Could a schizophrenia drug tame stubborn high blood pressure?

NCT ID NCT07090161

Recruiting now Disease control Sponsor: Vanda Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether iloperidone, a drug already used for schizophrenia, can help lower blood pressure in people whose hypertension is not controlled by their current medications. About 240 adults will receive either iloperidone or a placebo for 4 weeks, and researchers will measure changes in systolic blood pressure. The goal is to see if this drug can be a safe and effective add-on treatment for uncontrolled hypertension.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: iloperidone (Fanapt)
What this could lead to: If it works, this could offer a new add-on treatment option for people whose high blood pressure is not controlled by current medications.
What could go wrong: This is an early Phase 2 trial with only 240 participants, so results may not apply to everyone. Iloperidone is already approved for other uses, but its safety and effectiveness for hypertension are not yet proven.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION UNCONTROLLED HYPERTENSION

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Vanda Investigative Site
NOT_YET_RECRUITING

Phoenix, Arizona, 85053, United States
Vanda Investigative Site
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Tempe, Arizona, 85281, United States
Vanda Investigative Site
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Tucson, Arizona, 85715, United States
Vanda Investigative Site
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Chula Vista, California, 91910, United States
Vanda Investigative Site
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Dublin, California, 94568, United States
Vanda Investigative Site
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Valencia, California, 91355, United States
Vanda Investigative Site
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Walnut Creek, California, 94596, United States
Vanda Investigative Site
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Doral, Florida, 33172, United States
Vanda Investigative Site
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Fort Myers, Florida, 33912, United States
Vanda Investigative Site
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Columbus, Georgia, 31904, United States
Vanda Investigative Site
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Oak Brook, Illinois, 60523, United States
Vanda Investigative Site
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Tinley Park, Illinois, 60477, United States
Vanda Investigative Site
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El Dorado, Kansas, 67042, United States
Vanda Investigative Site
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Wichita, Kansas, 67226, United States
Vanda Investigative Site
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Lexington, Kentucky, 40509, United States
Vanda Investigative Site
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Hazelwood, Missouri, 63042, United States
Vanda Investigative Site
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Las Vegas, Nevada, 89119, United States
Vanda Investigative Site
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Mount Kisco, New York, 10549, United States
Vanda Investigative Site
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Rochester, New York, 14609, United States
Vanda Investigative Site
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Kinston, North Carolina, 28501, United States
Vanda Investigative Site
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Cincinnati, Ohio, 45212, United States
Vanda Investigative Site
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Norman, Oklahoma, 73069, United States
Vanda Investigative Site
NOT_YET_RECRUITING

Oklahoma City, Oklahoma, 73112, United States
Vanda Investigative Site
RECRUITING

Charleston, South Carolina, 29414, United States
Vanda Investigative Site
NOT_YET_RECRUITING

Carrollton, Texas, 75006, United States
Vanda Investigative Site
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Salt Lake City, Utah, 84124, United States
Vanda Investigative Site
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Burke, Virginia, 22015, United States
Vanda Investigative Site
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Norfolk, Virginia, 23502, United States

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