and Mexican American participants. The goal was to find specific gene variations linked to hypertension, …

This early-stage trial tested whether a single pill containing two medicines (pitavastatin for cholesterol and valsartan for blood pressure) works the same in the body as taking the two pills separately. Fifty-two healthy men took both versions in random order. The study only mea…

This completed study investigated why patients with Cytochrome P450 Oxidoreductase (POR) deficiency, a rare genetic condition, often develop high blood pressure and blood vessel damage. Researchers compared 51 participants (patients and healthy controls) using 24-hour blood press…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study tested a clinical decision support tool that helps doctors identify social needs—like food, housing, or transportation—in African American patients with chronic diseases such as diabetes or heart failure. The tool uses a social risk score to flag patients who may need …

This study tested how well different blood pressure drugs work in White, Black, and South Asian people. About 940 adults with high blood pressure took one or two common medicines. The goal was to see if response differs by ethnicity, which could help doctors personalize treatment…

This study tested a new laser-based device (Laser Doppler Vibrometer) to measure how stiff the arteries are in 100 people with high blood pressure. The goal was to see if this painless, non-invasive method works as well as the standard techniques (applanation tonometry and echotr…