Can a common blood pressure drug better protect the heart?

NCT ID NCT05593055

Recruiting now Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two blood pressure medications, eplerenone and chlorthalidone, in 75 adults with high blood pressure and thickened heart muscle. Researchers want to see if eplerenone improves blood flow to the heart and how efficiently the heart uses oxygen. Participants will take one of the two drugs for several weeks, and heart function will be measured using imaging tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eplerenone and Chlorthalidone (with potassium)
What this could lead to: If eplerenone works better, it could point to a more effective way to protect the heart in people with high blood pressure and thickened heart muscle.
What could go wrong: This is a small, early-phase study (75 people) comparing two existing drugs, so results may not apply to everyone. The study looks at heart function measures, not long-term outcomes like heart attacks.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder Hypertrophy, Left Ventricular

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION LEFT VENTRICULAR HYPERTROPHY

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States

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