Primary viral infectious disease

This study looks at whether a 2-dose regimen of the Gardasil 9 HPV vaccine, given 12 months apart, triggers a strong immune response in children aged 4 to 8. The vaccine is currently approved for ages 9 and up, but this research explores if starting earlier could provide protecti…

This early-stage trial tests three experimental mRNA vaccines designed to train the immune system to fight HIV. The study involves 96 healthy adults without HIV in South Africa. Researchers will check for side effects and measure whether the vaccines trigger specific immune cells…

This study tests Cervavac, an HPV vaccine, in women aged 15-25 who are living with HIV. HPV infection can lead to cervical cancer, and women with HIV are at higher risk. The trial compares two-dose and three-dose schedules of Cervavac against a standard vaccine to see how well th…

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This early-stage trial is testing two mRNA vaccines in children aged 5 months to under 24 months. One vaccine targets RSV alone, and the other targets both RSV and hMPV. The main goals are to check safety and see how well the vaccines trigger an immune response. About 186 childre…

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot with or without adjuvants (ingredients that boost immune response) or as a nasal spray without adjuv…

This study tests an experimental oral COVID-19 vaccine tablet (VXA-CoV2-3.3) against approved mRNA booster shots in about 5,500 adults who have already been vaccinated. The goal is to see if the tablet can prevent symptomatic COVID-19 as well as or better than the injectable vacc…

This early-stage trial tests a new COVID-19 booster vaccine called Prime-2-CoV_Beta, made from a modified orf virus. It involves 96 healthy adults aged 18-55 who have already been vaccinated or infected. The main goal is to check safety and how well the vaccine boosts the immune …

This study examines how well the ABRYSVO vaccine works when given during pregnancy to prevent RSV in infants. Researchers will compare health outcomes of babies born to vaccinated mothers versus unvaccinated mothers using electronic medical records. The goal is to see if the vacc…

This early-stage trial tests a new shingles vaccine in 120 adults aged 40 and older. The main goal is to check safety and side effects at different doses, while also looking at how well the vaccine triggers an immune response. Participants receive either the vaccine or a placebo,…

This study looks at whether a booster dose of the Ebola vaccine (ERVEBO) can strengthen the immune system of people who have already survived Ebola. Researchers will compare their response to that of healthy people who have never had the virus. The goal is to see if the booster p…

This study looks at whether giving money to clinics can encourage doctors to talk about and offer the HPV vaccine more often. Some clinics get training on how to talk about the vaccine, while others get the same training plus a financial reward and monthly progress reports. The g…

This study was designed to check how long the Ebola vaccine (ERVEBO) protects people who might be exposed at work, like lab workers or healthcare staff. It also planned to see if a booster shot could extend that protection. However, the trial was withdrawn before enrolling any pa…

This Phase 2 study tests a new yellow fever vaccine (vYF) against the current licensed vaccine (Stamaril) in 690 healthy adults aged 18-60 in Europe and Asia. Participants receive one shot, and researchers measure immune response and safety over 5 years. The goal is to see if the…

This early-stage trial is testing a new vaccine called LASSARAB, designed to protect against Lassa fever, a serious viral illness. The vaccine uses a modified rabies virus to deliver the Lassa antigen and includes an adjuvant to boost the immune response. 55 healthy adults will r…

This study tests a new shingles vaccine called Z-1018 in about 764 healthy adults aged 50 and older. It compares Z-1018 to the current vaccine, Shingrix, to see if it is safe and triggers a strong immune response. The trial is in early phases (1 and 2), so the main focus is on sa…

This study tests whether training popular community leaders to share vaccine information can increase COVID-19 booster shots among Black individuals with rheumatic conditions like lupus. About 60 people will take part, including leaders and their social network members. The goal …

This massive study is testing whether the Abrysvo RSV vaccine can prevent hospitalizations due to RSV in adults aged 18 and older. Half of the 690,000 participants will receive the vaccine, while the other half will not. Researchers will track how many in each group end up hospit…

This study looks at the best timing for a booster shot of the RSV vaccine in adults aged 60 and older. It will follow over 10,000 participants for up to 5 years to see how long protection lasts and whether a second dose is needed. The goal is to help prevent serious RSV infection…

This study looks at whether a second, inactivated hepatitis A vaccine can safely boost protection in healthy Thai children and teens who did not develop enough antibodies after a single dose of a live-attenuated hepatitis A vaccine. About 36 participants who took part in an earli…

This study tests two new vaccines (SCB-1022 and SCB-1033) designed to protect against RSV, human metapneumovirus, and parainfluenza virus. About 612 healthy adults aged 60-85 will receive either a vaccine or a placebo. The main goal is to check safety and how well the vaccines tr…

This early-stage study tests a new vaccine called VXB-241 in healthy adults aged 60-83, with a smaller group of younger adults (18-40) first. The vaccine is designed to protect against two viruses that can cause serious lung infections: RSV and HMPV. Researchers will check how sa…

This early-stage study tests a new vaccine called VXB-251 in 240 healthy adults aged 60-83. The vaccine is designed to protect against three viruses that can cause serious lung infections: RSV, hMPV, and PIV3. Researchers will check if the vaccine is safe and how well it triggers…

This study tests whether the Gardasil 9 vaccine can help stem cell transplant patients build immunity against HPV. About 48 adults who had a stem cell transplant for blood cancer will receive the vaccine. Researchers will measure antibody levels to see if the vaccine works in the…

This study tests an mRNA vaccine (mRNA-1647) to prevent cytomegalovirus (CMV) infection in people who have had a stem cell transplant. About 84 participants will receive either the vaccine or a placebo. The goal is to see if the vaccine can safely prevent CMV after stopping stand…

This study checks how well the ABRYSVO® vaccine protects infants from severe RSV when given to pregnant women. Researchers will look at hospital records from Argentina and Uruguay over several RSV seasons. The goal is to see if the vaccine reduces hospitalizations and severe illn…

This early-stage trial tests a new type of COVID-19 booster vaccine called PepGNP-COVID19. It uses tiny gold nanoparticles to train the immune system's T cells to recognize and fight the virus. The study involves 60 healthy adults aged 18-64 who will receive one of three doses to…

This large Phase 3 study is testing an mRNA vaccine called mRNA-1403 to prevent norovirus, a common cause of severe stomach upset and diarrhea. About 38,000 adults aged 18 and older will receive either the vaccine or a placebo. The goal is to see if the vaccine can safely prevent…

This study looks at how getting the flu vaccine year after year changes your body's immune response. Researchers are testing two types of flu vaccines—a nasal spray (FluMist) and a shot (Flublok)—in 600 adults aged 22 to 50 in Hong Kong. They will measure antibodies and immune ce…

This early-stage trial is testing a new mRNA vaccine called ABO1108 to prevent shingles in adults aged 40 and above. Around 180 healthy volunteers will receive two shots of either the new vaccine at different doses, a placebo, or the existing Shingrix vaccine. The main goal is to…

This phase II trial tests a vaccine designed to protect stem cell transplant recipients from cytomegalovirus (CMV), a common virus that can cause serious illness in people with weakened immune systems. The vaccine uses a modified, harmless virus to deliver three CMV proteins, tra…

This study tests a new mRNA vaccine called ABO1108 to see if it can prevent shingles in adults aged 40 and above. About 300 healthy volunteers will receive two shots, two months apart, and be compared to a placebo group. The goal is to measure the immune response and check for sa…

This study reviews medical records to see how effective Pfizer's ABRYSVO vaccine is at preventing severe RSV lung infections in adults 60 and older. Researchers will analyze existing health data from routine doctor visits over several years. No new treatments or active participat…

This study tests a single dose of an updated Novavax COVID-19 vaccine designed to target the JN.1 variant. About 6,500 healthy adults aged 50 to under 65 who are not at high risk for severe COVID will receive either the vaccine or a placebo. Researchers will track how well the va…

This study is testing an experimental mRNA vaccine called mRNA-1189 to see if it can safely prevent Epstein-Barr virus (EBV) infection in healthy people aged 10 to 30. EBV is a common virus that can cause mononucleosis and has been linked to some cancers. The vaccine is given as …

This study tests an inactivated EV71 vaccine (Envacgen®) in healthy children aged 6 to under 10 years and compares their immune response and safety to children aged 2 to under 6 years. Around 378 children will receive two shots 57 days apart. The goal is to see if the vaccine wor…

This study looks at whether giving a smaller (one-fifth) dose of the HPV vaccine, either into the skin or muscle, can still trigger a strong immune response in adults aged 27 to 45. About 92 men and women in Seattle will have their antibody levels checked over a year. The goal is…

This phase 3 trial is testing a non-live, adjuvanted RSV vaccine (Arexvy) in 100 adults who have received a lung or stem cell transplant. The goal is to see if the vaccine is safe and helps their immune system fight RSV, a common virus that can be dangerous for them. Participants…

This study looks at how well the HPV9 vaccine (Gardasil 9) works in people who have had a kidney transplant. Researchers will measure antibody levels in 30 transplant recipients over 24 months and compare them to published data from healthy individuals. The goal is to see if the …

This Phase 3 study is testing the MVA-BN mpox vaccine in 344 infants and children aged 4 to 24 months in the Democratic Republic of the Congo, a region heavily affected by mpox. Researchers are comparing a standard dose to a half-dose to see if the lower dose is still effective a…

This study tests two updated mRNA COVID-19 vaccines (mRNA-1283 and mRNA-1273 variant formulation) in 30,000 healthy adults aged 50 to 64 who are not at high risk for severe COVID-19. The goal is to see if these vaccines prevent symptomatic COVID-19 compared to a placebo. Research…

This study is testing whether a 2-dose schedule of the HPV vaccine (Gardasil 9) is as effective as the standard 3-dose schedule in women aged 16 to 45. Researchers will measure antibody levels in 352 women to compare immune responses. If the 2-dose regimen works well, it could si…

This study tests whether the HPV vaccine Gardasil 9 can trigger an immune response in people with idiopathic CD4 T cell lymphocytopenia (ICL), a rare condition that weakens the immune system. About 54 adults with ICL and some healthy volunteers will receive three doses of the vac…

This study tests a new shingles vaccine called JCXH-105 in healthy adults aged 50 and older. It compares the new vaccine to the current standard, Shingrix, to see if it is safe and triggers a strong immune response. About 467 participants will receive either JCXH-105 or Shingrix,…

This early-stage study tests an experimental mRNA vaccine called JCXH-108 to see if it is safe and triggers an immune response against RSV, a common respiratory virus. About 75 healthy volunteers, split into two age groups (18-45 and 60+), will receive either the vaccine or a pla…

This study tests a nasal spray flu vaccine in 200 people aged 3 to 17. Researchers will measure specific antibodies in the nose to see how well the vaccine works. The goal is to understand the immune response and improve flu prevention.

This early-phase trial tests a new HIV vaccine strategy in 36 healthy adults without HIV. The vaccine uses ferritin nanoparticles to display HIV envelope proteins, followed by an mRNA boost. The goal is to safely trigger broadly neutralizing antibodies that could protect against …

This early-stage trial tests a new vaccine called AVX70371, designed to treat chronic hepatitis B by training the immune system to fight the virus. It involves 16 healthy adults aged 18 to 40 to check for safety and immune responses. The study is not yet testing if it works again…

This study is testing whether giving the HPV vaccine (Gardasil 9) on a different schedule still works well in healthy 9-11 year olds. The standard schedule uses two or three doses, but this study gives a first dose and then a booster later. Researchers will measure antibody level…

This early-phase trial is testing two experimental HIV vaccines in 52 healthy adults without HIV. The goal is to see if the vaccines are safe and can stimulate the immune system to produce broadly neutralizing antibodies, which are key to fighting many HIV strains. Participants r…

This large study is testing updated mRNA vaccines designed to protect against newer Omicron variants of COVID-19 in healthy children aged 6 months to 12 years. Over 4,000 participants will receive one or more doses depending on their age and vaccination history. Researchers are m…

This study tests a variant-adapted COVID-19 vaccine in about 5,240 healthy adults aged 50 to 64. Half receive the vaccine, half a placebo, to see if it safely prevents COVID-19 caused by new virus variants. The goal is to find out how well the updated shot works in this age group…

This early-stage trial tests a new vaccine designed to protect against multiple coronaviruses, not just COVID-19. 51 healthy adults aged 18-55 will receive two doses to check safety and immune response. The vaccine uses a protein nanoparticle to target the virus's spike protein, …

This study tests whether the MVA-BN mpox vaccine (Jynneos) works as well when made in quail cells instead of chicken cells. About 970 healthy adults aged 18 to 49 will receive two doses four weeks apart. Researchers will compare immune responses and side effects between the two v…

This study tests two experimental mRNA vaccines, mRNA-1403 and mRNA-1405, designed to prevent norovirus, a common cause of severe vomiting and diarrhea. Around 1,400 healthy adults aged 18 to 80 will receive either a vaccine or a placebo. The main goals are to check safety and me…

This early-stage trial is testing a new mRNA vaccine called IN006 that targets respiratory syncytial virus (RSV). About 240 healthy adults aged 18 and older will receive either the vaccine or a placebo. The main goal is to check if the vaccine is safe and triggers an immune respo…

This large study enrolled over 15,000 U.S. military members to compare three types of licensed flu vaccines: egg-based, recombinant, and cell-culture-based. Participants were randomly assigned to one of the three vaccines over four flu seasons. The main goal is to see which vacci…

This study tests an experimental nasal vaccine made from a harmless virus (Sendai virus) that is similar to the one causing croup. The goal is to see if it is safe and helps children ages 1 to 5 build protection against croup. About 54 children will receive the vaccine as nose dr…

This study tests a new shingles vaccine in 960 healthy adults aged 40 and older. The goal is to see if it is safe and triggers a strong immune response. Researchers will monitor side effects and measure antibody levels over time. This is an early-stage trial to help develop a bet…

This phase 3 study tests a new quadrivalent seasonal influenza vaccine in healthy infants aged 6 months to under 3 years. The goal is to see if the vaccine triggers a strong immune response and is safe compared to an existing flu shot. About 245 children will take part, and resea…

This study tests two experimental vaccines, AZD4117 and AZD5315, designed to protect against certain strains of avian influenza (bird flu), specifically H5N1 and H7N9. Around 405 healthy adults will receive either a vaccine or a placebo to see if the vaccines are safe and trigger…

This study tests an experimental RSV vaccine in adults aged 60 and older. The goal is to see how well the vaccine triggers the immune system, how safe it is, and how long protection lasts—up to 5 years. About 1,720 participants will receive one or more doses of the vaccine at dif…

This study tests two injected medications, bleomycin and pingyangmycin, for treating plantar warts. Each of the 200 adult participants will receive both drugs on different warts to compare which works better. The main goal is complete clearing of the warts, with follow-up for 36 …

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

This study tests whether a simpler two-drug pill (dolutegravir/lamivudine) works as well as a standard three-drug pill (bictegravir/emtricitabine/tenofovir alafenamide) for adults with HIV who have never been treated. About 473 participants will take one of the two pills daily fo…

This study tests if gabapentin, a medication for nerve pain, can help people with HIV who drink heavily achieve undetectable viral loads. About 220 participants will receive either gabapentin or a placebo for 3 months, along with counseling. The goal is to see if the drug improve…

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…

This study tests whether a single infusion of hyperimmune immunoglobulin (hIVIG) — concentrated antibodies from recovered COVID-19 patients — can help adults at high risk (age 55+ or with weakened immune systems) who have early COVID-19. Participants receive either the antibody i…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

This early-stage study tests a new lab-made antibody called VH4527079 in healthy adults and people with HIV. The goal is to check if it is safe and how the body processes it when given as a single shot or multiple infusions. About 102 participants aged 18-55 will take part. This …

This study tests a non-invasive pneumatic vest designed to apply pressure to the chest wall in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 who are on mechanical ventilators. The goal is to see if the vest can improve oxygen levels in the blood. Up …

This study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…

This study tests whether specially grown immune cells can fight three common viruses—adenovirus, CMV, and EBV—in people whose immune systems are weak due to a stem cell or organ transplant, or an inherited immune disorder. The cells are made from a donor's blood and trained to re…

This Phase 3 trial tests a drug called brelovitug (BJT-778) in 80 people with chronic hepatitis delta, a serious liver infection. Participants receive either brelovitug or delayed treatment to see if the drug can lower virus levels and improve liver enzyme counts. The study is re…

This study tests whether personalized text messages can motivate people living with HIV in Vietnam to quit smoking. Participants receive motivational texts over six months and are encouraged to use a free government quitline that provides nicotine patches. The goal is to see if t…

This study tests a new two-drug combination, BEM/RZR, against an approved treatment, SOF/VEL, in 880 adults with chronic hepatitis C. The goal is to see if BEM/RZR can clear the virus as effectively and safely. Participants must not have taken prior HCV drugs and may have compens…

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

This study tests a counseling program for people living with HIV who also face mental health challenges or substance use. The program uses one-on-one sessions to help with medication adherence, stress, and other life issues. Researchers will see if participants complete the progr…

This phase 2 trial tests two experimental drugs, Elebsiran and Tobevibart, in 95 adults with chronic hepatitis D, a serious liver infection. Participants receive the drugs as injections along with a standard oral antiviral. The goal is to see if the combination can lower virus le…

This study tests a virus called AdAPT-001 that is injected directly into tumors to kill cancer cells. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial will check if the virus is safe and whether it works better when combined wi…

This phase 2 trial tests a drug called VK-2019 in 13 patients with Epstein-Barr virus (EBV)-positive nasopharyngeal cancer that has returned or spread and has no standard treatment. VK-2019 works by blocking a key viral protein, EBNA1, which the virus needs to survive. The main g…

This study tested whether monthly injections of two HIV drugs (cabotegravir and rilpivirine) work better than daily oral pills for people with HIV who have a history of missing doses. Over 450 participants were enrolled. The goal was to see if the long-acting shots reduce the cha…

This study looks at the safety and effectiveness of the HIV medication B/F/TAF in pregnant women who have had their virus under control for at least six months. About 50 women in their first trimester will continue taking the drug through pregnancy and 12 weeks after birth. Resea…

This study tests whether a blood test for Epstein-Barr virus (EBV) DNA can help doctors choose the best chemotherapy after standard radiation for nasopharyngeal cancer. About 685 patients will first receive standard chemoradiation. Then, based on whether EBV DNA is still detectab…

This study looks at two antiviral drugs, TAF and TDF, in pregnant women with chronic hepatitis B. It aims to see which one better controls the virus and keeps the mother's liver healthy without harming the baby. About 816 women in early or middle pregnancy will take one of the dr…

This early-stage study is testing the safety and how the body handles a new combination HIV drug (B/F/TAF) in full-term newborns who were exposed to HIV at birth. The goal is to see if this drug can be used to prevent the babies from getting infected. The study involves 16 infant…

This phase 2 trial is testing whether adjusting treatment based on risk level can improve outcomes for people with HIV who have anal cancer. Low-risk patients receive standard chemotherapy and radiation, while high-risk patients also get the immunotherapy drug nivolumab after sta…

This study tests a new HIV medicine, fostemsavir, in people whose HIV has become resistant to many other drugs. About 371 adults with multi-drug resistant HIV took part. The goal was to see if fostemsavir could lower the amount of virus in their blood. This is a disease control s…

This study looks at whether giving lower doses of radiation to a smaller area after robotic surgery can still keep HPV-positive throat cancer from coming back. About 150 adults with early-stage throat cancer will receive this gentler radiation plan. The goal is to see if two year…

This study tests a drug called tenofovir alafenamide (TAF) in 150 children and teens with chronic hepatitis B. Half receive TAF and half receive a placebo for 24 weeks. Researchers are checking how safe the drug is, how the body processes it, and whether it lowers virus levels. T…

This phase 2 trial tests whether immune cells from donors who have been exposed to CMV can treat persistent CMV infections in patients who have had a stem cell transplant. The study includes 49 participants with CMV that hasn't improved with standard antiviral drugs. The cells ar…

This study was designed to see if corticosteroids (prednisone or hydrocortisone) could help COVID-19 patients who need extra oxygen. It planned to enroll adults with confirmed COVID-19 and pneumonia, using CT scans to identify those likely to benefit. However, the trial was withd…

This study tests whether switching to a new 2-drug combination pill (bictegravir/lenacapavir) is as safe and effective as staying on the standard 3-drug pill (Biktarvy) for people with HIV-1 whose virus is already suppressed. About 577 participants who have been on Biktarvy for a…

This study tests a 4-session behavioral program to reduce alcohol use in 450 people with TB and HIV in India. Unhealthy drinking can worsen TB and HIV outcomes. The program is added to usual care, and researchers will check if it lowers alcohol use and improves health. The goal i…

This early-stage trial tests a biologic treatment for 20 people with moderate COVID-19 who also have controlled cancer. The treatment aims to help the immune system recognize and kill the virus. Researchers will check if the virus clears and if the immune response improves.

This study tests a mobile app called Connections for people living with HIV who also have substance use disorders. The app provides resources, weekly check-ins, discussion rooms, and private messaging with peer mentors and care teams. Researchers want to see if using the app help…

This early-stage trial tests a therapeutic vaccine called ISA104 in 24 people with chronic hepatitis B who are already on antiviral drugs. The goal is to see if the vaccine is safe and can boost the immune system to better fight the virus. Participants will receive either ISA104 …

This study tests a combination of three drugs—bintrafusp alfa, PDS01ADC, and entinostat—in adults with advanced HPV-related cancers (like cervical, anal, or throat cancer) or certain colon cancers that haven't responded to standard treatment. The goal is to find a safe dose and s…

This study provides access to the drug bulevirtide (Hepcludex®) for people with chronic hepatitis delta virus infection who have compensated liver disease (with or without cirrhosis). Participants must meet specific health criteria, including a positive HDV RNA test. The goal is …

This study tests different ways to help people with HIV take their medication regularly. Researchers will enroll 534 people starting HIV treatment in Cape Town. They will use a device to track pill-taking and try different outreach methods, like calls or texts, to support adheren…

This pilot study in Malawi tests whether adding stigma-reduction counseling to standard depression treatment helps people living with HIV. Two hundred adults with HIV and depressive symptoms will receive counseling sessions that challenge myths and build coping skills. Researcher…

This study tests a program called Healthy Choices, which uses text messages and telehealth sessions to help young people with HIV (ages 18-29) in Florida manage their alcohol use and take their HIV medication every day. The goal is to improve daily medication adherence and viral …

This study is for adult women living with HIV who have experienced intimate partner violence. It tests a program that combines trauma-informed counseling with a safety planning app to improve mental health, HIV management, and safety. The goal is to see if this approach can reduc…

This study tests whether giving a guaranteed income of $6,750—either as a lump sum or monthly payments—helps people with HIV who have recently been in jail stay connected to care and keep the virus under control. Thirty-three participants will be randomly assigned to receive the …

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This study tests whether two lab-made antibodies, 3BNC117-LS and 10-1074-LS, can safely reduce the hidden HIV reservoir in people already on suppressive antiretroviral therapy (ART). The trial involves 105 adults with HIV who will receive three infusions of the antibodies or a pl…

This study planned to test a blend of plant extracts and vitamin C, called Ahah, in people with HIV/AIDS. The goal was to see if it could protect and increase CD4+ T cells and B cells. However, the trial was withdrawn before enrolling any participants, so no results are available…

This study tests whether using a dried blood spot test (a simple finger prick) can help people with hepatitis C start treatment faster than the usual method that requires a blood draw. The trial involves 141 participants who work with a peer support program and telemedicine. The …

This early-phase trial tested whether combining two anti-cancer drugs, pomalidomide (taken as a pill) and liposomal doxorubicin (given through an IV), is safe and tolerable for people with advanced or hard-to-treat Kaposi sarcoma. The study enrolled 62 adults, including those wit…

This study gives children with HIV-1 who previously benefited from rilpivirine continued access to the drug along with other antiretrovirals. About 48 kids are taking part to monitor long-term safety and side effects. The goal is to keep their virus under control while checking f…

This study tests a new combination of two HIV drugs, bictegravir and lenacapavir, in children and adolescents aged 2 to 17 with HIV-1. The goal is to see if this once-daily pill is safe and works well enough to replace more complex daily medication routines. About 75 participants…

This study provides early access to the experimental drug TMC125 (etravirine) for HIV-1 patients who have failed multiple treatments and have few options left. Participants take TMC125 along with other antiretroviral drugs chosen by their doctor. The study tracks safety and how w…

This study looks at a rare disease called KSHV-associated multicentric Castleman's disease (MCD), caused by a virus. Researchers are testing several drug combinations, including chemotherapy and antivirals, to see if they can control the disease. The study also tracks how the dis…

This study tests whether intravenous immunoglobulin (IVIG) can reduce symptoms of autonomic dysfunction—such as dizziness, rapid heartbeat, and fatigue—in people with long COVID. Two hundred participants will receive either IVIG or a placebo (saline) for 9 months, plus coordinate…

This Phase 2 trial tests whether a combination of dasatinib and quercetin (D+Q) can safely improve physical function in 82 older adults with HIV who are frail or prefrail. Participants take D+Q or a placebo in six 2-day cycles over 12 weeks, then are monitored for another 12 week…

This study tests a new oral antiviral drug, ARN-75039, for treating Lassa fever, a serious viral illness common in West Africa. About 135 hospitalized adults will receive either a high or low dose of the new drug or the standard IV treatment, ribavirin, for 10 days. The goal is t…

This study tests whether a single injection of peramivir can safely treat uncomplicated flu in adults. Participants receive either 150 mg, 300 mg of peramivir, or a placebo, and researchers measure how quickly symptoms improve. The goal is to see if this antiviral shot offers a f…

This study looks at whether sending reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors are involved. The goal is to see if these nudges lead to more referrals and partici…

This Phase 2 trial tests whether adding Gammora® (a peptide) to standard antiretroviral therapy can reduce the hidden HIV reservoir in people newly diagnosed with HIV. Forty participants who have never taken HIV drugs will be randomly assigned to receive either Gammora® plus stan…

This early-stage study tests a single dose of a new long-acting antibody in 20 people with HIV who are not on regular medication. The goal is to see if the antibody is safe and can lower the amount of virus in the blood. Results will help design future studies for both HIV treatm…

This phase II trial tests whether bevacizumab, a drug that blocks blood vessel growth, can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a rare condition causing wart-like growths in the airways. Participants receive 11 doses of t…

This phase 2 trial tests whether giving the HPV vaccine (Gardasil 9) to adults before a kidney transplant helps their immune system fight HPV after transplant, when they must take drugs that weaken immunity. About 51 participants will receive the vaccine before surgery, and resea…

This phase 3 trial tests whether a once-weekly pill (islatravir/lenacapavir) can keep HIV under control as well as daily standard care. About 600 people with HIV who already have undetectable virus levels will switch to the weekly pill or stay on their current daily regimen. The …

This study compares two methods of rolling out a program called Bridges, which gives financial literacy training and one-on-one mentors to 1,440 teens aged 11-17 who lost parents to AIDS in Uganda. The goal is to see which approach works better at reducing HIV risk and improving …

This study looks at two drug combinations to treat BK virus infection in kidney transplant recipients. BK virus can cause the new kidney to fail. The trial compares everolimus with a lower dose of tacrolimus versus a lower dose of tacrolimus plus leflunomide in 50 adults whose vi…

This study tests whether a combination of two antibodies (TMB-365 and TMB-380) given as an infusion every 8 weeks can keep HIV under control in people who are already suppressed on daily oral medication. About 88 adults with HIV will either switch to the antibody infusions or sta…

This early-phase trial tests the safety of combining two cancer drugs, nivolumab and cabozantinib, in people with HIV who have advanced solid tumors. Only 8 participants were enrolled. The goal is to see if the combination is safe and can shrink or stabilize tumors.

This phase 2 trial tests a nasal spray called Optate in 24 adults with mild COVID-19. The spray aims to lower virus levels in the nose and improve symptoms like congestion. Participants receive either Optate or a placebo, and researchers measure changes in virus levels and sympto…

This study tests whether the antiviral drug tecovirimat can help people with monkeypox heal faster. About 480 adults and teens (14+) with active lesions will receive either tecovirimat or a placebo, alongside standard care. The main goal is to see how quickly skin and mouth sores…

This study tests whether the antiviral drug entecavir can prevent hepatitis B from reactivating in people with a type of blood cancer (CD20-positive B-cell lymphoma) who have had hepatitis B in the past but cleared it. The 84 participants will take entecavir before starting their…

This study tests a mobile app called HealthMPowerment (HMP) designed to help young gay and bisexual men (ages 15-24) either start HIV prevention (PrEP) or stay on HIV treatment. About 1500 participants will get the app right away or after a delay. Researchers will see if the app …

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. The trial includes 65 adults with COVID-19-related acute respiratory distress syndrome (ARDS). Researchers will compare stem cell treatment plus standard care…

This early-phase trial tests a biological product mix designed to train the immune system to recognize and clear multiple strains of HPV. The study involves 20 participants with cervical HPV infection who do not have symptoms or signs of cancer. The treatment is given through the…

This phase 2 trial tests a new COVID-19 booster vaccine (GEO-CM04S1) in 80 people with chronic lymphocytic leukemia (CLL). The goal is to see if this vaccine triggers a stronger immune response than standard mRNA boosters. Participants will receive either the new vaccine or a sta…

This early-phase trial tests a gene therapy approach for people with HIV who also have lymphoma that has returned or not responded to treatment. Researchers take the patient's own stem cells, add anti-HIV genes in the lab, and return them after a stem cell transplant. The goal is…

This early-stage trial tests adding lenalidomide to standard chemotherapy (EPOCH) for adult T-cell leukemia-lymphoma, a rare and aggressive blood cancer linked to HTLV-1 infection. The main goal is to find the safest dose of lenalidomide when used with chemo. Up to 30 adults with…

This study tests a new drug called bepirovirsen in 153 people who have both HIV and chronic hepatitis B and are already on HIV treatment. The goal is to see if bepirovirsen can clear the hepatitis B virus from the body better than a placebo. Participants will continue their regul…

This study was designed to test whether an inhaled drug called ZYESAMI could help people with severe COVID-19 avoid getting worse and needing a ventilator. It was a Phase 3 trial, meaning it was in the final stage of testing. However, the study was withdrawn before any participan…

This study was designed to test whether the drug itolizumab could help hospitalized COVID-19 patients recover faster. The trial was planned for 18 years and older with confirmed COVID-19 pneumonia and low oxygen levels. However, the study was withdrawn before enrolling any partic…

This study looks at whether VIGIV, a blood product with antibodies, helps people who have serious reactions to the smallpox vaccine. It will track 100 patients to see if their skin lesions improve and if their antibody levels change. The goal is to confirm that VIGIV works as a t…

This study tests whether a combination of weekly video-counseling sessions and a mobile app can help young adults (18-29) living with HIV achieve viral suppression. Participants who are not virally suppressed will be randomly assigned to receive the intervention or standard care.…

This study was designed for people with HPV-positive oropharyngeal cancer who still had signs of the virus in their blood after completing standard treatment. Researchers planned to give an immunotherapy drug called BALSTILIMAB to see if it could clear the virus and improve long-…

This study is testing a mobile app called Suubi-Mhealth for Ugandan teens aged 14-17 who have both HIV and depression. The app uses cognitive-behavioral therapy (CBT) to help improve mood and make it easier to stick with HIV medication. About 248 teens will take part to see if th…

This study tests whether lungs from donors with hepatitis C can be safely transplanted into people without the virus. The lungs are treated with a special machine to try to reduce the virus. If the recipient gets infected, they will be treated with standard antiviral medication. …

This study tests a new drug called AHB-137 in 86 adults with chronic hepatitis B who are already on standard antiviral pills. The goal is to see if AHB-137 can clear the hepatitis B surface antigen from the blood, which would mean the virus is under control and patients might be …

This study tests a program called Khanya, where trained peers (people with lived substance use experience) help HIV patients stick to their medication and reduce drug or alcohol use. The program is offered in steps: a basic version first, then a more intensive one if needed. Rese…

This phase 1 trial is testing whether combining two drugs, azacitidine and abatacept, can shrink tumors in adults with T-cell lymphoma that has relapsed or not responded to prior treatment. Up to 20 participants will receive the drugs in 28-day cycles for up to 13 cycles. The stu…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people with HIV reduce unhealthy alcohol use and improve their overall health. About 308 participants in Alabama will receive either the combined program or b…

This Phase 2 trial tests an experimental drug called AHB-137 in 105 adults with chronic hepatitis B who have not been treated before. The goal is to see if the drug can clear the hepatitis B surface antigen and lower the virus to undetectable levels, potentially leading to a func…

This study tests whether offering small prizes (phone credit) can encourage young people aged 15-30 with HIV to take their medication every day. 560 participants in Uganda are split into groups with different reward rules. The goal is to see if these low-cost incentives improve a…

This study tests whether pomalidomide, a drug currently used for multiple myeloma, can help control HIV when people temporarily stop their standard antiretroviral therapy (ART). Thirty-two adults with well-controlled HIV will receive either pomalidomide or a placebo alongside low…

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This study tests an injection called AHB-137 in 20 adults with chronic hepatitis B who are already on standard antiviral pills. The goal is to see if the drug can lower or eliminate hepatitis B surface antigen (HBsAg) and viral DNA, potentially leading to a functional cure. Parti…

This phase 3 trial tests an experimental drug called AHB-137 in 577 adults with HBeAg-negative chronic hepatitis B who are already on standard antiviral pills. Participants receive weekly injections of AHB-137 or a placebo for a set period, then stop all hepatitis B treatment. Th…

This study aimed to test a drug called IC14 in adults with early dengue fever to see if it is safe and could help reduce symptoms and viral levels. It was designed for people in areas where dengue is common, but the trial was withdrawn before any participants were enrolled. No re…

This study looks at switching kidney or liver transplant patients with chronic hepatitis B to a drug called tenofovir alafenamide (TAF). The goal is to see if TAF is safer for the kidneys, controls the virus well, and is easier for patients to stick with. The study involves 52 ad…

This early-phase trial tests a new type of immune cell therapy called WU-CART-007 for people with certain blood cancers, including acute myeloid leukemia and T-cell lymphoma, that have come back or not responded to treatment. The therapy uses donor cells that are genetically modi…

This early-stage trial tests whether a new drug called PDI204, an antibody that targets the COVID-19 virus, is safe and tolerable in healthy adults. 32 participants will receive a single dose of PDI204 or a placebo and be monitored for side effects and how the drug behaves in the…

This study tests whether semaglutide, a drug used for diabetes, can reduce harmful belly fat and improve heart health in people with HIV who have excess fat around the midsection (lipohypertrophy). About 108 participants will receive either semaglutide or a placebo for 32 weeks. …

This early-phase trial tests a new approach for ovarian cancer that has stopped responding to platinum chemotherapy. It combines TILT-123, a virus engineered to kill cancer cells and boost immune activity, with the immunotherapy drug pembrolizumab, and in some cases also with a c…

This study tests a 12-week course of three antiviral drugs (sofosbuvir, velpatasvir, and voxilaprevir) in 200 adults with chronic hepatitis C whose virus returned after previous treatment. The main goal is to see if the virus becomes undetectable 12 weeks after therapy ends. Rese…

This study looks at whether a trained friend, family member, or partner can safely give long-acting HIV injections at home. It involves 1,000 people with HIV who are already on the injectable treatment and have the virus under control. The goal is to make it easier for people to …

This study is testing a new drug called Golcadomide (BMS-986369) in about 85 people in Japan whose T-cell lymphoma has come back or not responded to treatment. The goal is to check the drug's safety and how well it works against the cancer. Participants will receive the drug and …

This phase 2 trial tests whether N-acetylcysteine, a drug already used for acetaminophen overdose and lung mucus, can help severe COVID-19 patients by boosting their immune system. About 48 critically ill adults will receive the drug alongside standard care. The goal is to see if…

This study tests whether a probiotic called Lactobacillus plantarum 299v (Lp299v) can improve blood vessel function in people with Long COVID (PASC). The trial includes 80 adults who had COVID-19 30-180 days ago and have ongoing symptoms. Participants take either the probiotic or…

This study tests whether people with HIV who are already well-controlled on a daily pill (B/F/TAF) can safely switch to a once-weekly tablet (islatravir/lenacapavir). About 600 participants will take either the weekly pill or continue their daily regimen for 48 weeks. The goal is…

This study tests an experimental cell therapy called tabelecleucel in 190 people with diseases caused by the Epstein-Barr virus (EBV), including certain lymphomas and post-transplant complications. The treatment uses specially prepared immune cells to fight the virus. The main go…

This study follows 500 people with HIV across Europe who are taking the medication doravirine. Researchers want to see how well the drug controls the virus over 12 months, how many people stop taking it, and if the virus becomes resistant. The study includes people new to treatme…

This early-phase study tests an experimental drug called DS-3201b in about 100 adults with non-Hodgkin lymphoma whose cancer has come back or is not responding to current treatments. The main goals are to find a safe dose and see how the drug works in the body. The study also che…

This study is testing a drug called pradefovir mesylate in 400 adults with chronic hepatitis B. The goal is to see how well it lowers the virus and how safe it is in everyday medical practice, not just in a strict research setting. Participants are being followed for up to 65 wee…

This study tests whether a combination of two lab-made antibodies and an antiviral drug called lenacapavir, given every 6 months, can keep HIV under control in adults whose virus is already suppressed by daily pills. About 83 participants will either switch to the new long-acting…

This study tests two experimental vaccines (HB-201 and HB-202) given with standard chemotherapy drugs (carboplatin and paclitaxel) to people with HPV16-positive oropharyngeal cancer. The goal is to see if this combination can shrink tumors enough to allow less intensive follow-up…

This study tests two antiviral medications, TAF and TDF, in 200 pregnant women with chronic hepatitis B. The goal is to see which drug better prevents passing the virus to the baby and causes fewer birth defects or side effects. Participants take the drug daily during pregnancy a…

This study monitors 45 people with chronic hepatitis B who already received the experimental gene editing treatment PBGENE-HBV in an earlier trial. Researchers will watch for any delayed side effects over time. No new treatment is given; the goal is to understand the long-term sa…

This study looks at how safe and effective certain HIV medicines are for children and teens (ages 4 weeks to under 18 years) who already have the virus under control. Participants take a combination of drugs (atazanavir or darunavir boosted with cobicistat, plus emtricitabine/ten…

This early-phase study tests a new treatment for advanced osteosarcoma and neuroblastoma that has not responded to standard therapy. Researchers take a patient's own immune cells (T cells), add a gene to help them recognize and attack cancer cells, and combine them with a chicken…

This study is testing two mobile health tools—a computer-delivered program and motivational text messages—to help young adults (ages 18-24) in Zambia better manage their HIV and cut down on alcohol use. The goal is to see if these tools are easy to use and acceptable to participa…

This trial tests a device called Seraph 100, a blood filter used to treat severe COVID-19. The goal is to see if filtering the blood can reduce organ failure in patients with COVID-19 who are in the intensive care unit. The study enrolled 42 adults with confirmed COVID-19 and org…

This study tests whether peer mentors—people with similar experiences—can help individuals recently released from jail or prison get connected to Hepatitis C care and stay in treatment. About 80 participants will either receive a peer mentor or standard referral. The goal is to s…

This study aimed to see if a special blood filter (Seraph 100) could reduce BK virus levels in kidney transplant patients with high viral loads. It planned to enroll adults with a BK virus level of 10,000 IU/mL or higher who already had dialysis access. However, the trial was wit…

This trial tests a video-based counseling program for adolescents living with HIV in Malawi. About 1,800 teens and their treatment supporters will either receive the video intervention or standard care. The goal is to see if the videos help teens take their medication regularly a…

This study tests whether a new once-weekly oral combination of two experimental drugs, lepetegravir and lenacapavir pacfosacil, can keep HIV under control as well as the daily pill Biktarvy. About 675 adults with already-suppressed HIV will take either the weekly combo or continu…

This study tests a program called PASEO that helps teenagers with HIV in Lima, Peru, successfully move from pediatric to adult HIV care. The program includes a helper who checks in monthly, peer support groups, education sessions, and mental health support. About 160 teens will t…

This study tests a 12-week course of the drug Sofosbuvir/Velpatasvir in about 100 pregnant women with chronic hepatitis C. The goal is to see if the treatment can cure the virus and whether it affects the timing of delivery. Mothers are followed for 12 weeks after treatment, and …

This phase 2 trial tests whether a single, low dose of radiation to the chest can reduce lung inflammation in hospitalized COVID-19 pneumonia patients. Researchers compare two radiation doses (35 cGy and 100 cGy) to standard care. The goal is to see if this treatment lowers the n…

This early-phase study tests whether taking prebiotic fiber and probiotics can improve fatty liver disease in people with HIV. Researchers believe changes in gut bacteria may contribute to liver problems. The trial involves 63 participants and measures liver fat and gut health ma…

This pilot study tests whether giving the smoking-cessation drug varenicline to people with HIV who also have alcohol use disorder is practical and safe. Thirty participants will receive the medication along with support from a pharmacist and psychiatrist. The goal is to see if t…

This study looks at whether older adults (60+) living with HIV in Kenya can safely switch from their current three-drug pill to a simpler two-drug pill called DTG/3TC. About 240 participants who are already stable on treatment will be followed for 96 weeks. The main goal is to se…

This early-stage trial tests a DNA vaccine called INO-8000, given with an immune booster, to see if it can help people with chronic hepatitis C fight the virus. The study involves 33 participants and focuses on safety and finding the best dose. The vaccine is delivered through in…

This study tests whether repeated doses of the BCG vaccine (originally for tuberculosis) can help adults with long-standing type 1 diabetes lower their blood sugar levels. About 150 participants receive either BCG or a placebo over 5 years, with follow-up for 10 years. The goal i…

This study tests a combination of two drugs, atezolizumab and bevacizumab, in 51 people with advanced liver cancer who also have chronic hepatitis B. The goal is to see if the treatment can shrink tumors and control the disease. Participants receive the drugs every three weeks, a…

This phase 3 study tests whether a combination of two drugs, tobevibart and elebsiran, can control chronic hepatitis delta better than waiting for treatment. About 124 adults with the infection will receive either the combo therapy or delayed treatment. The goal is to see if the …

This study tests whether the drug tocilizumab can help people with severe or critical COVID-19 who have serious lung problems (ARDS). About 200 adults will receive one or two doses and be followed for 30 days. The goal is to see if the drug improves survival and recovery. There i…

This study tests whether two lab-made antibodies can safely control HIV in people who stop their regular antiretroviral therapy for a short time. Thirty-two adults in Sub-Saharan Africa who are currently on HIV treatment will receive either the antibodies or a placebo. The goal i…

This study tests a program where trained peers use motivational interviewing to encourage people who use drugs to check their drugs for dangerous substances and adopt safer use behaviors. The goal is to reduce fatal and non-fatal overdoses, as well as HIV and hepatitis C infectio…

This study tested a treatment called CG0070, a virus designed to attack cancer cells, in people with high-grade non-muscle invasive bladder cancer. Participants had already tried standard therapy (BCG) without success and chose not to have their bladder removed. The goal was to s…

This study looks at people with HPV-positive throat cancer that has spread but can still be removed with surgery. After surgery, some patients get the usual high-dose radiation plus chemo, while others get a lower dose. The goal is to see if the lower dose works just as well and …

This study tests whether a newer drug, letermovir, works better and causes fewer side effects than the standard drug valganciclovir for preventing CMV infection in African American kidney transplant recipients. About 30 high-risk patients will take letermovir for 6 months after t…

This study compares a shortened steroid regimen (8 days for moderate, 14 days for severe pneumonia) against the standard 21-day course in 196 HIV patients with Pneumocystis pneumonia. The goal is to see if the shorter treatment is non-inferior in preventing death and complication…

This study looks at whether the shingles vaccine is safe and works well in young adults (19 and older) who have had a solid organ transplant. About 80 participants will get two doses of the vaccine and be monitored for side effects and immune response. The goal is to help protect…

This early-stage study tests whether adding an experimental drug (VH3810109) with or without another drug (fostemsavir) to standard HIV therapy can reduce the hidden viral reservoir in people living with HIV. About 107 adults, either new to treatment or already on stable therapy,…

This study is testing the HIV medication Biktarvy (a combination of three drugs) in adolescents and children who have HIV-1. The goal is to see how the drug works in younger bodies, confirm the right dose, and check for side effects. About 177 participants will take the pill once…

This study tests a modified virus (BioTTT001) injected directly into brain tumors in 30 adults with recurrent high-grade glioma. The goal is to see if it is safe, how it spreads in the body, and whether it can help control the cancer. Participants will receive multiple injections…

This study tests a special treatment for red blood cells that aims to kill the Zika virus, making transfusions safer. About 692 people who need blood transfusions will receive either treated or standard blood. The goal is to see if the treated blood works just as well and is safe…

This study looks at whether having a nurse case manager helps people with multidrug-resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 patients in South Africa are involved. Half of the clinics have a nurse case manager to guide care, while the oth…

This Phase 3 trial tests whether people with HIV who are already well-controlled on daily pills can switch to a monthly injection of two drugs (cabotegravir and rilpivirine) and stay just as healthy. About 630 adults whose virus is suppressed on a standard three-drug pill regimen…

This study compares different HPV tests to find the best way to screen for cervical cancer in women living with HIV in Latin America. Over 1,000 participants will provide cervical, vaginal, and urine samples, plus undergo colposcopy and biopsies. The goal is to identify which tes…

This study compares self-collected vaginal samples to clinician-collected samples for HPV testing in 500 people referred for colposcopy. The goal is to see if self-collection is accurate enough to improve cervical cancer screening rates. Participants will provide both types of sa…

This study tests whether women can collect their own vaginal samples for HPV testing as accurately as a doctor's sample. It involves 750 women referred for colposcopy or cervical procedures. The goal is to see if self-collection is a reliable alternative to traditional pelvic exa…

This study is testing a blood test that looks for HPV DNA in the blood of people treated for HPV-positive oropharyngeal cancer. The goal is to see if the test can find cancer recurrence earlier than standard follow-up methods. About 150 participants are being followed after treat…

This study compares a new device, cureVision cV, to an existing one (MolecuLight i:X) to see if it can accurately detect moderate to high levels of bacteria in wounds. About 100 adults with various wound types (like diabetic foot ulcers or surgical wounds) will be enrolled. The g…

This study compares HPV testing on self-collected vaginal samples versus samples collected by a doctor during a pelvic exam. About 500 people referred for colposcopy or cervical procedures will provide both types of samples. The goal is to see if self-collection is accurate enoug…

This study planned to compare a rapid antigen detection test against the standard PCR test for diagnosing COVID-19 in people who were close contacts of infected patients but had no symptoms. The goal was to see if the quick, inexpensive antigen test could reliably identify contag…

This study is testing whether adding a blood test called the GAAD score to regular ultrasound scans can improve the detection of liver cancer in people at high risk, such as those with cirrhosis or chronic hepatitis. About 2,100 participants will get both tests every six months f…

This study evaluates a new blood test called Xpert Tropical Fever that can quickly detect several tropical diseases like malaria, dengue, and Zika from a small blood sample. Researchers will enroll 2,500 people with fever symptoms to see how accurate the test is compared to stand…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This study looks at how to keep a youth-friendly HIV self-testing program called 4YBY running in Nigeria. It will involve over 1,200 young people aged 14-24 who are at risk for HIV. Researchers will compare standard program delivery with an enhanced version that includes extra su…

This study tests whether a campaign designed and run by high school students can increase HPV vaccination in Chambers County, Alabama, which has the state's highest cervical cancer rate. Twenty-nine students will create and spread messages through multiple channels to encourage t…

This phase 3 trial tests whether giving antiviral medication to pregnant women with hepatitis B and their newborns can prevent the virus from passing to the baby. The study involves 450 women and their infants in Africa. The goal is to find a safe and effective way to reduce moth…

This study tests two counseling programs to help women who use drugs in Tanzania start and stay on PrEP, an HIV prevention pill. 200 women will be randomly assigned to receive either brief motivational counseling, the same plus extra mental health support, or standard information…

This study tests a new shot called lenacapavir, given once a year, to see if it can safely prevent HIV in people at risk. About 350 participants will receive the injection and be monitored for side effects and drug levels. If successful, this could offer a much more convenient op…

This study tests a program called ZAIMARA that brings together adolescent girls (ages 15-19) and their mother figures for a two-day workshop. The goal is to improve communication about HIV, sexually transmitted infections, and PrEP, and to increase HIV testing and prevention. Res…

This phase 3 trial is testing whether a single dose of CD388, a long-acting antiviral injection, can prevent the flu in 10,000 adults and teens at higher risk of complications. Participants receive either CD388 or a placebo and are monitored for flu-like illness over 24 weeks. Th…

This study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…

This study tests whether providing HIV prevention (PrEP) and hepatitis C treatment together at one location works better than sending patients to separate clinics. About 446 people who inject drugs will be randomly assigned to either on-site integrated care or off-site referrals …

This study tests a new option for preventing HIV: a shot given under the skin every 6 months, called lenacapavir. It compares how well people stick with the shot versus taking a daily pill (Truvada). About 268 people at higher risk for HIV will take part. The goal is to see if th…

This study looks at whether giving girls aged 9-14 two different HPV vaccines in a sequence is safe and boosts immunity. The researchers will measure antibody levels and side effects in 400 participants. The goal is to see if this approach can improve protection against HPV, whic…

This study is testing a web-based platform called Jom-TestPlus that lets transgender women in Malaysia order HIV self-test kits online and get real-time counseling. The goal is to help them quickly connect to HIV prevention or treatment services. Fifty participants will use the p…

This study is testing a web-based platform called Jom-TestPlus for men who have sex with men in Malaysia. The platform offers HIV self-testing, real-time online counseling, and help connecting to prevention or treatment services. Researchers want to see if this approach increases…

This study tests a new drug called VYD2311, a monoclonal antibody that blocks the COVID-19 virus from entering cells. About 1,770 adults and teens aged 12 and older receive either VYD2311 or a placebo as a monthly shot for 3 months. The goal is to see if it safely prevents COVID-…

This study adapts an existing HIV prevention program, Many Men Many Voices, into a version called LAFIYA for young sexual minority men living in slums in Ghana. The goal is to reduce stigma and increase the use of HIV self-testing kits. Researchers will test whether the program i…

This study tests whether offering women a simple self-collection kit for HPV testing at Express Care clinics (which have evening and weekend hours) increases cervical cancer screening rates. About 500 women aged 30–63 who are overdue for screening will either receive usual care o…

This study tests whether a clinic-based outreach program can help more rural parents get their children (ages 9-17) the HPV vaccine. Researchers are working with 1,455 families at community clinics in the Mountain West. The goal is to see if simple communication and engagement st…

This phase 3 study tests a 9-valent HPV vaccine (V503) in 6,000 Chinese women aged 20-45 to see if it prevents persistent infection and cervical disease from five additional HPV types compared to the current 4-valent vaccine. Participants receive either the new vaccine or Gardasi…

This study is testing a mobile-friendly app called DASH that provides information and guidance about PrEP (a daily pill that prevents HIV) to people who have used an HIV self-test kit. The app helps users explore their values and make informed decisions about starting PrEP, with …

This study tests whether trained peer navigators, connecting with students through a mobile health app, can increase the use of HIV prevention pills (PrEP) and contraception among sexually active female university students aged 18-24 in Zambia. 324 participants will be randomly a…

This study looks at better ways to find and prevent tuberculosis (TB) in people living with HIV. Researchers will test a new screening method and offer patients a choice of TB preventive medicines with extra support like text reminders. The goal is to improve TB detection and hel…

This study tests whether offering lottery-based rewards for saving money can help Kenyan men reduce behaviors that raise their risk for HIV and other STIs. About 1,500 men aged 18-39 who drink alcohol and have paid for sex in the past will be split into two groups. One group gets…

This study is testing whether the MVA-BN mpox vaccine is safe and triggers a strong immune response in 600 adults living with HIV in Kinshasa, DRC. Participants receive two vaccine doses 28 days apart and are grouped by their CD4 count. The goal is to see if the vaccine works wel…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was designed as a randomized trial but was withdrawn before enrolling any participants. No results are available.

This study tests a program to help HIV-positive adults get the HPV vaccine, which can prevent HPV-related cancers. The program gives clinics and staff tools to encourage vaccination. Researchers will track how many people start and finish the vaccine series over two years.

This study tests whether nurse-navigators can help adolescent girls and young women in Kenya start and continue taking PrEP, a daily medication that prevents HIV. About 1,900 participants will get PrEP at local pharmacies after buying birth control, and half will also receive ext…

This study tests whether offering HIV prevention medication (PrEP) through telehealth visits at local health departments helps more people who inject drugs start and stay on PrEP compared to standard education and referrals. Eighty participants in rural Appalachia will be randoml…

This study tests different support strategies to help people who inject drugs in rural areas start and continue taking PrEP, a daily pill that prevents HIV. About 424 participants from three syringe service programs will be randomly assigned to receive either peer-led counseling …

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

This phase 3 study tested a daily pill called F/TAF (Descovy) to prevent HIV infection in nearly 5,400 men and transgender women who have sex with men and are at high risk. Participants took either F/TAF or the existing prevention drug Truvada. The goal was to see if F/TAF is as …

This study tests a personalized support program (C4) to help Black men who have sex with men take their HIV prevention medication (PrEP) consistently. About 350 men will either get the program or standard care. The program addresses personal needs like mental health and housing t…

This study tests whether adding trauma-coping lessons to a relationship skills program helps teens aged 13-19 in Miami avoid unprotected sex and pregnancy. Nearly 1,000 youth will be split into three groups: one gets the combined program, one gets relationship skills only, and a …

This study compares a 5-day versus a 10-day course of oseltamivir (Tamiflu) to prevent influenza in people exposed to the virus while in the hospital. About 200 adults with flu risk factors will be randomly assigned to one of the two treatment lengths. The goal is to see if the s…

This study tests if giving the HPV vaccine to children at age 9-10, instead of the usual 11-12, leads to more kids getting fully vaccinated before they are exposed to the virus. The goal is to prevent HPV-related cancers later in life. About 3,100 children in Colorado and Califor…

This study tests whether a short educational session plus weekly text reminders can increase HPV vaccination rates among children of Mexican-American parents. About 672 parents will be randomly assigned to receive either education alone or education plus text reminders. The goal …

This trial tests whether training primary care clinics to better use HPV vaccine standing orders can increase vaccination rates in children ages 9-12. Some clinics receive communication training alone, while others also get help optimizing their standing orders. The study uses va…

This study works with primary care and reproductive health clinics to make it easier for women who inject drugs to get PrEP, a daily pill that prevents HIV. Researchers are testing a program where clinic staff get extra training and support to identify and prescribe PrEP to these…

This study tests whether a community-based communication program can increase flu vaccination rates among people over 65 in Can Tho City, Vietnam. The program includes direct counseling, weekly health tips via the Zalo app, and printed leaflets. Researchers will compare vaccinati…

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This study aimed to see if the BCG vaccine, originally for tuberculosis, could reduce the severity of COVID-19 in healthcare workers in Medellín, Colombia. It planned to give a single dose of BCG or a placebo to 0 participants (doctors, nurses, and nursing assistants) who were di…

This study tests whether giving a long-acting HIV prevention shot (lenacapavir) in community pharmacies is practical and acceptable. Seventy-five HIV-negative adults will receive the injection either twice a year or every three months, and researchers will track how many stay on …

This study tests whether a mobile app called LifeSkills can lower the number of new HIV infections among young transgender women aged 16-29 in the U.S. About 5,100 participants will use either the app or standard care, and their HIV status will be checked over time. The goal is t…

This study compares two low-burden strategies to increase HIV PrEP use among emergency department patients seeking care for sexual health issues. One strategy involves follow-up outreach after the visit, while the other offers a tele-sexual health visit during the ER stay. The go…

This study tested two ways to prevent HIV in over 5,000 adolescent girls and young women at risk. One group received a long-acting shot every six months, while others took daily pills. The goal was to see how well each method works to keep participants HIV-free.

This study tests several new mRNA-based flu vaccines in about 971 healthy adults aged 18 and older. The goal is to see how well they trigger an immune response and how safe they are compared to standard flu shots. Participants receive one dose of an experimental vaccine or a comp…

This early-stage trial is testing whether a new long-acting antiviral medicine called CD388 can be safely given at the same time as the high-dose flu vaccine. About 100 healthy adults aged 18 to 49 will receive either the vaccine plus CD388 or the vaccine plus a placebo. Research…

This study looks at how safe and effective nirsevimab is at preventing severe RSV in babies and young children. About 110 infants and toddlers up to 24 months old will receive the medicine as part of their regular care. Researchers will track side effects and how many children ge…

This study aimed to test whether the drug obeldesivir could safely prevent filovirus diseases like Ebola in people who had been exposed. It was designed for adults with known or suspected high-risk contact within the past 21 days. However, the study was withdrawn before enrolling…

This study looks at ways to help more teens in rural areas get the HPV vaccine, which can prevent certain cancers. Researchers are working with 203 primary care practices to test a program called PC TEACH. The goal is to make it easier for families to get the vaccine on time.

This study tests whether sending HIV self-test kits to men who have sex with men on a subscription basis encourages them to test more regularly. 240 participants in Hong Kong will receive reminders to test during a control period, then receive actual test kits during an intervent…

This study tests whether breathing techniques and meditation can help healthcare workers at MD Anderson Cancer Center reduce stress and improve lung health during the COVID-19 pandemic. One hundred participants will learn these techniques through videos and practice them at home.…

This study tests a program called PRISM that teaches teens with HIV how to manage stress, set goals, and build resilience. It involves three one-on-one sessions with a nurse. The goal is to see if the program is feasible and acceptable, and whether it reduces psychological distre…

This study compares two types of talk therapy—Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT)—for HIV/AIDS patients experiencing psychological distress. 72 adults on antiretroviral therapy will receive 8 weekly sessions of either therapy or standard…

This study tests whether a treatment called IVIG (intravenous immunoglobulin) can help with ongoing neurological symptoms after COVID-19, like dizziness, trouble walking, or memory problems. About 45 adults who had COVID-19 at least 12 weeks ago will receive either IVIG or a plac…

This study planned to test a single IV dose of peramivir against placebo in teens and adults with uncomplicated flu. The goal was to see if it could shorten flu symptoms like cough, sore throat, and fever. However, the trial was withdrawn before any participants were enrolled, so…

This study looks at whether a program that combines physical activity with support from a peer is acceptable and practical for women living with both HIV and high blood pressure. About 50 women aged 40 and older will take part. The goal is to see if women stick with the program a…

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This study tests a drug called bezisterim (NE3107) in 203 adults with long COVID who struggle with brain fog and fatigue. Participants take either the drug or a placebo twice daily for 84 days, and researchers measure changes in thinking, memory, and energy levels. The goal is to…

This study tests ORCHID, an online skills-building program designed to improve mental health and reduce the risk of dropping out of care for aging women with HIV who also have HPV. The program includes 8 online sessions and optional meetings with a navigator. The study aims to se…

This study tests whether a 10-week aerobic exercise program can improve physical function and reduce symptoms in adults still struggling after a COVID-19 infection. Participants will exercise three times a week and attend weekly education classes. The goal is to see if exercise h…

This study tests a personalized health pathway for 400 people with persistent COVID-19 symptoms lasting more than 12 weeks. Participants receive nurse follow-up and can choose workshops on disease management, anxiety, and fatigue. The goal is to see if this approach improves qual…

This small study is testing Corplex P, a device made from donated human umbilical cord tissue, to see if it helps heal wounds that won't close on their own, like diabetic foot ulcers. Ten people will receive the device as part of their standard wound care. Researchers will track …

This study tests a gentle electrical stimulation of the vagus nerve in the ear (taVNS) to reduce chronic joint pain in the legs caused by Chikungunya fever. 51 adults with pain lasting at least 3 months will be randomly assigned to taVNS, standard TENS, or a sham device. The goal…

This early-stage study tests different doses of an experimental flu medicine called TRX-100, taken alongside standard care, in 105 people with mild to moderate influenza. The main goals are to check safety and find the best dose. Researchers will also track how well it eases flu …

This study follows nearly 1,900 cancer patients who tested positive for COVID-19. Researchers collect blood samples, medical records, and images to see how the virus impacts their cancer treatment and overall health. The goal is to learn which factors make COVID-19 more severe in…

This study enrolls up to 10,000 cancer patients at the National Cancer Institute who are not on an active treatment research protocol. Participants receive standard medical care, including lab tests and scans, while researchers collect their health information to build a data rep…

This study follows over 8,600 women in Costa Rica who received the HPV vaccine (types 16 and 18) years ago, plus unvaccinated controls, to see how well the vaccine protects over time. Researchers are checking for cervical lesions, immune markers, and any increase in infections fr…

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study explores how low-level laser therapy (LLLT) affects skin stiffness and thickness. Researchers will use a special imaging system to track tiny skin movements in 20 healthy adults. The goal is to find the best laser settings for future wound healing treatments.

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study looks at HIV-infected adults who have been on antiretroviral therapy for a long time and have very low virus levels. Researchers want to see if the virus stays stable or changes over time. Participants visit the clinic every six months for blood tests and a special whi…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This study follows people with chronic hepatitis B or C for up to 10 years to track how the disease changes over time. A smaller group with hepatitis B will receive the drug tenofovir alafenamide for 2 years to see if it reduces liver stiffness. Participants provide blood samples…

This study tests whether a virtual training and peer-mentoring program called Project ECHO can help healthcare providers in Ethiopia improve cervical cancer screening and treatment for women living with HIV. The program focuses on using HPV self-sampling, a simpler screening meth…

This study tests a new AI-powered toolkit designed to help public health officials at local CDC offices respond more quickly to emerging infectious diseases such as COVID-19, mpox, influenza, and dengue. The toolkit combines data analysis, risk assessment, decision support, and e…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study looks at how HIV infection and aging impact the body's response to the Prevnar 13 vaccine, which protects against pneumococcal bacteria. Researchers will measure antibody levels in the lungs, nasal passages, and blood of participants aged 21-45 or 55-75, comparing thos…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This study investigates whether hospital caregivers working in COVID-19 patient areas are more likely to get infected than those in non-COVID areas. Researchers will take blood samples from participants on day 0, day 15, and day 30 to check for antibodies that signal past infecti…

This study tests whether training primary care providers on how to talk to patients about vaccines can increase flu and COVID-19 vaccination rates. Over 24,500 patients and their doctors at multiple clinics will take part. Doctors in some clinics will receive special communicatio…

This observational study follows 168 women living with HIV in Zimbabwe who have been treated for cervical pre-cancer. Researchers want to learn how often the disease comes back and whether HPV or DNA tests can predict recurrence. Participants will be monitored every six months fo…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This pilot study tracks 24 adults who were hospitalized for COVID-19. Researchers use diaphragm ultrasound to see how well the main breathing muscle works 3 and 6 months after leaving the hospital. The goal is to describe long-term breathing changes, not to test a treatment.

This study tracks 56 follicular lymphoma patients to see how long their COVID-19 and other vaccine immunity lasts while they receive chemotherapy and maintenance therapy. Researchers will collect blood samples at several time points to measure immune responses. The goal is to und…

This study looks at how chronic hepatitis B virus (HBV) infection affects natural killer (NK) cells, which are key immune cells that fight infections. Researchers will collect blood samples from 80 people with HBV and compare them to healthy donors. The goal is to understand why …

This study follows about 360 people with chronic hepatitis B who had a good response to the experimental drug bepirovirsen in earlier trials. No new drug is given; researchers simply monitor whether the response lasts over time. Participants may or may not continue standard antiv…

This study looks at whether a rapid HIV antibody test can detect when the virus rebounds in people taking antiretroviral therapy (ART). Researchers will analyze stored blood samples from 6100 HIV-positive individuals in the US and sub-Saharan Africa. They will compare antibody le…

This study aimed to see if the antibiotic doxycycline could protect people from severe COVID-19. Researchers planned to analyze health records of patients who took doxycycline for acne during the pandemic. However, the study was withdrawn before enrolling any participants, so no …

This study examines whether senescent cells—sometimes called 'zombie cells' that accumulate with age—contribute to Long-Hauler Syndrome, a condition where COVID-19 symptoms persist long after the initial infection. Researchers at Mayo Clinic will compare markers of cellular aging…

This study looks at HIV patients over 40 (or those on HIV therapy for over 10 years) who switched to either a three-drug or a two-drug antiretroviral regimen. Researchers will measure markers of inflammation in the blood and track how many patients develop other health conditions…

This study tests a strategy called EMPOWER that uses patient portals to send women educational materials about PrEP (medication that prevents HIV) and lets them easily schedule a doctor visit if interested. The goal is to see if this approach improves women's knowledge about PrEP…

This study tests a new digital tool called INCLUDE, designed to help clinics in Nepal identify and reduce stigma faced by people living with HIV. The tool includes a stigma assessment, a dashboard linking stigma to care data, and a library of stigma-reduction activities. Research…

This study follows 583 adults who recovered from COVID-19 or were close contacts. Researchers will track their health, mental well-being, and immune responses over 3 years to understand long-term effects and whether prior infection prevents reinfection. Participants undergo regul…

This study was designed to see if the drug raltegravir could reduce hidden HIV in immune cells (lymphocytes and monocytes) in people with HIV who already had undetectable virus levels. It planned to enroll adults aged 18-60 with well-controlled HIV. However, the study was withdra…

This study uses a special bronchoscopy technique called narrow band imaging to look at blood vessel patterns in the airways of people with COVID-19. Researchers will compare images from three groups: patients with COVID-19, patients with other lung infections, and patients with l…

This study looks at how COVID-19 impacts people with hepatocellular carcinoma, a type of liver cancer. Researchers will track infection rates and see how the virus affects liver function, cancer treatment, and overall health. About 23 participants from a French national liver can…

This study follows 98 elderly residents in French nursing homes to see how long their COVID-19 antibodies last. Researchers will also measure immune markers linked to aging to understand why some older people have weaker immune responses. The goal is to learn how to better protec…

This study looks at 300 patients with advanced liver scarring (cirrhosis) caused by hepatitis B or alcohol who have shown signs of getting better. Researchers want to understand what predicts this improvement and how long it lasts. The goal is to create clearer guidelines for whe…

This study checks if some people with HIV might be cured. Ten patients who have had undetectable HIV for at least 6 months will stop their antiretroviral therapy under close medical supervision. Doctors will watch for the virus to come back. The goal is to see if the infection is…

This study follows 300 adults in the Democratic Republic of the Congo who received either the MVA-BN or LC16m8 mpox vaccine as part of a national campaign. Researchers collect blood samples at several time points to measure how well the vaccines trigger and maintain antibodies ag…

This study tracked 81 critically ill COVID-19 patients admitted to a French intensive care unit. Researchers compared factors like age, medical history, and treatments to understand who becomes severely ill. The goal is to improve care for future patients.

This study planned to test a program called Lafiya (meaning 'Wellness') designed to reduce stigma and discrimination faced by young gay, bisexual, and other men who have sex with men living in Ghanaian slums. The goal was to see if the program could increase HIV testing, use of P…

This study follows about 100 healthy adults aged 18 to 29 who have had Epstein-Barr virus (EBV) in the past. Researchers collect blood and saliva samples over 6 to 12 months to see when the virus becomes active again and how the immune system responds. No treatments or vaccines a…

This study examines whether the COVID-19 pandemic increased frailty and muscle loss (sarcopenia) in people waiting for a liver transplant. Researchers will compare data from 208 patients assessed before and during the pandemic. The goal is to understand how the pandemic affected …

This study follows 300 families with children aged 2 to 6 years over three years to understand how ongoing stress might lead to weight gain. Researchers will measure stress hormones and behaviors to see what role they play. The goal is to learn, not to test a treatment, so no new…

This study planned to test telemonitoring for older adults (75+) in nursing homes with confirmed or probable COVID-19. The goal was to see if remote monitoring could improve healthcare management and reduce deaths within 30 days. However, the study was withdrawn before enrolling …

This study is testing whether a computer can automatically measure how much lung tissue is damaged in patients with severe breathing problems from COVID-19 or after surgery. Researchers will compare the computer's lung measurements to standard severity scores in 500 patients. The…

This study follows 1,520 mostly Black and Latino individuals and their households who had COVID-19 in New York City. Researchers will use surveys and medical records to track long-term health problems, and for 500 hospitalized patients, they will collect nasal swabs and blood sam…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This pilot study aimed to see if a home viral load test (TASSO device) is accurate and easy to use for people starting HIV treatment or trying to lower a high viral load. Participants would have collected samples at home and in the clinic. However, the study was withdrawn before …

This study looks at why people with HIV and certain cancers caused by KSHV (Kaposi sarcoma herpesvirus) may lose bone density faster. Researchers will review past CT scans and health records from 40 adults treated at the NIH between 2005 and 2020. The goal is to find factors link…

This study looks at whether a combination of two anti-HIV antibodies can keep the virus under control after people stop their daily HIV medications. Researchers will compare people who received the antibodies in a previous study to those who got a placebo. Participants will pause…

This study tracks 2,500 people with HIV in Brazil who are taking a common first-line treatment (tenofovir/lamivudine and dolutegravir) to see why some develop drug resistance. Researchers will test blood samples from those whose viral load remains detectable to look for resistanc…

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This study examines tissue from people who died after a COVID-19 infection to understand why some develop Long COVID. Researchers will look for signs of inflammation, scarring, blood clots, and tissue death in the body. The goal is to learn more about the long-term effects of the…

This study follows 298 older adults with HIV in Zambia to compare brain health between those who have had HIV for a long time (7+ years) and those with a shorter infection (1-2 years). Researchers will track memory, thinking, mental health, frailty, and nerve health over 6 years.…

This study follows 90 people who survived severe COVID-19 pneumonia and needed intensive care. Researchers will check their physical health, mental health, and quality of life at 3 months, 6 months, 1 year, and 5 years after leaving the ICU. The goal is to better understand the l…

This study collects blood samples and medical information from 201 adults diagnosed with COVID-19. The goal is to create a resource that researchers can use to study the virus and improve understanding of the disease. Participants provide samples and allow their health data to be…

This study tracks side effects and severe dengue cases in 2,000 people who already got the QDENGA dengue vaccine in Malaysia. No new vaccine is given—researchers simply collect health data from participants. The goal is to understand real-world safety and whether vaccinated peopl…

This study gives a single dose of bepirovirsen to 32 adults with hepatitis B, some with kidney disease and some healthy. Researchers measure how much drug gets into the blood and how long it stays. The goal is to see if kidney problems change drug levels, which could affect futur…

This study was designed to track how many healthcare workers at Lille University Hospital caught COVID-19 over 10 weeks. Researchers planned to test 100 workers every two weeks using nasal swabs and blood tests, along with questionnaires about their work and home exposures. The g…

This study aimed to collect medical information from people who developed unusual blood clots within four weeks of receiving a COVID-19 vaccine. The goal was to better understand any possible link between the vaccine and these rare events. However, the study was withdrawn before …

This study was designed to track how COVID-19 infection might worsen the condition of people with inherited metabolic diseases (IMD). Researchers planned to collect information from French patients with IMD who had or had COVID-19 to see how often their metabolic disease got wors…

This study follows 60 healthy Thai children and teens who received a single dose of a live-attenuated hepatitis A vaccine about a year ago. Researchers want to see how many still have protective antibodies and at what levels. The goal is to understand long-term immunity and help …

This study was designed to compare how often patients with severe COVID-19 developed lung infections while on a ventilator during the first and second waves of the pandemic. It was an observational study that would have looked back at patient records across European ICUs. However…

This study is creating a biobank of blood samples and health data from 100 people who have recovered from COVID-19. Researchers will use this information to better understand recovery and long-term effects. No new treatments are being tested; the goal is to provide resources for …

This study looks at whether cancer patients feel their doctors show more empathy during in-person visits with protective gear (PPE) or during video calls without it. About 107 adults from MD Anderson's emergency center will share their views after a conversation with their doctor…

This study follows 300 pregnant women who had respiratory infections to see if RSV can pass from mother to baby before birth. Researchers will test blood from mothers and umbilical cords for RSV antibodies and viruses. Babies will be tracked for up to 4 years to monitor respirato…

This study is a medical registry that follows over 21,000 adults hospitalized in 2021 at a Russian hospital. Researchers will analyze their health records, including chronic conditions, COVID-19 history, and outcomes like heart attacks or strokes, over five years. The goal is to …

This study looks at blood samples from 400 people with and without HIV to understand how aging and HIV infection change the body's immune response to the flu vaccine. Researchers will measure antibody levels and immune cell types to see who responds well to the vaccine and who do…

This study looks at heart problems in adults hospitalized with COVID-19. Researchers will review medical records to see how often heart issues like heart failure, inflammation, or arrhythmias occur. No new treatments are tested; the goal is to learn more about the virus's effects…

This study aims to understand why people who use drugs in Baltimore may be hesitant to get a COVID-19 vaccine. Researchers will interview 40 participants about their views and barriers to vaccination. The goal is to improve vaccine access and acceptance in this community.

This study looks at how well the HPV vaccine works in women living with HIV and whether self-collected HPV tests can improve cervical cancer screening. About 650 women will use a self-swab kit at home or in the clinic. Those with positive results will get follow-up exams. The goa…

This study follows 549 children, teens, and young adults with cancer to see how their immune systems respond to COVID-19 vaccines. Researchers collect blood samples to measure protective antibodies. The goal is to learn how cancer and its treatment affect vaccine effectiveness, a…

This study is checking how long the HPV vaccine protects women who received one, two, or three doses. Researchers are following about 946 women from an earlier trial in Costa Rica for up to 20 years after their shots. By testing blood samples, they hope to learn if one dose might…

This pilot study is testing whether two natural dietary supplements—taxifolin (found in apples and onions) and ergothioneine (found in mushrooms)—can improve immune function in healthy adults aged 50 to 65. Researchers will measure how well immune cells engulf and destroy threats…

This study looks at how four different FDA-approved flu vaccines affect the immune system in 50 adults aged 18-50 and 65-80. Researchers will measure antibody levels and memory B cells to see how age and past vaccination history influence the body's response. The goal is to under…

This study was designed to collect information on pregnancy and baby outcomes in women who received the PREHEVBRIO hepatitis B vaccine around the time of conception or during pregnancy. The goal was to watch for any safety concerns, such as miscarriage or birth defects. However, …

This study follows 319 people under 21 who developed heart inflammation (myocarditis or pericarditis) within 21 days of receiving the Comirnaty (Pfizer) COVID-19 vaccine. Researchers will monitor their heart function with imaging tests for up to 5 years to see if there are lastin…

This study tests whether AI-powered X-ray analysis and portable molecular tests can help find tuberculosis (TB) and COVID-19 cases in African communities where many cases go undetected. Over 26,000 adults will be screened using these tools, and researchers will measure how quickl…

This study looks at how the Shingrix vaccine, which protects against shingles, affects immune cells in the skin and blood. Researchers will give the vaccine to 50 healthy adults in two age groups: 30-40 years old and 70 years or older. They will measure specific antibodies and T-…

This study follows up on 220 children who received the EV71 vaccine (Envacgen®) or a placebo about 6 years ago. Researchers will measure antibody levels in the blood to see if protection against enterovirus 71, which causes hand-foot-mouth disease, has lasted. The goal is to unde…

This study planned to see if faster testing and treatment for hepatitis C could be given to inmates right when they enter prison. The goal was to start medication sooner to reduce the spread of the virus. However, the study was withdrawn and no one took part.

This study compares how well two FDA-approved COVID-19 vaccines—Novavax (a protein-based vaccine) and Pfizer (an mRNA vaccine)—trigger the immune system. Researchers will measure antibody levels against several virus variants in 54 healthy adults aged 18-79 who have risk factors …

This study is testing whether a smaller, one-fifth dose of the HPV vaccine, given into the skin instead of the muscle, can still trigger a good immune response in adults aged 27 to 45. Researchers are comparing two types of HPV vaccines in 40 volunteers in Seattle. The goal is to…

This study is collecting blood samples and health information from 1,613 HIV patients to learn more about the infection and how to improve care. Researchers will track heart and brain health, as well as other medical conditions. The goal is to use this knowledge to make HIV treat…

This study follows 500 children under 18 who tested positive for flu, RSV, or COVID-19. Each child takes a daily nose swab for 14 days to measure how the virus levels change over time. Researchers also check if family members get sick. The goal is to understand when kids are most…

This study follows 75 adults aged 65 and older over three to four flu seasons to learn why the flu vaccine becomes less effective as people age. Participants will receive a different FDA-approved flu vaccine each year, and researchers will collect blood, nasal swab, and stool sam…

This study looks at why more than half of people who recover from COVID-19 still feel very tired. Researchers are measuring fatigue in 398 adults using questionnaires and muscle tests. The goal is to better understand who is most affected and how severe the fatigue can be.

This study looks at 40 people with HIV to see if a common drug, tenofovir, causes more immune system activation and helps the virus hide better in the body. Participants are already on stable HIV treatment and will provide blood and gut samples. The goal is to find ways to reduce…

This study looks back at medical records of 50 adults who had a shingles virus infection in their brain or spinal cord. Researchers want to find out what makes some people more likely to get these serious infections and what leads to long-term problems like memory loss or seizure…

This study looks at how the COVID-19 pandemic impacted the quality of life of 274 cancer patients who also have neuropathy (nerve pain). All participants had taken part in earlier clinical trials. Researchers want to see if there are differences between those who received a brain…

This study was designed to test a new system that uses tiny silica particles on HIV medication (Biktarvy) and a smartphone app to help people track whether they have taken their pills. The goal was to see if the system is easy to use and accurate over 90 days. However, the study …

This study intentionally exposes healthy adults aged 18-40 who have had a COVID-19 vaccine or prior infection to the Omicron BA.5 virus via nasal drops. The goal is to find the safest dose that causes a mild, controlled infection in 50-75% of participants, while monitoring side e…

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 participants over several years to track changes in lung function. The goal is to better understand why some patients struggle wi…

This study aims to understand how the immune system responds to a second infection with a mild bird flu virus (H10N7). Healthy adults who were infected with H10N7 in a previous study will be infected again and monitored closely in the hospital for 9 days. The goal is to learn mor…

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' facilities, using medical records and lab data to forecast risks like frailty, …

This study looks at 57 people who received a COVID-19 vaccine to understand why some develop heart injury or myocarditis. Researchers use advanced heart scans (PET/MRI) and blood tests to find early warning signs. The goal is to better identify those at risk and improve follow-up…

This study aims to improve how we predict and prevent dengue outbreaks by looking at how people move around the city. Researchers in Cuba will collect information from 810 residents about their daily travel, along with mosquito and weather data. The goal is to build better comput…

This study tests a program called LIFT to help people who inject drugs in Kyrgyzstan face less stigma and lower their risk of HIV. About 80 participants will join peer-led group sessions to build support and learn how to use HIV prevention services. The goal is to see if the prog…

This study tests whether a WhatsApp chatbot can improve HIV knowledge in 314 adults recently diagnosed with HIV in Nigeria. Participants use the chatbot for information, reminders, and questions, while a control group receives standard care. The study also looks at effects on res…

This study is monitoring the safety of the Pfizer-BioNTech COVID-19 vaccine (BNT162b2) in 12,000 people in South Korea who received the vaccine as part of routine care. Researchers are tracking side effects like sore arms or fever within a week of each dose, as well as any other …

This study compares new, less invasive ways to collect samples for respiratory virus testing—like a nasal wash or saliva—against the standard deep nose swab. Researchers want to see if these gentler methods work just as well and cause less pain. About 1,000 adults in the emergenc…

This study tracks over 4,200 people in South Korea who received a SPIKEVAX COVID-19 vaccine to see if any side effects occur over time. Participants are aged 12 or older depending on the vaccine version. The goal is to gather real-world safety data, not to test if the vaccine wor…

This study looks at how well a long-acting HIV injection (CAB+RPV LA) works for people who live far from their doctor. About 55 patients and clinic staff will share their experiences through surveys and interviews over 15 months. The goal is to understand what helps or hinders ge…

This study reviews the records of up to 800,000 people who received the TAK-003 (Qdenga) dengue vaccine at VNVC centers in Vietnam between September 2024 and September 2025. Researchers will look at age, sex, location, and vaccination history to see who got the vaccine and how. N…

This study follows 200 people who have had the flu to see how their immune system changes over two years. Participants give blood and nasal samples every three months. The goal is to learn how long antibodies last and how they change, which could help create more effective flu va…

This study looks at medical records and follow-up data from 10 people living with HIV in four cities in southern Sichuan, China. The goal is to see how well HIV treatment is working by checking virus levels after 12 months. This is an observational study that does not test a new …

This study tests a program called ENHANCE-TTS that trains pharmacists at HIV clinics to provide tobacco treatment. Researchers will see if the program helps pharmacists offer more smoking cessation services and if it helps patients quit. About 172 people from six clinics will tak…

This study looks at whether taking the smallpox drug TPOXX changes how well the JYNNEOS vaccine works. About 100 healthy adults aged 18 to 42 will get two doses of the vaccine and either TPOXX or a placebo for 28 days. Researchers will check for side effects and measure immune re…

This study looks at whether temporarily reducing immunosuppressive medication can help kidney transplant recipients mount a stronger immune response to a third dose of the COVID-19 mRNA vaccine. Fourteen participants with low or no antibodies will have their antimetabolite dose l…

This study compares immune responses to flu and COVID-19 vaccines between people with chronic spinal cord injuries and healthy individuals. Researchers will analyze blood samples to see if gene activity and antibody levels differ between the groups. The goal is to understand why …

This study follows about 1,000 adults in the U.S. who test positive for COVID-19 or influenza. Participants fill out surveys about their symptoms and quality of life over six months. The goal is to understand how these illnesses affect daily activities and whether COVID-19 vaccin…

This study looks at organ changes in people recovering from COVID-19, comparing those with and without type 2 diabetes. Researchers will use scans to measure organ size and volume. The goal is to learn more about how COVID-19 affects the body long-term in diabetic patients.

This study looks at how opioid use affects the immune system's response to the flu vaccine in people with and without HIV. Researchers will analyze blood samples from 400 participants to measure antibody levels and immune cell activity. The goal is to understand why opioid users …

This study compares two flu vaccines: a nasal spray and a standard shot. Researchers will measure immune responses in the nose and blood of 60 healthy adults aged 18-49. The goal is to understand how each vaccine triggers protection and find ways to improve future flu vaccines.

This study follows 69 people infected with HTLV-1, some of whom have developed a rare blood cancer called adult T-cell leukemia/lymphoma. Researchers will track survival rates over 2 and 5 years, along with viral levels and genetic markers. The goal is to better understand how th…

This study reviews medical records of 50 adults who received a simultaneous liver-kidney transplant between 2015 and 2020. Researchers want to find out how many of them developed BK virus in their blood, which can harm the new kidney. The goal is to better understand this risk in…

This study collected data from 7,500 adults admitted to Swedish ICUs with COVID-19 during the first two years of the pandemic. Researchers looked at patient characteristics, treatments, and survival rates at 30 days and one year. The goal is to understand the disease's impact and…

This study tests whether changing how people interact in online social networks can improve their attitudes and intentions toward COVID-19 vaccination. Over 4,400 adults in the US with internet access will be placed into different online groups and answer health questions while s…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This trial is studying a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety. Participants will be monitored closely. The study sponsor and current status are not publicly available.