Exercise may unlock heart health secrets for seniors with hypertension

NCT ID NCT06247774

Not yet recruiting Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a 12-week cardiac rehabilitation exercise program affects the heart and blood proteins in 42 older adults with high blood pressure who don't exercise regularly. Participants will be randomly assigned to either the exercise program or a control group that receives regular phone calls. Researchers will measure heart structure, physical function, and protein levels to find clues about how exercise might reduce heart failure risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cardiac rehabilitation exercise program
What this could lead to: If successful, this could identify specific proteins that explain how exercise reduces heart failure risk, potentially leading to targeted therapies or personalized exercise plans.
What could go wrong: This is a small, early-stage study with only 42 participants, so results may not apply to everyone. It focuses on measuring proteins, not directly testing a treatment, so it won't prove that exercise prevents heart failure.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC REHABILITATION EXERCISE TRAINING HYPERTENSION PROTEOMICS

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