Can a common blood pressure drug better protect the heart?
NCT ID NCT05593055
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two blood pressure medications, eplerenone and chlorthalidone, in 75 adults with high blood pressure and thickened heart muscle. Researchers want to see if eplerenone improves blood flow to the heart and how efficiently the heart uses oxygen. Participants will take one of the two drugs for several weeks, and heart function will be measured using imaging tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Eplerenone and Chlorthalidone (with potassium)
What this could lead to
If eplerenone works better, it could point to a more effective way to protect the heart in people with high blood pressure and thickened heart muscle.
What could go wrong
This is a small, early-phase study (75 people) comparing two existing drugs, so results may not apply to everyone. The study looks at heart function measures, not long-term outcomes like heart attacks.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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